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Leanna Graham - One of the best experts on this subject based on the ideXlab platform.
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burnout and distress among allied health care professionals in a Cardiovascular Centre of a quaternary hospital network a cross sectional survey
CMAJ Open, 2021Co-Authors: Barry B Rubin, Rebecca Goldfarb, Daniel Satele, Leanna GrahamAbstract:Background Burnout and distress negatively affect the well-being of health care professionals and the treatment they provide. Our aim was to measure the prevalence of burnout and distress among allied health care staff at a Cardiovascular Centre of a quaternary hospital network in Canada, and compare outcomes to those for nonphysician employees in the United States. Methods We conducted a survey of allied health care staff, including physical, respiratory and occupational therapists, pharmacists, social workers, dietitians and speech-language pathologists, in a Cardiovascular Centre at 2 quaternary referral hospitals in Toronto, Ontario, between Nov. 27, 2018, and Jan. 31, 2019. The survey tool included the Well-Being Index (WBI), which measures fatigue, depression, burnout, anxiety or stress, quality of life, work-life integration, meaning in work and overall distress; a score of 2 or higher indicated high distress. We carried out standard univariate statistical comparisons using the χ2, Fisher exact or Kruskal-Wallis test as appropriate to perform univariate comparisons in the sample of respondents. We assessed the relation between a WBI score of 2 or higher and demographic characteristics. We compared univariate associations among WBI data for nonphysician employees in the US who completed the WBI to responses from our participants. Results The response rate to the survey was 86% (45/52). Thirty-three respondents (73%) reported experiencing burnout in the previous month, and 31 (69%) reported emotional problems. Compared to respondents who perceived fair treatment in the workplace, those who perceived unfair treatment (20 [44%]) were more likely to report emotional problems (17 [85%] v. 13 [54%], p = 0.05), to worry that work was hardening them emotionally (15 [75%] v. 8 [33%], p = 0.008), and to feel down, depressed or hopeless (12 [60%] v. 4 [17%], p = 0.005). Twenty-five respondents (56%) and 13 respondents (29%) reported WBI scores consistent with high (≥ 2) or severe (≥ 5) distress, respectively. Respondents were more likely to have a high WBI score if they perceived unfair treatment or inadequate staffing levels. Our respondents had a higher prevalence of burnout (73.3% v. 53.6%, p = 0.008) and a higher average WBI score (2.6 [SD 2.8] v. 1.7 [SD 2.6], p = 0.05) than 9096 nonphysician employees in the US. Interpretation The prevalence of burnout, emotional problems and distress was high among allied health care staff. Fair treatment in the workplace and adequate staffing may lower distress levels and improve the work experience of these health care professionals.
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burnout and distress among physicians in a Cardiovascular Centre of a quaternary hospital network a cross sectional survey
CMAJ Open, 2021Co-Authors: Barry B Rubin, Rebecca Goldfarb, Daniel Satele, Leanna GrahamAbstract:BACKGROUND Burnout and distress have a negative impact on nurses and the treatment they provide. Our aim was to measure the prevalence of burnout and distress among nurses in a Cardiovascular Centre at 2 quaternary referral hospitals in Canada, and compare these outcomes to those for nurses at academic health science Centres (AHSCs) in the United States. METHODS We conducted a survey of nurses practising in a Cardiovascular Centre at 2 quaternary referral hospitals in Toronto, Ontario, between Nov. 27, 2018, and Jan. 31, 2019. The survey tool included the Well-Being Index (WBI), which measures fatigue, depression, burnout, anxiety or stress, mental and physical quality of life, work-life integration, meaning in work and distress; a score of 2 or higher on the WBI indicated high distress. We also evaluated nurses' perception of the adequacy of staffing levels and of fair treatment in the workplace, and satisfaction with the electronic health record. We carried out standard univariate statistical comparisons using the χ2, Fisher exact or Kruskal-Wallis test as appropriate to perform univariate comparisons in the sample of respondents. We assessed the relation between a WBI score of 2 or higher and demographic characteristics. We compared univariate associations among WBI data for nurses at AHSCs in the US who completed the WBI to responses from our participants. RESULTS The response rate to the survey was 49.1% (242/493). Of the 242 respondents, 188 (77.7%) reported burnout in the previous month; 189 (78.1%) had a WBI score of 2 or higher, and 132 (54.5%) had a score of 4 or higher (indicative of severe distress). Ordinal multivariable analysis showed that lower WBI scores were associated with satisfaction with staffing levels (odds ratio [OR] 0.33, 95% confidence interval [CI] 0.16-0.69) and the perception of fair treatment in the workplace (OR 0.41, 95% CI 0.23-0.74). Higher proportions of our respondents than nurses at AHSCs in the US reported burnout (77.7% v. 60.5%, p < 0.001) and had a WBI score of 2 or higher (78.1% v. 57.0%) or 4 or higher (54.5% v. 32.0%) (both p < 0.001). INTERPRETATION Although levels of burnout and distress were high among nurses, their perceptions of adequate staffing and fair treatment were associated with lower distress. Addressing inadequate staffing and unfair treatment may decrease burnout and other dimensions of distress among nurses, and improve their work experience and patient outcomes.
