The Experts below are selected from a list of 1026 Experts worldwide ranked by ideXlab platform

Metin Sitti - One of the best experts on this subject based on the ideXlab platform.

  • magnetically actuated soft Capsule Endoscope for fine needle biopsy
    Soft robotics, 2020
    Co-Authors: Donghoon Son, Metin Sitti, Hunter B Gilbert
    Abstract:

    Wireless Capsule Endoscopes have revolutionized diagnostic procedures in the gastrointestinal (GI) tract by minimizing discomfort and trauma. Biopsy procedures, which are often necessary for a confirmed diagnosis of an illness, have been incorporated recently into robotic Capsule Endoscopes to improve their diagnostic functionality beyond only imaging. However, Capsule robots to date have only been able to acquire biopsy samples of superficial tissues of the GI tract, which could generate false-negative diagnostic results if the diseased tissue is under the surface of the GI tract. To improve their diagnostic accuracy for submucosal tumors/diseases, we propose a magnetically actuated soft robotic Capsule robot, which takes biopsy samples in a deep tissue of a stomach using the fine-needle biopsy technique. We present the design, control, and human-machine interfacing methods for the fine-needle biopsy Capsule robot. Ex vivo experiments in a porcine stomach show 85% yield for the biopsy of phantom tumors located underneath the first layers of the stomach wall.

  • Magnetically actuated soft Capsule Endoscope for fine-needle aspiration biopsy
    Proceedings - IEEE International Conference on Robotics and Automation, 2017
    Co-Authors: Donghoon Son, Mustafa Doga Dogan, Metin Sitti
    Abstract:

    — This paper presents a magnetically actuated soft Capsule Endoscope for fine-needle aspiration biopsy (B-MASCE) in the upper gastrointestinal tract. A thin and hollow needle is attached to the Capsule, which can penetrate deeply into tissues to obtain subsurface biopsy sample. The design utilizes a soft elastomer body as a compliant mechanism to guide the needle. An internal permanent magnet provides a means for both actuation and tracking. The Capsule is designed to roll towards its target and then deploy the biopsy needle in a precise location selected as the target area. B-MASCE is controlled by multiple custom-designed electromagnets while its position and orientation are tracked by a magnetic sensor array. In in vitro trials, B-MASCE demonstrated rolling locomotion and biopsy of a swine tissue model positioned inside an anatomical human stomach model. It was confirmed after the experiment that a tissue sample was retained inside the needle.

  • biopsy using a magnetic Capsule Endoscope carrying releasing and retrieving untethered microgrippers
    IEEE Transactions on Biomedical Engineering, 2014
    Co-Authors: Evin Gultepe, David H Gracias, Metin Sitti
    Abstract:

    This paper proposes a new wireless biopsy method where a magnetically actuated untethered soft Capsule Endoscope carries and releases a large number of thermo-sensitive, untethered microgrippers (μ-grippers) at a desired location inside the stomach and retrieves them after they self-fold and grab tissue samples. We describe the working principles and analytical models for the μ-gripper release and retrieval mechanisms, and evaluate the proposed biopsy method in ex vivo experiments. This hierarchical approach combining the advanced navigation skills of centimeter-scaled untethered magnetic Capsule Endoscopes with highly parallel, autonomous, submillimeter scale tissue sampling μ-grippers offers a multifunctional strategy for gastrointestinal Capsule biopsy.

  • 3 d localization method for a magnetically actuated soft Capsule Endoscope and its applications
    International Conference on Robotics and Automation, 2013
    Co-Authors: Sehyuk Yim, Metin Sitti
    Abstract:

    In this paper, we present a 3-D localization method for a magnetically actuated soft Capsule Endoscope (MASCE). The proposed localization scheme consists of three steps. First, MASCE is oriented to be coaxially aligned with an external permanent magnet (EPM). Second, MASCE is axially contracted by the enhanced magnetic attraction of the approaching EPM. Third, MASCE recovers its initial shape by the retracting EPM as the magnetic attraction weakens. The combination of the estimated direction in the coaxial alignment step and the estimated distance in the shape deformation (recovery) step provides the position of MASCE in 3-D. It is experimentally shown that the proposed localization method could provide 2.0-3.7 mm of distance error in 3-D. This study also introduces two new applications of the proposed localization method. First, based on the trace of contact points between the MASCE and the surface of the stomach, the 3-D geometrical model of a synthetic stomach was reconstructed. Next, the relative tissue compliance at each local contact point in the stomach was characterized by measuring the local tissue deformation at each point due to the preloading force. Finally, the characterized relative tissue compliance parameter was mapped onto the geometrical model of the stomach toward future use in disease diagnosis.

