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Chao Zhu - One of the best experts on this subject based on the ideXlab platform.
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The effect of Capsule tension ring on posterior Capsule Opacification: A meta-analysis.
PloS one, 2021Co-Authors: Kaikai Zhang, Yuchen Dong, Meisheng Zhao, Lili Nie, Xinfen Ding, Chao ZhuAbstract:Posterior Capsule Opacification is one of the most common complications after cataract surgery. Studies have suggested that the introduction of a Capsule tension ring might play a critical role in the prevention of Capsule Opacification, yet quantitative evidence is still lacking. This work consists of a meta-analysis on available data in order to explore the influence of a Capsule tension ring on posterior Capsule Opacification. A comprehensive review of the literature on Capsule tension ring and posterior Capsule Opacification was carried out using the Embase, Pubmed, Web of Science, and Cochrane electronic databases. The selected studies included randomized controlled trials, retrospective studies and prospective studies published before June 2020. The studies of interest were selected by two reviewers independently from the included studies. Odds ratios (ORs) and standardized mean differences (SMD) were used in order to assess the association. A fixed-effects model or a random-effects model was applied to combine data according to heterogeneities. Sensitivity analysis was used to assess the heterogeneity of the studies. Publication bias was estimated using the Egger test. Statistical analysis was performed using the stata15.1 software. The meta-analysis included in total 8 studies involving 379 cases and 333 controls. There was a statistically significant difference of Nd:YAG laser capsulotomy rate (OR=0.241, 95% CI: 0.145, 0.400 I2=42.1%) between the Capsule tension ring group and the control group, indicating that the tension ring reduced the Nd:YAG laser capsulotomy rate. Further studies with continuous data also revealed that the use of Capsule tension ring was associated with a lower posterior Capsule Opacification score (SMD = -1.402, 95% CI: -2.448, -0.355 I2=95.0%). The sensitivity analysis suggested that the result of the re-combined analysis did not change notably, indicating that the result was reliable and stable. Both pooled analysis showed no evidence of publication bias. The findings of this meta-analysis confirmed that Capsule tension ring might reduce Capsule Opacification. Further studies should be made to validate the result.
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The effect of Capsule tension ring on posterior Capsule Opacification: A meta-analysis
PloS one, 2021Co-Authors: Kaikai Zhang, Yuchen Dong, Meisheng Zhao, Lili Nie, Xinfen Ding, Chao ZhuAbstract:Background Posterior Capsule Opacification is one of the most common complications after cataract surgery. Studies have suggested that the introduction of a Capsule tension ring might play a critical role in the prevention of Capsule Opacification, yet quantitative evidence is still lacking. This work consists of a meta-analysis on available data in order to explore the influence of a Capsule tension ring on posterior Capsule Opacification. Methods A comprehensive review of the literature on Capsule tension ring and posterior Capsule Opacification was carried out using the Embase, Pubmed, Web of Science, and Cochrane electronic databases. The selected studies included randomized controlled trials, retrospective studies and prospective studies published before June 2020. The studies of interest were selected by two reviewers independently from the included studies. Odds ratios (ORs) and standardized mean differences (SMD) were used in order to assess the association. A fixed-effects model or a random-effects model was applied to combine data according to heterogeneities. Sensitivity analysis was used to assess the heterogeneity of the studies. Publication bias was estimated using the Egger test. Statistical analysis was performed using the stata15.1 software. Results The meta-analysis included in total 8 studies involving 379 cases and 333 controls. There was a statistically significant difference of Nd:YAG laser capsulotomy rate (OR=0.241, 95% CI: 0.145, 0.400 I2=42.1%) between the Capsule tension ring group and the control group, indicating that the tension ring reduced the Nd:YAG laser capsulotomy rate. Further studies with continuous data also revealed that the use of Capsule tension ring was associated with a lower posterior Capsule Opacification score (SMD = -1.402, 95% CI: -2.448, -0.355 I2=95.0%). The sensitivity analysis suggested that the result of the re-combined analysis did not change notably, indicating that the result was reliable and stable. Both pooled analysis showed no evidence of publication bias. Conclusion The findings of this meta-analysis confirmed that Capsule tension ring might reduce Capsule Opacification. Further studies should be made to validate the result.
