The Experts below are selected from a list of 2697 Experts worldwide ranked by ideXlab platform
Ana C. Fernandes - One of the best experts on this subject based on the ideXlab platform.
-
Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
-
cyclopentadienyl ruthenium ii and iron ii organometallic compounds with Carbohydrate Derivative ligands as good colorectal anticancer agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
Pedro R. Florindo - One of the best experts on this subject based on the ideXlab platform.
-
Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
-
cyclopentadienyl ruthenium ii and iron ii organometallic compounds with Carbohydrate Derivative ligands as good colorectal anticancer agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
Diane M. Pereira - One of the best experts on this subject based on the ideXlab platform.
-
Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
-
cyclopentadienyl ruthenium ii and iron ii organometallic compounds with Carbohydrate Derivative ligands as good colorectal anticancer agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
M. F. M. Piedade - One of the best experts on this subject based on the ideXlab platform.
-
Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
-
cyclopentadienyl ruthenium ii and iron ii organometallic compounds with Carbohydrate Derivative ligands as good colorectal anticancer agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
Cecília M. P. Rodrigues - One of the best experts on this subject based on the ideXlab platform.
-
Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
-
cyclopentadienyl ruthenium ii and iron ii organometallic compounds with Carbohydrate Derivative ligands as good colorectal anticancer agents
Journal of Medicinal Chemistry, 2015Co-Authors: Pedro R. Florindo, Diane M. Pereira, Pedro M. Borralho, Cecília M. P. Rodrigues, M. F. M. Piedade, Ana C. FernandesAbstract:New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing Carbohydrate Derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR’s data analysis within this library showed an interesting dependency of the cytotoxic activity on the Carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.