  • design and rolling locomotion of a magnetically actuated soft Capsule Endoscope
    IEEE Transactions on Robotics, 2012
    Co-Authors: Metin Sitti
    Abstract:

    This paper proposes a magnetically actuated soft Capsule Endoscope (MASCE) as a tetherless miniature mobile robot platform for diagnostic and therapeutic medical applications inside the stomach. Two embedded internal permanent magnets and a large external magnet are used to actuate the robot remotely. The proposed MASCE has three novel features. First, its outside body is made of soft elastomer-based compliant structures. Such compliant structures can deform passively during the robot-tissue contact interactions, which makes the device safer and less invasive. Next, it can be actively deformed in the axial direction by using external magnetic actuation, which provides an extra degree of freedom that enables various advanced functions such as axial position control, drug releasing, drug injection, or biopsy. Finally, it navigates in three dimensions by rolling on the stomach surface as a new surface locomotion method inside the stomach. Here, the external attractive magnetic force is used to anchor the robot on a desired location, and the external magnetic torque is used to roll it to another location, which provides a stable, continuous, and controllable motion. The paper presents design and fabrication methods for the compliant structures of the robot with its axial deformation and position control capability. Rolling-based surface locomotion of the robot using external magnetic torques is modeled, and its feasibility is tested and verified on a synthetic stomach surface by using a magnetically actuated Capsule Endoscope prototype.

Si Young Song - One of the best experts on this subject based on the ideXlab platform.

  • active locomotion of a paddling based Capsule Endoscope in an in vitro and in vivo experiment with videos
    Gastrointestinal Endoscopy, 2010
    Co-Authors: Hee Man Kim, Jeong Youp Park, Tae Song Kim, Si Young Song, Sungwook Yang, Jin Seok Kim, Semi Park, Jae Hee Cho, Euisung Yoon, Seungmin Bang
    Abstract:

    Background Capsule endoscopy that could actively move and approach a specific site might be more valuable for the diagnosis or treatment of GI diseases. Objective We tested the performance of active locomotion of a novel wired Capsule Endoscope with a paddling-based locomotion mechanism, using 3 models: a silicone tube, an extracted porcine colon, and a living pig. Design In vitro, ex vivo, and in vivo experiments in a pig model. Setting Study in an animal laboratory. Interventions For the in vitro test, the locomotive Capsule was controlled to actively move from one side of a silicone tube to the other by a controller-operated automatic traveling program. The velocity was calculated by following a video recording. We performed ex vivo tests by using an extracted porcine colon in the same manner we performed the in vitro test. In in vivo experiments, the Capsule was inserted into the rectum of a living pig under anesthesia, and was controlled to move automatically forward. After 8 consecutive trials, the velocity was calculated. Main Outcome Measurements Elapsed time, velocity, and mucosal damage. Results The locomotive Capsule showed stable and active movement inside the lumen both in vitro and ex vivo. The velocity was 60 cm/min in the silicone tube, and 36.8 and 37.5 cm/min in the extracted porcine colon. In the in vivo experiments, the Capsule stably moved forward inside the colon of a living pig without any serious complications. The mean velocity was 17 cm/min over 40 cm length. We noted pinpoint erythematous mucosal injuries in the colon. Limitation Porcine model experiments, wired Capsule Endoscope. Conclusions The novel paddling-based locomotive Capsule Endoscope performed fast and stable movement in a living pig colon with consistent velocity. Further investigation is necessary for practical use in humans.

