The Experts below are selected from a list of 198 Experts worldwide ranked by ideXlab platform
Archie Bleyer - One of the best experts on this subject based on the ideXlab platform.
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Breast Cancer in Adolescents and young adults
Pediatric Blood & Cancer, 2018Co-Authors: Rebecca H. Johnson, Carey K. Anders, Jennifer K. Litton, Kathryn J. Ruddy, Archie BleyerAbstract:Breast Cancer is the most common Cancer of Adolescents and young adult (AYA) women aged 15 to 39 years, accounting for 5.6% of all invasive breast Cancer in women. in comparison with older women, AYAs are more likely to have familial Cancer predisposition genes, larger breast tumors, unfavorable biological characteristics, distant metastatic disease at diagnosis, and adverse outcome. Endocrine therapy and some chemotherapy recommendations differ between young and older women. AYAs require coordinated multidisciplinary care, treatment regimens that minimize late effects such as premature menopause and osteoporosis, and proactive management of psychological and sexual health during and after Cancer treatment.
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Thyroid Cancer in Adolescents and young adults.
Pediatric Blood & Cancer, 2018Co-Authors: Maura Massimino, Douglas B. Evans, Marta Podda, Claudio Spinelli, Paola Collini, N. Pizzi, Archie BleyerAbstract:Despite the increase in thyroid Cancer incidence among Adolescents and young adults (AYAs), this group has received limited attention. We reviewed the epidemiology and challenges of thyroid Cancer care among AYAs, and proposed a research agenda to improve their care. Thyroid Cancer is the most common Cancer in American adults 16–33 years of age. AYAs with thyroid Cancer face challenges including overdiagnosis reduced healthcare access and inconsistent care. Successful treatment of these patients results in additional challenges due to ongoing side effects of treatment as well as lasting impacts on their quality of life. These challenges should fuel a collaborative research agenda aimed at improving the quality of care for AYAs with thyroid Cancer across the spectrum of diagnosis, treatment and survivorship.
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Synthetic Turf Fields, Crumb Rubber, and Alleged Cancer Risk
Sports Medicine, 2017Co-Authors: Archie BleyerAbstract:Most synthetic turf fields have crumb rubber interspersed among the simulated grass fibers to reduce athletic injuries by allowing users to turn and slide more readily as they play sports or exercise on the fields. Recently, the crumbs have been implicated in causing Cancer in Adolescents and young adults who use the fields, particularly lymphoma and primarily in soccer goalkeepers. This concern has led to the initiation of large-scale studies by local and federal governments that are expected to take years to complete. Meanwhile, should the existing synthetic turf fields with crumb rubber be avoided? What should parents, players, coaches, school administrators, and playground developers do? What should sports medicine specialists and other health professionals recommend? Use grass fields when weather and field conditions permit? Exercise indoors? Three basic premises regarding the nature of the reported Cancers, the latency of exposure to environmental causes of Cancer to the development of clinically detectable Cancer, and the rarity of environmental causation of Cancer in children, Adolescents, and young adults suggest otherwise.
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Erratum to: Cancer in Adolescents and Young Adults
Cancer in Adolescents and Young Adults, 2017Co-Authors: Archie Bleyer, Ronald D Barr, Lynn A. G. Ries, Jeremy Whelan, Andrea FerrariAbstract:in the original version for chapter 13, the chapter author name was wrongly given as James Trocoli. The name of the author should be read: James V. Tricoli in the original version for chapter 34, the chapter title was wrongly given as DRAFT: AYA Advocacy in Action-Achievements, Lessons, and Challenges from a Global Movement for Change The correct chapter title should be: AYA Advocacy in Action-Achievements, Lessons, and Challenges from a Global Movement for Change The above mentioned corrections also updated in Table of Contents
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Adolescent and Young Adult Oncology: Historical and Global Perspectives
Cancer in Adolescents and Young Adults, 2016Co-Authors: Ronald D Barr, Lynn A. G. Ries, Jeremy Whelan, Andrea Ferrari, Archie BleyerAbstract:Since the first edition of Cancer in Adolescents and Young Adults was published in 2007, there have been numerous milestones in the journey of adolescent and young adult (AYA) oncology. These include an expansion of the age range from 15–29 to 15–39 years and a commensurate increase in the number and scope of the constituent chapters.
Sidnei Epelman - One of the best experts on this subject based on the ideXlab platform.
