The Experts below are selected from a list of 455124 Experts worldwide ranked by ideXlab platform
John W Waterbor - One of the best experts on this subject based on the ideXlab platform.
-
an evaluation methodology for longitudinal studies of short term Cancer Research training programs
Journal of Cancer Education, 2016Co-Authors: Luz A Padilla, Raam Venkatesh, Casey L Daniel, Renee A Desmond, Michael C Brooks, John W WaterborAbstract:The need to familiarize medical students and graduate health professional students with Research training opportunities that cultivate the appeal of Research careers is vital to the future of Research. Comprehensive evaluation of a Cancer Research training program can be achieved through longitudinal tracking of program alumni to assess the program’s impact on each participant’s career path and professional achievements. With advances in technology and smarter means of communication, effective ways to track alumni have changed. In order to collect data on the career outcomes and achievements of nearly 500 short-term Cancer Research training program alumni from 1999–2013, we sought to contact each alumnus to request completion of a survey instrument online, or by means of a telephone interview. The effectiveness of each contact method that we used was quantified according to ease of use and time required. The most reliable source of contact information for tracking alumni from the early years of the program was previous tracking results, and for alumni from the later years, the most important source of contact information was university alumni records that provided email addresses and telephone numbers. Personal contacts with former preceptors were sometimes helpful, as were generic search engines and people search engines. Social networking was of little value for most searches. Using information from two or more sources in combination was most effective in tracking alumni. These results provide insights and tools for other Research training programs that wish to track their alumni for long-term program evaluation.
-
career outcomes of graduates of r25e short term Cancer Research training programs
Journal of Cancer Education, 2016Co-Authors: Renee A Desmond, Luz A Padilla, Raam Venkatesh, Casey L Daniel, Michael C Brooks, Charles T Prickett, John W WaterborAbstract:The efficacy of short-term Cancer Research educational programs in meeting its immediate goals and long-term Cancer Research career objectives has not been well studied. The purpose of this report is to describe the immediate impact on, and the long-term career outcomes of, 499 medical students and graduate students who completed the Cancer Research Experiences for Students (CaRES) program at the University of Alabama at Birmingham (UAB) from 1999 to 2013. In summer 2014, all 499 program alumni were located and 96.4 % (481 of 499) agreed to complete a longitudinal tracking survey. About 23 % of CaRES alumni (110 of 499) have published at least one Cancer-related paper. Overall 238 Cancer-related papers have been published by CaRES alumni, one third of this number being first-authored publications. Nearly 15 % (71 of 481 respondents) reported that their current professional activities include Cancer Research, primarily clinical Research and outcomes Research. Of these 71 individuals, 27 (38 %) have completed their training and 44 (62 %) remain in training. Of all respondents, 58 % reported that they administered care to Cancer patients and 30 % reported other Cancer-related professional responsibilities such as working with a health department or community group on Cancer control activities. Of the 410 respondents not currently engaged in Cancer Research, 118 (29 %) stated intentions to conduct Cancer Research in the next few years. Nearly all respondents (99.6 %) recommended CaRES to today’s students. Challenging short-term educational Cancer Research programs for medical students and graduate health professional students can help them refine and solidify their career plans, with many program alumni choosing Cancer Research careers.
Erinn B Rankin - One of the best experts on this subject based on the ideXlab platform.
-
genomics and molecular mechanisms of high grade serous ovarian Cancer the 12th biennial rivkin center ovarian Cancer Research symposium
International Journal of Gynecological Cancer, 2019Co-Authors: Erinn B RankinAbstract:Objective The aim of this study was to review current Research efforts in genomics and molecular mechanisms of high grade serous ovarian Cancer, presented at the 12th Biennial Rivkin Center Ovarian Cancer Research Symposium, held at the University of Washington. Methods The 12th Biennial Rivkin Center Ovarian Cancer Research Symposium brought together leaders in the field to discuss recent advances in ovarian Cancer Research and therapy. Results The genomics and molecular mechanisms of ovarian Cancer session featured invited speaker presentations by Dr Alan D’ Andrea on ‘Deoxyribonucleic acid (DNA) repair in ovarian Cancer’ and Dr Kathleen Cho on ‘Modeling the genomics of high grade serous carcinoma in the mouse’. Eight additional oral presentations and 46 poster presentations were selected from the submitted abstracts that highlighted current Research efforts in p53, DNA repair, genomic instability and modeling disease in mice, and organoids in high grade serous ovarian Cancer. Conclusions New technologies utilizing clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (CAS9) approaches in mice, organoids, and cell based screens continue to advance our knowledge of key molecular drivers of ovarian Cancer initiation, progression, and drug resistance. Improved understanding of the mechanisms of poly ADP ribose polymerase inhibitor resistance may lead to new therapeutic strategies to enhance outcomes in women with high grade serous ovarian Cancer.
