The Experts below are selected from a list of 135 Experts worldwide ranked by ideXlab platform
Frank Helle - One of the best experts on this subject based on the ideXlab platform.
-
high salt diet increases hormonal sensitivity in skin pre Capillary Resistance vessels
Acta Physiologica, 2013Co-Authors: Frank Helle, Tine Veronica Karlsen, Olav Tenstad, Jens Titze, Helge WiigAbstract:Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major Resistance vessel of rat skin, the pre-Capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m (P < 0.01). Pre-Capillary arterioles from muscle displayed similar contractions to ANG II, independent of the diet. As ANG II and the renin–angiotensin system are strongly involved in salt conservation, we explored whether vasoreactivity for noradrenaline was increased as well, because this is a functionally unrelated hormone. At low doses, contractions were similar, but at 10−5 and 10−4 m, noradrenaline produced stronger contractions in skin vessels from high-salt compared with low-salt rats (P < 0.01). Conclusions Our data demonstrate significantly increased hormonal vasoreactivity of skin vessels from rats on a high-salt diet, which could increase peripheral Resistance in many situations and contribute to higher pressure in salt-sensitive hypertension. As vessels from adjacent muscle were unaffected, we raise the interesting possibility that increased vasoreactivity in the skin could be linked to osmotically inactive Na+ accumulation.
-
High-salt diet increases hormonal sensitivity in skin pre-Capillary Resistance vessels.
Acta Physiologica, 2013Co-Authors: Frank Helle, Tine Veronica Karlsen, Olav Tenstad, Jens Titze, Helge WiigAbstract:Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major Resistance vessel of rat skin, the pre-Capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m (P
Helge Wiig - One of the best experts on this subject based on the ideXlab platform.
-
high salt diet increases hormonal sensitivity in skin pre Capillary Resistance vessels
Acta Physiologica, 2013Co-Authors: Frank Helle, Tine Veronica Karlsen, Olav Tenstad, Jens Titze, Helge WiigAbstract:Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major Resistance vessel of rat skin, the pre-Capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m (P < 0.01). Pre-Capillary arterioles from muscle displayed similar contractions to ANG II, independent of the diet. As ANG II and the renin–angiotensin system are strongly involved in salt conservation, we explored whether vasoreactivity for noradrenaline was increased as well, because this is a functionally unrelated hormone. At low doses, contractions were similar, but at 10−5 and 10−4 m, noradrenaline produced stronger contractions in skin vessels from high-salt compared with low-salt rats (P < 0.01). Conclusions Our data demonstrate significantly increased hormonal vasoreactivity of skin vessels from rats on a high-salt diet, which could increase peripheral Resistance in many situations and contribute to higher pressure in salt-sensitive hypertension. As vessels from adjacent muscle were unaffected, we raise the interesting possibility that increased vasoreactivity in the skin could be linked to osmotically inactive Na+ accumulation.
-
High-salt diet increases hormonal sensitivity in skin pre-Capillary Resistance vessels.
Acta Physiologica, 2013Co-Authors: Frank Helle, Tine Veronica Karlsen, Olav Tenstad, Jens Titze, Helge WiigAbstract:Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major Resistance vessel of rat skin, the pre-Capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m (P
Peter Rohdewald - One of the best experts on this subject based on the ideXlab platform.
-
Pycnogenol for diabetic retinopathy. A review.
International Ophthalmology, 2020Co-Authors: Frank Schönlau, Peter RohdewaldAbstract:Diabetic retinopathy represents a serious health threat to a rapidly growing numberof patients with diabetes mellitus. The retinal microangiopathy is characterised byvascular lesions with exudate deposits and haemorrhages causing vision loss.Pycnogenol®, a standardised extract of the bark of the French maritime pine (Pinus pinaster), is known to increase Capillary Resistance. Pycnogenol® has been tested for treatment and prevention of retinopathy in five clinical trials with atotal number of 1289 patients since the late 1960's. All but one of these studies have been reported in French and German and, today, are of limited accessibility, giving the impetus for reviewing them in detail in this article.There were two open case studies and two double blind studies (one controlledagainst calcium dobesilate and another against placebo) and, finally, one multi-centerfield study with 1169 diabetics. All of these studies unequivocally showed thatPycnogenol® retains progression of retinopathy and partly recoversvisual acuity. Treatment efficacy of Pycnogenol® was at least asgood as that of calcium dobesilate. Pycnogenol® was shown toimprove Capillary Resistance and reduce leakages into the retina. Tolerance wasgenerally very good and side effects were rare, mostly referring to gastric discomfort.In conclusion, treatment with Pycnogenol® had a favourable outcomein the majority of the patients with diabetic retinopathy.
-
Pycnogenol^® for diabetic retinopathy
International Ophthalmology, 2001Co-Authors: Frank Schönlau, Peter RohdewaldAbstract:Diabetic retinopathy represents a serious health threat to a rapidly growing numberof patients with diabetes mellitus. The retinal microangiopathy is characterised byvascular lesions with exudate deposits and haemorrhages causing vision loss.Pycnogenol^®, a standardised extract of the bark of the French maritime pine ( Pinus pinaster ), is known to increase Capillary Resistance. Pycnogenol^® has been tested for treatment and prevention of retinopathy in five clinical trials with atotal number of 1289 patients since the late 1960's. All but one of these studies have been reported in French and German and, today, are of limited accessibility, giving the impetus for reviewing them in detail in this article.There were two open case studies and two double blind studies (one controlledagainst calcium dobesilate and another against placebo) and, finally, one multi-centerfield study with 1169 diabetics. All of these studies unequivocally showed thatPycnogenol^® retains progression of retinopathy and partly recoversvisual acuity. Treatment efficacy of Pycnogenol^® was at least asgood as that of calcium dobesilate. Pycnogenol^® was shown toimprove Capillary Resistance and reduce leakages into the retina. Tolerance wasgenerally very good and side effects were rare, mostly referring to gastric discomfort.In conclusion, treatment with Pycnogenol^® had a favourable outcomein the majority of the patients with diabetic retinopathy.
