The Experts below are selected from a list of 213 Experts worldwide ranked by ideXlab platform

J. Vander Sloten - One of the best experts on this subject based on the ideXlab platform.

  • Changes in contact area characteristics of the ankle after a Cartilage Biopsy at the postero-medial rim of the talar dome.
    Osteoarthritis and cartilage, 2009
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, G.ph.e. Dereymaeker, Frank P. Luyten, J. Vander Sloten
    Abstract:

    Summary Objective Study the changes in local and generalized biomechanical characteristics of the ankle joint, associated with a well defined Cartilage Biopsy at the postero-medial rim of the talar dome, to evaluate its safety. Methods Ten cadaver ankles were (sub-) physiologically loaded pre- and post-Biopsy; in neutral position, 10° of plantar-flexion (PF) and 10° of dorsi-flexion (DF). Fuji film was used as transducer. Qualitatively, the coverage of the Biopsy by the tibial plafond, and changes in the shape of the footprint were analyzed. Quantitatively, the pressure profile plot, normalized-tibio-talar contact area and the centroid position of pressure were examined. Results were reported as a mean for all specimens, and as individual values for every single specimen as well. Results Mean results did not show significant changes, but those of some single specimens did. The majority of those changes were in PF. Some occurred in N, and besides two exceptions none occurred in DF. Two specimens did not show any change. One specimen showed an isolated quantitative change. Seven specimens showed both qualitative and quantitative changes. However, all changes were of low-magnitude and contact stresses did not show any rebound effect. Conclusions Although biopsies at the postero-medial rim of the talar dome did not induce on average significant changes in quantitative contact characteristics, few specimens did show some alterations. Currently, the investigated Biopsy site seems safe, but long term follow-up studies in patients are needed for confirmation.

  • Pressure profile changes after Cartilage Biopsy at the postero-medial rim of the talar dome
    Journal of Foot and Ankle Research, 2008
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, Frank P. Luyten, Greta Dereymaeker, J. Vander Sloten
    Abstract:

    Autologous chondrocytes implantation is a promising technique to treat joint surface defects of the talar dome, especially when it is considered that a complete arthroscopic procedure is available yet [1]. However, the exact Biopsy site as source of the cells to be expanded remains an issue of debate. Recently we showed that a limited Biopsy can be harvested reliably and consistently at the postero-medial rim of the talar dome by arthroscopy [2]. Further research must establish if this location is indeed a "lesser weight bearing area". This study aims to determine the changes occurring in the pressure profile across the aforementioned site after a Biopsy has been harvested.

Giovanni Matricali - One of the best experts on this subject based on the ideXlab platform.

  • Donor site morbidity after articular Cartilage repair procedures: a review.
    Acta orthopaedica Belgica, 2010
    Co-Authors: Giovanni Matricali, Greta Dereymaeker, Frank P. Luyten
    Abstract:

    In order to perform an Osteochondral Autologous Transplantation (OAT) or an Autologous Chondrocyte Implantation (ACI), the integrity of healthy intact articular Cartilage at a second location needs to be violated. This creates the possibility for donor site morbidity. Only recently have any publications addressed this issue. The aim of this manuscript is to review the current knowledge on donor site morbidity after an OAT or an ACI. Reports were identified by searching Medline and Pubmed up to March 2010. Donor site morbidity was described mostly considering a clinical outcome, both in a qualitative (parameters in history or physical examination) and/or quantitative way (knee status reported by means of a numerical score). An increasing rate of problems is noted when using quantitative instead of qualitative parameters, and when donor site morbidity is the focus of attention, affecting up to more than half of the patients, in particular for an OAT procedure. The decision to harvest an osteochondral or Cartilage Biopsy to perform a repair procedure should therefore be taken with caution. This also underscores the need for further research to identify safe donor sites or to develop techniques that eliminate the need for a formal Biopsy ccompletely.

