The Experts below are selected from a list of 124317 Experts worldwide ranked by ideXlab platform
James M Pribble - One of the best experts on this subject based on the ideXlab platform.
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does local television news coverage cultivate fatalistic beliefs about Cancer Prevention
Journal of Communication, 2010Co-Authors: Jeff Niederdeppe, Erika Franklin Fowler, Kenneth M Goldstein, James M PribbleAbstract:Many U.S. adults hold fatalistic beliefs about Cancer Prevention despite evidence that a large proportion of Cancer deaths are preventable. We report findings from two studies that assess the plausibility of the claim that local television (TV) news cultivates fatalistic beliefs about Cancer Prevention. Study 1 features a content analysis of an October 2002 national sample of local TV and newspaper coverage about Cancer. Study 2 describes an analysis of the 2005 Annenberg National Health Communication Survey (ANHCS). Overall, findings are consistent with the claim that local TV news coverage may promote fatalistic beliefs about Cancer Prevention. We conclude with a discussion of study implications for cultivation theory and the knowledge gap hypothesis and suggest foci for future research.
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does local television news coverage cultivate fatalistic beliefs about Cancer Prevention
Journal of Communication, 2010Co-Authors: Jeff Niederdeppe, Erika Franklin Fowler, Kenneth M Goldstein, James M PribbleAbstract:A substantial proportion of American adults hold fatalistic beliefs about Cancer Prevention despite evidence that a large proportion of Cancer deaths are preventable. Several scholars suggest that news media coverage is one source of these beliefs, but scant evidence has been brought to bear on this assertion. We report findings from two studies that assess the plausibility of the claim that local television (TV) news cultivates fatalistic beliefs about Cancer Prevention. Study 1 features a content analysis of an October 2002 national sample of local TV and newspaper coverage about Cancer (n=122 television stations; n=60 newspapers). Study 2 describes an analysis of the 2005 Annenberg National Health Communication Survey (ANHCS, n=1,783 respondents). Study 1 indicates that local TV news stories were more likely than newspaper stories to mention Cancer causes and scientific research and less likely to provide follow-up information. Study 2 reveals that local TV news viewing was positively associated with fatalistic beliefs about Cancer Prevention. Overall, findings are consistent with the claim that local TV news coverage may promote fatalistic beliefs about Cancer Prevention. We conclude with a discussion of study implications for cultivation theory and the knowledge gap hypothesis and suggest foci for future research.
Masami Suganuma - One of the best experts on this subject based on the ideXlab platform.
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Primary Cancer Prevention by green tea, and tertiary Cancer Prevention by the combination of green tea catechins and antiCancer compounds.
Journal of cancer prevention, 2015Co-Authors: Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami SuganumaAbstract:Green tea is a daily beverage, a non-oxidized non-fermented product containing at least four green tea catechins. Considering our first results when repeated applications of (-)-epigallocatechin gallate (EGCG) prevented tumor promotion in mouse skin, we have continued to look at green tea as a possible Cancer preventive agent. 1) The 10-year prospective cohort study by Drs. K. Nakachi and K. Imai revealed that drinking 10 Japanese-size cups (120 mL/cup) of green tea per day delayed Cancer onset in humans by 7.3 years among females and by 3.2 years among males. The delay of Cancer onset is of course significant evidence of primary Cancer Prevention in humans. 2) In collaboration with Dr. H. Moriwaki's group we successfully presented a prototype of tertiary Cancer Prevention showing that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (G.T.E), reduced recurrence of colorectal adenomas in polypectomy patients by 51.6% (from 31% to 15%). 3) In 1999, we first reported that the combination of green tea catechins and non-steroidal anti-inflammatory drugs showed synergistic antiCancer effects in both in vitro and in vivo experiments, along with elucidation of the mechanism. 4) Further studies by other investigators have revealed that various combinations of EGCG or green tea extract and antiCancer compounds inhibit tumor volume in xenograft mouse models implanted with various human Cancer cell lines. Green tea is a Cancer preventive, and green tea catechins act as synergists with antiCancer compounds.
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challenging the effectiveness of green tea in primary and tertiary Cancer Prevention
Journal of Cancer Research and Clinical Oncology, 2012Co-Authors: Hirota Fujiki, Kazue Imai, Kei Nakachi, Masahito Shimizu, Hisataka Moriwaki, Masami SuganumaAbstract:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a Cancer preventive. We here review our progress in Cancer Prevention with green tea on 12 main topics, from basic to clinical level. Biochemical and biological studies of green tea catechins, a prospective cohort study, preclinical safety trials with tablets of green tea extract, double-blind randomized clinical phase II Prevention trial for recurrence of colorectal adenomas, and synergistically enhanced inhibition by the combination of green tea catechins and antiCancer drugs. All results were significant, including human studies with informed consent. Drinking 10 Japanese-size cups of green tea per day delayed the Cancer onset of humans 7 years for females. For tertiary Cancer Prevention, consuming 10 cups of green tea per day fortified by green tea tablets, 50 %, significantly prevented the recurrence of colorectal adenomas. A minimum effective amount of green tea catechins for Cancer Prevention was found in humans. In addition, the combination of green tea catechins and antiCancer drugs engendered a new Cancer therapeutic strategy. The consumption of 10 Japanese-size cups of green tea per day is a significant factor in primary Cancer Prevention for the general population, and the preventive effect on recurrence of colorectal adenomas in patients is vital evidence in tertiary Cancer Prevention.
