The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform

Jen San Tsai - One of the best experts on this subject based on the ideXlab platform.

  • Carcinomatous Meningitis: are surgery or gamma knife radiosurgery treatment risk factors?
    Journal of Neurosurgery, 2020
    Co-Authors: Anita Mahajan, Jonathan A Borden, Jen San Tsai
    Abstract:

    Object. The purpose of this study was to identify possible risk factors leading to Carcinomatous Meningitis in patients with a known brain metastasis and who were treated with gamma knife radiosurgery (GKS). Methods. Two hundred eighty lesions in 101 patients were treated during 121 GKS procedures. The clinical and neuroimaging history, tumor histology, and follow-up studies were reviewed for all patients. Evidence as demonstrated by magnetic resonance imaging criteria and/or cerebrospinal fluid (CSF) cytology of Carcinomatous Meningitis was evaluated. The data were then analyzed to identify potential risk factors for the development of CSF dissemination. Conclusions. It appears that Carcinomatous Meningitis is exclusively identified in patients with adenocarcinoma, in particular with primary lung cancer. Furthermore, the incidence is higher if surgery is performed and the interval to subsequent GKS is prolonged.

  • Carcinomatous Meningitis are surgery and gamma knife radiosurgery treatment risk factors
    Journal of Neurosurgery, 2002
    Co-Authors: Anita Mahajan, Jonathan A Borden, Jen San Tsai
    Abstract:

    Object. The purpose of this study was to identify possible risk factors leading to Carcinomatous Meningitis in patients with a known brain metastasis and who were treated with gamma knife radiosurgery (GKS). Methods. Two hundred eighty lesions in 101 patients were treated during 121 GKS procedures. The clinical and neuroimaging history, tumor histology, and follow-up studies were reviewed for all patients. Evidence as demonstrated by magnetic resonance imaging criteria and/or cerebrospinal fluid (CSF) cytology of Carcinomatous Meningitis was evaluated. The data were then analyzed to identify potential risk factors for the development of CSF dissemination. Conclusions. It appears that Carcinomatous Meningitis is exclusively identified in patients with adenocarcinoma, in particular with primary lung cancer. Furthermore, the incidence is higher if surgery is performed and the interval to subsequent GKS is prolonged.

Anita Mahajan - One of the best experts on this subject based on the ideXlab platform.

  • Carcinomatous Meningitis: are surgery or gamma knife radiosurgery treatment risk factors?
    Journal of Neurosurgery, 2020
    Co-Authors: Anita Mahajan, Jonathan A Borden, Jen San Tsai
    Abstract:

    Object. The purpose of this study was to identify possible risk factors leading to Carcinomatous Meningitis in patients with a known brain metastasis and who were treated with gamma knife radiosurgery (GKS). Methods. Two hundred eighty lesions in 101 patients were treated during 121 GKS procedures. The clinical and neuroimaging history, tumor histology, and follow-up studies were reviewed for all patients. Evidence as demonstrated by magnetic resonance imaging criteria and/or cerebrospinal fluid (CSF) cytology of Carcinomatous Meningitis was evaluated. The data were then analyzed to identify potential risk factors for the development of CSF dissemination. Conclusions. It appears that Carcinomatous Meningitis is exclusively identified in patients with adenocarcinoma, in particular with primary lung cancer. Furthermore, the incidence is higher if surgery is performed and the interval to subsequent GKS is prolonged.

  • Carcinomatous Meningitis are surgery and gamma knife radiosurgery treatment risk factors
    Journal of Neurosurgery, 2002
    Co-Authors: Anita Mahajan, Jonathan A Borden, Jen San Tsai
    Abstract:

    Object. The purpose of this study was to identify possible risk factors leading to Carcinomatous Meningitis in patients with a known brain metastasis and who were treated with gamma knife radiosurgery (GKS). Methods. Two hundred eighty lesions in 101 patients were treated during 121 GKS procedures. The clinical and neuroimaging history, tumor histology, and follow-up studies were reviewed for all patients. Evidence as demonstrated by magnetic resonance imaging criteria and/or cerebrospinal fluid (CSF) cytology of Carcinomatous Meningitis was evaluated. The data were then analyzed to identify potential risk factors for the development of CSF dissemination. Conclusions. It appears that Carcinomatous Meningitis is exclusively identified in patients with adenocarcinoma, in particular with primary lung cancer. Furthermore, the incidence is higher if surgery is performed and the interval to subsequent GKS is prolonged.