  • first clinical trial of the miro Capsule Endoscope by using a novel transmission technology electric field propagation
    Gastrointestinal Endoscopy, 2009
    Co-Authors: Seungmin Bang, Jeong Youp Park, Seok Jeong, Young Ho Kim, Han Bo Shim, Tae Song Kim, Don Haeng Lee, Si Young Song
    Abstract:

    Background We developed a Capsule Endoscope (CE), "MiRo," with the novel transmission technology of electric-field propagation. The technology uses the human body as a conductive medium for data transmission. Specifications of the prototype include the ability to receive real-time images; size, 10.8 × 24 mm; weight, 3.3 g; field of view, 150°; resolution of power, 320 × 320 pixels; and transmittal speed, 2 frames per second. Objective To evaluate the clinical safety and diagnostic feasibility of the prototype MiRo, we conducted a multicenter clinical trial. Design and Patients All volunteers underwent baseline examinations, including EGD and electrocardiography for the screening of GI obstructive and cardiovascular diseases, before the trial. In the first 10 cases, 24-hour Holter monitoring was also performed. To evaluate the diagnostic feasibility, transmission rate of the captured images, inspection rate of the entire small bowel, and quality of transmitted images (graded as outstanding, excellent, good/average, below average, and poor) were analyzed. Results Of the 49 healthy volunteers, 45 were included in the trial, and 4 were excluded because of baseline abnormalities. No adverse effects were noted. All CEs were expelled within 2 days, and the entire small bowel could be explored in all cases. The transmission rates of the captured image in the stomach, small bowel, and colon were 99.5%, 99.6%, and 97.2%, respectively. The mean total duration of image transmission was 9 hours, 51 minutes, and the mean transit time of the entire small bowel was 4 hours, 33 minutes. Image quality was graded as good or better in 41 cases (91.1%). Details of the villi and vascular structures of the entire small bowel were clearly visualized in 31 cases (68.9%). Conclusions MiRo is safe and effective for exploring the entire small bowel, with good image quality and real-time feasibility. This novel transmission technology may have applications beyond the field of Capsule endoscopy.

  • first clinical trial of the miro Capsule Endoscope by using a novel transmission technology electric field propagation
    Gastrointestinal Endoscopy, 2009
    Co-Authors: Seungmin Bang, Jeong Youp Park, Seok Jeong, Han Bo Shim, Si Young Song
    Abstract:

    BACKGROUND: We developed a Capsule Endoscope (CE), "MiRo," with the novel transmission technology of electric-field propagation. The technology uses the human body as a conductive medium for data transmission. Specifications of the prototype include the ability to receive real-time images; size, 10.8 x 24 mm; weight, 3.3 g; field of view, 150 degrees; resolution of power, 320 x 320 pixels; and transmittal speed, 2 frames per second. OBJECTIVE: To evaluate the clinical safety and diagnostic feasibility of the prototype MiRo, we conducted a multicenter clinical trial. DESIGN AND PATIENTS: All volunteers underwent baseline examinations, including EGD and electrocardiography for the screening of GI obstructive and cardiovascular diseases, before the trial. In the first 10 cases, 24-hour Holter monitoring was also performed. To evaluate the diagnostic feasibility, transmission rate of the captured images, inspection rate of the entire small bowel, and quality of transmitted images (graded as outstanding, excellent, good/average, below average, and poor) were analyzed. RESULTS: Of the 49 healthy volunteers, 45 were included in the trial, and 4 were excluded because of baseline abnormalities. No adverse effects were noted. All CEs were expelled within 2 days, and the entire small bowel could be explored in all cases. The transmission rates of the captured image in the stomach, small bowel, and colon were 99.5%, 99.6%, and 97.2%, respectively. The mean total duration of image transmission was 9 hours, 51 minutes, and the mean transit time of the entire small bowel was 4 hours, 33 minutes. Image quality was graded as good or better in 41 cases (91.1%). Details of the villi and vascular structures of the entire small bowel were clearly visualized in 31 cases (68.9%). CONCLUSIONS: MiRo is safe and effective for exploring the entire small bowel, with good image quality and real-time feasibility. This novel transmission technology may have applications beyond the field of Capsule endoscopy.

Seungmin Bang - One of the best experts on this subject based on the ideXlab platform.