Milenkovic Dragan - One of the best experts on this subject based on the ideXlab platform.
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Transcriptomic Alterations of the Aortic Intima and Media in Long-term High-fat Diet Fed Pigs and Its Reversal (P15-010-19)
'Oxford University Press (OUP)', 2019Co-Authors: Milenkovic Dragan, Gomułkiewicz Agnieszka, Gladine Cécile, Janczak Dariusz, Grzegorek Irmina, Jabłońska Karolina, Drożdż Katarzyna, Chmielewska Magdalena, Piotrowska Aleksandra, Pasławski RobertAbstract:Nutrition 2019 Abstracts Nutrient-Gene Interactions Funding Sources: WROVASC Integrated Cardiovascular Centre, co-financed by the European Regional Development FundInternational audienceWe have previously shown that 12 months (mo.) highfat diet (HFD) in pigs led to pathophysiological alterations, incl. fattening and increased femoral artery intima-media-thickness, which were partly reversed after 3 mo. return to control diet (Zabek et al., PLoS One 2017). The aim of this study was to decipher underlying mechanism of action of these dietary interventions on the arteries by nutrigenomics analyses of intima and media of aorta
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Transcriptomic Alterations of the Aortic Intima and Media in Long-term High-fat Diet Fed Pigs and Its Reversal
HAL CCSD, 2019Co-Authors: Mazur André, Milenkovic Dragan, Gladine Cécile, Gomulkiewicz A., Janczak D., Jablonska K., Drozdz K., Chmielewska M., Piotrowska A.Abstract:Topical Area: Nutrient-Gene InteractionsObjectives : We have previously shown that 12 months (mo.) high-fat diet (HFD) in pigs led to pathophysiological alterations, incl. fattening and increased femoral artery intima-media-thickness, which were partly reversed after 3 mo. return to control diet (Zabek et al., PLoS One 2017). The aim of this study was to decipher underlying mechanism of action of these dietary interventions on the arteries by nutrigenomics analyses of intima and media of aorta.Methods : 32 female pigs were divided into 3 groups: Control diet (CD) for 12 mo.; HFD for 12 mo.; 3) Reversal diet group (RD): HFD for 9 mo. followed by CD for 3 mo. After 12 mo. animals were killed and abdominal aorta collected. RNA was isolated from aorta intima and media for whole genome microarray analyses followed by bioinformatics analyses.Results :HFD compared to CD group significantly affected gene expression profile in intima with genes belonging to the chemotaxis, inflammation or endothelial permeability. RD induced gene expression profile was distinct from the CD group. This suggests that 3 mo. of reversal to CD is not sufficient to correct gene expression changes induced by HFD. Comparison of RD profile with that of HFD group revealed a group of genes with opposite expression, e.g. genes regulating inflammation, toll-like cell signaling pathway or cytoskeleton organization involved in the regulation of cell permeability. This suggests that return to the RD only partly restored gene expression alterations due to the HFD. Significant changes in expression of genes in media following HFD were also observed, such as genes involved in cytoskeleton organization and migration MAPK signaling. As for intima, the expression profile of media of pigs on RD was different on that of these on CD diet. Compared to HFD, a group of genes involved in PI3K or MAPK pathways presented opposite expression suggesting that RD can partly correct the changes in genomic effect induced by HFD.Conclusions : This study revealed genomic modifications induced by long-term HFD consumption on arterial intima and media. The return to normal diet for 3 mo. was not sufficient to counteract the genomic effect of long-term HFD consumption.Funding Sources : WROVASC Integrated Cardiovascular Centre, co-financed by the European Regional Development Fund
Robert Paslawski - One of the best experts on this subject based on the ideXlab platform.