A Karabelis - One of the best experts on this subject based on the ideXlab platform.

  • cerebrospinal fluid tumor marker levels in predicting response to treatment and survival of Carcinomatous Meningitis in patients with advanced breast cancer
    Medical Science Monitor, 2005
    Co-Authors: Christos Kosmas, Nicolas Tsavaris, George Tsakonas, Georgia Soukouli, Argyris Gassiamis, N Mylonakis, A Karabelis
    Abstract:

    Background: The aim of this study was to evaluate the predictive value of cerebrospinal fluid (CSF) tumor marker levels in patients with breast cancer and Carcinomatous Meningitis. Material/Methods: Serial CSF and serum tumor marker (CEA, CA-15.3, CA-125, and CA-19.9) measurements were performed in five patients with breast cancer developing Carcinomatous Meningitis in an attempt to correlate these with clinical outcome under treatment. Results: CSF tumor marker levels correlated with response to treatment and outcome in each patient; despite achieving negative CSF cytology after therapy, in two patients it heralded disease progression. Conclusions: Given our findings, CSF tumor marker evaluation may provide a reliable means and surrogate endpoints of monitoring response of Carcinomatous Meningitis to treatment. Therefore, large studies to assess the value of CSF tumor marker changes in Carcinomatous Meningitis are warranted.

  • Changes of cerebrospinal fluid tumor marker levels may predict response to treatment and survival of Carcinomatous Meningitis in patients with advanced breast cancer
    Medical Oncology, 2005
    Co-Authors: Christos Kosmas, Nicolas Tsavaris, George Tsakonas, Georgia Soukouli, N Mylonakis, Panagiotis Gouveris, John Katselis, Heraklis Alexopoulos, A Karabelis
    Abstract:

    The aim of the present study was to evaluate the predictive value of cerebrospinal fluid (CSF) tumor marker levels in patients with breast cancer and Carcinomatous Meningitis. Serial CSF and serum tumor marker (CEA, CA-15.3, CA-125, and CA-19.9) measurements were performed in five patients with breast cancer developing Carcinomatous Meningitis in an attempt to correlate these with clinical outcome under treatment. CSF tumor marker levels correlated with response to treatment and outcome in each patient, and, despite achieving negative CSF cytology after therapy in two patients, it heralded disease progression. Given our findings, CSF tumor marker evaluation may provide a reliable means and surrogate end-points of monitoring response of Carcinomatous Meningitis to treatment. Therefore, large studies to assess the value of CSF tumor marker changes in Carcinomatous Meningitis are warranted.

Anca L Grosu - One of the best experts on this subject based on the ideXlab platform.

  • Carcinomatous Meningitis appearing as acoustic neuromas
    Strahlentherapie Und Onkologie, 2007
    Co-Authors: Sabrina T Astner, Carsten Nieder, Konrad Stock, Anca L Grosu
    Abstract:

    For acoustic neuromas, stereotactic radiotherapy (radiosurgery or stereotactic fractionated radiotherapy) has been established as an important alternative to microsurgery. In most cases initial symptoms are slow progression of unilateral hearing loss, tinnitus or vertigo or acute hearing loss with vertigo. MRI scan shows a contrast-enhancing tumor within the inner auditory channel. If the patient undergoes primary radiotherapy, diagnosis is usually not verified histologically. Therefore, careful evaluation of the medical history is mandatory despite a typical appearance on the MRI scan. If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or Carcinomatous Meningitis. Two patients with hearing loss, vertigo and the diagnosis of acoustic neuromas by MRI scan were referred for radiotherapy. In both cases the symptoms progressed very rapidly, not typical of acoustic neuromas, and in both patients repeated liquor puncture finally revealed Carcinomatous Meningitis. One patient died during therapy; in the second patient intrathecal chemotherapy and additional radiotherapy of the skull base led to partial remission continuing for several months. Before primary radiotherapy of small intrameatal lesions diagnosis must be reassessed carefully. This is especially true for bilateral lesions suspicious for acoustic neuromas and rapid progression and persistence of clinical symptoms where Carcinomatous Meningitis has to be taken into account.

