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Kristina Sundquist - One of the best experts on this subject based on the ideXlab platform.

  • Cardiovascular Fitness in young males and risk of unprovoked venous thromboembolism in adulthood
    Annals of Medicine, 2017
    Co-Authors: Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
    Abstract:

    Background: Whether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high Cardiovascular Fitness reduces the risk of VTE. Methods: A Swedish cohort of male conscripts (n = 773,925) born in 1954–1970 with no history of previous VTE were followed from enlistment (1972–1990) until 2010. Data on Cardiovascular Fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register. We identified all full-siblings and first-cousin pairs discordant for maximal aerobic workload. This co-relative design allows for adjustment for familial resemblance. Results: In total, 3005 (0.39%) males were affected by VTE. Cardiovascular Fitness estimated with Wmax was not associated with VTE risk when adjusted for body mass index (BMI). However, Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (Hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.78–0.85 per standard deviation compared with mean Wmax/kg). The association was weaker over time and also when examining discordant first cousins and full-sibling pairs. Conclusions: These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk.Key messagesWhether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown.A Swedish cohort of male conscripts (n = 773,925) tested with a cycle ergometric test with no history of previous VTE were followed from enlistment (1972–1990) until 2010.Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (HR 0.81, 95% CI 0.78–0.85).These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk. (Less)

  • Cardiovascular Fitness in young males and risk of unprovoked venous thromboembolism in adulthood
    Annals of medicine, 2016
    Co-Authors: Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
    Abstract:

    Whether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high Cardiovascular Fitness reduces the risk of VTE. A Swedish cohort of male conscripts (n = 773,925) born in 1954-1970 with no history of previous VTE were followed from enlistment (1972-1990) until 2010. Data on Cardiovascular Fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register. We identified all full-siblings and first-cousin pairs discordant for maximal aerobic workload. This co-relative design allows for adjustment for familial resemblance. In total, 3005 (0.39%) males were affected by VTE. Cardiovascular Fitness estimated with Wmax was not associated with VTE risk when adjusted for body mass index (BMI). However, Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (Hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.78-0.85 per standard deviation compared with mean Wmax/kg). The association was weaker over time and also when examining discordant first cousins and full-sibling pairs. These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk. Key messages Whether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. A Swedish cohort of male conscripts (n = 773,925) tested with a cycle ergometric test with no history of previous VTE were followed from enlistment (1972-1990) until 2010. Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (HR 0.81, 95% CI 0.78-0.85). These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk.

Franklin Lynch - One of the best experts on this subject based on the ideXlab platform.

  • Effect of total hip arthroplasty on Cardiovascular Fitness
    The Journal of arthroplasty, 1997
    Co-Authors: Michael D. Ries, Edward F. Philbin, Gerald D. Groff, Karen A. Sheesley, Jonathan A. Richman, Franklin Lynch
    Abstract:

    Thirty patients who underwent total hip arthroplasty and 18 patients with medically treated arthritis participated in this study. Both groups of patients underwent a Cardiovascular Fitness exercise test on entering the study and 6 months, 1 year, and 2 years later. Fitness was assessed by patient performance on a graded maximal exercise test using a bicycle ergometer and metabolic cart. In the group of total hip arthroplasty patients, significant improvements in exercise duration (P = .011), maximum workload (P = .0013), peak oxygen consumption (P = .0036), and percentage of predicted maximum oxygen uptake achieved (P = .0002) were observed during the follow-up evaluation. In the group of control patients, decreases in exercise duration (P = .0001), maximum workload (P = .0001), and workload at anaerobic threshold (P = .0108) occurred without a significant change in the other measures of Cardiovascular Fitness. The results indicate that resumption of routine physical activities after total hip arthroplasty is associated with a corresponding improvement in Cardiovascular Fitness.

  • Improvement in Cardiovascular Fitness after Total Knee Arthroplasty
    The Journal of bone and joint surgery. American volume, 1996
    Co-Authors: Michael D. Ries, Edward F. Philbin, Gerald D. Groff, Karen A. Sheesley, Jonathan A. Richman, Franklin Lynch
    Abstract:

    Patients who have osteoarthrosis involving weight-bearing joints typically have a gradual decline in physical activity, which is often associated with Cardiovascular deconditioning. After joint replacement, many patients resume routine walking and recreational activities, which may improve aerobic capacity. The purpose of the present study was to determine the effect of total knee arthroplasty on Cardiovascular Fitness. Nineteen patients who had had total knee arthroplasty (the arthroplasty group) performed an exercise test for Cardiovascular Fitness preoperatively. Sixteen of these patients were tested again at one year postoperatively and thirteen, at two years postoperatively. Sixteen patients in whom osteoarthrosis of the knee was being treated medically (the control group) were tested at the time of enrollment in the study and one year later. Nine of these patients also were tested two years after enrollment. All of the patients completed the Arthritis Impact-Measurement Scales (AIMS) at each examination. Fitness was assessed by the performance of a progressive maximum exercise test with use of a bicycle ergometer and a metabolic cart. All patients achieved the anaerobic threshold. One year postoperatively, the patients in the arthroplasty group demonstrated an increase, which approached significance, in maximum oxygen consumption (measured in milliliters of oxygen per minute) (p = 0.07), maximum oxygen consumption corrected for body weight (p = 0.08), and percentage of predicted maximum uptake of oxygen (p = 0.06). Two years after the total knee arthroplasty, the patients had a significant improvement with regard to all three parameters (p = 0.008, 0.005, and 0.005, respectively). The patients in the control group demonstrated a significant decrease in duration of exercise and in maximum workload at one year (p = 0.003 and 0.005, respectively) and at two years (p = 0.008 for both parameters). Physical activity had increased in the arthroplasty group but not in the control group, as demonstrated by the results of the Arthritis Impact-Measurement Scales. These findings demonstrate a trend toward improvement in Cardiovascular Fitness one year after total knee arthroplasty and a significant improvement two years postoperatively for patients who had been able to resume routine functional activities because of the arthroplasty. These improvements compared favorably with the static pattern or the decline in the measures of Fitness that were observed in the control group. Our results should be considered preliminary because of the relatively small number of patients who were studied.

Bengt Zöller - One of the best experts on this subject based on the ideXlab platform.

  • Cardiovascular Fitness in young males and risk of unprovoked venous thromboembolism in adulthood
    Annals of Medicine, 2017
    Co-Authors: Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
    Abstract:

    Background: Whether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high Cardiovascular Fitness reduces the risk of VTE. Methods: A Swedish cohort of male conscripts (n = 773,925) born in 1954–1970 with no history of previous VTE were followed from enlistment (1972–1990) until 2010. Data on Cardiovascular Fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register. We identified all full-siblings and first-cousin pairs discordant for maximal aerobic workload. This co-relative design allows for adjustment for familial resemblance. Results: In total, 3005 (0.39%) males were affected by VTE. Cardiovascular Fitness estimated with Wmax was not associated with VTE risk when adjusted for body mass index (BMI). However, Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (Hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.78–0.85 per standard deviation compared with mean Wmax/kg). The association was weaker over time and also when examining discordant first cousins and full-sibling pairs. Conclusions: These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk.Key messagesWhether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown.A Swedish cohort of male conscripts (n = 773,925) tested with a cycle ergometric test with no history of previous VTE were followed from enlistment (1972–1990) until 2010.Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (HR 0.81, 95% CI 0.78–0.85).These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk. (Less)

  • Cardiovascular Fitness in young males and risk of unprovoked venous thromboembolism in adulthood
    Annals of medicine, 2016
    Co-Authors: Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
    Abstract:

    Whether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high Cardiovascular Fitness reduces the risk of VTE. A Swedish cohort of male conscripts (n = 773,925) born in 1954-1970 with no history of previous VTE were followed from enlistment (1972-1990) until 2010. Data on Cardiovascular Fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register. We identified all full-siblings and first-cousin pairs discordant for maximal aerobic workload. This co-relative design allows for adjustment for familial resemblance. In total, 3005 (0.39%) males were affected by VTE. Cardiovascular Fitness estimated with Wmax was not associated with VTE risk when adjusted for body mass index (BMI). However, Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (Hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.78-0.85 per standard deviation compared with mean Wmax/kg). The association was weaker over time and also when examining discordant first cousins and full-sibling pairs. These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk. Key messages Whether high Cardiovascular Fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. A Swedish cohort of male conscripts (n = 773,925) tested with a cycle ergometric test with no history of previous VTE were followed from enlistment (1972-1990) until 2010. Cardiovascular Fitness estimated with Wmax/kg and adjusted for BMI was associated with reduced risk for VTE (HR 0.81, 95% CI 0.78-0.85). These results suggest that there is a relationship between Cardiovascular Fitness and weight that is important for future VTE risk.

Michael D. Ries - One of the best experts on this subject based on the ideXlab platform.

