The Experts below are selected from a list of 120 Experts worldwide ranked by ideXlab platform
Fred Rappaport - One of the best experts on this subject based on the ideXlab platform.
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disseminated candidiasis Candida Arthritis and unilateral skin lesions
Journal of The American Academy of Dermatology, 1992Co-Authors: Jeffrey Marcus, Marc E Grossman, Michael J Yunakov, Fred RappaportAbstract:Candida species are the most common cause of systemic fungal infections in patients with hematologic malignancies. These infections are aggressive with rapid dissemination to various organs. Cutaneous lesions occur in 10% to 13% of cases, whereas Candida Arthritis occurs infrequently. This report describes the first case of disseminated candidiasis in a patient with both Candida Arthritis and unilateral cutaneous lesions.
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disseminated candidiasis unilateral skin lesions Candida Arthritis and
1992Co-Authors: Jeffrey Marcus, Marc E Grossman, Michael J Yunakov, Fred RappaportAbstract:Candida species are the most common cause of systemic fungal infections in patients with hematologic malignancies. These infections are aggressive with rapid dissemination to various organs. Cutaneous lesions occur in 10% to 13% of cases, whereas Candida Arthritis occurs infrequently. This report describes the first case of disseminated candidiasis in a patient with both Candida Arthritis and unilateral cutaneous lesions. (J AM ACAD DERMATOL 1992;26:295-7.) The incidence of fungal infections in patients with hematologic malignancies has increased greatly during the past 4 decades. Postmortem studies of patients with leukemia in the 1950s revealed that 10% died of fungal infections; this increased to more than 40% in the 1970s, 1-3 The most common of these fungal infections is disseminated candidiasis.1, 2, 4 The infection is aggressive and often difficult to diagnose because blood cultures are positive in only 25% of patients) Because the clinical signs and symptoms of disseminated candidiasis are nonspecific, death can occur before diagnosis and treatment can be initiated. Although present in only 10% to 13% of cases of disseminated candidiasis, cutaneous manifestations can aid in rapid diagnosis), 6 A less common manifestation of disseminated candidiasis is Candida Arthritis; only 31 cases in adults who were not drug abusers have been reported. 79 We report a case of disseminated candidiasis in a patient with both Candida Arthritis and unilateral skin lesions. CASE REPORT An 84-year-old white man had a 4-day history of erythema and muscle tenderness of the left lower extremity. The patient had a 3-year history of myelodysplastic syndrome with recent worsening of pancytopenia. When admitted to the hospital, he had a temperature of 38.3 ~ C and swelling, warmth, erythema, and tenderness of the
Jeffrey Marcus - One of the best experts on this subject based on the ideXlab platform.
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disseminated candidiasis Candida Arthritis and unilateral skin lesions
Journal of The American Academy of Dermatology, 1992Co-Authors: Jeffrey Marcus, Marc E Grossman, Michael J Yunakov, Fred RappaportAbstract:Candida species are the most common cause of systemic fungal infections in patients with hematologic malignancies. These infections are aggressive with rapid dissemination to various organs. Cutaneous lesions occur in 10% to 13% of cases, whereas Candida Arthritis occurs infrequently. This report describes the first case of disseminated candidiasis in a patient with both Candida Arthritis and unilateral cutaneous lesions.
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disseminated candidiasis unilateral skin lesions Candida Arthritis and
1992Co-Authors: Jeffrey Marcus, Marc E Grossman, Michael J Yunakov, Fred RappaportAbstract:Candida species are the most common cause of systemic fungal infections in patients with hematologic malignancies. These infections are aggressive with rapid dissemination to various organs. Cutaneous lesions occur in 10% to 13% of cases, whereas Candida Arthritis occurs infrequently. This report describes the first case of disseminated candidiasis in a patient with both Candida Arthritis and unilateral cutaneous lesions. (J AM ACAD DERMATOL 1992;26:295-7.) The incidence of fungal infections in patients with hematologic malignancies has increased greatly during the past 4 decades. Postmortem studies of patients with leukemia in the 1950s revealed that 10% died of fungal infections; this increased to more than 40% in the 1970s, 1-3 The most common of these fungal infections is disseminated candidiasis.1, 2, 4 The infection is aggressive and often difficult to diagnose because blood cultures are positive in only 25% of patients) Because the clinical signs and symptoms of disseminated candidiasis are nonspecific, death can occur before diagnosis and treatment can be initiated. Although present in only 10% to 13% of cases of disseminated candidiasis, cutaneous manifestations can aid in rapid diagnosis), 6 A less common manifestation of disseminated candidiasis is Candida Arthritis; only 31 cases in adults who were not drug abusers have been reported. 79 We report a case of disseminated candidiasis in a patient with both Candida Arthritis and unilateral skin lesions. CASE REPORT An 84-year-old white man had a 4-day history of erythema and muscle tenderness of the left lower extremity. The patient had a 3-year history of myelodysplastic syndrome with recent worsening of pancytopenia. When admitted to the hospital, he had a temperature of 38.3 ~ C and swelling, warmth, erythema, and tenderness of the
Seongrheol Oh - One of the best experts on this subject based on the ideXlab platform.