Charlotta Zetterström - One of the best experts on this subject based on the ideXlab platform.
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Position of anterior capsulorhexis and posterior Capsule Opacification.
Acta Ophthalmologica Scandinavica, 2004Co-Authors: Gisela Wejde, Maria Kugelberg, Charlotta ZetterströmAbstract:. Purpose: To evaluate whether the position of the anterior continuous curvilinear capsulorhexis influences the rate of posterior Capsule Opacification (PCO). Methods: A total of 119 patients, aged 61–86 years, underwent cataract surgery with phacoemulsification performed by a single surgeon. The patients were randomized to implantation with either a silicone intraocular lens (IOL) (SI40NB, Allergan) or an AcrySof IOL (MA60BM, Alcon). Three years after surgery, the rate of PCO was analysed using the evaluation of posterior Capsule Opacification computer software (EPCO). The results were related to the capsulorhexis position, which was assessed with a retroillumination photograph. Results: If the capsulorhexis was located partially or completely off the optics of the IOL, compared to totally on the IOL, significantly more PCO was found (p = 0.0014). When comparing within each IOL type, patients with AcrySof IOLs were found to have significantly less PCO when the capsulorhexis was totally on the optic (p = 0.0048). This difference was also significant in the silicone group (p = 0.041). Conclusion: A relatively small and central capsulorhexis allowing for the complete covering of the IOL optics by the rhexis edges seems to protect against PCO in cataract surgery, with both round-edged silicone IOLs and sharp-edged hydrophobic acrylic IOLs.
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Posterior Capsule Opacification after phacoemulsification in patients with postoperative steroidal and nonsteroidal treatment.
Journal of cataract and refractive surgery, 2004Co-Authors: Anna Zaczek, Carl-gustaf Laurell, Charlotta ZetterströmAbstract:Abstract Purpose: To evaluate the effect of dexamethasone, diclofenac, and a placebo given for 3 weeks after phacoemulsification and intraocular lens (IOL) implantation on the formation of posterior Capsule Opacification (PCO). Setting: St. Erik's Eye Hospital, Stockholm, Sweden. Methods: In a 2-year prospective randomized double-blind study, a laser flare meter was used to measure aqueous flare intensity preoperatively and 3 days, 2 weeks, and 2 years after phacoemulsification and IOL implantation. Posterior Capsule Opacification was evaluated 2 years postoperatively using retroillumination images taken with a Scheimpflug camera. The Evaluation of Posterior Capsule Opacification system was used to score the areas of PCO density. Results: The median rate of PCO 2 years after phacoemulsification was 0.72 (range 0.32 to 1.57) in the dexamethasone group, 0.78 (range 0.19 to 2.14) in the diclofenac group, and 0.70 (range 0.35 to 1.70) in the placebo group. The differences were not statistically significant ( P >.05; Kruskal-Wallis analysis of variance, multiple comparisons). The rate of neodymium:YAG laser posterior capsulotomy during the 2 years after surgery was not statistically different between groups ( P >.05, chi-square test). There was no correlation (Spearman rank coefficient) between laser flare measurements and PCO formation in any group during the study ( P >.05). Conclusion: Topical instillation of diclofenac, dexamethasone, or a placebo in the immediate period after phacoemulsification and IOL implantation did not seem to influence the formation of PCO 2 years after cataract surgery.
