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Jin-ao Duan - One of the best experts on this subject based on the ideXlab platform.

  • A New Ceramide from the Florets of Carthamus Tinctorius
    Chemistry of Natural Compounds, 2017
    Co-Authors: Cheng Qu, Liang Wu, Yuping Tang, Shujiao Li, Juan Shen, Jin-ao Duan
    Abstract:

    A new ceramide, rel-(3S,4S,5S)-3-[(2S)-2-hydroxyheneicosanoylamino]-4-hydroxy-5-[(4Z)-tetradecan-4-ene]-2,3,4,5-tetrahydrofuran (1), was isolated from the florets of Carthamus Tinctorius along with two compounds, 10,12-nonacosanedione (2) and apigenin-7-O-β-apiofuranosyl-6,8-di-C-β-glucopyranoside (3), for the first time. Their structures were elucidated by means of spectral techniques including MS and 1D/2D NMR.

  • two new quinochalcone c glycosides from the florets of Carthamus Tinctorius
    International Journal of Molecular Sciences, 2014
    Co-Authors: Yuping Tang, Shujiao Li, Chengmei Xu, Jin-ao Duan
    Abstract:

    Two new quinochalcone C-glycosides, named hydroxysafflor yellow B (1) and hydroxysafflor yellow C (2), along with two known quinochalcone C-glycosides, safflomin C (3) and saffloquinoside C (4), and one known flavanone, (2R)-4',5-dihydroxyl-6, 7-di-O-β-d-glucopyranosyl flavanone (5), were isolated from the florets of Carthamus Tinctorius. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these quinochalcone C-glycosides together with hydroxysafflor yellow A and anhydrosafflor yellow B were evaluated for their anti-oxidative effects against H2O2-induced cytotoxicity in cultured H9c2 cells. Among them, compound 2 exhibited significant anti-oxidative effects.

  • chemical and biological properties of quinochalcone c glycosides from the florets of Carthamus Tinctorius
    Molecules, 2013
    Co-Authors: Yuping Tang, Shujiao Li, Jin-ao Duan
    Abstract:

    Quinochalcone C-glycosides are regarded as characteristic components that have only been isolated from the florets of Carthamus Tinctorius. Recently, quinochalcone C-glycosides were found to have multiple pharmacological activities, which has attracted the attention of many researchers to explore these compounds. This review aims to summarize quinochalcone C-glycosides’ physicochemical properties, chromatographic behavior, spectroscopic characteristics, as well as their biological activities, which will be helpful for further study and development of quinochalcone C-glycosides.

Yuping Tang - One of the best experts on this subject based on the ideXlab platform.

  • A New Ceramide from the Florets of Carthamus Tinctorius
    Chemistry of Natural Compounds, 2017
    Co-Authors: Cheng Qu, Liang Wu, Yuping Tang, Shujiao Li, Juan Shen, Jin-ao Duan
    Abstract:

    A new ceramide, rel-(3S,4S,5S)-3-[(2S)-2-hydroxyheneicosanoylamino]-4-hydroxy-5-[(4Z)-tetradecan-4-ene]-2,3,4,5-tetrahydrofuran (1), was isolated from the florets of Carthamus Tinctorius along with two compounds, 10,12-nonacosanedione (2) and apigenin-7-O-β-apiofuranosyl-6,8-di-C-β-glucopyranoside (3), for the first time. Their structures were elucidated by means of spectral techniques including MS and 1D/2D NMR.

  • two new quinochalcone c glycosides from the florets of Carthamus Tinctorius
    International Journal of Molecular Sciences, 2014
    Co-Authors: Yuping Tang, Shujiao Li, Chengmei Xu, Jin-ao Duan
    Abstract:

    Two new quinochalcone C-glycosides, named hydroxysafflor yellow B (1) and hydroxysafflor yellow C (2), along with two known quinochalcone C-glycosides, safflomin C (3) and saffloquinoside C (4), and one known flavanone, (2R)-4',5-dihydroxyl-6, 7-di-O-β-d-glucopyranosyl flavanone (5), were isolated from the florets of Carthamus Tinctorius. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these quinochalcone C-glycosides together with hydroxysafflor yellow A and anhydrosafflor yellow B were evaluated for their anti-oxidative effects against H2O2-induced cytotoxicity in cultured H9c2 cells. Among them, compound 2 exhibited significant anti-oxidative effects.