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transcriptomic alterations of the aortic intima and media in long term high fat diet fed pigs and its reversal p15 010 19
Current Developments in Nutrition, 2019Co-Authors: Dragan Milenkovic, Agnieszka Gomulkiewicz, Cecile Gladine, Dariusz Janczak, Irmina Grzegorek, Karolina Jablonska, Katarzyna Drozdz, Magdalena Chmielewska, Aleksandra Piotrowska, Robert PaslawskiAbstract:Objectives : We have previously shown that 12 months (mo.) high-fat diet (HFD) in pigs led to pathophysiological alterations, incl. fattening and increased femoral artery intima-media-thickness, which were partly reversed after 3 mo. return to control diet (Zabek et al., PLoS One 2017). The aim of this study was to decipher underlying mechanism of action of these dietary interventions on the arteries by nutrigenomics analyses of intima and media of aorta. Methods : 32 female pigs were divided into 3 groups: Control diet (CD) for 12 mo.; HFD for 12 mo.; 3) Reversal diet group (RD): HFD for 9 mo. followed by CD for 3 mo. After 12 mo. animals were killed and abdominal aorta collected. RNA was isolated from aorta intima and media for whole genome microarray analyses followed by bioinformatics analyses. Results : HFD compared to CD group significantly affected gene expression profile in intima with genes belonging to the chemotaxis, inflammation or endothelial permeability. RD induced gene expression profile was distinct from the CD group. This suggests that 3 mo. of reversal to CD is not sufficient to correct gene expression changes induced by HFD. Comparison of RD profile with that of HFD group revealed a group of genes with opposite expression, e.g. genes regulating inflammation, toll-like cell signaling pathway or cytoskeleton organization involved in the regulation of cell permeability. This suggests that return to the RD only partly restored gene expression alterations due to the HFD. Significant changes in expression of genes in media following HFD were also observed, such as genes involved in cytoskeleton organization and migration MAPK signaling. As for intima, the expression profile of media of pigs on RD was different on that of these on CD diet. Compared to HFD, a group of genes involved in PI3K or MAPK pathways presented opposite expression suggesting that RD can partly correct the changes in genomic effect induced by HFD. Conclusions : This study revealed genomic modifications induced by long-term HFD consumption on arterial intima and media. The return to normal diet for 3 mo. was not sufficient to counteract the genomic effect of long-term HFD consumption. Funding Sources : WROVASC Integrated Cardiovascular Centre, co-financed by the European Regional Development Fund.
Pasławski Robert - One of the best experts on this subject based on the ideXlab platform.
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Transcriptomic Alterations of the Aortic Intima and Media in Long-term High-fat Diet Fed Pigs and Its Reversal (P15-010-19)
'Oxford University Press (OUP)', 2019Co-Authors: Milenkovic Dragan, Gomułkiewicz Agnieszka, Gladine Cécile, Janczak Dariusz, Grzegorek Irmina, Jabłońska Karolina, Drożdż Katarzyna, Chmielewska Magdalena, Piotrowska Aleksandra, Pasławski RobertAbstract:Nutrition 2019 Abstracts Nutrient-Gene Interactions Funding Sources: WROVASC Integrated Cardiovascular Centre, co-financed by the European Regional Development FundInternational audienceWe have previously shown that 12 months (mo.) highfat diet (HFD) in pigs led to pathophysiological alterations, incl. fattening and increased femoral artery intima-media-thickness, which were partly reversed after 3 mo. return to control diet (Zabek et al., PLoS One 2017). The aim of this study was to decipher underlying mechanism of action of these dietary interventions on the arteries by nutrigenomics analyses of intima and media of aorta
Piotrowska A. - One of the best experts on this subject based on the ideXlab platform.
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Transcriptomic Alterations of the Aortic Intima and Media in Long-term High-fat Diet Fed Pigs and Its Reversal
HAL CCSD, 2019Co-Authors: Mazur André, Milenkovic Dragan, Gladine Cécile, Gomulkiewicz A., Janczak D., Jablonska K., Drozdz K., Chmielewska M., Piotrowska A.Abstract:Topical Area: Nutrient-Gene InteractionsObjectives : We have previously shown that 12 months (mo.) high-fat diet (HFD) in pigs led to pathophysiological alterations, incl. fattening and increased femoral artery intima-media-thickness, which were partly reversed after 3 mo. return to control diet (Zabek et al., PLoS One 2017). The aim of this study was to decipher underlying mechanism of action of these dietary interventions on the arteries by nutrigenomics analyses of intima and media of aorta.Methods : 32 female pigs were divided into 3 groups: Control diet (CD) for 12 mo.; HFD for 12 mo.; 3) Reversal diet group (RD): HFD for 9 mo. followed by CD for 3 mo. After 12 mo. animals were killed and abdominal aorta collected. RNA was isolated from aorta intima and media for whole genome microarray analyses followed by bioinformatics analyses.Results :HFD compared to CD group significantly affected gene expression profile in intima with genes belonging to the chemotaxis, inflammation or endothelial permeability. RD induced gene expression profile was distinct from the CD group. This suggests that 3 mo. of reversal to CD is not sufficient to correct gene expression changes induced by HFD. Comparison of RD profile with that of HFD group revealed a group of genes with opposite expression, e.g. genes regulating inflammation, toll-like cell signaling pathway or cytoskeleton organization involved in the regulation of cell permeability. This suggests that return to the RD only partly restored gene expression alterations due to the HFD. Significant changes in expression of genes in media following HFD were also observed, such as genes involved in cytoskeleton organization and migration MAPK signaling. As for intima, the expression profile of media of pigs on RD was different on that of these on CD diet. Compared to HFD, a group of genes involved in PI3K or MAPK pathways presented opposite expression suggesting that RD can partly correct the changes in genomic effect induced by HFD.Conclusions : This study revealed genomic modifications induced by long-term HFD consumption on arterial intima and media. The return to normal diet for 3 mo. was not sufficient to counteract the genomic effect of long-term HFD consumption.Funding Sources : WROVASC Integrated Cardiovascular Centre, co-financed by the European Regional Development Fund