  • active locomotion of a paddling based Capsule Endoscope in an in vitro and in vivo experiment with videos
    Gastrointestinal Endoscopy, 2010
    Co-Authors: Hee Man Kim, Jeong Youp Park, Tae Song Kim, Si Young Song, Sungwook Yang, Jin Seok Kim, Semi Park, Jae Hee Cho, Euisung Yoon, Seungmin Bang
    Abstract:

    Background Capsule endoscopy that could actively move and approach a specific site might be more valuable for the diagnosis or treatment of GI diseases. Objective We tested the performance of active locomotion of a novel wired Capsule Endoscope with a paddling-based locomotion mechanism, using 3 models: a silicone tube, an extracted porcine colon, and a living pig. Design In vitro, ex vivo, and in vivo experiments in a pig model. Setting Study in an animal laboratory. Interventions For the in vitro test, the locomotive Capsule was controlled to actively move from one side of a silicone tube to the other by a controller-operated automatic traveling program. The velocity was calculated by following a video recording. We performed ex vivo tests by using an extracted porcine colon in the same manner we performed the in vitro test. In in vivo experiments, the Capsule was inserted into the rectum of a living pig under anesthesia, and was controlled to move automatically forward. After 8 consecutive trials, the velocity was calculated. Main Outcome Measurements Elapsed time, velocity, and mucosal damage. Results The locomotive Capsule showed stable and active movement inside the lumen both in vitro and ex vivo. The velocity was 60 cm/min in the silicone tube, and 36.8 and 37.5 cm/min in the extracted porcine colon. In the in vivo experiments, the Capsule stably moved forward inside the colon of a living pig without any serious complications. The mean velocity was 17 cm/min over 40 cm length. We noted pinpoint erythematous mucosal injuries in the colon. Limitation Porcine model experiments, wired Capsule Endoscope. Conclusions The novel paddling-based locomotive Capsule Endoscope performed fast and stable movement in a living pig colon with consistent velocity. Further investigation is necessary for practical use in humans.

  • first clinical trial of the miro Capsule Endoscope by using a novel transmission technology electric field propagation
    Gastrointestinal Endoscopy, 2009
    Co-Authors: Seungmin Bang, Jeong Youp Park, Seok Jeong, Young Ho Kim, Han Bo Shim, Tae Song Kim, Don Haeng Lee, Si Young Song
    Abstract:

    Background We developed a Capsule Endoscope (CE), "MiRo," with the novel transmission technology of electric-field propagation. The technology uses the human body as a conductive medium for data transmission. Specifications of the prototype include the ability to receive real-time images; size, 10.8 × 24 mm; weight, 3.3 g; field of view, 150°; resolution of power, 320 × 320 pixels; and transmittal speed, 2 frames per second. Objective To evaluate the clinical safety and diagnostic feasibility of the prototype MiRo, we conducted a multicenter clinical trial. Design and Patients All volunteers underwent baseline examinations, including EGD and electrocardiography for the screening of GI obstructive and cardiovascular diseases, before the trial. In the first 10 cases, 24-hour Holter monitoring was also performed. To evaluate the diagnostic feasibility, transmission rate of the captured images, inspection rate of the entire small bowel, and quality of transmitted images (graded as outstanding, excellent, good/average, below average, and poor) were analyzed. Results Of the 49 healthy volunteers, 45 were included in the trial, and 4 were excluded because of baseline abnormalities. No adverse effects were noted. All CEs were expelled within 2 days, and the entire small bowel could be explored in all cases. The transmission rates of the captured image in the stomach, small bowel, and colon were 99.5%, 99.6%, and 97.2%, respectively. The mean total duration of image transmission was 9 hours, 51 minutes, and the mean transit time of the entire small bowel was 4 hours, 33 minutes. Image quality was graded as good or better in 41 cases (91.1%). Details of the villi and vascular structures of the entire small bowel were clearly visualized in 31 cases (68.9%). Conclusions MiRo is safe and effective for exploring the entire small bowel, with good image quality and real-time feasibility. This novel transmission technology may have applications beyond the field of Capsule endoscopy.