  • chemical and biological properties of quinochalcone c glycosides from the florets of Carthamus Tinctorius
    Molecules, 2013
    Co-Authors: Yuping Tang, Shujiao Li, Jin-ao Duan
    Abstract:

    Quinochalcone C-glycosides are regarded as characteristic components that have only been isolated from the florets of Carthamus Tinctorius. Recently, quinochalcone C-glycosides were found to have multiple pharmacological activities, which has attracted the attention of many researchers to explore these compounds. This review aims to summarize quinochalcone C-glycosides’ physicochemical properties, chromatographic behavior, spectroscopic characteristics, as well as their biological activities, which will be helpful for further study and development of quinochalcone C-glycosides.

Shujiao Li - One of the best experts on this subject based on the ideXlab platform.

  • A New Ceramide from the Florets of Carthamus Tinctorius
    Chemistry of Natural Compounds, 2017
    Co-Authors: Cheng Qu, Liang Wu, Yuping Tang, Shujiao Li, Juan Shen, Jin-ao Duan
    Abstract:

    A new ceramide, rel-(3S,4S,5S)-3-[(2S)-2-hydroxyheneicosanoylamino]-4-hydroxy-5-[(4Z)-tetradecan-4-ene]-2,3,4,5-tetrahydrofuran (1), was isolated from the florets of Carthamus Tinctorius along with two compounds, 10,12-nonacosanedione (2) and apigenin-7-O-β-apiofuranosyl-6,8-di-C-β-glucopyranoside (3), for the first time. Their structures were elucidated by means of spectral techniques including MS and 1D/2D NMR.

  • two new quinochalcone c glycosides from the florets of Carthamus Tinctorius
    International Journal of Molecular Sciences, 2014
    Co-Authors: Yuping Tang, Shujiao Li, Chengmei Xu, Jin-ao Duan
    Abstract:

    Two new quinochalcone C-glycosides, named hydroxysafflor yellow B (1) and hydroxysafflor yellow C (2), along with two known quinochalcone C-glycosides, safflomin C (3) and saffloquinoside C (4), and one known flavanone, (2R)-4',5-dihydroxyl-6, 7-di-O-β-d-glucopyranosyl flavanone (5), were isolated from the florets of Carthamus Tinctorius. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these quinochalcone C-glycosides together with hydroxysafflor yellow A and anhydrosafflor yellow B were evaluated for their anti-oxidative effects against H2O2-induced cytotoxicity in cultured H9c2 cells. Among them, compound 2 exhibited significant anti-oxidative effects.

  • chemical and biological properties of quinochalcone c glycosides from the florets of Carthamus Tinctorius
    Molecules, 2013
    Co-Authors: Yuping Tang, Shujiao Li, Jin-ao Duan
    Abstract:

    Quinochalcone C-glycosides are regarded as characteristic components that have only been isolated from the florets of Carthamus Tinctorius. Recently, quinochalcone C-glycosides were found to have multiple pharmacological activities, which has attracted the attention of many researchers to explore these compounds. This review aims to summarize quinochalcone C-glycosides’ physicochemical properties, chromatographic behavior, spectroscopic characteristics, as well as their biological activities, which will be helpful for further study and development of quinochalcone C-glycosides.

Lijun Wu - One of the best experts on this subject based on the ideXlab platform.

  • hydroxysafflor yellow a hsya from flowers of Carthamus Tinctorius l and its vasodilatation effects on pulmonary artery
    Molecules, 2012
    Co-Authors: Ping Lu, Chunyue Yu, Minggang Chen, Fa He, Dan Yi, Lijun Wu
    Abstract:

    Flowers of Carthamus Tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus Tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus Tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).

Peicheng Zhang - One of the best experts on this subject based on the ideXlab platform.