  • Changes in contact area characteristics of the ankle after a Cartilage Biopsy at the postero-medial rim of the talar dome.
    Osteoarthritis and cartilage, 2009
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, G.ph.e. Dereymaeker, Frank P. Luyten, J. Vander Sloten
    Abstract:

    Summary Objective Study the changes in local and generalized biomechanical characteristics of the ankle joint, associated with a well defined Cartilage Biopsy at the postero-medial rim of the talar dome, to evaluate its safety. Methods Ten cadaver ankles were (sub-) physiologically loaded pre- and post-Biopsy; in neutral position, 10° of plantar-flexion (PF) and 10° of dorsi-flexion (DF). Fuji film was used as transducer. Qualitatively, the coverage of the Biopsy by the tibial plafond, and changes in the shape of the footprint were analyzed. Quantitatively, the pressure profile plot, normalized-tibio-talar contact area and the centroid position of pressure were examined. Results were reported as a mean for all specimens, and as individual values for every single specimen as well. Results Mean results did not show significant changes, but those of some single specimens did. The majority of those changes were in PF. Some occurred in N, and besides two exceptions none occurred in DF. Two specimens did not show any change. One specimen showed an isolated quantitative change. Seven specimens showed both qualitative and quantitative changes. However, all changes were of low-magnitude and contact stresses did not show any rebound effect. Conclusions Although biopsies at the postero-medial rim of the talar dome did not induce on average significant changes in quantitative contact characteristics, few specimens did show some alterations. Currently, the investigated Biopsy site seems safe, but long term follow-up studies in patients are needed for confirmation.

  • Pressure profile changes after Cartilage Biopsy at the postero-medial rim of the talar dome
    Journal of Foot and Ankle Research, 2008
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, Frank P. Luyten, Greta Dereymaeker, J. Vander Sloten
    Abstract:

    Autologous chondrocytes implantation is a promising technique to treat joint surface defects of the talar dome, especially when it is considered that a complete arthroscopic procedure is available yet [1]. However, the exact Biopsy site as source of the cells to be expanded remains an issue of debate. Recently we showed that a limited Biopsy can be harvested reliably and consistently at the postero-medial rim of the talar dome by arthroscopy [2]. Further research must establish if this location is indeed a "lesser weight bearing area". This study aims to determine the changes occurring in the pressure profile across the aforementioned site after a Biopsy has been harvested.

  • The posteromedial rim of the talar dome as the site for harvesting Cartilage in the ankle: an anatomic study
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the Internation, 2006
    Co-Authors: Giovanni Matricali, Greta Dereymaeker, Frank P. Luyten
    Abstract:

    Purpose: The goal of this study was to determine whether a Biopsy specimen of a fixed size can be harvested reliably and consistently by arthroscopy at the posteromedial rim of the talar dome. Methods: A Cartilage Biopsy specimen was taken post mortem arthroscopically from the posteromedial rim of the talar dome in 20 ankles. We aimed to take a full-thickness Biopsy specimen of 10 × 5 mm in size. The shape, length, width, position, and depth of the created defect were determined. Subsequently, 2 observers analyzed the Biopsy sites twice. The same set of parameters and the surface area of the lesion were determined. Differences between aimed and observed sizes were studied. Results: In all ankles the aimed Biopsy site could be seen and reached. The observed mean size of the Biopsy specimens, when compared with the aimed size, was only significantly different for the mediolateral size. A wide variation of surface area was found. Nearly all Biopsy specimens started exactly at the posterior border of the dome, but they were somewhat more lateral than intended. In only half of the Biopsy specimens was the shape linear or oval, the others being rounded or irregular. In case a pre-existing posteromedial Cartilage lesion was present, its position did not coincide with that of the Biopsy specimen. Conclusions: A limited Cartilage Biopsy specimen could be harvested reliably and consistently by arthroscopy at the posteromedial rim of the talar dome, although the size tended to be somewhat larger than we intended. Containment of a pre-existing posteromedial lesion was never jeopardized. Clinical Relevance: A safe Biopsy site for Cartilage in the ankle eliminates donor-site morbidity in the knee and may improve the suitability and biology of the obtained chondrocytes for successful repair of symptomatic joint surface defects of the ankle.

