The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Ayman Marei - One of the best experts on this subject based on the ideXlab platform.
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evaluation of intralesional Candida Antigen in diabetic patients with multiple warts
Journal of Cosmetic Dermatology, 2021Co-Authors: Ayman Marei, Rania Alakad, Reham M WahidAbstract:BACKGROUND Treatment of warts in diabetic patients with ablative modalities poses a significant risk owing to increased possibility of secondary infection, slow healing, and recurrence. Intralesional immunotherapy has gained popularity in the treatment of warts due to its proven efficacy and good tolerability compared with destructive methods. AIM To evaluate the intralesional Candida Antigen injection for the treatment of multiple warts in diabetic patients. PATIENTS/METHODS Fifty diabetic patients with multiple genital/nongenital warts were divided into two groups. The first group (30 patients) received intralesional Candida Antigen, and the second group (20 patients) had intralesional saline as control. The treatments were injected into the largest wart every 2 weeks until complete clearance of warts or for a maximum of five sessions. RESULTS Complete clearance of warts was observed in 80% of the diabetic patients in the Candida Antigen group compared with 15% in the control group (P < .001). Side effects to Candida Antigen included pain during injection in all patients, flu-like symptoms, and localized reaction at the injection site in few patients. CONCLUSION Intralesional Candida Antigen injection can be a promising effective and safe therapeutic option for the treatment of warts in diabetic patients.
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Effect of varicella zoster vaccine vs Candida Antigen injection in treatment of warts.
Dermatologic therapy, 2021Co-Authors: Amin Amer, Amany Nassar, Doaa Gamal, Ayman MareiAbstract:Treatment of warts is considered as a big challenge for patients as well as doctors. Immunotherapy represents a promising and successful method of warts treatment. A great attention has been paid for various types of immunotherapeutic agents. One of the immunotherapeutic approaches is intralesional immunotherapy that showed a successful result in treatment of warts. Complete resolution of warts was achieved in many of studied patients, while some of them showed partial response and only few patients showed no response. Our study was based on the previous observations and reports of regression of several types of warts after administration of Candida Antigen and other new immunotherapeutic Antigens. Candida Antigen group showed complete clearance in 16 patients (69.6%), partial response in seven patients (30.4%). In VZV vaccine group, complete clearance was observed in 15 patients (65.2%), partial response in eight patients (34.8%). These results showed that the therapeutic response in two groups had a close statistical result and more chances must be given to VZV vaccine specially after its promising and successful results. In conclusion, we presented a novel approach for the treatment of recalcitrant wart using intralesional immunotherapy with Candida Antigen and VZV vaccine. VZV vaccine seems to be promising, safe and effective remedy for any type warts mainly plantar warts.
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Effect of Varicella Zoster Vaccine Versus Candida Antigen Injection in Treatment of Warts.
Dermatologic therapy, 2020Co-Authors: Amin Amer, Amany Nassar, Doaa Gamal, Ayman MareiAbstract:Treatment of warts is considered as a big challenge for patients as well as doctors. Immunotherapy represents a promising and successful method of warts treatment. A great attention has been paid for various types of immunotherapeutic agents. One of the immunotherapeutic approaches is intralesional immunotherapy that showed a successful result in treatment of warts (1-3). Complete resolution of warts was achieved in many of studied patients, while some of them showed partial response and only few patients showed no response. Our study was based on the previous observations and reports of regression of several types of warts after administration of Candida Antigen and other new immunotherapeutic Antigens. Candida Antigen group showed complete clearance in 16 patients (69.6%), partial response in 7 patients (30.4%). In VZV vaccine group, complete clearance was observed in 15 patients (65.2%), partial response in 8 patients (34.8%). These results showed that the therapeutic response in two groups had a close statistical result and more chances must be given to VZV vaccine specially after its promising and successful results. IN CONCLUSION, we presented a novel approach for the treatment of recalcitrant wart using intralesional immunotherapy with Candida Antigen and VZV vaccine. VZV vaccine seems to be promising, safe and effective remedy for any type warts mainly plantar warts. This article is protected by copyright. All rights reserved.
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Evaluation of intralesional Candida Antigen in diabetic patients with multiple warts.