Fred K Tabung - One of the best experts on this subject based on the ideXlab platform.
-
adherence to the world Cancer Research fund american institute for Cancer Research 2018 recommendations for Cancer prevention and risk of colorectal Cancer
Cancer Epidemiology Biomarkers & Prevention, 2019Co-Authors: Joshua Petimar, Edward Giovannucci, Stephanie A Smithwarner, Bernard Rosner, Andrew T Chan, Fred K TabungAbstract:Background: The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 2018 diet, nutrition, and physical activity recommendations aim to reduce Cancer risk. We examined adherence to the WCRF/AICR recommendations and colorectal Cancer risk in two prospective cohorts. Methods: We followed 68,977 women in the Nurses9 Health Study and 45,442 men in the Health Professionals Follow-up Study from 1986 until 2012. We created cumulatively averaged WCRF/AICR scores using updated diet, adiposity, and physical activity data from questionnaires, and used Cox regression to estimate sex-specific HRs and 95% confidence intervals (CI) for incident colorectal Cancer. Results: We documented 2,449 colorectal Cancer cases. Men in the highest quintile of the WCRF/AICR lifestyle score had a lower risk of colorectal Cancer compared with those in the lowest quintile (HRQ5vsQ1 = 0.64; 95% CI, 0.52–0.77). The result was weaker in women (HRQ5vsQ1 = 0.86; 95% CI, 0.72–1.02; Pheterogeneity by sex = 0.006). When analyzing the diet recommendations alone, we similarly observed stronger inverse associations in men (HRQ5vsQ1 = 0.74; 95% CI, 0.61–0.90) compared with women (HRQ5vsQ1 = 0.93; 95% CI, 0.77–1.12; Pheterogeneity by sex = 0.06). In men, the lifestyle score was more strongly inversely associated with risk of distal colon Cancer compared with proximal colon or rectal Cancer (Pcommon effects = 0.03); we did not observe significant differences between anatomic locations in women. Conclusions: The 2018 WCRF/AICR Cancer prevention recommendations are associated with lower colorectal Cancer risk in men, with weaker results in women. Impact: Consideration of adiposity and physical activity in conjunction with diet is important for colorectal Cancer prevention.
Judy Mouchawar - One of the best experts on this subject based on the ideXlab platform.