  • first clinical trial of the miro Capsule Endoscope by using a novel transmission technology electric field propagation
    Gastrointestinal Endoscopy, 2009
    Co-Authors: Seungmin Bang, Jeong Youp Park, Seok Jeong, Han Bo Shim, Si Young Song
    Abstract:

    BACKGROUND: We developed a Capsule Endoscope (CE), "MiRo," with the novel transmission technology of electric-field propagation. The technology uses the human body as a conductive medium for data transmission. Specifications of the prototype include the ability to receive real-time images; size, 10.8 x 24 mm; weight, 3.3 g; field of view, 150 degrees; resolution of power, 320 x 320 pixels; and transmittal speed, 2 frames per second. OBJECTIVE: To evaluate the clinical safety and diagnostic feasibility of the prototype MiRo, we conducted a multicenter clinical trial. DESIGN AND PATIENTS: All volunteers underwent baseline examinations, including EGD and electrocardiography for the screening of GI obstructive and cardiovascular diseases, before the trial. In the first 10 cases, 24-hour Holter monitoring was also performed. To evaluate the diagnostic feasibility, transmission rate of the captured images, inspection rate of the entire small bowel, and quality of transmitted images (graded as outstanding, excellent, good/average, below average, and poor) were analyzed. RESULTS: Of the 49 healthy volunteers, 45 were included in the trial, and 4 were excluded because of baseline abnormalities. No adverse effects were noted. All CEs were expelled within 2 days, and the entire small bowel could be explored in all cases. The transmission rates of the captured image in the stomach, small bowel, and colon were 99.5%, 99.6%, and 97.2%, respectively. The mean total duration of image transmission was 9 hours, 51 minutes, and the mean transit time of the entire small bowel was 4 hours, 33 minutes. Image quality was graded as good or better in 41 cases (91.1%). Details of the villi and vascular structures of the entire small bowel were clearly visualized in 31 cases (68.9%). CONCLUSIONS: MiRo is safe and effective for exploring the entire small bowel, with good image quality and real-time feasibility. This novel transmission technology may have applications beyond the field of Capsule endoscopy.

Max Q H Meng - One of the best experts on this subject based on the ideXlab platform.

  • perspective of active Capsule Endoscope actuation and localisation
    International Journal of Mechatronics and Automation, 2011
    Co-Authors: Xiaona Wang, Max Q H Meng
    Abstract:

    The self-contained wireless Capsule Endoscope provides non-invasive, painless and effective diagnosis of the diseases in the small intestine. One anticipation is to embed the Capsule with therapeutic tools and enable not only diagnosis but also treatment of the GI diseases. Prior to the accomplishment of this objective, controlled movement of the Capsule should be achieved first. In this paper, we focused on the actuation and localisation issues of the active Capsule Endoscope. After a survey on the related work, the challenges were presented and the possible solutions were discussed.

  • a locomotion mechanism with external magnetic guidance for active Capsule Endoscope
    International Conference of the IEEE Engineering in Medicine and Biology Society, 2010
    Co-Authors: Xiaona Wang, Max Q H Meng, Xijun Chen
    Abstract:

    Gastrointestinal (GI) disorder is one of the most common diseases in human body. The swallowable wireless Capsule endoscopy has been proved to be a convenient, painless and effective way to examine the whole GI tract. However, lack of motion control makes the movement of the Capsule substantially random, resulting in missing diagnosis. In this paper, a locomotion mechanism is developed for the next-generation active Capsule Endoscope. An internal actuator integrated on-board the Capsule is designed to provide driving force and improve the dexterity. A small permanent magnet enclosed inside the Capsule interacts with an external magnetic field to control the Capsule's orientation and offer extra driving force. This mechanism avoids sophisticated and bulky control system and reduces power consumption inside the Capsule. Ex-vivo experimental results showed that it can make a controllable movement inside the porcine large intestine. The mechanism also has the potential to be a platform for further development, such as devices of operations, spraying medicine, biopsy etc.

  • Capsule Endoscope localization based on computer vision technique
    International Conference of the IEEE Engineering in Medicine and Biology Society, 2009
    Co-Authors: Li Liu, Wentao Cai, Max Q H Meng
    Abstract:

    To build a new type of wireless Capsule Endoscope with interactive gastrointestinal tract examination, a localization and orientation system is needed for tracking 3D location and 3D orientation of the Capsule movement. The magnetic localization and orientation method produces only 5 DOF, but misses the information of rotation angle along Capsule’s main axis. In this paper, we presented a complementary orientation approach for the Capsule Endoscope, and the 3D rotation can be determined by applying computer vision technique on the captured endoscopic images. The experimental results show that the complementary orientation method has good accuracy and high feasibility.