Journal of cosmetic dermatology, 2020Co-Authors: Ayman Marei, Rania Alakad, Reham M WahidAbstract:BACKGROUND Treatment of warts in diabetic patients with ablative modalities poses a significant risk owing to increased possibility of secondary infection, slow healing, and recurrence. Intralesional immunotherapy has gained popularity in the treatment of warts due to its proven efficacy and good tolerability compared with destructive methods. AIM To evaluate the intralesional Candida Antigen injection for the treatment of multiple warts in diabetic patients. PATIENTS/METHODS Fifty diabetic patients with multiple genital/nongenital warts were divided into two groups. The first group (30 patients) received intralesional Candida Antigen, and the second group (20 patients) had intralesional saline as control. The treatments were injected into the largest wart every 2 weeks until complete clearance of warts or for a maximum of five sessions. RESULTS Complete clearance of warts was observed in 80% of the diabetic patients in the Candida Antigen group compared with 15% in the control group (P
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complement component 3c and tumor necrosis factor α systemic assessment after Candida Antigen immunotherapy in cutaneous warts
Brazilian Journal of Microbiology, 2020Co-Authors: Noha M Hammad, Amina A Abdelhadi, Manal M Fawzy, Ayman MareiAbstract:Cutaneous warts are the commonest benign lesion produced by human papillomavirus. Lesions often regress spontaneously yet have a high rate of recurrence. They impair patients’ quality of life and carry the potential risk of cancer. Nowadays, Candida Antigen immunotherapy has become an encouraging therapeutic modality for warts. We tried to assess the role of the complement pathway and T helper 1 immune response in clinical response to Candida Antigen immunotherapy via complement component 3c (C3c) and tumor necrosis factor (TNF)-α, respectively. A total of 44 patients with cutaneous warts were enrolled in the study. Patients were injected with Candida Antigen at 2-week interval until complete clearance of the lesion or for a maximum of 5 sessions. Blood samples were collected before initiation and after completion of immunotherapy. C3 and C4 were measured using an automated turbidimetric method. Mannose-binding lectin (MBL), C3c, and TNF-α were measured using enzyme-linked immune sorbent assay. A total of 56.4%, 17.9%, and 25.7% of the patients showed complete, partial, and no response to immunotherapy, respectively. Lesions on the dorsum of the foot and sole showed significant clearance (p value = 0.037). All patients had no deficient C3, C4, and MBL serum levels. C3c and TNF-α serum levels were significantly higher in non-responder group (p value < 0.001 and < 0.001, respectively). C3c and TNF-α serum levels were strongly correlated in all the studied patients (r = 0.8, p value < 0.001). Candida Antigen immunotherapy is an effective therapeutic modality for cutaneous warts. C3c and TNF-α serum levels were higher in patients who failed to respond to immunotherapy. NCT04399577 , May 2020 “retrospectively registered”
Jack D. Sobel - One of the best experts on this subject based on the ideXlab platform.
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Vaginal-Associated Immunity in Women with Recurrent Vulvovaginal Candidiasis: Evidence for Vaginal Th1-Type Responses following Intravaginal Challenge with Candida Antigen
The Journal of infectious diseases, 1997Co-Authors: Paul L. Fidel, Kenneth A. Ginsburg, Jessica Cutright, Norbert A. Wolf, Deborah Leaman, Kathleen Dunlap, Jack D. SobelAbstract:Studies from women with recurrent vulvovaginal candidiasis (RVVC) and from an animal model of experimental vaginitis suggest that deficiencies in immune function should be examined at the local rather than systemic level. Evidence of vaginal cell-mediated immunity (CMI) was evaluated for the first time in cervicovaginal lavage (CVL) fluid from RVVC patients. Results showed that although constitutive Th1- and Th2-type cytokine expression was detectable in CVL fluid from normal women, and differences in cytokines were observed in RVVC patients, limitations in experimental design of such de novo analyses urged caution in interpretation. Alternatively, attempts were made to establish conditions in control subjects whereby vaginal immunity could be detected after intravaginal challenge with Candida Antigen. Preliminary results showed that Th1-type cytokines (interleukin-2 and -12, interferon-gamma) and histamine were increased 16-18 h after intravaginal introduction of Candida skin test Antigen. Intravaginal Antigenic challenge represents a novel approach for studying Candida-specific vaginal CMI.