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Candida Arthritis after arthroscopic arthroplasty in a patient without predisposing factors
The Open Rheumatology Journal, 2010Co-Authors: Jaemin Oh, Seongrheol OhAbstract:Because candidiasis is usually associated with immunosuppression, Candida Arthritis in an immunocompetent patient is rare. The symptoms of candidiasis are similar to bacterial infections, tuberculosis, and autoimmune diseases. In our patient with no predisposing factors, Candida Arthritis was initially excluded because the probability of occurrence was low. The patient had no leukocytosis, the acid-fast bacteria (AFB) stain was negative, and the autoimmune antibody screen was negative. After Candida parapsilosis was cultured in the synovial fluid, the patient was treated with amphotericin B (0.7 mg/kg/day) and oral fluconazole (400 mg/day). The treatment was successful and there were no side effects of the medications.
Shigeji Aoki - One of the best experts on this subject based on the ideXlab platform.
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radiographic features of experimental Candida Arthritis in rats
Mycopathologia, 1993Co-Authors: Y Nakamura, T Masuhara, S Itokuwa, S Noda, Kenjirou Nakamura, Shigeji AokiAbstract:Sprague-Dawley rats were inoculated intravenously (i.v.) withCandida albicans, and limb joints showing signs ofCandida-induced Arthritis were subjected to radiographic and histologic examination. New bone formation and bone resorption were morbidly enhanced in bones sampled from the arthritic joints. Sparsely distributed needle-shaped calcified deposits began to be formed on bony surfaces in parallel with the onset of joint swelling. The calcified deposits gradually became denser and then covered the bony surfaces almost entirely, giving rise to an exostosis-like profile. In addition to the new bone formation, bone resorption was also observed in regions adjacent to the sites of new bone formation, and punched-out bone lesions were produced. Eventually, severe deformation of joint bones due to new bone formation and bone resorption was evident. Reflecting these unusual radiographic changes, abundant osteoblasts and osteoclasts were demonstrated histologically in the bones. On the basis of these results, possible mechanisms for the induction of Arthritis byCandida infection are discussed.
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induction of experimental Candida Arthritis in rats
Medical Mycology, 1991Co-Authors: Y Nakamura, T Masuhara, S Itokuwa, Shigeji AokiAbstract:Experimental Arthritis, caused by intravenously (IV) introduced Candida albicans, has been induced for the first time in rats. Four-week-old Sprague-Dawley rats were inoculated IV with three different strains of C. albicans and observed for 4 weeks. Each of the three strains tested was able to produce Arthritis. The incidence of Candida Arthritis increased in a dose-dependent manner and was more than 90% at sublethal doses. Joints of the limbs were affected predominantly, and at higher doses Arthritis was produced in multiple (four or five) joints in individual animals, showing it to be polyArthritis. C. albicans was recovered from all cultures of affected limb joints, which were excised 12, 19 and 28 days after inoculation and showed different stages and degrees of joint swelling. Results of histopathology and radiography showed that the Candida Arthritis involved not only periarticular inflammation but also changes in joint bones. In particular, metaphyseal enlargement, punched-out lesions at the diaphy...
He Huang - One of the best experts on this subject based on the ideXlab platform.
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Candida tropicalis Arthritis of the knee in a patient with acute monocytic leukemia
Blood, 2006Co-Authors: Jingsong He, Xiujin Ye, Weiyan Zheng, Wenjun Wu, He HuangAbstract:The patients with malignant hematopathy are the high-risk group of invasive fungal infections (IFI). Candidemia and IFI caused by Candidas in patients with a hematological malignancy are common but Candida Arthritis is rare. Here, we reported a case of Candida tropicalis Arthritis of the knee that occurred with acute monocytic leukemia during the recovery period of post chemotherapy myelosuppression and agranulocytosis. Case report: A 45-year-old Chinese woman was diagnosed with acute monocytic leukemia with normal caryotype in november 2004. Complete remission was achieved upon completion of 2 courses of induction chemotherapy. Treatment was administered via a Hickman catheter in the left elbow. Two days after phase V consolidation chemotherapy, the patient experienced high fever accompanied by the development of Arthritis in the right knee. The diagnosis of Candida tropicalis Arthritis of the knee was confirmed by the appearance of Candida tropicalis isolated from the synovial fluid, but no leukemic cells and acid-fast bacilli were found. According to the susceptibility test in vitro, itraconazole and amphotericin B injection were used sequentially for therapy for 4–5 weeks, which effectively inhibited bacterial growth. However, the Arthritis relapsed after 4–6 weeks of drug withdrawal. The Arthritis was fully resolved after 8 weeks of therapy with fluconazol injection at a dose of 400mg/d and douching articular cavity with amphotericin B once a week. And then sequential therapy with oral fluconazole was commenced. There was no any adverse effect occurrence during the course of treatment. Discussion: Although Candida Arthritis in patient with a hematological malignancy is rare, it still occurred in patient with hypoimmunity. Early diagnosis is difficult due to no distinctive clinical manifestation and hysteresis of pathogenic organism detection. It was found that the knee was the sole joint affected according to the review of fourteen other reports of Candida Arthritis in patients with a hematological malignancy but the reason remains unclear. Fungal Arthritis must be taken into consideration when dealing with patients with immune deficiency accompanied by Arthritis, especially gonArthritis. We emphasize that the most important factors for the successful treatment of fungal Arthritis are identified diagnosis and adequate dosage through out the course of treatment.
