The Experts below are selected from a list of 2631 Experts worldwide ranked by ideXlab platform

Marvin J Slepian - One of the best experts on this subject based on the ideXlab platform.

Danny Bluestein - One of the best experts on this subject based on the ideXlab platform.

Xin Wang - One of the best experts on this subject based on the ideXlab platform.

  • construction and application of service quality evaluation system in the preclinical research on Cardiovascular Implant devices
    BMC Medical Informatics and Decision Making, 2019
    Co-Authors: Yongchun Cui, Fuliang Luo, Boqing Yang, Qi Zhang, Gopika Das, Guangxin Yue, Yue Tang, Xin Wang
    Abstract:

    Services for the preclinical development and evaluation of Cardiovascular Implant devices (CVIDs) is a new industry. However, there is still no indicator system for quality evaluation. Our aim is to construct a service for quality evaluation system for the preclinical research and development of CVIDs based on Fuzzy Analytical Hierarchy Process (FAHP). First, we reviewed the related literature to identify and select possible factors. Second, we developed an analytic hierarchy process framework. Third, we developed a questionnaire based on pairwise comparisons and invited 10 experienced specialists to rate these factors. We then used FAHP to compute the weights of these factors and prioritize them. Finally, to demonstrate the effectiveness of the proposed indicator system, a case study was performed as a practical example. Four main indicators (professionalism, functionality, stability and security) and 15 subindicators were selected to form the service evaluation system based on literature review and expert’s proposals. According to the weight calculation data, the order of primary indicators by importance, is professionalism (0.6457), security (0.1193), functionality (0.0958) and stability (0.0596) in sequence. Top five secondary indices are personnel’s technical ability, facility and equipment attractiveness, data auditability, confidentiality capability and professional service procedures. In the case study, FW’s final actual effectiveness value was 0.9076, which is the same as the actual situation. The indicator system established in this study is comprehensive, reasonable, reliable and with strong practicality. It is worth popularizing and applying. The implementation of this evaluation system can provide measurable evidence for service demander and a way to improve service quality for suppliers.

  • Construction and application of service quality evaluation system in the preclinical research on Cardiovascular Implant devices
    BMC, 2019
    Co-Authors: Yongchun Cui, Fuliang Luo, Boqing Yang, Qi Zhang, Gopika Das, Guangxin Yue, Yue Tang, Xin Wang
    Abstract:

    Abstract Background Services for the preclinical development and evaluation of Cardiovascular Implant devices (CVIDs) is a new industry. However, there is still no indicator system for quality evaluation. Our aim is to construct a service for quality evaluation system for the preclinical research and development of CVIDs based on Fuzzy Analytical Hierarchy Process (FAHP). Methods First, we reviewed the related literature to identify and select possible factors. Second, we developed an analytic hierarchy process framework. Third, we developed a questionnaire based on pairwise comparisons and invited 10 experienced specialists to rate these factors. We then used FAHP to compute the weights of these factors and prioritize them. Finally, to demonstrate the effectiveness of the proposed indicator system, a case study was performed as a practical example. Results Four main indicators (professionalism, functionality, stability and security) and 15 subindicators were selected to form the service evaluation system based on literature review and expert’s proposals. According to the weight calculation data, the order of primary indicators by importance, is professionalism (0.6457), security (0.1193), functionality (0.0958) and stability (0.0596) in sequence. Top five secondary indices are personnel’s technical ability, facility and equipment attractiveness, data auditability, confidentiality capability and professional service procedures. In the case study, FW’s final actual effectiveness value was 0.9076, which is the same as the actual situation. Conclusion The indicator system established in this study is comprehensive, reasonable, reliable and with strong practicality. It is worth popularizing and applying. The implementation of this evaluation system can provide measurable evidence for service demander and a way to improve service quality for suppliers

Phat L Tran - One of the best experts on this subject based on the ideXlab platform.

  • shear mediated platelet activation in the free flow perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating Cardiovascular Implant thrombosis
    Journal of Biomechanics, 2017
    Co-Authors: Phat L Tran, Marvin J Slepian, Jawaad Sheriff, Marcus Hutchinson, Naing Bajaj, Joe G N Garcia, Scott S Saavedra, Danny Bluestein
    Abstract:

    Abstract Shear-mediated platelet activation (SMPA) is central in thrombosis of Implantable Cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall Implant device safety.

  • nanoscale feature composite an ensemble surface for enhancing Cardiovascular Implant endothelialization
    2011
    Co-Authors: Phat L Tran
    Abstract:

    The establishment and maintenance of functional endothelial cells (ECs) on an engineered surface is central to tissue engineering. As the field advances, the role of cellular mechanisms, particularly the adhesive interaction between the surface of Implantable devices and biological systems, becomes more relevant in both research and clinical practice. Knowledge of these interactions can address many fundamental biological questions and would provide key design parameters for medical Implants. It has been shown that EC functionality and adhesivity, crucial for the re-endothelialization process, can be induced by nanotopographical modification. Therefore, the goal of this dissertation research was to develop an ensemble surface composing of nanoscale features for the enhancement of endothelial cell adhesion. Without adhesion, subsequent vital mechanism involved in cell alignment, elongation or spreading, proliferation, migration, and ECM proteins deposition will not occur. Experiments in support of this goal were broken down into three specific aims. The first aim was to characterize and develop a size-dependent self-assembly (SDSA) nanoarray of Octamer transcription factor 4 as a demonstration to the fabrication of nanoscale feature surface. This nanoparticle array platform was a pilot studied for the second aim, which was the development of an ensemble surface of nanoscale features for endothelial cell adhesion. The third aim was to evaluate and assess EC response to the ensemble surface.

Yi Yan Yang - One of the best experts on this subject based on the ideXlab platform.

  • peptide functionalized polyurethane coatings prepared via grafting to strategy to selectively promote endothelialization
    Advanced Healthcare Materials, 2018
    Co-Authors: Xin Ding, Willy Chin, James L Hedrick, Yi Yan Yang
    Abstract:

    : Endothelialization, formation of endothelial cells (ECs) layer on Cardiovascular Implant surface, is considered an ideal approach to prevent restenosis (renarrowing of blood vessel mainly due to the accumulation of proliferated vascular smooth muscle cells, SMCs) and thrombosis. In this study, the possibility of using polyurethane (PU) as a coating platform for functionalization with peptide to enhance endothelialization on Implants is explored. PUs are synthesized through metal-free organocatalytic polymerization followed by chemical conjugation with an EC-specific REDV peptide through thiol-ene reaction. Meanwhile, the free isocyanate groups of PU allow for covalent grafting of REDV-functionalized PU (PU/REDV) to silanize Implant materials (nitinol and PET). PU/REDV coating with peptide grafting density of ≈2 nmol cm-2 selectively accommodates primary human umbilical vein ECs (HUVECs) and retards spreading of primary human umbilical artery SMCs (HUASMCs). In addition, a layer of HUVECs is formed within 3 d on PU/REDV-coated surfaces, while proliferation of HUASMCs is inhibited. The selectivity is further confirmed by coculture of HUVECs and HUASMCs. Moreover, the PU/REDV-coated surfaces are less thrombogenic as evidenced by reduced number and activity of adhered platelets. Therefore, PU/REDV can be potentially used as a coating of Cardiovascular Implants to prevent restenosis and thrombosis by promoting endothelialization.