  • saffloflavonesides a and b two rearranged derivatives of flavonoid c glycosides with a furan tetrahydrofuran ring from Carthamus Tinctorius
    Organic Letters, 2014
    Co-Authors: Jun He, Jianshuang Jiang, Ziming Feng, Yanan Yang, Peicheng Zhang
    Abstract:

    Two new rearranged derivatives of flavonoid C-glycosides, saffloflavonesides A (1) and B (2), were isolated from the florets of Carthamus Tinctorius. Their structures were determined using UV, IR, HRESIMS, and 1D and 2D NMR data and by comparing experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were unprecedented chalcone and flavanone derivatives possessing a furan conjoining tetrahydrofuran ring. A potential biosynthetic pathway was proposed. At 10 μM, 1 and 2 both showed strong inhibitory activity against PC12 cell damage induced by rotenone.

  • Two new glycosides from the florets of Carthamus Tinctorius
    Journal of Asian Natural Products Research, 2013
    Co-Authors: Jianshuang Jiang, Ziming Feng, Yanan Yang, Zhong Chen, Peicheng Zhang
    Abstract:

    Two new glycoside compounds, named saffloquinoside C (1) and (-)-4-hydroxybenzoic acid-4-O-[6′-O-(2″-methylbutyryl)-β-D-glucopyranoside] (2), were isolated from the florets of Carthamus Tinctorius. Their structures were elucidated by detailed spectroscopic means including UV, IR, HR-ESI-MS, 1D and 2D NMR, and CD data. Compound 1 was a rare quinochalcone glycoside with six five-membered dioxaspirocycle.

  • new polyacetylene glucosides from the florets of Carthamus Tinctorius and their weak anti inflammatory activities
    Carbohydrate Research, 2011
    Co-Authors: Jun He, Jianshuang Jiang, Ziming Feng, Peicheng Zhang, Yanan Yang, Yi Shen, Shaopeng Yuan
    Abstract:

    Abstract Eight new linear polyacetylene glucosides ( 1 – 8 ), containing two C 10 -, one C 13 - and five C 14 -acetylenes, together with three known polyacetylenes ( 9 – 11 ) were isolated from the florets of Carthamus Tinctorius L. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The absolute configurations of compounds 3 – 9 were confirmed by Snatzke and Gerards’s method, observing the induced circular dichroism after addition of dirhodium tetrakis (trifluoroacetate) [Rh 2 (OCOCF 3 ) 4 ] in CHCl 3 . All the isolated compounds ( 1 – 11 ) were also tested for inhibitory activities against LPS-induced NO production in murine macrophages and just showed weak activities at concentrations of 1 × 10 −5  M.

  • two new quinochalcones from the florets of Carthamus Tinctorius
    Organic Letters, 2010
    Co-Authors: Jianshuang Jiang, Ziming Feng, Jun He, Peicheng Zhang
    Abstract:

    Two new quinochalcone compounds, named saffloquinoside A (1) and saffloquinoside B (2), were isolated from the florets of Carthamus Tinctorius. Their unusual structures including their absolute stereochemistry were elucidated based on UV, IR, HRESIMS, 1D and 2D NMR data, and CD spectrum. Saffloquinoside A has an uncommon six−five member dioxaspirocycle and saffloquinoside B has a cyclohexatrione skeleton with a benzyl group and two C-glycosyl units. Saffloquinoside A exhibited middling anti-inflammatory activity.

  • New spermidines from the florets of Carthamus Tinctorius.
    Journal of Asian Natural Products Research, 2008
    Co-Authors: Jianshuang Jiang, Liang Lü, Yajun Yang, Jinlan Zhang, Peicheng Zhang
    Abstract:

    Two new spermidine compounds, namely safflospermidine A (1) and safflospermidine B (2), together with two known compounds, N 1,N 5,N 10-(Z)-tri-p-coumaroylspermidine (3) and N 1,N 5,N 10-(E)-tri-p-coumaroylspermidine (4), were isolated from the florets of Carthamus Tinctorius L. Their structures were elucidated by spectroscopic means.