  • Carcinomatous Meningitis appearing as acoustic neuromas two cases
    Strahlentherapie Und Onkologie, 2007
    Co-Authors: Sabrina T Astner, Carsten Nieder, Konrad Stock, Anca L Grosu
    Abstract:

    BACKGROUND: For acoustic neuromas, stereotactic radiotherapy (radiosurgery or stereotactic fractionated radiotherapy) has been established as an important alternative to microsurgery. In most cases initial symptoms are slow progression of unilateral hearing loss, tinnitus or vertigo or acute hearing loss with vertigo. MRI scan shows a contrast-enhancing tumor within the inner auditory channel. If the patient undergoes primary radiotherapy, diagnosis is usually not verified histologically. Therefore, careful evaluation of the medical history is mandatory despite a typical appearance on the MRI scan. If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or Carcinomatous Meningitis. CASE REPORT: Two patients with hearing loss, vertigo and the diagnosis of acoustic neuromas by MRI scan were referred for radiotherapy. In both cases the symptoms progressed very rapidly, not typical of acoustic neuromas, and in both patients repeated liquor puncture finally revealed Carcinomatous Meningitis. One patient died during therapy; in the second patient intrathecal chemotherapy and additional radiotherapy of the skull base led to partial remission continuing for several months. CONCLUSION: Before primary radiotherapy of small intrameatal lesions diagnosis must be reassessed carefully. This is especially true for bilateral lesions suspicious for acoustic neuromas and rapid progression and persistence of clinical symptoms where Carcinomatous Meningitis has to be taken into account.

Jonathan A Borden - One of the best experts on this subject based on the ideXlab platform.

  • Carcinomatous Meningitis: are surgery or gamma knife radiosurgery treatment risk factors?
    Journal of Neurosurgery, 2020
    Co-Authors: Anita Mahajan, Jonathan A Borden, Jen San Tsai
    Abstract:

    Object. The purpose of this study was to identify possible risk factors leading to Carcinomatous Meningitis in patients with a known brain metastasis and who were treated with gamma knife radiosurgery (GKS). Methods. Two hundred eighty lesions in 101 patients were treated during 121 GKS procedures. The clinical and neuroimaging history, tumor histology, and follow-up studies were reviewed for all patients. Evidence as demonstrated by magnetic resonance imaging criteria and/or cerebrospinal fluid (CSF) cytology of Carcinomatous Meningitis was evaluated. The data were then analyzed to identify potential risk factors for the development of CSF dissemination. Conclusions. It appears that Carcinomatous Meningitis is exclusively identified in patients with adenocarcinoma, in particular with primary lung cancer. Furthermore, the incidence is higher if surgery is performed and the interval to subsequent GKS is prolonged.

  • Carcinomatous Meningitis are surgery and gamma knife radiosurgery treatment risk factors
    Journal of Neurosurgery, 2002
    Co-Authors: Anita Mahajan, Jonathan A Borden, Jen San Tsai
    Abstract:

    Object. The purpose of this study was to identify possible risk factors leading to Carcinomatous Meningitis in patients with a known brain metastasis and who were treated with gamma knife radiosurgery (GKS). Methods. Two hundred eighty lesions in 101 patients were treated during 121 GKS procedures. The clinical and neuroimaging history, tumor histology, and follow-up studies were reviewed for all patients. Evidence as demonstrated by magnetic resonance imaging criteria and/or cerebrospinal fluid (CSF) cytology of Carcinomatous Meningitis was evaluated. The data were then analyzed to identify potential risk factors for the development of CSF dissemination. Conclusions. It appears that Carcinomatous Meningitis is exclusively identified in patients with adenocarcinoma, in particular with primary lung cancer. Furthermore, the incidence is higher if surgery is performed and the interval to subsequent GKS is prolonged.