  • Effect of total hip arthroplasty on Cardiovascular Fitness
    The Journal of arthroplasty, 1997
    Co-Authors: Michael D. Ries, Edward F. Philbin, Gerald D. Groff, Karen A. Sheesley, Jonathan A. Richman, Franklin Lynch
    Abstract:

    Thirty patients who underwent total hip arthroplasty and 18 patients with medically treated arthritis participated in this study. Both groups of patients underwent a Cardiovascular Fitness exercise test on entering the study and 6 months, 1 year, and 2 years later. Fitness was assessed by patient performance on a graded maximal exercise test using a bicycle ergometer and metabolic cart. In the group of total hip arthroplasty patients, significant improvements in exercise duration (P = .011), maximum workload (P = .0013), peak oxygen consumption (P = .0036), and percentage of predicted maximum oxygen uptake achieved (P = .0002) were observed during the follow-up evaluation. In the group of control patients, decreases in exercise duration (P = .0001), maximum workload (P = .0001), and workload at anaerobic threshold (P = .0108) occurred without a significant change in the other measures of Cardiovascular Fitness. The results indicate that resumption of routine physical activities after total hip arthroplasty is associated with a corresponding improvement in Cardiovascular Fitness.

  • Improvement in Cardiovascular Fitness after Total Knee Arthroplasty
    The Journal of bone and joint surgery. American volume, 1996
    Co-Authors: Michael D. Ries, Edward F. Philbin, Gerald D. Groff, Karen A. Sheesley, Jonathan A. Richman, Franklin Lynch
    Abstract:

    Patients who have osteoarthrosis involving weight-bearing joints typically have a gradual decline in physical activity, which is often associated with Cardiovascular deconditioning. After joint replacement, many patients resume routine walking and recreational activities, which may improve aerobic capacity. The purpose of the present study was to determine the effect of total knee arthroplasty on Cardiovascular Fitness. Nineteen patients who had had total knee arthroplasty (the arthroplasty group) performed an exercise test for Cardiovascular Fitness preoperatively. Sixteen of these patients were tested again at one year postoperatively and thirteen, at two years postoperatively. Sixteen patients in whom osteoarthrosis of the knee was being treated medically (the control group) were tested at the time of enrollment in the study and one year later. Nine of these patients also were tested two years after enrollment. All of the patients completed the Arthritis Impact-Measurement Scales (AIMS) at each examination. Fitness was assessed by the performance of a progressive maximum exercise test with use of a bicycle ergometer and a metabolic cart. All patients achieved the anaerobic threshold. One year postoperatively, the patients in the arthroplasty group demonstrated an increase, which approached significance, in maximum oxygen consumption (measured in milliliters of oxygen per minute) (p = 0.07), maximum oxygen consumption corrected for body weight (p = 0.08), and percentage of predicted maximum uptake of oxygen (p = 0.06). Two years after the total knee arthroplasty, the patients had a significant improvement with regard to all three parameters (p = 0.008, 0.005, and 0.005, respectively). The patients in the control group demonstrated a significant decrease in duration of exercise and in maximum workload at one year (p = 0.003 and 0.005, respectively) and at two years (p = 0.008 for both parameters). Physical activity had increased in the arthroplasty group but not in the control group, as demonstrated by the results of the Arthritis Impact-Measurement Scales. These findings demonstrate a trend toward improvement in Cardiovascular Fitness one year after total knee arthroplasty and a significant improvement two years postoperatively for patients who had been able to resume routine functional activities because of the arthroplasty. These improvements compared favorably with the static pattern or the decline in the measures of Fitness that were observed in the control group. Our results should be considered preliminary because of the relatively small number of patients who were studied.

  • Relationship between severity of gonarthrosis and Cardiovascular Fitness.
    Clinical orthopaedics and related research, 1995
    Co-Authors: Michael D. Ries, E. F. Philbin, G. D. Groff
    Abstract:

    Cardiovascular Fitness was assessed in 3 groups of patients having varying severity of gonarthrosis. Group I consisted of 16 patients with severe knee symptoms scheduled for total knee arthroplasty. Group II included 17 patients with medically treated osteoarthrosis who were not considered surgical candidates because knee symptoms were not severe. Group III consisted of 14 healthy control patients with no lower extremity arthritis. All patients were evaluated with Hospital for Special Surgery knee scores, Arthritis Impact Measurement Scale questionnaires, and a cardiopulmonary exercise test using semi-upright bicycle ergometry. All patients achieved anaerobic threshold during exercise. Mean (+/- standard deviation) maximum oxygen consumption (VO2) at peak exercise was 13.9 +/- 3.3 for Group I, 16.2 +/- 4.1 for Group II, and 21.5 +/- 3.9 for Group III. Mean (+/- standard deviation) Hospital for Special Surgery score was 55 +/- 7 for Group I, 70 +/- 14 for Group II, and 100 +/- 1 for Group III. Lower Hospital for Special Surgery score was associated with lower VO2 at peak exercise, suggesting that inactivity secondary to more severe arthritic symptoms can result in Cardiovascular deconditioning. The association between severity of gonarthrosis and Cardiovascular deconditioning supports the concept that a regular exercise program should be recommended for patients with arthritis. Also, for patients who are surgical candidates, the practice of delaying total knee arthroplasty may be associated with worsening Cardiovascular Fitness, particularly when physical activity becomes more limited. The expected longevity of implant function as well as the effect of continued arthritic symptoms on Cardiovascular Fitness should be considered when determining the optimal time for a patient to undergo total knee arthroplasty.

Sif Gylfadottir - One of the best experts on this subject based on the ideXlab platform.

  • water based exercise for Cardiovascular Fitness in people with chronic stroke a randomized controlled trial
    Archives of Physical Medicine and Rehabilitation, 2004
    Co-Authors: Kelly S Chu, Janice J Eng, Andrew S Dawson, Jocelyn E Harris, Atila Ozkaplan, Sif Gylfadottir
    Abstract:

    Abstract Chu KS, Eng JJ, Dawson AS, Harris JE, Ozkaplan A, Gylfadottir S. Water-based exercise for Cardiovascular Fitness in people with chronic stroke: a randomized controlled trial. Arch Phys Med Rehabil 2004;85:870–4. Objective To evaluate the effect of an 8-week, water-based exercise program (experimental group) with that of an upper-extremity function program (control group) to increase Cardiovascular Fitness within a community setting for people with stroke. Design Single-blind randomized controlled trial. Setting Public community center. Participants A volunteer sample of 12 community-dwelling people with stroke with mild to moderate residual motor deficits. Intervention Study subjects participated in group exercise programs for 1 hour, 3 times a week for 8 weeks. The experimental group exercised in chest-deep water at targeted heart rates. The control group performed arm and hand exercises while sitting. Main outcome measures The primary outcome measure was Cardiovascular Fitness (Vo 2 max). Secondary measures were maximal workload, muscle strength, gait speed, and the Berg Balance Scale score. Results The experimental group attained significant improvements over the control group in Cardiovascular Fitness, maximal workload, gait speed, and paretic lower-extremity muscle strength. The relatively short program (8wk) of water-based exercise resulted in a 22% improvement in Cardiovascular Fitness in a small group of people with stroke who had relatively high function. Conclusions A water-based exercise program undertaken as a group program may be an effective way to promote Fitness in people with stroke.

  • Water-based exercise for Cardiovascular Fitness in people with chronic stroke: a randomized controlled trial.
    Archives of physical medicine and rehabilitation, 2004
    Co-Authors: Kelly S Chu, Janice J Eng, Andrew S Dawson, Jocelyn E Harris, Atila Ozkaplan, Sif Gylfadottir
    Abstract:

    To evaluate the effect of an 8-week, water-based exercise program (experimental group) with that of an upper-extremity function program (control group) to increase Cardiovascular Fitness within a community setting for people with stroke. Single-blind randomized controlled trial. Public community center. A volunteer sample of 12 community-dwelling people with stroke with mild to moderate residual motor deficits. Study subjects participated in group exercise programs for 1 hour, 3 times a week for 8 weeks. The experimental group exercised in chest-deep water at targeted heart rates. The control group performed arm and hand exercises while sitting. Main outcome measures The primary outcome measure was Cardiovascular Fitness (V(O2)max). Secondary measures were maximal workload, muscle strength, gait speed, and the Berg Balance Scale score. The experimental group attained significant improvements over the control group in Cardiovascular Fitness, maximal workload, gait speed, and paretic lower-extremity muscle strength. The relatively short program (8 wk) of water-based exercise resulted in a 22% improvement in Cardiovascular Fitness in a small group of people with stroke who had relatively high function. A water-based exercise program undertaken as a group program may be an effective way to promote Fitness in people with stroke.