The Experts below are selected from a list of 1974 Experts worldwide ranked by ideXlab platform
S Attapattu - One of the best experts on this subject based on the ideXlab platform.
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acute yellow oleander thevetia peruviana poisoning Cardiac arrhythmias electrolyte disturbances and serum Cardiac Glycoside concentrations on presentation to hospital
Heart, 2000Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S AttapattuAbstract:OBJECTIVE—To describe the Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing Cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum Cardiac Glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum Cardiac Glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum Cardiac Glycoside concentrations and hyperkalaemia but not with disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; Cardiac Glycosides
Michael Eddleston - One of the best experts on this subject based on the ideXlab platform.
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acute yellow oleander thevetia peruviana poisoning Cardiac arrhythmias electrolyte disturbances and serum Cardiac Glycoside concentrations on presentation to hospital
Heart, 2000Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S AttapattuAbstract:OBJECTIVE—To describe the Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing Cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum Cardiac Glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum Cardiac Glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum Cardiac Glycoside concentrations and hyperkalaemia but not with disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; Cardiac Glycosides
Robert F Siliciano - One of the best experts on this subject based on the ideXlab platform.
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a novel cell based high throughput screen for inhibitors of hiv 1 gene expression and budding identifies the Cardiac Glycosides
Journal of Antimicrobial Chemotherapy, 2014Co-Authors: Gregory M Laird, Evelyn E Eisele, Alireza S Rabi, Daria Nikolaeva, Robert F SilicianoAbstract:Objectives: Highly active antiretroviral therapy (HAART) is the mainstay of treatment for HIV-1 infection. While current HAART regimens have been extremely effective, issues of associated toxicity, cost and resistance remain and there is a need for novel antiretroviral compounds to complement the existing therapy. We sought to develop a novel high-throughput method for identifying compounds that block later steps in the life cycle not targeted by current therapy. Methods: We designed a high-throughput screen to identify inhibitors of post-integration steps in the HIV-1 life cycle. The screening method was applied to a library of compounds that included numerous FDA-approved small molecules. Results: Among the small molecules that inhibited late stages in HIV-1 replication were members of the Cardiac Glycoside family. We demonstrate that Cardiac Glycosides potently inhibit HIV-1 gene expression, thereby reducing the production of infectious HIV-1. We demonstrate that this inhibition is dependent upon the human Na + /K + ATPase, but independent of Cardiac Glycoside-induced increases in intracellular Ca 2+ . Conclusions: We have validated a novel high-throughput screen to identify small molecule inhibitors of HIV-1 gene expression, virion assembly and budding. Using this screen, we have demonstrated that a number of FDA-approved compounds developed for other purposes potently inhibit HIV-1 replication, including the Cardiac Glycosides. Our work indicates that the entire Cardiac Glycoside family of drugs shows potential for antiretroviral drug development.
C A Ariaratnam - One of the best experts on this subject based on the ideXlab platform.
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acute yellow oleander thevetia peruviana poisoning Cardiac arrhythmias electrolyte disturbances and serum Cardiac Glycoside concentrations on presentation to hospital
Heart, 2000Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S AttapattuAbstract:OBJECTIVE—To describe the Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing Cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum Cardiac Glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum Cardiac Glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum Cardiac Glycoside concentrations and hyperkalaemia but not with disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; Cardiac Glycosides
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Acute yellow oleander (Thevetia peruviana) poisoning: Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside concentrations on presentation to hospital.
'BMJ', 2000Co-Authors: Eddleston M, C A Ariaratnam, W P Meyer, Sjöström L, Jayalath S, Rajakanthan K, Rajapakse S, Colbert D, Perera G, Attapattu SAbstract:OBJECTIVE: To describe the Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN: Case series. SETTING: Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS: 351 patients with a history of oleander ingestion. MEASUREMENTS: ECG and blood sample analysis on admission. RESULTS: Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing Cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum Cardiac Glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum Cardiac Glycoside levels. CONCLUSIONS: Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum Cardiac Glycoside concentrations and hyperkalaemia but not with disturbances of magnesium
W P Meyer - One of the best experts on this subject based on the ideXlab platform.
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acute yellow oleander thevetia peruviana poisoning Cardiac arrhythmias electrolyte disturbances and serum Cardiac Glycoside concentrations on presentation to hospital
Heart, 2000Co-Authors: Michael Eddleston, C A Ariaratnam, L Sjostrom, S Jayalath, K Rajakanthan, Senaka Rajapakse, D Colbert, W P Meyer, G Perera, S AttapattuAbstract:OBJECTIVE—To describe the Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN—Case series. SETTING—Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS—351 patients with a history of oleander ingestion. MEASUREMENTS—ECG and blood sample analysis on admission. RESULTS—Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing Cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum Cardiac Glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum Cardiac Glycoside levels. CONCLUSIONS—Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum Cardiac Glycoside concentrations and hyperkalaemia but not with disturbances of magnesium. Keywords: oleander poisoning; arrhythmias; Cardiac Glycosides
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Acute yellow oleander (Thevetia peruviana) poisoning: Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside concentrations on presentation to hospital.
'BMJ', 2000Co-Authors: Eddleston M, C A Ariaratnam, W P Meyer, Sjöström L, Jayalath S, Rajakanthan K, Rajapakse S, Colbert D, Perera G, Attapattu SAbstract:OBJECTIVE: To describe the Cardiac arrhythmias, electrolyte disturbances, and serum Cardiac Glycoside levels seen in patients presenting to hospital with acute yellow oleander (Thevetia peruviana) poisoning and to compare these with published reports of digitalis poisoning. DESIGN: Case series. SETTING: Medical wards of Anuradhapura District General Hospital, Sri Lanka, and coronary care unit of the Institute of Cardiology, National Hospital of Sri Lanka, Colombo, the national tertiary referral centre for cardiology. PATIENTS: 351 patients with a history of oleander ingestion. MEASUREMENTS: ECG and blood sample analysis on admission. RESULTS: Most symptomatic patients had conduction defects affecting the sinus node, the atrioventricular (AV) node, or both. Patients showing Cardiac arrhythmias that required transfer for specialised management had significantly higher mean serum Cardiac Glycoside and potassium but not magnesium concentrations. Although there was considerable overlap between groups, those with conduction defects affecting both sinus and AV nodes had significantly higher mean serum Cardiac Glycoside levels. CONCLUSIONS: Most of these young previously healthy patients had conduction defects affecting the sinus or AV nodes. Relatively few had the atrial or ventricular tachyarrhythmias or ventricular ectopic beats that are typical of digoxin poisoning. Serious yellow oleander induced arrhythmias were associated with higher serum Cardiac Glycoside concentrations and hyperkalaemia but not with disturbances of magnesium