The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Thibault Cantat - One of the best experts on this subject based on the ideXlab platform.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie (International ed. in English), 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2 , this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [14 C] and [13 C]. A proof of concept with [11 C] was also obtained with low molar activity valuable for distribution studies.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie International Edition, 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Charles Elmore, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activities valuable for distribution studies.
Gianluca Destro - One of the best experts on this subject based on the ideXlab platform.
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A Photochemical Strategy for Carbon Isotope Exchange with CO 2
ACS Catalysis, 2021Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Antoine Sallustrau, Charles Elmore, Davide AudisioAbstract:A photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [ 13 C]CO2 and [ 14 C]CO2 as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into phenyl acetic acids without the need of structural modifications or prefunctionalization, in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with previous methods requiring the use of harsh thermal conditions.
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Photochemical Strategy for Carbon Isotope Exchange with CO2
ACS Catalysis, 2021Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Davide AudisioAbstract:A photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [13C]CO2 and [14C]CO2 as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into pheny...
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A Photochemical Strategy for Carbon Isotope Exchange with CO2
2020Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Antonio Del Vecchio, Davide AudisioAbstract:A novel photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [<sup>13</sup>C]CO<sub>2</sub> as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into phenyl acetic acids without the need of structural modifications or pre-functionalization, in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with previous methods requiring the use of harsh thermal conditions.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie (International ed. in English), 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2 , this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [14 C] and [13 C]. A proof of concept with [11 C] was also obtained with low molar activity valuable for distribution studies.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie International Edition, 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Charles Elmore, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activities valuable for distribution studies.
James R Ehleringer - One of the best experts on this subject based on the ideXlab platform.
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Carbon Isotope composition gas exchange and heterotrophy in australian mistletoes
Functional Ecology, 1994Co-Authors: John D Marshall, James R Ehleringer, Ernst Detlef Schulze, Graham D FarquharAbstract:Photosynthesis, transpiration and Carbon Isotope ratios of 11 mistletoes and their hosts were measured in central and eastern Australia to test hypotheses regarding similarity of photosynthetic rate between host and parasite and significance of host xylem Carbon as a contributor to parasite Carbon gain. Differences in photosynthetic rates of mistletoes and their hosts were not statistically significant, although most mistletoes had slightly lower photosynthetic rates and much higher transpiration rates than their hosts. Uptake of Carbon dissolved in the xylem sap of the host was estimated from the discrepancy between observed and predicted Carbon Isotope ratios. Dividing xylem Carbon gain by measured transpiration yielded a mean ± SE xylem Carbon concentration of 10 ± 2.0 mM (...)
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heritability of Carbon Isotope discrimination in gutierrezia microcephala asteraceae
American Journal of Botany, 1992Co-Authors: William S F Schuster, Susan L Phillips, Darren R Sandquist, James R EhleringerAbstract:The Carbon Isotope composition (13C/'2C) of C3 plant tissues provides a long-term, integrated measure of photosynthetic metabolism. Quantitative genetic methods were used to study the inheritance of Carbon Isotope composition and several morphological characters in Gutierrezia microcephala, a short-lived desert perennial. Open-pollinated seed was collected from a population located near Lee's Ferry, Arizona, in an area that was disturbed approximately 20 years ago. Seeds were germinated and seedlings grown in a common greenhouse environment. Carbon Isotope discrimination (A) and all morphological characters varied significantly among maternal families. Heritability of A was estimated as 81% in the greenhouse and as 92% using the regression of family mean A on parent A from field samples. Using both field and greenhouse data, we estimated a lower bound for heritability in nature of 54%. Offspring size and biomass both showed significant, positive correlations with A. The corresponding genetic correlations were similar in magnitude and direction, but did not differ significantly from zero. These results imply the existence of heritable differences in physiology associated with Carbon assimilation and water loss within populations, and the potential for microevolutionary change through natural selection.