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Posterior Capsule Opacification: comparison of 3 intraocular lenses of different materials and design
Journal of cataract and refractive surgery, 2003Co-Authors: Gisela Wejde, Maria Kugelberg, Charlotta ZetterströmAbstract:Abstract Purpose To compare posterior Capsule Opacification (PCO) after cataract surgery with implantation of 3 intraocular lenses (IOLs) of different materials and design. Setting St. Erik's Eye Hospital, Stockholm, Sweden. Methods In this prospective clinical study, 180 patients had standardized phacoemulsification performed by a single surgeon and were randomized to have implantation of a heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) IOL (809C, Pharmacia & Upjohn), a silicone IOL (SI-40NB, Allergan), or an acrylic IOL (AcrySof® MA60BM, Alcon). To morphologically evaluate PCO, retroillumination photographs were obtained and analyzed using Evaluation of Posterior Capsule Opacification computer software. The neodymium:YAG (Nd:YAG) capsulotomy rate was recorded. Results After 2 years, the HSM PMMA IOL group had significantly more PCO than the silicone and AcrySof IOL groups; the silicone group had significantly more PCO than the AcrySof group ( P Conclusion Patients with an AcrySof IOL developed significantly less PCO than those with a silicone or HSM PMMA IOL with a round-edged design.
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Posterior Capsule Opacification after phacoemulsification in patients with diabetes mellitus
Journal of cataract and refractive surgery, 1999Co-Authors: Anna Zaczek, Charlotta ZetterströmAbstract:Abstract Purpose: To compare posterior Capsule Opacification (PCO) after phacoemulsificationand implantation of heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) in the capsular bag in patients with diabetes mellitus with that in a control group. Setting: St. Erik's Eye Hospital, Stockholm, Sweden. Methods: This prospective study comprised 26 patients with diabetes mellitus and 26 control patients without diabetes. Those with glaucoma, exfoliation syndrome, uveitis, and pupil size smaller than 6.0 mm after dilation were excluded. All patients received the same standardized phacoemulsification procedure with implantation of an HSM PMMA IOL in the capsular bag. Posterior Capsule Opacification was scored 1 and 2 years after surgery by evaluating retroillumination images taken with a Scheimpflug camera (Nidek Anterior Eye Segment Analysis System) after pupil dilation with phenylephrine 10% and cyclopentolate 1%. The PCO density behind the IOL optic was graded clinically from 0 to 4 (0 = none, 1=minimal, 2=mild, 3=moderate, 4=severe) and scored using the Evaluation of Posterior Capsule Opacification medical software developing system. Results: No differences in PCO were found between the diabetic and control group Results: year after surgery. The total PCO score was significantly less in diabetic than in control eyes 2 years after surgery ( P P ≤ .05, Kruskal-Wallis analysis of variance and multiple comparisons). Conclusion: The rate of PCO after phacoemulsification was statistically significantlylower in patients with diabetes mellitus than in those without diabetes.
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Incidence of posterior Capsule Opacification in eyes with exfoliation syndrome and heparin-surface-modified intraocular lenses
Journal of cataract and refractive surgery, 1993Co-Authors: Charlotta ZetterströmAbstract:Abstract Conventional poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) and heparin-surface-modified (HSM) IOLs were implanted after extracapsular cataract extraction in 40 human eyes with exfoliation syndrome. The study was doublemasked and randomized. Two years after surgery 17 cases with HSM IOLs and 15 with PMMA IOLs were examined. We observed that pigment and cell deposits were more frequent on the PMMA than on the HSM IOLs. The incidence of posterior synechia formation was similar in both groups. However, the incidence of neodymium:YAG laser posterior capsulotomy and posterior Capsule Opacification was more frequent in the PMMA IOL group. Visual acuity did not differ between the two groups before or two years after surgery. The results suggest that in eyes with exfoliation syndrome, implanting an HSM IOL reduces the incidence of posterior Capsule Opacification often associated with extracapsular cataract extraction.
Tetsuro Oshika - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous regression of Elschnig pearl posterior Capsule Opacification.
Journal of cataract and refractive surgery, 2007Co-Authors: Hitoshi Yoneya, Satoshi Kato, Gentaro Sugita, Tetsuro OshikaAbstract:A 60-year-old man with senile cataract had phacoemulsification and implantation of a single-piece acrylic intraocular lens (IOL) in July 2000. There were no intraoperative or short-term postoperative complications, and the visual acuity was 20/20 on the day after surgery. In February 2002, 19 months postoperatively, posterior Capsule Opacification (PCO) extending from the base of the IOL loops was observed. Capsulotomy was not performed, and the PCO regressed spontaneously between April 2003 and March 2005. This is the first documented case of spontaneous PCO regression after phacoemulsification and IOL implantation.