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a new process of Cancer Prevention mediated through inhibition of tumor necrosis factor α expression
Cancer Research, 1996Co-Authors: Masami Suganuma, Eisaburo Sueoka, Naoyuki Iida, Atsumasa Komori, Sachiko Okabe, Hirota FujikiAbstract:Abstract Mechanisms of Cancer Prevention were studied using structurally different Cancer-preventive agents, sarcophytol A, canventol, (-)-epigallocatechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor α (TNF-α) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF -α mRNA expression and TNF-α release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c- jun , jun B, c- fos , and fos B) was enhanced. These results strongly suggest that inhibition of TNF -α mRNA expression and its release is a new process of Cancer Prevention.
Jeff Niederdeppe - One of the best experts on this subject based on the ideXlab platform.
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does local television news coverage cultivate fatalistic beliefs about Cancer Prevention
Journal of Communication, 2010Co-Authors: Jeff Niederdeppe, Erika Franklin Fowler, Kenneth M Goldstein, James M PribbleAbstract:Many U.S. adults hold fatalistic beliefs about Cancer Prevention despite evidence that a large proportion of Cancer deaths are preventable. We report findings from two studies that assess the plausibility of the claim that local television (TV) news cultivates fatalistic beliefs about Cancer Prevention. Study 1 features a content analysis of an October 2002 national sample of local TV and newspaper coverage about Cancer. Study 2 describes an analysis of the 2005 Annenberg National Health Communication Survey (ANHCS). Overall, findings are consistent with the claim that local TV news coverage may promote fatalistic beliefs about Cancer Prevention. We conclude with a discussion of study implications for cultivation theory and the knowledge gap hypothesis and suggest foci for future research.
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does local television news coverage cultivate fatalistic beliefs about Cancer Prevention
Journal of Communication, 2010Co-Authors: Jeff Niederdeppe, Erika Franklin Fowler, Kenneth M Goldstein, James M PribbleAbstract:A substantial proportion of American adults hold fatalistic beliefs about Cancer Prevention despite evidence that a large proportion of Cancer deaths are preventable. Several scholars suggest that news media coverage is one source of these beliefs, but scant evidence has been brought to bear on this assertion. We report findings from two studies that assess the plausibility of the claim that local television (TV) news cultivates fatalistic beliefs about Cancer Prevention. Study 1 features a content analysis of an October 2002 national sample of local TV and newspaper coverage about Cancer (n=122 television stations; n=60 newspapers). Study 2 describes an analysis of the 2005 Annenberg National Health Communication Survey (ANHCS, n=1,783 respondents). Study 1 indicates that local TV news stories were more likely than newspaper stories to mention Cancer causes and scientific research and less likely to provide follow-up information. Study 2 reveals that local TV news viewing was positively associated with fatalistic beliefs about Cancer Prevention. Overall, findings are consistent with the claim that local TV news coverage may promote fatalistic beliefs about Cancer Prevention. We conclude with a discussion of study implications for cultivation theory and the knowledge gap hypothesis and suggest foci for future research.
Donna P Ankerst - One of the best experts on this subject based on the ideXlab platform.
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prostate Cancer Prevention trial risk calculator 2 0 for the prediction of low vs high grade prostate Cancer
Urology, 2014Co-Authors: Donna P Ankerst, Josef Hoefler, Sebastian Bock, Phyllis J Goodman, Andrew J Vickers, Javier Hernandez, Lori J Sokoll, Martin G Sanda, John T WeiAbstract:Objective To modify the Prostate Cancer Prevention Trial risk calculator (PCPTRC) to predict low- vs high-grade (Gleason grade ≥7) prostate Cancer and incorporate percent free–prostate-specific antigen (PSA). Methods Data from 6664 Prostate Cancer Prevention Trial placebo arm biopsies (5826 individuals), where prostate-specific antigen and digital rectal examination results were available within 1 year before the biopsy and PSA was ≤10 ng/mL, were used to develop a nominal logistic regression model to predict the risk of no vs low-grade (Gleason grade Results Of all the Prostate Cancer Prevention Trial biopsies, 5468 (82.1%) were negative for prostate Cancer, 942 (14.1%) detected low-grade, and 254 (3.8%) detected high-grade disease. Significant predictors were (log base 2) PSA (odds ratio for low-grade vs no Cancer, 1.29*; high-grade vs no Cancer, 2.02*; high-grade vs low-grade Cancer, 1.57*), digital rectal examination (0.96, 1.49*, 1.55*, respectively), age (1.02*, 1.05*, 1.03*, respectively), African American race (1.13, 2.83*, 2.51*, respectively), prior biopsy (0.63*, 0.81, 1.27, respectively), and family history (1.31*, 1.25, 0.95, respectively), where * indicates P value Conclusion By differentiating the risk of low- vs high-grade disease on biopsy, PCPTRC 2.0 better enables physician-patient counseling concerning whether to proceed to biopsy.