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Cancer in Adolescents and Young Adults in Countries with Limited Resources
Current Oncology Reports, 2013Co-Authors: Ian Magrath, Sidnei EpelmanAbstract:Cancer in Adolescents and young adults (AYA) represents a higher fraction of all Cancer in countries that are still undergoing a demographic transition. Such countries tend to have much younger populations, and therefore unless they have a particularly low incidence of Cancer in this age group, will have a higher burden of Cancer (absolute number of cases with Cancer) in AYA. Cancers in AYA are comprised of the tail end of the incidence curve of Cancers that have their peak incidence, or occur almost exclusively in childhood, the beginning of the incidence curve of Cancers that primarily affect the elderly, and a third set of Cancers that have their peak incidence (or are at least common) in the AYA age group (e.g., testicular Cancer, sarcomas, melanoma, thyroid Cancer). Many, but not all, of these Cancers require radiation or Cancer surgery, but the poorest countries do not have a sufficient number of radiation therapy units and surgical oncologists, or indeed medical and pediatric oncologists, to deal with the burden of Cancer they face. The AYA age group is particularly important, both with regard to their contribution to the economy now and in the future (the majority are in the “working” age-group defined as 15–64 years), as well as their important role in caring for their families. Moreover, some of these Cancers are eminently curable with chemotherapy alone, and more could be cured by simply improving the efficiency of existing health services and providing education and training to both the public as well as oncologists and other specialists required for the care of AYA (although such individuals will not necessarily be exclusively concerned with this age group). Of particular importance is the detection and diagnosis of Cancer patients at the earliest possible time in the course of their disease. Avoiding delays in initiating therapy, which are partly due to the poverty and lack of education of the public as well as to a failure on the part of primary health care providers to recognize the possibility of Cancer, would lead not only to improved survival and less toxicity, but is likely to reduce the need for radiation as well as the cost of treatment. There are few good quality clinical trials that take place in the LMIC (in relationship to the extent of the existing Cancer burden), and research training should be an integral component of capacity building. Research on the efficacy and toxicity of standardized treatment approaches that are either based on principles established in the HIC, or adapted from treatment protocols used in the HIC, would be a good place to begin, but health policy and multisectoral collaboration are essential if improved survival rates are to be achieved. Decisions will also need to be made regarding the treatment of diseases in which radiation or Cancer surgery are important elements, when one or both of the latter are unavailable. Late effects are important in this young population in HIC, and protocol adaptations or design in LMIC should take into consideration the significant fraction of cured patients with late effects who were treated in HIC in an era where improving response and survival rates was the paramount consideration—the situation that applies today in less developed countries. Special adolescent units which better deal with psychological issues of young Cancer patients are rare in LMIC and the psychosocial issues faced by Adolescents are much less studied. Although survival is the first consideration, attention to psychosocial and financial issues may reduce existing delays in initiating therapy and also the fraction of patients that abandon therapy.
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Cancer in Adolescents and young adults in countries with limited resources
Current Oncology Reports, 2013Co-Authors: Ian Magrath, Sidnei EpelmanAbstract:Cancer in Adolescents and young adults (AYA) represents a higher fraction of all Cancer in countries that are still undergoing a demographic transition. Such countries tend to have much younger populations, and therefore un- less they have a particularly low incidence of Cancer in this age group, will have a higher burden of Cancer (absolute number of cases with Cancer) in AYA. Cancers in AYA are comprised of the tail end of the incidence curve of Cancers that have their peak incidence, or occur almost exclusively in childhood, the beginning of the incidence curve of can- cers that primarily affect the elderly, and a third set of Cancers that have their peak incidence (or are at least com- mon) in the AYA age group (e.g., testicular Cancer, sarco- mas, melanoma, thyroid Cancer). Many, but not all, of these Cancers require radiation or Cancer surgery, but the poorest countries do not have a sufficient number of radiation ther- apy units and surgical oncologists, or indeed medical and pediatric oncologists, to deal with the burden of Cancer they face. The AYA age group is particularly important, both with regard to their contribution to the economy now and in the future (the majority are in the "working" age-group defined as 15-64 years), as well as their important role in caring for their families. Moreover, some of these Cancers are eminently curable with chemother- apy alone, and more could be cured by simply improving the efficiency of existing health services and providing education and trainingto both the public as well as oncologists and other specialists required for the care of AYA (although such in- dividuals will not necessarily be exclusively concerned with this age group). Of particular importance is the detection and diagnosis of Cancer patients at the earliest possible time in the course of their disease. Avoiding delays in initiating therapy, which are partly due to the poverty and lack of education of the public as well as to a failure on the part of primary health care providers to recognize the possibility of Cancer, would lead not only to improved survival and less toxicity, but is likely to reduce the need for radiation as well as the cost of treatment. There are few good quality clinical trials that take place in the LMIC (in relationship to the extent of the existing Cancer burden), and research training should be an integral
Archie Bleyer - One of the best experts on this subject based on the ideXlab platform.