  • Real time algorithm for magnet's localization in Capsule Endoscope
    2009 IEEE International Conference on Automation and Logistics, 2009
    Co-Authors: Shuang Song, Wanan Yang, Chao Hu, Mao Li, Max Q H Meng
    Abstract:

    To track the movement of a wireless Capsule, a magnetic localization and orientation system is designed. In this system, a permanent magnet is enclosed in the Capsule, which generates a magnetic field around. With the magnetic sensor array arranged out of the human body, we can measure the magnet's magnetic signals, and compute the Capsule's 3D localization and 2D orientation parameters by applying an appropriate algorithm. In this paper, we presented a real time localization algorithm that consists of the Levenberg-Marquardt (LM) algorithm and the Least Squares Curve Fitting Method. The experimental results show that this algorithm has good accuracy, high speed and high robustness.

  • An improved magnetic localization and orientation algorithm for wireless Capsule Endoscope
    2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2008
    Co-Authors: Chao Hu, Wanan Yang, Dongmei Chen, Max Q H Meng
    Abstract:

    In this paper, we propose a novel localization algorithm for tracking a magnet inside the Capsule Endoscope by 3-axis magnetic sensors array. In the algorithm, we first use an improved linear algorithm to obtain the localization parameters by finding the eigenvector corresponding to the minimum eigenvalue of the objective matrix. These parameters are used as the initial guess of the localization parameters in the nonlinear localization algorithm, and the nonlinear algorithm searches for more appropriate parameters that can minimize the objective error function. As the results, we obtain more robust and accurate localization results than those by using linear algorithm only. Nevertheless, the time efficiency of the nonlinear algorithm is enhanced. The real experimental data show that the average localization accuracy is about 2mm and the average orientation accuracy is about 1.6° when the magnet moves within the sensing area of 240mm ×240mm square.

Jeong Youp Park - One of the best experts on this subject based on the ideXlab platform.

  • active locomotion of a paddling based Capsule Endoscope in an in vitro and in vivo experiment with videos
    Gastrointestinal Endoscopy, 2010
    Co-Authors: Hee Man Kim, Jeong Youp Park, Tae Song Kim, Si Young Song, Sungwook Yang, Jin Seok Kim, Semi Park, Jae Hee Cho, Euisung Yoon, Seungmin Bang
    Abstract:

    Background Capsule endoscopy that could actively move and approach a specific site might be more valuable for the diagnosis or treatment of GI diseases. Objective We tested the performance of active locomotion of a novel wired Capsule Endoscope with a paddling-based locomotion mechanism, using 3 models: a silicone tube, an extracted porcine colon, and a living pig. Design In vitro, ex vivo, and in vivo experiments in a pig model. Setting Study in an animal laboratory. Interventions For the in vitro test, the locomotive Capsule was controlled to actively move from one side of a silicone tube to the other by a controller-operated automatic traveling program. The velocity was calculated by following a video recording. We performed ex vivo tests by using an extracted porcine colon in the same manner we performed the in vitro test. In in vivo experiments, the Capsule was inserted into the rectum of a living pig under anesthesia, and was controlled to move automatically forward. After 8 consecutive trials, the velocity was calculated. Main Outcome Measurements Elapsed time, velocity, and mucosal damage. Results The locomotive Capsule showed stable and active movement inside the lumen both in vitro and ex vivo. The velocity was 60 cm/min in the silicone tube, and 36.8 and 37.5 cm/min in the extracted porcine colon. In the in vivo experiments, the Capsule stably moved forward inside the colon of a living pig without any serious complications. The mean velocity was 17 cm/min over 40 cm length. We noted pinpoint erythematous mucosal injuries in the colon. Limitation Porcine model experiments, wired Capsule Endoscope. Conclusions The novel paddling-based locomotive Capsule Endoscope performed fast and stable movement in a living pig colon with consistent velocity. Further investigation is necessary for practical use in humans.

