The Experts below are selected from a list of 432 Experts worldwide ranked by ideXlab platform

Fiona D Mcbryde - One of the best experts on this subject based on the ideXlab platform.

  • Carotid Sinus Denervation ameliorates renovascular hypertension in adult wistar rats
    The Journal of Physiology, 2016
    Co-Authors: Wioletta Pijacka, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Lavinia Woodward, David J Paterson, Julian F R Paton
    Abstract:

    Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid Sinus nerve Denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation. Our data suggest that the peripheral chemoreflex may be a viable therapeutic target for renovascular hypertension. Abstract The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n = 9) or sham CSD (n = 9) 5 weeks after renal artery clipping, in comparison with normal Wistar rats (n = 5). After 21 days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+]i) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by week 3 (P < 0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+]i evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.

  • Carotid Sinus Denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats.
    'Royal College of Obstetricians & Gynaecologists (RCOG)', 2016
    Co-Authors: Pijacka W, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Woodward L, Li D, Paterson David, Jf Paton
    Abstract:

    The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (2 kidney 1 clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. Here, we show that CSD ameliorates 2K1C hypertension and reveal potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, then underwent CSD (n = 9) or sham CSD (n = 9) five weeks after renal artery clipping, versus normal Wistar (n = 5). After 21 days renal function was assessed, and tissue collected to assess sympathetic postganglionic intracellular calcium transients ([Ca(2+) ]i ) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuro-inflammatory markers and enhanced [Ca(2+) ]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by Week 3 (P < 0.01), accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca(2+) ]i evoked responses from stellate neurons, and reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurones and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension

  • Carotid Sinus Denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats.
    'Wiley', 2016
    Co-Authors: Pijacka W, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Woodward L, Li D, Paterson David, Jf Paton
    Abstract:

    The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (2 kidney 1 clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. Here, we show that CSD ameliorates 2K1C hypertension and reveal potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, then underwent CSD (n = 9) or sham CSD (n = 9) five weeks after renal artery clipping, versus normal Wistar (n = 5). After 21 days renal function was assessed, and tissue collected to assess sympathetic postganglionic intracellular calcium transients ([Ca(2+) ]i ) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P 

  • the Carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
    Nature Communications, 2013
    Co-Authors: Fiona D Mcbryde, Ana P Abdala, Wioletta Pijacka, Paul J Marvar, Emma B Hendy, Davi J A Moraes, Paul A Sobotka, Julian F R Paton
    Abstract:

    Enhanced sympathetic drive from chemoreceptors in the Carotid body contributes to hypertension. Here McBryde et al. show that Carotid Sinus Denervation is an effective antihypertensive treatment in rats with neurogenic hypertension even if performed in addition to renal Denervation.

Julian F R Paton - One of the best experts on this subject based on the ideXlab platform.

  • Carotid Sinus Denervation ameliorates renovascular hypertension in adult wistar rats
    The Journal of Physiology, 2016
    Co-Authors: Wioletta Pijacka, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Lavinia Woodward, David J Paterson, Julian F R Paton
    Abstract:

    Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid Sinus nerve Denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation. Our data suggest that the peripheral chemoreflex may be a viable therapeutic target for renovascular hypertension. Abstract The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n = 9) or sham CSD (n = 9) 5 weeks after renal artery clipping, in comparison with normal Wistar rats (n = 5). After 21 days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+]i) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by week 3 (P < 0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+]i evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.

  • the Carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
    Nature Communications, 2013
    Co-Authors: Fiona D Mcbryde, Ana P Abdala, Wioletta Pijacka, Paul J Marvar, Emma B Hendy, Davi J A Moraes, Paul A Sobotka, Julian F R Paton
    Abstract:

    Enhanced sympathetic drive from chemoreceptors in the Carotid body contributes to hypertension. Here McBryde et al. show that Carotid Sinus Denervation is an effective antihypertensive treatment in rats with neurogenic hypertension even if performed in addition to renal Denervation.

Ana P Abdala - One of the best experts on this subject based on the ideXlab platform.

  • Carotid Sinus Denervation ameliorates renovascular hypertension in adult wistar rats
    The Journal of Physiology, 2016
    Co-Authors: Wioletta Pijacka, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Lavinia Woodward, David J Paterson, Julian F R Paton
    Abstract:

    Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid Sinus nerve Denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation. Our data suggest that the peripheral chemoreflex may be a viable therapeutic target for renovascular hypertension. Abstract The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n = 9) or sham CSD (n = 9) 5 weeks after renal artery clipping, in comparison with normal Wistar rats (n = 5). After 21 days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+]i) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by week 3 (P < 0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+]i evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.

  • Carotid Sinus Denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats.
    'Royal College of Obstetricians & Gynaecologists (RCOG)', 2016
    Co-Authors: Pijacka W, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Woodward L, Li D, Paterson David, Jf Paton
    Abstract:

    The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (2 kidney 1 clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. Here, we show that CSD ameliorates 2K1C hypertension and reveal potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, then underwent CSD (n = 9) or sham CSD (n = 9) five weeks after renal artery clipping, versus normal Wistar (n = 5). After 21 days renal function was assessed, and tissue collected to assess sympathetic postganglionic intracellular calcium transients ([Ca(2+) ]i ) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuro-inflammatory markers and enhanced [Ca(2+) ]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by Week 3 (P < 0.01), accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca(2+) ]i evoked responses from stellate neurons, and reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurones and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension

  • Carotid Sinus Denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats.
    'Wiley', 2016
    Co-Authors: Pijacka W, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Woodward L, Li D, Paterson David, Jf Paton
    Abstract:

    The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (2 kidney 1 clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. Here, we show that CSD ameliorates 2K1C hypertension and reveal potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, then underwent CSD (n = 9) or sham CSD (n = 9) five weeks after renal artery clipping, versus normal Wistar (n = 5). After 21 days renal function was assessed, and tissue collected to assess sympathetic postganglionic intracellular calcium transients ([Ca(2+) ]i ) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P 

  • the Carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
    Nature Communications, 2013
    Co-Authors: Fiona D Mcbryde, Ana P Abdala, Wioletta Pijacka, Paul J Marvar, Emma B Hendy, Davi J A Moraes, Paul A Sobotka, Julian F R Paton
    Abstract:

    Enhanced sympathetic drive from chemoreceptors in the Carotid body contributes to hypertension. Here McBryde et al. show that Carotid Sinus Denervation is an effective antihypertensive treatment in rats with neurogenic hypertension even if performed in addition to renal Denervation.

Paul J Marvar - One of the best experts on this subject based on the ideXlab platform.

  • Carotid Sinus Denervation ameliorates renovascular hypertension in adult wistar rats
    The Journal of Physiology, 2016
    Co-Authors: Wioletta Pijacka, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Lavinia Woodward, David J Paterson, Julian F R Paton
    Abstract:

    Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid Sinus nerve Denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation. Our data suggest that the peripheral chemoreflex may be a viable therapeutic target for renovascular hypertension. Abstract The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n = 9) or sham CSD (n = 9) 5 weeks after renal artery clipping, in comparison with normal Wistar rats (n = 5). After 21 days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+]i) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by week 3 (P < 0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+]i evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.

  • Carotid Sinus Denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats.
    'Royal College of Obstetricians & Gynaecologists (RCOG)', 2016
    Co-Authors: Pijacka W, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Woodward L, Li D, Paterson David, Jf Paton
    Abstract:

    The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (2 kidney 1 clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. Here, we show that CSD ameliorates 2K1C hypertension and reveal potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, then underwent CSD (n = 9) or sham CSD (n = 9) five weeks after renal artery clipping, versus normal Wistar (n = 5). After 21 days renal function was assessed, and tissue collected to assess sympathetic postganglionic intracellular calcium transients ([Ca(2+) ]i ) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuro-inflammatory markers and enhanced [Ca(2+) ]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by Week 3 (P < 0.01), accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca(2+) ]i evoked responses from stellate neurons, and reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurones and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension

  • Carotid Sinus Denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats.
    'Wiley', 2016
    Co-Authors: Pijacka W, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Woodward L, Li D, Paterson David, Jf Paton
    Abstract:

    The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (2 kidney 1 clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. Here, we show that CSD ameliorates 2K1C hypertension and reveal potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, then underwent CSD (n = 9) or sham CSD (n = 9) five weeks after renal artery clipping, versus normal Wistar (n = 5). After 21 days renal function was assessed, and tissue collected to assess sympathetic postganglionic intracellular calcium transients ([Ca(2+) ]i ) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P 

  • the Carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
    Nature Communications, 2013
    Co-Authors: Fiona D Mcbryde, Ana P Abdala, Wioletta Pijacka, Paul J Marvar, Emma B Hendy, Davi J A Moraes, Paul A Sobotka, Julian F R Paton
    Abstract:

    Enhanced sympathetic drive from chemoreceptors in the Carotid body contributes to hypertension. Here McBryde et al. show that Carotid Sinus Denervation is an effective antihypertensive treatment in rats with neurogenic hypertension even if performed in addition to renal Denervation.

Wioletta Pijacka - One of the best experts on this subject based on the ideXlab platform.

  • Carotid Sinus Denervation ameliorates renovascular hypertension in adult wistar rats
    The Journal of Physiology, 2016
    Co-Authors: Wioletta Pijacka, Ana P Abdala, Fiona D Mcbryde, Paul J Marvar, Gisele S Lincevicius, Lavinia Woodward, David J Paterson, Julian F R Paton
    Abstract:

    Key points Peripheral chemoreflex sensitization is a feature of renovascular hypertension. Carotid Sinus nerve Denervation (CSD) has recently been shown to relieve hypertension and reduce sympathetic activity in other rat models of hypertension. We show that CSD in renovascular hypertension halts further increases in blood pressure. Possible mechanisms include improvements in baroreceptor reflex sensitivity and renal function, restoration of cardiac calcium signalling towards control levels, and reduced neural inflammation. Our data suggest that the peripheral chemoreflex may be a viable therapeutic target for renovascular hypertension. Abstract The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip; 2K1C) rats. We have previously shown that Carotid Sinus nerve Denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n = 9) or sham CSD (n = 9) 5 weeks after renal artery clipping, in comparison with normal Wistar rats (n = 5). After 21 days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+]i) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 98 ± 4 mmHg vs. 2K1C: 147 ± 8 mmHg; P < 0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+]I in stellate neurons (P < 0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 14 ± 2 mmHg by week 3 (P < 0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+]i evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.

  • the Carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
    Nature Communications, 2013
    Co-Authors: Fiona D Mcbryde, Ana P Abdala, Wioletta Pijacka, Paul J Marvar, Emma B Hendy, Davi J A Moraes, Paul A Sobotka, Julian F R Paton
    Abstract:

    Enhanced sympathetic drive from chemoreceptors in the Carotid body contributes to hypertension. Here McBryde et al. show that Carotid Sinus Denervation is an effective antihypertensive treatment in rats with neurogenic hypertension even if performed in addition to renal Denervation.