Stanley Read - One of the best experts on this subject based on the ideXlab platform.
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Cellular immunity of patients with recurrent or refractory vulvovaginal moniliasis.
American journal of obstetrics and gynecology, 1992Co-Authors: Ignatius W. Fong, Paul Mccleary, Stanley ReadAbstract:Cellular immunity was studied in 73 patients with recurrent vaginal moniliasis and 37 healthy controls, by skin testing with the multitest CMI kit and Candida Antigen, with measurement of lymphoblastic transformation to phytohemagglutinin, Antigens of Candida albicans , mumps, and streptokinase. Eighteen patients (24.7%) had a hypoergic or anergic response to Candida Antigen on skin testing versus two controls (5.4%), p = 0.01. Overall, the patient's lymphoblastic proliferation to mitogen and various Antigens was not significantly different from that of the controls. However, a subgroup of younger women (19 to 29 years old) had impaired responses to Candida Antigen when compared with age-matched controls, 58% versus 17%, p
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Cellular immunity of patients with recurrent or refractory vulvovaginal moniliasis
International Journal of Gynecology & Obstetrics, 1992Co-Authors: Ignatius W. Fong, Paul Mccleary, Stanley ReadAbstract:Cellular immunity was studied in 73 patients with recurrent vaginal moniliasis and 37 healthy controls, by skin testing with the multitest CMI kit and Candida Antigen, with measurement of lymphoblastic transformation to phytohemagglutinin, Antigens of Candida albicans, mumps, and streptokinase. Eighteen patients (24.7%) had a hypoergic or anergic response to Candida Antigen on skin testing versus two controls (5.4%), p = 0.01. Overall, the patient's lymphoblastic proliferation to mitogen and various Antigens was not significantly different from that of the controls. However, a subgroup of younger women (19 to 29 years old) had impaired responses to Candida Antigen when compared with age-matched controls, 58% versus 17%, p < 0.005. Most women with recurrent vaginal moniliasis had normal cellular immunity. (AM J OasTET GVNECOL 1992;166:887-90.)
Julie Y. Djeu - One of the best experts on this subject based on the ideXlab platform.
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Intact autocrine activation and cytokine production by PMNs from injured adults with elevated Candida Antigen titres
Injury, 1998Co-Authors: John F. Sweeney, Alexander S. Rosemurgy, Sheng Wei, Julie Y. DjeuAbstract:Injured patients with Candida Antigen titres have increased mortality due to sepsis. Polymorphonuclear leucocytes (PMNs) from injured patients with elevated Candida Antigen titres demonstrate impaired function against Candida albicans growth when compared with PMNs from injury matched controls. To determine if PMN dysfunction is global, PMNs from patients with positive Candida Antigen titres were evaluated for their ability to activate the antiCandidal function of normal PMNs (autocrine activation) and to produce tumour necrosis factor (TNF) and interleukin 8 (IL8), known activators of PMN antiCandidal function, this study demonstrates that the PMN dysfunction is not global, as PMN cytokine production and autocrine activation remain intact.
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Candida Antigen titre dilution and death after injury
The British journal of surgery, 1997Co-Authors: Alexander S. Rosemurgy, E. E. Zervos, J. F. Sweeney, Julie Y. DjeuAbstract:Background Candida infections affect outcome after injury. Candida Antigen titres were used to detect these infections early. This study was undertaken to correlate Candida Antigen titre dilution with conventional injury scoring and outcome after severe injury. Methods Candida Antigen titres were determined by agglutination when clinically apparent source(s) of Candida were noted, when Candida was grown in culture of body fluids, or when unexplained clinical deterioration occurred. The findings were compared with the Injury Severity Score (ISS). Results Seventy-five seriously injured adults (median ISS 25 (range 18-50)) developed raised Candida Antigen titres. Multivariate analysis showed that age and Candida Antigen titre correlated significantly with mortality, but not with each other. Culture evidence of Candida, or lack thereof, did not correlate with Candida Antigen titre or mortality. Sixteen of 75 patients died, 14 from bacterial sepsis and none from Candida infection. Conclusion In seriously injured adults, the mortality rate is related to raised Candida Antigen titres. The association between Candida Antigen titre and mortality, although real, remains unexplained.