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Posterior Capsule Opacification after cataract surgery in patients with diabetes mellitus.
Journal of cataract and refractive surgery, 2006Co-Authors: Yoko Ebihara, Satoshi Kato, Tetsuro Oshika, Mayumi Yoshizaki, Gentaro SugitaAbstract:Purpose To prospectively compare the degree of posterior Capsule Opacification (PCO) after cataract surgery in patients with and without diabetes mellitus. Setting Sugita Eye Hospital, Nagoya, Japan. Methods Forty-two eyes of 42 consecutive diabetes mellitus patients (DM group) and 42 eyes of 42 non-DM patients (control group) scheduled to have cataract surgery were enrolled. The PCO value was determined using the posterior Capsule Opacification (POCO) system 3, 6, and 12 months after surgery. Results Posterior Capsule Opacification values 3 months after surgery did not differ significantly between the 2 groups ( P >.05). At 6 and 12 months, the PCO values of the DM group were significantly higher than those of the control group ( P = .002 and P = .03, respectively). Conclusion Diabetic patients had significantly more severe PCO after cataract surgery than nondiabetic patients.
Okihiro Nishi - One of the best experts on this subject based on the ideXlab platform.
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Capsule-Bending Ring for the Prevention of Posterior Capsule Opacification
Lens Epithelium and Posterior Capsular Opacification, 2014Co-Authors: Okihiro Nishi, Kayo Nishi, Rupert MenapaceAbstract:In 64 patients, a Capsule-bending ring (CBR), an open poly(methyl methacrylate) (PMMA) ring with a truncated edge profile that should create a sharp bend in the equatorial Capsule, was implanted in one eye of patients with a hydroxy(ethyl methacrylate) (HEMA) intraocular lens (IOL). The contralateral eye received only the IOL as control. Anterior Capsule Opacification (ACO) and shrinkage were significantly reduced in the eyes with the ring. Posterior Capsule Opacification (PCO) score (EPCO) was 0.235 ± 0.215, 0.287 ± 0.200, and 0.398 ± 0.248 with the ring and 0.530 ± 0.190, 0.670 ± 0.225, and 1.111 ± 0.298 without the ring, at 6 months, 1 year, and 2 years, respectively (P < 0.01 at each period). Nd:YAG laser posterior capsulotomy was performed in 4 eyes with ring and 17 eyes without the ring, respectively, after 2 years (P < 0.01). The CBR significantly reduced anterior capsular fibrosis and shrinkage as well as PCO. The ring may be useful for those patients who are at high risk of developing eye complications from capsular Opacification requiring Nd:YAG laser capsulotomy, for those who are expected to undergo vitreoretinal surgery and photocoagulation by facilitating better fundus visualization, and for those who have pediatric cataracts.
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Evaluation of posterior Capsule Opacification using a new posterior view method in rabbits: single-piece acrylic versus 3-piece acrylic intraocular lens.
Journal of cataract and refractive surgery, 2005Co-Authors: Okihiro Nishi, Kayo Nishi, Yasuhiro OsakabeAbstract:Purpose To introduce a new procedure for evaluating posterior Capsule Opacification (PCO) in rabbit eyes and to perform a comparative study of the single-piece and 3-piece acrylic intraocular lenses (IOLs) on PCO using the new evaluation method. Setting Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan. Methods A single-piece or 3-piece acrylic IOL was implanted in 1 eye and the other in the contralateral eye of 5 rabbits. Three weeks after surgery, PCO was scored by Evaluation of Posterior Capsule Opacification (EPCO) in posterior view. Before the posterior view was photographed, the anterior Capsule was removed from the whole optic area to eliminate disturbing anterior Capsule Opacification (ACO) for the PCO evaluation. Results Posterior Capsule Opacification could be well observed and viewed in the posterior view so that it could be scored by EPCO without confusion with ACO. The mean PCO score of the single-piece and 3-piece acrylic IOLs was 3.12 ± 0.19 and 2.41 ± 0.70, respectively ( P P = .03, respectively). Conclusion The removal of ACO allowed scoring of PCO by EPCO in rabbit eyes. The single-piece acrylic IOL showed singnificantly more PCO than the 3-piece acrylic IOL at least 3 weeks after surgery in rabbits.