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Adolescent and young adult (aya) Cancers: distinct biology, different therapy?
2009Co-Authors: Archie BleyerAbstract:That Cancer may have a different biology in young adults and older Adolescents than in younger or older persons is becoming more evident. This review summarises recent reports that contain such data in five of the common types of Cancer in Adolescents and young adults: sarcomas, acute lymphoblastic and myelogenous leukaemia, colorectal and breast Cancer. The findings, along with those in other Cancers and with the unique array of Cancer types in Adolescents and young adults and their age-dependent incidence patterns, suggest that Cancer biology in the age group may be different more often than not. Regardless, there is now sufficient evidence to merit methodical research of the underlying biology of Cancer in young adults and older Adolescents, with the implication that Cancer therapy in the age group cannot be optimised until differences and similarities are established. initiatives underway to address this need include implementation of the US National Cancer institute Adolescent and Young Adult Oncology Program Review Group by the LiveStrong Young Adult Alliance, the Aflac/CureSearch Adolescent and Young Adult Cancer Research Program, the Children's Oncology Group Adolescent and Young Adult Committee and a combined effort of the US National Adult Cancer Cooperative Groups.
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older Adolescents with Cancer in north america deficits in outcome and research
Pediatric Clinics of North America, 2002Co-Authors: Archie BleyerAbstract:Abstract in the two decades from the mid 1970s to the mid 1990s, the proportion of 5-year survivors among children in North America with Cancer has increased nearly 40%. Advances in otherwise fatal leukemias, lymphomas, sarcomas, brain tumors, germ cell neoplasms and Cancer of the kidney account for much of the improvement. Unfortunately, older Adolescents have not fared as well. Their epidemiological, medical, physical, psychological and social needs remain largely unmet despite their age juxtaposition with younger patients whose outcomes have so much improved. in the United States and Canada, Cancer in Adolescents 15 to 19 years of age occurs at nearly twice the rate observed in 5 to 14 year-olds. Many of the types of Cancer that occur in older Adolescents are unique to this age group, and the pattern of distribution occurs at no other age interval. Overall, the Cancers in older Adolescents are more similar to the spectrum of Cancer in children than to the common types of Cancer in adults, but they are also distinctly different and require an age-specific approach. There is evidence of a lower degree in reduction in Cancer mortality in the United States and Canada in this age range than in younger or older persons. Moreover, the disparity appears to be increasing. The improvement in 5-year survival from diagnosis of Cancer from the mid 1970s to the early 1990s was lower than the rate of improvement in the younger age groups. Survival rates of older Adolescents with Cancer in the general population have not improved as much, especially in comparison with results of the national pediatric cooperative Cancer groups. in the United States and Canada, only about 5% of 15 to 25 year-olds with Cancer are entered onto clinical trials, in contrast to 60% to 65% of younger patients. Thus, Cancer during adolescence and early adulthood has been relatively neglected and merits enhanced national research programs and resources.
Ian Magrath - One of the best experts on this subject based on the ideXlab platform.