-
building a Research consortium of large health systems the Cancer Research network
Journal of The National Cancer Institute Monographs, 2005Co-Authors: Edward H. Wagner, Mark C Hornbrook, Gene Hart, Christine Cole Johnson, Suzanne W Fletcher, Lisa J. Herrinton, Sarah M. Greene, Ann M Geiger, Terry S. Field, Judy MouchawarAbstract:Critical questions about Cancer prevention, care, and outcomes increasingly require Research involving large patient populations and their care delivery organizations. The Cancer Research Network (CRN) includes 11 integrated health systems funded by the National Cancer Institute (NCI) to conduct collaborative Cancer Research. This article describes the challenges of constructing a productive consortium of large health systems, and explores the CRN’s responses. The CRN was initially funded through an NCI cooperative agreement in 1999 and has since received a second 4-year grant. Leadership and policy development are provided through a steering committee, subcommittees, and an external advisory committee. The CRN includes integral and affi liated Research projects supported by a Scientifi c and Data Resources Core. Three characteristics of the CRN intensifi ed the general challenges of consortium Research: 1) its members are large health systems with legitimate concerns about confi dentiality of data about enrollees, providers, and the organization; 2) CRN Research projects often generate highly sensitive data about quality of care; and therefore 3) each participating organization wants a strong voice in CRN direction. CRN experience to date confi rms that a consortium of health systems with internal Research capacity can address a range of important Cancer Research questions that would be diffi cult to study in other venues. The advantages and chal lenges of consortium Research are explored, with suggestions for the development, execution, and management of multisystem population laboratories. [J Natl Cancer Inst Monogr 2005;35:3 – 11]
-
building a Research consortium of large health systems the Cancer Research network
Journal of The National Cancer Institute Monographs, 2005Co-Authors: Edward H. Wagner, Mark C Hornbrook, Gene Hart, Christine Cole Johnson, Suzanne W Fletcher, Lisa J. Herrinton, Sarah M. Greene, Ann M Geiger, Terry S. Field, Judy MouchawarAbstract:Critical questions about Cancer prevention, care, and outcomes increasingly require Research involving large patient populations and their care delivery organizations. The Cancer Research Network (CRN) includes 11 integrated health systems funded by the National Cancer Institute (NCI) to conduct collaborative Cancer Research. This article describes the challenges of constructing a productive consortium of large health systems, and explores the CRN's responses. The CRN was initially funded through an NCI cooperative agreement in 1999 and has since received a second 4-year grant. Leadership and policy development are provided through a steering committee, subcommittees, and an external advisory committee. The CRN includes integral and affiliated Research projects supported by a Scientific and Data Resources Core. Three characteristics of the CRN intensified the general challenges of consortium Research: 1) its members are large health systems with legitimate concerns about confidentiality of data about enrollees, providers, and the organization; 2) CRN Research projects often generate highly sensitive data about quality of care; and therefore 3) each participating organization wants a strong voice in CRN direction. CRN experience to date confirms that a consortium of health systems with internal Research capacity can address a range of important Cancer Research questions that would be difficult to study in other venues. The advantages and challenges of consortium Research are explored, with suggestions for the development, execution, and management of multisystem population laboratories.
Mark C Hornbrook - One of the best experts on this subject based on the ideXlab platform.
-
Collaborating on Data, Science, and Infrastructure: The 20-Year Journey of the Cancer Research Network
EGEMS (Washington DC), 2019Co-Authors: V. Paul Doria-rose, Heather A. Clancy, Leah Tuzzio, Lisa M. Moy, Douglas A Corley, Jeffrey S. Brown, Diana L. Miglioretti, Diana S M Buist, Robert T Greenlee, Mark C HornbrookAbstract:The Cancer Research Network (CRN) is a consortium of 12 Research groups, each affiliated with a nonprofit integrated health care delivery system, that was first funded in 1998. The overall goal of the CRN is to support and facilitate collaborative Cancer Research within its component delivery systems. This paper describes the CRN’s 20-year experience and evolution. The network combined its members’ scientific capabilities and data resources to create an infrastructure that has ultimately supported over 275 projects. Insights about the strengths and limitations of electronic health data for Research, approaches to optimizing multidisciplinary collaboration, and the role of a health services Research infrastructure to complement traditional clinical trials and large observational datasets are described, along with recommendations for other Research consortia.