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capsular bending ring to prevent posterior Capsule Opacification 2 year follow up
Journal of Cataract and Refractive Surgery, 2001Co-Authors: Okihiro Nishi, Rupert Menapace, Kayo Nishi, Junsuke AkuraAbstract:Purpose: To evaluate the preventive effect of a capsular bending ring on anterior and posterior Capsule (PCO) Opacification in a 2 year clinical study. Setting: Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan. Methods: This study comprised 60 patients with senile cataract (35 women, 25 men) with a mean age of 69 years. An open poly(methyl methacrylate) capsular bending ring with a truncated edge profile designed to create a sharp bend in the equatorial Capsule was implanted in 1 eye of patients with a hydroxyethyl methacrylate intraocular lens (IOL). The contralateral eye, which acted as a control, received an IOL but no ring. Patients were examined 6 months (n = 52), 1 year (n = 48), and 2 years (n = 42) postoperatively. Anterior Capsule Opacification was determined by slitlamp evaluation. Anterior Capsule shrinkage (area within the capsulorhexis) and PCO were evaluated and scored using a computer software package for image analysis. Posterior Capsule Opacification was also measured by the rate of neodymium:YAG (Nd:YAG) capsulotomies. Results: Anterior Capsule Opacification and shrinkage were significantly less in eyes with the ring. The mean PCO score was 0.235 ± 0.215 (SD), 0.287 ± 0.200, and 0.398 ± 0.248 with the ring and 0.530 ± 0.190, 0.670 ± 0.225, and 1.111 ± 0.298 without the ring at 6 months, 1 year, and 2 years, respectively (P < .01 at each follow-up). An Nd:YAG laser capsulotomy was performed in 4 eyes with and 17 eyes without the ring after 2 years (P < .01). Conclusions: The capsular bending ring significantly reduced anterior Capsule fibrosis and shrinkage as well as PCO. The ring may be useful in patients who are at high risk of developing eye complications from Capsule Opacification that require Nd:YAG laser capsulotomy, in those expected to have vitreoretinal surgery and photocoagulation, and in cases of pediatric cataract.
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Capsule Opacification after refilling the Capsule with an inflatable endocapsular balloon
Journal of cataract and refractive surgery, 1997Co-Authors: Okihiro Nishi, Yoshiko Nakai, Yuriko Mizumoto, Yoshiharu YamadaAbstract:Abstract Purpose: To describe the features of Capsule Opacification in rabbits and cynomolgus monkeys after the Capsules were refilled with an inflatable endocapsular balloon. Setting: Nishi Eye Hospital, Jinshikai Medical Foundation, Osaka, Japan. Method: Capsule Opacification was evaluated by slitlamp examination, Miyake view, and histopathological examination in 15 eyes of 15 rabbits and 16 eyes of 13 primates from 4 to 32 months after the lens Capsule had been refilled. Results: The incidence of Capsule Opacification was 94%. In the eyes that did not have lens epithelial cell (LEC) removal, a monolayer of LECs was seen on the posterior Capsule when the lens Capsule was tautly refilled, whereas a thick layer was seen when the lens Capsule was moderately or poorly refilled. In the eyes that had LEC removal, the Opacification was generally less marked regardless of the amount of refilling. In two rabbit Capsules that were refilled moderately or tautly and had LEC removal, the Capsule remained clear. Neodymium:YAG capsulotomy in two eyes did not cause herniation of the injected silicone. Conclusions: Filling the Capsule tautly and removing the LECs effectively reduced Capsule Opacification but could not completely inhibit LEC migration. This suggests the need for more efficient and thorough LEC removal or even a pharmaceutical approach to prevent Capsule Opacification after lens refilling.
Kaikai Zhang - One of the best experts on this subject based on the ideXlab platform.
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The effect of Capsule tension ring on posterior Capsule Opacification: A meta-analysis.
