Cancer Invasion

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In Kyoung Lim - One of the best experts on this subject based on the ideXlab platform.

Yong Sik Jung - One of the best experts on this subject based on the ideXlab platform.

Hyukhoon Kim - One of the best experts on this subject based on the ideXlab platform.

Jong Yeop Kim - One of the best experts on this subject based on the ideXlab platform.

Dong Soon Choi - One of the best experts on this subject based on the ideXlab platform.

  • endometrial Cancer Invasion depends on Cancer derived tumor necrosis factor α and stromal derived hepatocyte growth factor
    International Journal of Cancer, 2009
    Co-Authors: Dong Soon Choi, Hyunjin Kim, Jonghyuck Yoon, Seungchul Yoo, So Yeon Lee, Churl K Min, Heesug Ryu
    Abstract:

    Cancer Invasion is an outcome of interactions of the Cancer and the host cell. It is now becoming increasingly clear that ovarian hormones have a huge influence on such intercommunications in various types of Cancers. Estrogen is known to aggravate the aggressiveness of the endometrial Cancer whereas progesterone seems to act as a negative factor. Insight into the mode of ovarian hormonal actions could come from the studies of its regulation of the paracrine interactions between the endometrial Cancer and the normal stromal cells during the Cancer Invasion. In this context, we report here that estrogen promotes the endometrial Cancer Invasion by inducing humoral interactions between the Cancer and the stromal cells, i.e., estrogen stimulates tumor necrosis factor-α expression from the endometrial Cancer cells, which, in turn, induces the stromal expression of hepatocyte growth factor (HGF), conferring the enhanced NK4 (HGF-antagonist/angiogenesis inhibitor)-sensitive Invasion characteristic of the endometrial Cancer cells. Additionally, we demonstrate a close correlation of the Invasion of endometrial Cancer cells with the expression and dimerization of integrin αvβ5 as well as the activation of focal adhesion kinase as the consequences of paracrine interactions. Thus, understanding of paracrine interactions of Cancer cells with host stromal cells can yield new insight into the architecture and function of Cancer Invasion and metastasis, leading to a development of a new Cancer therapeutic intervention. © 2008 Wiley-Liss, Inc.

  • Endometrial Cancer Invasion depends on Cancer‐derived tumor necrosis factor‐α and stromal derived hepatocyte growth factor
    International journal of cancer, 2008
    Co-Authors: Dong Soon Choi, Hyunjin Kim, Jonghyuck Yoon, Seungchul Yoo, So Yeon Lee, Churl K Min, Heesug Ryu
    Abstract:

    Cancer Invasion is an outcome of interactions of the Cancer and the host cell. It is now becoming increasingly clear that ovarian hormones have a huge influence on such intercommunications in various types of Cancers. Estrogen is known to aggravate the aggressiveness of the endometrial Cancer whereas progesterone seems to act as a negative factor. Insight into the mode of ovarian hormonal actions could come from the studies of its regulation of the paracrine interactions between the endometrial Cancer and the normal stromal cells during the Cancer Invasion. In this context, we report here that estrogen promotes the endometrial Cancer Invasion by inducing humoral interactions between the Cancer and the stromal cells, i.e., estrogen stimulates tumor necrosis factor-α expression from the endometrial Cancer cells, which, in turn, induces the stromal expression of hepatocyte growth factor (HGF), conferring the enhanced NK4 (HGF-antagonist/angiogenesis inhibitor)-sensitive Invasion characteristic of the endometrial Cancer cells. Additionally, we demonstrate a close correlation of the Invasion of endometrial Cancer cells with the expression and dimerization of integrin αvβ5 as well as the activation of focal adhesion kinase as the consequences of paracrine interactions. Thus, understanding of paracrine interactions of Cancer cells with host stromal cells can yield new insight into the architecture and function of Cancer Invasion and metastasis, leading to a development of a new Cancer therapeutic intervention. © 2008 Wiley-Liss, Inc.

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