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Seasonal Carbon Isotope discrimination in a grassland community
Oecologia, 1991Co-Authors: Mark P. Smedley, Todd E. Dawson, Jonathan P. Comstock, Lisa A. Donovan, Dorothy E. Sherrill, Craig S. Cook, James R EhleringerAbstract:Grassland communities of arid western North America are often characterized by a seasonal increase in ambient temperature and evaporative demand and a corresponding decline in soil moisture availability. As the environment changes, particular species could respond differently, which should be reflected in a number of physiological processes. Carbon Isotope discrimination varies during photosynthetic activity as a function of both stomatal aperture and the biochemistry of the fixation process, and provides an integrated measure of plant response to seasonal changes in the environment. We measured the seasonal course of Carbon Isotope discrimination in 42 grassland species to evaluate changes in gas exchange processes in response to these varying environmental factors. The seasonal courses were then used to identify community-wide patterns associated with life form, with phenology and with differences between grasses and forbs. Significant differences were detected in the following comparisons: (1) Carbon Isotope discrimination decreased throughout the growing season; (2) perennial species discriminated less than annual species; (3) grasses discriminated less than forbs; and (4) early flowering species discriminated more than the later flowering ones. These comparisons suggested that (1) species active only during the initial, less stressful months of the growing season used water less efficiently, and (2) that physiological responses increasing the ratio of Carbon fixed to water lost were common in these grassland species, and were correlated with the increase in evaporative demand and the decrease in soil moisture.
Antonio Del Vecchio - One of the best experts on this subject based on the ideXlab platform.
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A Photochemical Strategy for Carbon Isotope Exchange with CO 2
ACS Catalysis, 2021Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Antoine Sallustrau, Charles Elmore, Davide AudisioAbstract:A photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [ 13 C]CO2 and [ 14 C]CO2 as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into phenyl acetic acids without the need of structural modifications or prefunctionalization, in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with previous methods requiring the use of harsh thermal conditions.
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Photochemical Strategy for Carbon Isotope Exchange with CO2
ACS Catalysis, 2021Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Davide AudisioAbstract:A photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [13C]CO2 and [14C]CO2 as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into pheny...
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie (International ed. in English), 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2 , this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [14 C] and [13 C]. A proof of concept with [11 C] was also obtained with low molar activity valuable for distribution studies.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie International Edition, 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Charles Elmore, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activities valuable for distribution studies.
Frédéric Taran - One of the best experts on this subject based on the ideXlab platform.
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A Photochemical Strategy for Carbon Isotope Exchange with CO 2
ACS Catalysis, 2021Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Antoine Sallustrau, Charles Elmore, Davide AudisioAbstract:A photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [ 13 C]CO2 and [ 14 C]CO2 as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into phenyl acetic acids without the need of structural modifications or prefunctionalization, in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with previous methods requiring the use of harsh thermal conditions.
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Photochemical Strategy for Carbon Isotope Exchange with CO2
ACS Catalysis, 2021Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Davide AudisioAbstract:A photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [13C]CO2 and [14C]CO2 as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into pheny...
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A Photochemical Strategy for Carbon Isotope Exchange with CO2
2020Co-Authors: Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Charles S. Elmore, Frédéric Taran, Antoine Sallustrau, Antonio Del Vecchio, Davide AudisioAbstract:A novel photocatalytic approach for Carbon Isotope exchange is reported. Utilizing [<sup>13</sup>C]CO<sub>2</sub> as primary C1 sources, this protocol allows the insertion of the desired Carbon Isotope into phenyl acetic acids without the need of structural modifications or pre-functionalization, in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with previous methods requiring the use of harsh thermal conditions.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie (International ed. in English), 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frédéric Taran, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2 , this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [14 C] and [13 C]. A proof of concept with [11 C] was also obtained with low molar activity valuable for distribution studies.
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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
Angewandte Chemie International Edition, 2020Co-Authors: Gianluca Destro, Antonio Del Vecchio, Frédéric Taran, Charles Elmore, Kaisa Horkka, Olivier Loreau, David-alexandre Buisson, Lee Kingston, Magnus Schou, Thibault CantatAbstract:A transition-metal-free Carbon Isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the Carbon Isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with Carbon Isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activities valuable for distribution studies.