Frank P. Luyten - One of the best experts on this subject based on the ideXlab platform.

  • Characterized Chondrocyte Implantation Challenges Current Paradigms for the Treatment of Symptomatic Joint Surface Lesions
    Developing Insights in Cartilage Repair, 2013
    Co-Authors: J. Vanlauwe, Mislav Jelić, M. J. Limbourg, Frank P. Luyten
    Abstract:

    The use of autologous cells derived from an articular Cartilage Biopsy to treat joint surface lesions was introduced in 1994 by Brittberg and Peterson. In a 2-step procedure, chondrocytes were harvested from a minor weight-bearing area of the knee joint during arthroscopy, expanded ex vivo and implanted during an arthrotomy 2–3 weeks later. However, throughout the in vitro expansion process, articular chondrocytes progressively lose their phenotypic traits and capacity to form stable Cartilage tissue, thereby jeopardizing proper in vivo repair.

  • Donor site morbidity after articular Cartilage repair procedures: a review.
    Acta orthopaedica Belgica, 2010
    Co-Authors: Giovanni Matricali, Greta Dereymaeker, Frank P. Luyten
    Abstract:

    In order to perform an Osteochondral Autologous Transplantation (OAT) or an Autologous Chondrocyte Implantation (ACI), the integrity of healthy intact articular Cartilage at a second location needs to be violated. This creates the possibility for donor site morbidity. Only recently have any publications addressed this issue. The aim of this manuscript is to review the current knowledge on donor site morbidity after an OAT or an ACI. Reports were identified by searching Medline and Pubmed up to March 2010. Donor site morbidity was described mostly considering a clinical outcome, both in a qualitative (parameters in history or physical examination) and/or quantitative way (knee status reported by means of a numerical score). An increasing rate of problems is noted when using quantitative instead of qualitative parameters, and when donor site morbidity is the focus of attention, affecting up to more than half of the patients, in particular for an OAT procedure. The decision to harvest an osteochondral or Cartilage Biopsy to perform a repair procedure should therefore be taken with caution. This also underscores the need for further research to identify safe donor sites or to develop techniques that eliminate the need for a formal Biopsy ccompletely.

  • Changes in contact area characteristics of the ankle after a Cartilage Biopsy at the postero-medial rim of the talar dome.
    Osteoarthritis and cartilage, 2009
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, G.ph.e. Dereymaeker, Frank P. Luyten, J. Vander Sloten
    Abstract:

    Summary Objective Study the changes in local and generalized biomechanical characteristics of the ankle joint, associated with a well defined Cartilage Biopsy at the postero-medial rim of the talar dome, to evaluate its safety. Methods Ten cadaver ankles were (sub-) physiologically loaded pre- and post-Biopsy; in neutral position, 10° of plantar-flexion (PF) and 10° of dorsi-flexion (DF). Fuji film was used as transducer. Qualitatively, the coverage of the Biopsy by the tibial plafond, and changes in the shape of the footprint were analyzed. Quantitatively, the pressure profile plot, normalized-tibio-talar contact area and the centroid position of pressure were examined. Results were reported as a mean for all specimens, and as individual values for every single specimen as well. Results Mean results did not show significant changes, but those of some single specimens did. The majority of those changes were in PF. Some occurred in N, and besides two exceptions none occurred in DF. Two specimens did not show any change. One specimen showed an isolated quantitative change. Seven specimens showed both qualitative and quantitative changes. However, all changes were of low-magnitude and contact stresses did not show any rebound effect. Conclusions Although biopsies at the postero-medial rim of the talar dome did not induce on average significant changes in quantitative contact characteristics, few specimens did show some alterations. Currently, the investigated Biopsy site seems safe, but long term follow-up studies in patients are needed for confirmation.