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Elevated Candida Antigen titers are associated with neutrophil dysfunction after injury.
Clinical and diagnostic laboratory immunology, 1994Co-Authors: John F. Sweeney, Alexander S. Rosemurgy, S Wei, Julie Y. DjeuAbstract:This study was undertaken to determine if impaired neutrophil (polymorphonuclear leukocytes [PMNL]) function is associated with an elevated Candida Antigen titer after injury. PMNL from eight severely injured adults with Candida Antigen titers of > or = 1:4 (titer positive) were evaluated for the ability to inhibit growth of Candida albicans in vitro by using a [3H]glucose incorporation assay. PMNL from eight severely injured adults with titers of
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Candida Antigen titer is a marker of neutrophil dysfunction after severe injury.
The Journal of trauma, 1994Co-Authors: John F. Sweeney, Alexander S. Rosemurgy, Sheng Wei, Julie Y. DjeuAbstract:Trauma patients with positive Candida Antigen titers have high mortality rates. Death is the result of sepsis and multi-organ system failure. Considerations of host immunity to Candida led us to concurrently study the function of neutrophils (PMNs) from severely injured adults with positive titers (n = 20), patients with negative titers matched for age, sex, and injury (n = 20), and volunteers (n = 20). AntiCandidal PMN function was determined using a 3 H-glucose incorporation assay. Results are expressed as mean percentage of growth inhibition ± SEM. Results: PMN, from all groups inhibited Candida growth, although PMNs from titer-positive patients demonstrated less growth inhibition. In vitro cytokines granulocyte macrophage-colony stimulating factor [(GM-CSF), interferon-gamma (IFN-γ), and interleukin 8 (IL-8)] improved function of PMNs from each group and corrected the impaired antiCandidal function of PMNs from titer-positive patients, with GM-CSF being most effective. Conclusions: Seriously injured patients with positive Candida Antigen titers have PMNs with impaired antiCandidal function, which can be restored by cytokines. These findings begin to explain why seriously injured patients with positive Candida Antigen titers have increased mortality and to offer hope of therapeutic intervention
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Monocytes overcome lymphocyte dysfunction in injured adults with elevated Candida Antigen titers.
The Journal of trauma, 1994Co-Authors: John F. Sweeney, Alexander S. Rosemurgy, Sheng Wei, Julie Y. DjeuAbstract:Objective: Severely injured adults with elevated Candida Antigen titers have increased mortality from sepsis, in part because of known neutrophil (PMN) dysfunction. Since PMN function is modulated by monocytes and lymphocytes, this study was undertaken to determine the ability of monocytes and lymphocytes isolated from injured adults with elevated Candida Antigen titers to activate the antiCandidal function of normal PMNs. Methods: Lymphocytes with or without monocytes, isolated from 18 injured adults with elevated titers, were cultured in the presence or absence of heat-killed Candida albicans for 48 hours. Culture supernatents were harvested, diluted 1:40, 1:160, and 1:640, and tested for the ability to stimulate the antiCandidal function of normal PMNs using an 3 H-glucose incorporation assay
S.a. Khashaba - One of the best experts on this subject based on the ideXlab platform.
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Photodynamic therapy versus Candida Antigen immunotherapy in plane wart treatment: a comparative controlled study.
Photodiagnosis and photodynamic therapy, 2020Co-Authors: A. Nassar, M. Mostafa, S.a. KhashabaAbstract:Abstract Introduction Plane warts, mostly found on the face, present a challenge to treat as most destructive methods can lead to unpleasant cosmetic outcome. Alternative therapeutic methods should be evaluated. The aim of this study is to evaluate the clinical efficacy and adverse effects of photodynamic therapy with methylene blue and intense pulsed light in comparison to Candida Antigen immunotherapy in the treatment of plane warts. Methods The study included 39 patients with plane warts assigned into 3 groups. Group I received photodynamic therapy using methylene blue followed by IPL illumination, group II received immunotherapy using 0.1 ml of Candida albicans Antigen and group III received 0.1 ml saline as a control. Results Complete response was detected in (46.1%) of patients in group I compared to (61.5%) in group II and no response in group III. Conclusion Candida Antigen immunotherapy is superior to photodynamic therapy in plane warts treatment with absence of recurrence and comparable side effects in both groups.