Frank Schönlau - One of the best experts on this subject based on the ideXlab platform.
-
Pycnogenol for diabetic retinopathy. A review.
International Ophthalmology, 2020Co-Authors: Frank Schönlau, Peter RohdewaldAbstract:Diabetic retinopathy represents a serious health threat to a rapidly growing numberof patients with diabetes mellitus. The retinal microangiopathy is characterised byvascular lesions with exudate deposits and haemorrhages causing vision loss.Pycnogenol®, a standardised extract of the bark of the French maritime pine (Pinus pinaster), is known to increase Capillary Resistance. Pycnogenol® has been tested for treatment and prevention of retinopathy in five clinical trials with atotal number of 1289 patients since the late 1960's. All but one of these studies have been reported in French and German and, today, are of limited accessibility, giving the impetus for reviewing them in detail in this article.There were two open case studies and two double blind studies (one controlledagainst calcium dobesilate and another against placebo) and, finally, one multi-centerfield study with 1169 diabetics. All of these studies unequivocally showed thatPycnogenol® retains progression of retinopathy and partly recoversvisual acuity. Treatment efficacy of Pycnogenol® was at least asgood as that of calcium dobesilate. Pycnogenol® was shown toimprove Capillary Resistance and reduce leakages into the retina. Tolerance wasgenerally very good and side effects were rare, mostly referring to gastric discomfort.In conclusion, treatment with Pycnogenol® had a favourable outcomein the majority of the patients with diabetic retinopathy.
-
Pycnogenol^® for diabetic retinopathy
International Ophthalmology, 2001Co-Authors: Frank Schönlau, Peter RohdewaldAbstract:Diabetic retinopathy represents a serious health threat to a rapidly growing numberof patients with diabetes mellitus. The retinal microangiopathy is characterised byvascular lesions with exudate deposits and haemorrhages causing vision loss.Pycnogenol^®, a standardised extract of the bark of the French maritime pine ( Pinus pinaster ), is known to increase Capillary Resistance. Pycnogenol^® has been tested for treatment and prevention of retinopathy in five clinical trials with atotal number of 1289 patients since the late 1960's. All but one of these studies have been reported in French and German and, today, are of limited accessibility, giving the impetus for reviewing them in detail in this article.There were two open case studies and two double blind studies (one controlledagainst calcium dobesilate and another against placebo) and, finally, one multi-centerfield study with 1169 diabetics. All of these studies unequivocally showed thatPycnogenol^® retains progression of retinopathy and partly recoversvisual acuity. Treatment efficacy of Pycnogenol^® was at least asgood as that of calcium dobesilate. Pycnogenol^® was shown toimprove Capillary Resistance and reduce leakages into the retina. Tolerance wasgenerally very good and side effects were rare, mostly referring to gastric discomfort.In conclusion, treatment with Pycnogenol^® had a favourable outcomein the majority of the patients with diabetic retinopathy.
Tine Veronica Karlsen - One of the best experts on this subject based on the ideXlab platform.
-
high salt diet increases hormonal sensitivity in skin pre Capillary Resistance vessels
Acta Physiologica, 2013Co-Authors: Frank Helle, Tine Veronica Karlsen, Olav Tenstad, Jens Titze, Helge WiigAbstract:Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major Resistance vessel of rat skin, the pre-Capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m (P < 0.01). Pre-Capillary arterioles from muscle displayed similar contractions to ANG II, independent of the diet. As ANG II and the renin–angiotensin system are strongly involved in salt conservation, we explored whether vasoreactivity for noradrenaline was increased as well, because this is a functionally unrelated hormone. At low doses, contractions were similar, but at 10−5 and 10−4 m, noradrenaline produced stronger contractions in skin vessels from high-salt compared with low-salt rats (P < 0.01). Conclusions Our data demonstrate significantly increased hormonal vasoreactivity of skin vessels from rats on a high-salt diet, which could increase peripheral Resistance in many situations and contribute to higher pressure in salt-sensitive hypertension. As vessels from adjacent muscle were unaffected, we raise the interesting possibility that increased vasoreactivity in the skin could be linked to osmotically inactive Na+ accumulation.
-
High-salt diet increases hormonal sensitivity in skin pre-Capillary Resistance vessels.
Acta Physiologica, 2013Co-Authors: Frank Helle, Tine Veronica Karlsen, Olav Tenstad, Jens Titze, Helge WiigAbstract:Aims Recent data indicate that the skin of rats on a high-salt diet is able to accumulate Na+ without commensurate water. This extrarenal mechanism of Na+ homoeostasis could affect skin vasoregulation. We hypothesized that the major Resistance vessel of rat skin, the pre-Capillary arterioles, has increased vasoreactivity within the physiological range of circulating ANG II, a hormone relevant to salt-sensitive hypertension. Methods and results Skin arterioles from skin and muscle were isolated using the agar-infusion technique. Vessels from rats fed high-salt and low-salt diet had similar lumen diameter and media area/lumen area ratio. Contractile sensitivity to ANG II was increased in skin vessels from high-salt vessels at all doses tested starting at 10−10 m (P