  • Pressure profile changes after Cartilage Biopsy at the postero-medial rim of the talar dome
    Journal of Foot and Ankle Research, 2008
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, Frank P. Luyten, Greta Dereymaeker, J. Vander Sloten
    Abstract:

    Autologous chondrocytes implantation is a promising technique to treat joint surface defects of the talar dome, especially when it is considered that a complete arthroscopic procedure is available yet [1]. However, the exact Biopsy site as source of the cells to be expanded remains an issue of debate. Recently we showed that a limited Biopsy can be harvested reliably and consistently at the postero-medial rim of the talar dome by arthroscopy [2]. Further research must establish if this location is indeed a "lesser weight bearing area". This study aims to determine the changes occurring in the pressure profile across the aforementioned site after a Biopsy has been harvested.

  • The posteromedial rim of the talar dome as the site for harvesting Cartilage in the ankle: an anatomic study
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the Internation, 2006
    Co-Authors: Giovanni Matricali, Greta Dereymaeker, Frank P. Luyten
    Abstract:

    Purpose: The goal of this study was to determine whether a Biopsy specimen of a fixed size can be harvested reliably and consistently by arthroscopy at the posteromedial rim of the talar dome. Methods: A Cartilage Biopsy specimen was taken post mortem arthroscopically from the posteromedial rim of the talar dome in 20 ankles. We aimed to take a full-thickness Biopsy specimen of 10 × 5 mm in size. The shape, length, width, position, and depth of the created defect were determined. Subsequently, 2 observers analyzed the Biopsy sites twice. The same set of parameters and the surface area of the lesion were determined. Differences between aimed and observed sizes were studied. Results: In all ankles the aimed Biopsy site could be seen and reached. The observed mean size of the Biopsy specimens, when compared with the aimed size, was only significantly different for the mediolateral size. A wide variation of surface area was found. Nearly all Biopsy specimens started exactly at the posterior border of the dome, but they were somewhat more lateral than intended. In only half of the Biopsy specimens was the shape linear or oval, the others being rounded or irregular. In case a pre-existing posteromedial Cartilage lesion was present, its position did not coincide with that of the Biopsy specimen. Conclusions: A limited Cartilage Biopsy specimen could be harvested reliably and consistently by arthroscopy at the posteromedial rim of the talar dome, although the size tended to be somewhat larger than we intended. Containment of a pre-existing posteromedial lesion was never jeopardized. Clinical Relevance: A safe Biopsy site for Cartilage in the ankle eliminates donor-site morbidity in the knee and may improve the suitability and biology of the obtained chondrocytes for successful repair of symptomatic joint surface defects of the ankle.

Ward Bartels - One of the best experts on this subject based on the ideXlab platform.

  • Changes in contact area characteristics of the ankle after a Cartilage Biopsy at the postero-medial rim of the talar dome.
    Osteoarthritis and cartilage, 2009
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, G.ph.e. Dereymaeker, Frank P. Luyten, J. Vander Sloten
    Abstract:

    Summary Objective Study the changes in local and generalized biomechanical characteristics of the ankle joint, associated with a well defined Cartilage Biopsy at the postero-medial rim of the talar dome, to evaluate its safety. Methods Ten cadaver ankles were (sub-) physiologically loaded pre- and post-Biopsy; in neutral position, 10° of plantar-flexion (PF) and 10° of dorsi-flexion (DF). Fuji film was used as transducer. Qualitatively, the coverage of the Biopsy by the tibial plafond, and changes in the shape of the footprint were analyzed. Quantitatively, the pressure profile plot, normalized-tibio-talar contact area and the centroid position of pressure were examined. Results were reported as a mean for all specimens, and as individual values for every single specimen as well. Results Mean results did not show significant changes, but those of some single specimens did. The majority of those changes were in PF. Some occurred in N, and besides two exceptions none occurred in DF. Two specimens did not show any change. One specimen showed an isolated quantitative change. Seven specimens showed both qualitative and quantitative changes. However, all changes were of low-magnitude and contact stresses did not show any rebound effect. Conclusions Although biopsies at the postero-medial rim of the talar dome did not induce on average significant changes in quantitative contact characteristics, few specimens did show some alterations. Currently, the investigated Biopsy site seems safe, but long term follow-up studies in patients are needed for confirmation.