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Cancer in Adolescents and Young Adults in Countries with Limited Resources
Current Oncology Reports, 2013Co-Authors: Ian Magrath, Sidnei EpelmanAbstract:Cancer in Adolescents and young adults (AYA) represents a higher fraction of all Cancer in countries that are still undergoing a demographic transition. Such countries tend to have much younger populations, and therefore unless they have a particularly low incidence of Cancer in this age group, will have a higher burden of Cancer (absolute number of cases with Cancer) in AYA. Cancers in AYA are comprised of the tail end of the incidence curve of Cancers that have their peak incidence, or occur almost exclusively in childhood, the beginning of the incidence curve of Cancers that primarily affect the elderly, and a third set of Cancers that have their peak incidence (or are at least common) in the AYA age group (e.g., testicular Cancer, sarcomas, melanoma, thyroid Cancer). Many, but not all, of these Cancers require radiation or Cancer surgery, but the poorest countries do not have a sufficient number of radiation therapy units and surgical oncologists, or indeed medical and pediatric oncologists, to deal with the burden of Cancer they face. The AYA age group is particularly important, both with regard to their contribution to the economy now and in the future (the majority are in the “working” age-group defined as 15–64 years), as well as their important role in caring for their families. Moreover, some of these Cancers are eminently curable with chemotherapy alone, and more could be cured by simply improving the efficiency of existing health services and providing education and training to both the public as well as oncologists and other specialists required for the care of AYA (although such individuals will not necessarily be exclusively concerned with this age group). Of particular importance is the detection and diagnosis of Cancer patients at the earliest possible time in the course of their disease. Avoiding delays in initiating therapy, which are partly due to the poverty and lack of education of the public as well as to a failure on the part of primary health care providers to recognize the possibility of Cancer, would lead not only to improved survival and less toxicity, but is likely to reduce the need for radiation as well as the cost of treatment. There are few good quality clinical trials that take place in the LMIC (in relationship to the extent of the existing Cancer burden), and research training should be an integral component of capacity building. Research on the efficacy and toxicity of standardized treatment approaches that are either based on principles established in the HIC, or adapted from treatment protocols used in the HIC, would be a good place to begin, but health policy and multisectoral collaboration are essential if improved survival rates are to be achieved. Decisions will also need to be made regarding the treatment of diseases in which radiation or Cancer surgery are important elements, when one or both of the latter are unavailable. Late effects are important in this young population in HIC, and protocol adaptations or design in LMIC should take into consideration the significant fraction of cured patients with late effects who were treated in HIC in an era where improving response and survival rates was the paramount consideration—the situation that applies today in less developed countries. Special adolescent units which better deal with psychological issues of young Cancer patients are rare in LMIC and the psychosocial issues faced by Adolescents are much less studied. Although survival is the first consideration, attention to psychosocial and financial issues may reduce existing delays in initiating therapy and also the fraction of patients that abandon therapy.
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Cancer in Adolescents and young adults in countries with limited resources
Current Oncology Reports, 2013Co-Authors: Ian Magrath, Sidnei EpelmanAbstract:Cancer in Adolescents and young adults (AYA) represents a higher fraction of all Cancer in countries that are still undergoing a demographic transition. Such countries tend to have much younger populations, and therefore un- less they have a particularly low incidence of Cancer in this age group, will have a higher burden of Cancer (absolute number of cases with Cancer) in AYA. Cancers in AYA are comprised of the tail end of the incidence curve of Cancers that have their peak incidence, or occur almost exclusively in childhood, the beginning of the incidence curve of can- cers that primarily affect the elderly, and a third set of Cancers that have their peak incidence (or are at least com- mon) in the AYA age group (e.g., testicular Cancer, sarco- mas, melanoma, thyroid Cancer). Many, but not all, of these Cancers require radiation or Cancer surgery, but the poorest countries do not have a sufficient number of radiation ther- apy units and surgical oncologists, or indeed medical and pediatric oncologists, to deal with the burden of Cancer they face. The AYA age group is particularly important, both with regard to their contribution to the economy now and in the future (the majority are in the "working" age-group defined as 15-64 years), as well as their important role in caring for their families. Moreover, some of these Cancers are eminently curable with chemother- apy alone, and more could be cured by simply improving the efficiency of existing health services and providing education and trainingto both the public as well as oncologists and other specialists required for the care of AYA (although such in- dividuals will not necessarily be exclusively concerned with this age group). Of particular importance is the detection and diagnosis of Cancer patients at the earliest possible time in the course of their disease. Avoiding delays in initiating therapy, which are partly due to the poverty and lack of education of the public as well as to a failure on the part of primary health care providers to recognize the possibility of Cancer, would lead not only to improved survival and less toxicity, but is likely to reduce the need for radiation as well as the cost of treatment. There are few good quality clinical trials that take place in the LMIC (in relationship to the extent of the existing Cancer burden), and research training should be an integral
Lonnie K Zeltzer - One of the best experts on this subject based on the ideXlab platform.
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Psychosocial dimensions of Cancer in Adolescents and young adults.
