The Experts below are selected from a list of 20961 Experts worldwide ranked by ideXlab platform
Jinlong Xiao - One of the best experts on this subject based on the ideXlab platform.
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Carboxymethylcellulose-Supported Palladium Nanoparticles Generated in Situ from Palladium(II) Carboxymethylcellulose: An Efficient and Reusable Catalyst for Suzuki–Miyaura and Mizoroki–Heck Reactions
Industrial & Engineering Chemistry Research, 2015Co-Authors: Jinlong XiaoAbstract:A very easy method is described here for direct preparation of palladium(II) Carboxymethylcellulose (CMC-PdII) by ion exchange of sodium Carboxymethylcellulose (CMC-Na) and PdCl2. When the resulting CMC-PdII was employed as a catalyst in Suzuki−Miyaura and Mizoroki−Heck cross-coupling reactions, PdII was reduced in situ to Pd0 and further grown on CMC to afford Carboxymethylcellulose-supported palladium nanoparticles (CMC-Pd0). The as-generated CMC-Pd0 proved to be an efficient catalyst for these mentioned cross-coupling reactions under mild aerobic conditions. The CMC-PdII and CMC-Pd0 were fully characterized by FT-IR, ICP-AES, XPS, XRD, SEM, EDX, TEM, and TGA. The characterized results demonstrated that the true catalytic species are Pd0 nanoparticles. Moreover, the catalyst showed no significant loss of efficiency after six catalytic cycles.
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Carboxymethylcellulose supported palladium nanoparticles generated in situ from palladium ii Carboxymethylcellulose an efficient and reusable catalyst for suzuki miyaura and mizoroki heck reactions
Industrial & Engineering Chemistry Research, 2015Co-Authors: Jinlong XiaoAbstract:A very easy method is described here for direct preparation of palladium(II) Carboxymethylcellulose (CMC-PdII) by ion exchange of sodium Carboxymethylcellulose (CMC-Na) and PdCl2. When the resulting CMC-PdII was employed as a catalyst in Suzuki−Miyaura and Mizoroki−Heck cross-coupling reactions, PdII was reduced in situ to Pd0 and further grown on CMC to afford Carboxymethylcellulose-supported palladium nanoparticles (CMC-Pd0). The as-generated CMC-Pd0 proved to be an efficient catalyst for these mentioned cross-coupling reactions under mild aerobic conditions. The CMC-PdII and CMC-Pd0 were fully characterized by FT-IR, ICP-AES, XPS, XRD, SEM, EDX, TEM, and TGA. The characterized results demonstrated that the true catalytic species are Pd0 nanoparticles. Moreover, the catalyst showed no significant loss of efficiency after six catalytic cycles.
Sergio W Larach - One of the best experts on this subject based on the ideXlab platform.
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Prevention of Postoperative Abdominal Adhesions by a Novel, Glycerol/Sodium Hyaluronate/Carboxymethylcellulose-Based Bioresorbable Membrane: A Prospective, Randomized, Evaluator-Blinded Multicenter Study
Diseases of the Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no antiadhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group ( P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group ( P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control ( P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
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prevention of postoperative abdominal adhesions by a novel glycerol sodium hyaluronate Carboxymethylcellulose based bioresorbable membrane a prospective randomized evaluator blinded multicenter study
Diseases of The Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION: Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS: Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no anti-adhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS: Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group (P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group (P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control (P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS: Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
Zane Cohen - One of the best experts on this subject based on the ideXlab platform.
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Prevention of Postoperative Abdominal Adhesions by a Novel, Glycerol/Sodium Hyaluronate/Carboxymethylcellulose-Based Bioresorbable Membrane: A Prospective, Randomized, Evaluator-Blinded Multicenter Study
Diseases of the Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no antiadhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group ( P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group ( P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control ( P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
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prevention of postoperative abdominal adhesions by a novel glycerol sodium hyaluronate Carboxymethylcellulose based bioresorbable membrane a prospective randomized evaluator blinded multicenter study
Diseases of The Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION: Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS: Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no anti-adhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS: Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group (P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group (P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control (P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS: Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
Merril T Dayton - One of the best experts on this subject based on the ideXlab platform.
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Prevention of Postoperative Abdominal Adhesions by a Novel, Glycerol/Sodium Hyaluronate/Carboxymethylcellulose-Based Bioresorbable Membrane: A Prospective, Randomized, Evaluator-Blinded Multicenter Study
Diseases of the Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no antiadhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group ( P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group ( P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control ( P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
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prevention of postoperative abdominal adhesions by a novel glycerol sodium hyaluronate Carboxymethylcellulose based bioresorbable membrane a prospective randomized evaluator blinded multicenter study
Diseases of The Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION: Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS: Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no anti-adhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS: Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group (P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group (P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control (P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS: Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
Kirk A Ludwig - One of the best experts on this subject based on the ideXlab platform.
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Prevention of Postoperative Abdominal Adhesions by a Novel, Glycerol/Sodium Hyaluronate/Carboxymethylcellulose-Based Bioresorbable Membrane: A Prospective, Randomized, Evaluator-Blinded Multicenter Study
Diseases of the Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no antiadhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group ( P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group ( P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control ( P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.
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prevention of postoperative abdominal adhesions by a novel glycerol sodium hyaluronate Carboxymethylcellulose based bioresorbable membrane a prospective randomized evaluator blinded multicenter study
Diseases of The Colon & Rectum, 2005Co-Authors: Zane Cohen, Anthony J Senagore, Merril T Dayton, Mark J Koruda, David E Beck, Bruce G Wolff, Phillip Fleshner, Richard C Thirlby, Kirk A Ludwig, Sergio W LarachAbstract:INTRODUCTION: Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/Carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in animals. This study was designed to assess the safety of glycerol hyaluronate/Carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients. METHODS: Twelve centers enrolled 120 patients with ulcerative colitis or familial polyposis who were scheduled for a restorative proctocolectomy and ileal pouch-anal anastomosis with diverting loop ileostomy. Before surgical closure, patients were randomized to no anti-adhesion treatment (control) or treatment with glycerol hyaluronate/Carboxymethylcellulose membrane under the midline incision. At ileostomy closure, laparoscopy was used to evaluate the incidence, extent, and severity of adhesion formation to the midline incision. RESULTS: Data were analyzed using the intent-to-treat population. Treatment with glycerol hyaluronate/Carboxymethylcellulose resulted in 19 of 58 patients (33 percent) with no adhesions compared with 6 of 60 adhesion-free patients (10 percent) in the no treatment control group (P = 0.002). The mean extent of postoperative adhesions to the midline incision was significantly lower among patients treated with glycerol hyaluronate/Carboxymethylcellulose compared with patients in the control group (P < 0.001). The severity of postoperative adhesions to the midline incision was significantly less with glycerol hyaluronate/Carboxymethylcellulose than with control (P < 0.001). Adverse events were similar between treatment and no treatment control groups with the exception of abscess and incisional wound complications were more frequently observed with glycerol hyaluronate/Carboxymethylcellulose. CONCLUSIONS: Glycerol hyaluronate/Carboxymethylcellulose was shown to effectively reduce adhesions to the midline incision and adhesions between the omentum and small bowel after abdominal surgery. Safety profiles for the treatment and no treatment control groups were similar with the exception of more infection complications associated with glycerol hyaluronate/Carboxymethylcellulose use. Animal models did not predict these complications.