-
building a Research consortium of large health systems the Cancer Research network
Journal of The National Cancer Institute Monographs, 2005Co-Authors: Edward H. Wagner, Mark C Hornbrook, Gene Hart, Christine Cole Johnson, Suzanne W Fletcher, Lisa J. Herrinton, Sarah M. Greene, Ann M Geiger, Terry S. Field, Judy MouchawarAbstract:Critical questions about Cancer prevention, care, and outcomes increasingly require Research involving large patient populations and their care delivery organizations. The Cancer Research Network (CRN) includes 11 integrated health systems funded by the National Cancer Institute (NCI) to conduct collaborative Cancer Research. This article describes the challenges of constructing a productive consortium of large health systems, and explores the CRN’s responses. The CRN was initially funded through an NCI cooperative agreement in 1999 and has since received a second 4-year grant. Leadership and policy development are provided through a steering committee, subcommittees, and an external advisory committee. The CRN includes integral and affi liated Research projects supported by a Scientifi c and Data Resources Core. Three characteristics of the CRN intensifi ed the general challenges of consortium Research: 1) its members are large health systems with legitimate concerns about confi dentiality of data about enrollees, providers, and the organization; 2) CRN Research projects often generate highly sensitive data about quality of care; and therefore 3) each participating organization wants a strong voice in CRN direction. CRN experience to date confi rms that a consortium of health systems with internal Research capacity can address a range of important Cancer Research questions that would be diffi cult to study in other venues. The advantages and chal lenges of consortium Research are explored, with suggestions for the development, execution, and management of multisystem population laboratories. [J Natl Cancer Inst Monogr 2005;35:3 – 11]
-
building a virtual Cancer Research organization
Journal of The National Cancer Institute Monographs, 2005Co-Authors: Mark C Hornbrook, Gene Hart, Sarah M. Greene, Edward H. Wagner, Jennifer L Ellis, Donald J Bachman, Gary Ansell, Roy Pardee, Mark Schmidt, Ann M GeigerAbstract:Background: The Cancer Research Network (CRN) comprises the National Cancer Institute and 11 nonprofit Research centers affiliated with integrated health care delivery systems. The CRN, a public/private partnership, fosters multisite collaborative Research on Cancer prevention, screening, treatment, survival, and palliation in diverse populations. Methods: The CRN's success hinges on producing innovative Cancer Research that likely would not have been developed by scientists working individually, and then translating those findings into clinical practice within multiple population laboratories. The CRN is a collaborative virtual Research organization characterized by user-defined sharing among scientists and health care providers of data files as well as direct access to Researchers, computers, software, data, Research participants, and other resources. The CRN's Research management Web site fosters a high-functioning virtual scientific community by publishing standardized data definitions, file specifications, and computer programs to support merging and analyzing data from multiple health care systems. Results: Seven major types of standardized data files developed to date include demographics, health plan eligibility, tumor registry, inpatient and ambulatory utilization, medication dispensing, laboratory tests, and imaging procedures; more will follow. Data standardization avoids rework, increases multisite data integrity, increases data security, generates shorter times from initial proposal concept to submission, and stimulates more frequent collaborations among scientists across multiple institutions. Conclusions: The CRN Research management Web site and associated standardized data files and procedures represent a quasi-public resource, and the CRN stands ready to collaborate with Researchers from outside institutions in developing and conducting innovative public domain Research.
-
building a Research consortium of large health systems the Cancer Research network
Journal of The National Cancer Institute Monographs, 2005Co-Authors: Edward H. Wagner, Mark C Hornbrook, Gene Hart, Christine Cole Johnson, Suzanne W Fletcher, Lisa J. Herrinton, Sarah M. Greene, Ann M Geiger, Terry S. Field, Judy MouchawarAbstract:Critical questions about Cancer prevention, care, and outcomes increasingly require Research involving large patient populations and their care delivery organizations. The Cancer Research Network (CRN) includes 11 integrated health systems funded by the National Cancer Institute (NCI) to conduct collaborative Cancer Research. This article describes the challenges of constructing a productive consortium of large health systems, and explores the CRN's responses. The CRN was initially funded through an NCI cooperative agreement in 1999 and has since received a second 4-year grant. Leadership and policy development are provided through a steering committee, subcommittees, and an external advisory committee. The CRN includes integral and affiliated Research projects supported by a Scientific and Data Resources Core. Three characteristics of the CRN intensified the general challenges of consortium Research: 1) its members are large health systems with legitimate concerns about confidentiality of data about enrollees, providers, and the organization; 2) CRN Research projects often generate highly sensitive data about quality of care; and therefore 3) each participating organization wants a strong voice in CRN direction. CRN experience to date confirms that a consortium of health systems with internal Research capacity can address a range of important Cancer Research questions that would be difficult to study in other venues. The advantages and challenges of consortium Research are explored, with suggestions for the development, execution, and management of multisystem population laboratories.