Cancer, 2006Co-Authors: Elana E Evan, Lonnie K ZeltzerAbstract:Psychosocial research examining the impact of Cancer on Adolescents and young adults has focused mostly on domains relating to family, psychological/emotional impact and social effects. An overview of the evidence-based literature available in each of these domains is presented to highlight the trends and provide a basis for clinical application. A review of the research literature was conducted to summarize what is known regarding the psychosocial dimensions of Cancer in Adolescents and young adults. Key elements critical to the psychosocial adaptation of the Adolescents and young adults with Cancer, as well as later effects of the Cancer experience, are discussed in terms of clinical implications. A case example is utilized to demonstrate the application of what has been investigated empirically in regard to psychosocial dimensions of Cancer in young adults and Adolescents. Studies have identified various psychosocial challenges that Adolescents and young adults experience when faced with Cancer. Further research, incorporating the effects of treatment stage and developmental level of the patient on specific psychosocial dimensions of the Cancer experience, is needed. Evidence-based information regarding the influence and interaction of family, psychological and emotional state, and social status of Adolescents and young adults with Cancer can aid clinicians when developing psychosocial assessment and treatment approaches for these patients.
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psychosocial dimensions of Cancer in Adolescents and young adults
Cancer, 2006Co-Authors: Elana E Evan, Lonnie K ZeltzerAbstract:Psychosocial research examining the impact of Cancer on Adolescents and young adults has focused mostly on domains relating to family, psychological/emotional impact and social effects. An overview of the evidence-based literature available in each of these domains is presented to highlight the trends and provide a basis for clinical application. A review of the research literature was conducted to summarize what is known regarding the psychosocial dimensions of Cancer in Adolescents and young adults. Key elements critical to the psychosocial adaptation of the Adolescents and young adults with Cancer, as well as later effects of the Cancer experience, are discussed in terms of clinical implications. A case example is utilized to demonstrate the application of what has been investigated empirically in regard to psychosocial dimensions of Cancer in young adults and Adolescents. Studies have identified various psychosocial challenges that Adolescents and young adults experience when faced with Cancer. Further research, incorporating the effects of treatment stage and developmental level of the patient on specific psychosocial dimensions of the Cancer experience, is needed. Evidence-based information regarding the influence and interaction of family, psychological and emotional state, and social status of Adolescents and young adults with Cancer can aid clinicians when developing psychosocial assessment and treatment approaches for these patients. Cancer 2006. © 2006 American Cancer Society.
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Walking Two Worlds—Adolescent and Young Adult Oncology. Proceedings of a Symposium held by the Pediatric Oncology Group of Ontario
2006Co-Authors: Elana E Evan, Miriam Kaufman, Andrew B. Cook, Lonnie K ZeltzerAbstract:Psychosocial research examining the impact of Cancer on Adolescents and young adults has focused mostly on domains relating to family, psychological/emotional impact and social effects. An overview of the evidence-based literature available in each of these domains is presented to highlight the trends and provide a basis for clinical application. A review of the research literature was conducted to summarize what is known regarding the psychosocial dimensions of Cancer in Adolescents and young adults. Key elements critical to the psychosocial adaptation of the Adolescents and young adults with Cancer, as well as later effects of the Cancer experience, are discussed in terms of clinical implications. A case example is utilized to demonstrate the application of what has been investigated empirically in regard to psychosocial dimensions of Cancer in young adults and Adolescents. Studies have identified various psychosocial challenges that Adolescents and young adults experience when faced with Cancer. Further research, incorporating the effects of treatment stage and developmental level of the patient on specific psychosocial dimensions of the Cancer experience, is needed. Evidence-based information regarding the influence and interaction of family, psychological and emotional state, and social status of Adolescents and young adults with Cancer can aid clinicians when developing psychosocial assessment and treatment approaches for these patients. Cancer 2006;107(7 Suppl):1663–71. � 2006 American Cancer Society.
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Cancer in Adolescents and Young Adults Psychosocial Aspects
1993Co-Authors: Lonnie K ZeltzerAbstract:Survivors of Cancer diagnosed during adolescence and young adulthood have had to muster the resources to cope with Cancer treatment while accomplishing the tasks unique to this developmental period, tasks such as the accomplishment of economic and emotional independence, capacity for intimacy, solidification of career goals, and formation of a comfortable identity. Studies of survivors of childhood Cancer have not found major psychiatric disorders but have pointed out some adjustment difficulties, such as increased health concerns, worries about the development of second neoplasms, increased somatic complaints, and academic problems. Marriage may be delayed, and women, unlike men, worry about their fertility and the health of their future offspring. Survivors of both genders do not appear to be troubled by obvious-to-the-observer physical sequelae. Future studies should examine the quality of life issues pertinent to the successful accomplishment of adult tasks and should include assessment of the facilitators and impediments to carrying out these tasks, particularly during the transition from adolescence into young adulthood. The ultimate goal of the above assessments is to permit not only survival but quality survival. Cancer 1993; 71:3463-8.