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validation in a multiple urology practice cohort of the prostate Cancer Prevention trial calculator for predicting prostate Cancer detection
The Journal of Urology, 2009Co-Authors: Stephen Eyre, Donna P Ankerst, Prakash V Nair, Meredith M Regan, Gerrardina Bueti, Jeffrey Tang, Mark A Rubin, Michael C Kearney, Ian M ThompsonAbstract:Purpose: The Prostate Cancer Prevention Trial prostate Cancer risk calculator was developed in a clinical trial cohort that does not represent men routinely referred for prostate biopsy. We assessed the generalizability of the Prostate Cancer Prevention Trial calculator in a cohort more representative of patients referred for consideration of prostate biopsy in American urology practice.Materials and Methods: Patients undergoing prostate biopsy by 12 urologists at 5 sites were enrolled in an Early Detection Research Network cohort. The Prostate Cancer Prevention Trial risk calculator was validated by examining area underneath the receiver operating characteristic curve, sensitivity, specificity and calibration comparing observed vs predicted risk of prostate Cancer detection.Results: Cancer incidence was greater (43% vs 22%, p = 0.001) in the Early Detection Research Network validation cohort (645) compared to the Prostate Cancer Prevention Trial group (5,519). Early Detection Research Network participant...
Hirota Fujiki - One of the best experts on this subject based on the ideXlab platform.
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Primary Cancer Prevention by green tea, and tertiary Cancer Prevention by the combination of green tea catechins and antiCancer compounds.
Journal of cancer prevention, 2015Co-Authors: Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami SuganumaAbstract:Green tea is a daily beverage, a non-oxidized non-fermented product containing at least four green tea catechins. Considering our first results when repeated applications of (-)-epigallocatechin gallate (EGCG) prevented tumor promotion in mouse skin, we have continued to look at green tea as a possible Cancer preventive agent. 1) The 10-year prospective cohort study by Drs. K. Nakachi and K. Imai revealed that drinking 10 Japanese-size cups (120 mL/cup) of green tea per day delayed Cancer onset in humans by 7.3 years among females and by 3.2 years among males. The delay of Cancer onset is of course significant evidence of primary Cancer Prevention in humans. 2) In collaboration with Dr. H. Moriwaki's group we successfully presented a prototype of tertiary Cancer Prevention showing that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (G.T.E), reduced recurrence of colorectal adenomas in polypectomy patients by 51.6% (from 31% to 15%). 3) In 1999, we first reported that the combination of green tea catechins and non-steroidal anti-inflammatory drugs showed synergistic antiCancer effects in both in vitro and in vivo experiments, along with elucidation of the mechanism. 4) Further studies by other investigators have revealed that various combinations of EGCG or green tea extract and antiCancer compounds inhibit tumor volume in xenograft mouse models implanted with various human Cancer cell lines. Green tea is a Cancer preventive, and green tea catechins act as synergists with antiCancer compounds.
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challenging the effectiveness of green tea in primary and tertiary Cancer Prevention
Journal of Cancer Research and Clinical Oncology, 2012Co-Authors: Hirota Fujiki, Kazue Imai, Kei Nakachi, Masahito Shimizu, Hisataka Moriwaki, Masami SuganumaAbstract:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a Cancer preventive. We here review our progress in Cancer Prevention with green tea on 12 main topics, from basic to clinical level. Biochemical and biological studies of green tea catechins, a prospective cohort study, preclinical safety trials with tablets of green tea extract, double-blind randomized clinical phase II Prevention trial for recurrence of colorectal adenomas, and synergistically enhanced inhibition by the combination of green tea catechins and antiCancer drugs. All results were significant, including human studies with informed consent. Drinking 10 Japanese-size cups of green tea per day delayed the Cancer onset of humans 7 years for females. For tertiary Cancer Prevention, consuming 10 cups of green tea per day fortified by green tea tablets, 50 %, significantly prevented the recurrence of colorectal adenomas. A minimum effective amount of green tea catechins for Cancer Prevention was found in humans. In addition, the combination of green tea catechins and antiCancer drugs engendered a new Cancer therapeutic strategy. The consumption of 10 Japanese-size cups of green tea per day is a significant factor in primary Cancer Prevention for the general population, and the preventive effect on recurrence of colorectal adenomas in patients is vital evidence in tertiary Cancer Prevention.
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a new process of Cancer Prevention mediated through inhibition of tumor necrosis factor α expression
Cancer Research, 1996Co-Authors: Masami Suganuma, Eisaburo Sueoka, Naoyuki Iida, Atsumasa Komori, Sachiko Okabe, Hirota FujikiAbstract:Abstract Mechanisms of Cancer Prevention were studied using structurally different Cancer-preventive agents, sarcophytol A, canventol, (-)-epigallocatechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor α (TNF-α) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF -α mRNA expression and TNF-α release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c- jun , jun B, c- fos , and fos B) was enhanced. These results strongly suggest that inhibition of TNF -α mRNA expression and its release is a new process of Cancer Prevention.