  • first clinical trial of the miro Capsule Endoscope by using a novel transmission technology electric field propagation
    Gastrointestinal Endoscopy, 2009
    Co-Authors: Seungmin Bang, Jeong Youp Park, Seok Jeong, Young Ho Kim, Han Bo Shim, Tae Song Kim, Don Haeng Lee, Si Young Song
    Abstract:

    Background We developed a Capsule Endoscope (CE), "MiRo," with the novel transmission technology of electric-field propagation. The technology uses the human body as a conductive medium for data transmission. Specifications of the prototype include the ability to receive real-time images; size, 10.8 × 24 mm; weight, 3.3 g; field of view, 150°; resolution of power, 320 × 320 pixels; and transmittal speed, 2 frames per second. Objective To evaluate the clinical safety and diagnostic feasibility of the prototype MiRo, we conducted a multicenter clinical trial. Design and Patients All volunteers underwent baseline examinations, including EGD and electrocardiography for the screening of GI obstructive and cardiovascular diseases, before the trial. In the first 10 cases, 24-hour Holter monitoring was also performed. To evaluate the diagnostic feasibility, transmission rate of the captured images, inspection rate of the entire small bowel, and quality of transmitted images (graded as outstanding, excellent, good/average, below average, and poor) were analyzed. Results Of the 49 healthy volunteers, 45 were included in the trial, and 4 were excluded because of baseline abnormalities. No adverse effects were noted. All CEs were expelled within 2 days, and the entire small bowel could be explored in all cases. The transmission rates of the captured image in the stomach, small bowel, and colon were 99.5%, 99.6%, and 97.2%, respectively. The mean total duration of image transmission was 9 hours, 51 minutes, and the mean transit time of the entire small bowel was 4 hours, 33 minutes. Image quality was graded as good or better in 41 cases (91.1%). Details of the villi and vascular structures of the entire small bowel were clearly visualized in 31 cases (68.9%). Conclusions MiRo is safe and effective for exploring the entire small bowel, with good image quality and real-time feasibility. This novel transmission technology may have applications beyond the field of Capsule endoscopy.

  • first clinical trial of the miro Capsule Endoscope by using a novel transmission technology electric field propagation
    Gastrointestinal Endoscopy, 2009
    Co-Authors: Seungmin Bang, Jeong Youp Park, Seok Jeong, Han Bo Shim, Si Young Song
    Abstract:

    BACKGROUND: We developed a Capsule Endoscope (CE), "MiRo," with the novel transmission technology of electric-field propagation. The technology uses the human body as a conductive medium for data transmission. Specifications of the prototype include the ability to receive real-time images; size, 10.8 x 24 mm; weight, 3.3 g; field of view, 150 degrees; resolution of power, 320 x 320 pixels; and transmittal speed, 2 frames per second. OBJECTIVE: To evaluate the clinical safety and diagnostic feasibility of the prototype MiRo, we conducted a multicenter clinical trial. DESIGN AND PATIENTS: All volunteers underwent baseline examinations, including EGD and electrocardiography for the screening of GI obstructive and cardiovascular diseases, before the trial. In the first 10 cases, 24-hour Holter monitoring was also performed. To evaluate the diagnostic feasibility, transmission rate of the captured images, inspection rate of the entire small bowel, and quality of transmitted images (graded as outstanding, excellent, good/average, below average, and poor) were analyzed. RESULTS: Of the 49 healthy volunteers, 45 were included in the trial, and 4 were excluded because of baseline abnormalities. No adverse effects were noted. All CEs were expelled within 2 days, and the entire small bowel could be explored in all cases. The transmission rates of the captured image in the stomach, small bowel, and colon were 99.5%, 99.6%, and 97.2%, respectively. The mean total duration of image transmission was 9 hours, 51 minutes, and the mean transit time of the entire small bowel was 4 hours, 33 minutes. Image quality was graded as good or better in 41 cases (91.1%). Details of the villi and vascular structures of the entire small bowel were clearly visualized in 31 cases (68.9%). CONCLUSIONS: MiRo is safe and effective for exploring the entire small bowel, with good image quality and real-time feasibility. This novel transmission technology may have applications beyond the field of Capsule endoscopy.