  • Pressure profile changes after Cartilage Biopsy at the postero-medial rim of the talar dome
    Journal of Foot and Ankle Research, 2008
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, Frank P. Luyten, Greta Dereymaeker, J. Vander Sloten
    Abstract:

    Autologous chondrocytes implantation is a promising technique to treat joint surface defects of the talar dome, especially when it is considered that a complete arthroscopic procedure is available yet [1]. However, the exact Biopsy site as source of the cells to be expanded remains an issue of debate. Recently we showed that a limited Biopsy can be harvested reliably and consistently at the postero-medial rim of the talar dome by arthroscopy [2]. Further research must establish if this location is indeed a "lesser weight bearing area". This study aims to determine the changes occurring in the pressure profile across the aforementioned site after a Biopsy has been harvested.

Luc Labey - One of the best experts on this subject based on the ideXlab platform.

  • Changes in contact area characteristics of the ankle after a Cartilage Biopsy at the postero-medial rim of the talar dome.
    Osteoarthritis and cartilage, 2009
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, G.ph.e. Dereymaeker, Frank P. Luyten, J. Vander Sloten
    Abstract:

    Summary Objective Study the changes in local and generalized biomechanical characteristics of the ankle joint, associated with a well defined Cartilage Biopsy at the postero-medial rim of the talar dome, to evaluate its safety. Methods Ten cadaver ankles were (sub-) physiologically loaded pre- and post-Biopsy; in neutral position, 10° of plantar-flexion (PF) and 10° of dorsi-flexion (DF). Fuji film was used as transducer. Qualitatively, the coverage of the Biopsy by the tibial plafond, and changes in the shape of the footprint were analyzed. Quantitatively, the pressure profile plot, normalized-tibio-talar contact area and the centroid position of pressure were examined. Results were reported as a mean for all specimens, and as individual values for every single specimen as well. Results Mean results did not show significant changes, but those of some single specimens did. The majority of those changes were in PF. Some occurred in N, and besides two exceptions none occurred in DF. Two specimens did not show any change. One specimen showed an isolated quantitative change. Seven specimens showed both qualitative and quantitative changes. However, all changes were of low-magnitude and contact stresses did not show any rebound effect. Conclusions Although biopsies at the postero-medial rim of the talar dome did not induce on average significant changes in quantitative contact characteristics, few specimens did show some alterations. Currently, the investigated Biopsy site seems safe, but long term follow-up studies in patients are needed for confirmation.

  • Pressure profile changes after Cartilage Biopsy at the postero-medial rim of the talar dome
    Journal of Foot and Ankle Research, 2008
    Co-Authors: Giovanni Matricali, Ward Bartels, Luc Labey, Frank P. Luyten, Greta Dereymaeker, J. Vander Sloten
    Abstract:

    Autologous chondrocytes implantation is a promising technique to treat joint surface defects of the talar dome, especially when it is considered that a complete arthroscopic procedure is available yet [1]. However, the exact Biopsy site as source of the cells to be expanded remains an issue of debate. Recently we showed that a limited Biopsy can be harvested reliably and consistently at the postero-medial rim of the talar dome by arthroscopy [2]. Further research must establish if this location is indeed a "lesser weight bearing area". This study aims to determine the changes occurring in the pressure profile across the aforementioned site after a Biopsy has been harvested.