PloS one, 2021Co-Authors: Kaikai Zhang, Yuchen Dong, Meisheng Zhao, Lili Nie, Xinfen Ding, Chao ZhuAbstract:Posterior Capsule Opacification is one of the most common complications after cataract surgery. Studies have suggested that the introduction of a Capsule tension ring might play a critical role in the prevention of Capsule Opacification, yet quantitative evidence is still lacking. This work consists of a meta-analysis on available data in order to explore the influence of a Capsule tension ring on posterior Capsule Opacification. A comprehensive review of the literature on Capsule tension ring and posterior Capsule Opacification was carried out using the Embase, Pubmed, Web of Science, and Cochrane electronic databases. The selected studies included randomized controlled trials, retrospective studies and prospective studies published before June 2020. The studies of interest were selected by two reviewers independently from the included studies. Odds ratios (ORs) and standardized mean differences (SMD) were used in order to assess the association. A fixed-effects model or a random-effects model was applied to combine data according to heterogeneities. Sensitivity analysis was used to assess the heterogeneity of the studies. Publication bias was estimated using the Egger test. Statistical analysis was performed using the stata15.1 software. The meta-analysis included in total 8 studies involving 379 cases and 333 controls. There was a statistically significant difference of Nd:YAG laser capsulotomy rate (OR=0.241, 95% CI: 0.145, 0.400 I2=42.1%) between the Capsule tension ring group and the control group, indicating that the tension ring reduced the Nd:YAG laser capsulotomy rate. Further studies with continuous data also revealed that the use of Capsule tension ring was associated with a lower posterior Capsule Opacification score (SMD = -1.402, 95% CI: -2.448, -0.355 I2=95.0%). The sensitivity analysis suggested that the result of the re-combined analysis did not change notably, indicating that the result was reliable and stable. Both pooled analysis showed no evidence of publication bias. The findings of this meta-analysis confirmed that Capsule tension ring might reduce Capsule Opacification. Further studies should be made to validate the result.
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The effect of Capsule tension ring on posterior Capsule Opacification: A meta-analysis
PloS one, 2021Co-Authors: Kaikai Zhang, Yuchen Dong, Meisheng Zhao, Lili Nie, Xinfen Ding, Chao ZhuAbstract:Background Posterior Capsule Opacification is one of the most common complications after cataract surgery. Studies have suggested that the introduction of a Capsule tension ring might play a critical role in the prevention of Capsule Opacification, yet quantitative evidence is still lacking. This work consists of a meta-analysis on available data in order to explore the influence of a Capsule tension ring on posterior Capsule Opacification. Methods A comprehensive review of the literature on Capsule tension ring and posterior Capsule Opacification was carried out using the Embase, Pubmed, Web of Science, and Cochrane electronic databases. The selected studies included randomized controlled trials, retrospective studies and prospective studies published before June 2020. The studies of interest were selected by two reviewers independently from the included studies. Odds ratios (ORs) and standardized mean differences (SMD) were used in order to assess the association. A fixed-effects model or a random-effects model was applied to combine data according to heterogeneities. Sensitivity analysis was used to assess the heterogeneity of the studies. Publication bias was estimated using the Egger test. Statistical analysis was performed using the stata15.1 software. Results The meta-analysis included in total 8 studies involving 379 cases and 333 controls. There was a statistically significant difference of Nd:YAG laser capsulotomy rate (OR=0.241, 95% CI: 0.145, 0.400 I2=42.1%) between the Capsule tension ring group and the control group, indicating that the tension ring reduced the Nd:YAG laser capsulotomy rate. Further studies with continuous data also revealed that the use of Capsule tension ring was associated with a lower posterior Capsule Opacification score (SMD = -1.402, 95% CI: -2.448, -0.355 I2=95.0%). The sensitivity analysis suggested that the result of the re-combined analysis did not change notably, indicating that the result was reliable and stable. Both pooled analysis showed no evidence of publication bias. Conclusion The findings of this meta-analysis confirmed that Capsule tension ring might reduce Capsule Opacification. Further studies should be made to validate the result.