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Siegfried Trattnig - One of the best experts on this subject based on the ideXlab platform.

  • Cartilage repair of the ankle first results of t2 mapping at 7 0 t after microfracture and matrix associated autologous Cartilage Transplantation
    Osteoarthritis and Cartilage, 2012
    Co-Authors: Stephan Domayer, Sebastian Apprich, David Stelzeneder, C Hirschfeld, M Sokolowski, Claudia Kronnerwetter, Catharina Chiari, Reinhard Windhager, Siegfried Trattnig
    Abstract:

    Summary Background Both microfracture (MFX) and matrix associated autologous Cartilage Transplantation (MACT) are currently used to treat Cartilage defects of the talus. T2 mapping of the ankle at 7 T has the potential to assess the collagen fibril network organization of the native hyaline Cartilage and of the repair tissue (RT). This study provides first results regarding the properties of Cartilage RT after MFX (mean follow-up: 113.8 months) and MACT (65.4 months). Methods A multi-echo spin-echo sequence was used at 7 T to assess T2 maps in 10 volunteer cases, and in 10 cases after MFX and MACT each. Proton weighted morphological images and clinical data were used to ensure comparable baseline criteria. Results A significant zonal variation of T2 was found in the volunteers. T2 of the superficial and the deep layer was 39.3 ± 5.9 ms and 21.1 ± 3.1 ms (zonal T2 index calculated by superficial T2/deep T2: 1.87 ± 0.2, P P P  = 0.009). In MACT, T2 of the reference Cartilage was 39.0 ± 9.1 ms and 27.1 ± 6.6 ms (1.45 ± 0.2, P P  = 0.003). The zonal RT T2 variation differed significantly from the reference Cartilage in both techniques (MFX: P  = 0.004, MACT: P  = 0.001). Conclusion T2 mapping at 7 T allows for the quantitative assessment of the collagen network organization of the talus. MACT and MFX yielded RT with comparable T2 properties.

  • quantitative t2 mapping during follow up after matrix associated autologous chondrocyte Transplantation mact full thickness and zonal evaluation to visualize the maturation of Cartilage repair tissue
    Journal of Orthopaedic Research, 2009
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, C Glaser, Klaus M Friedrich, Friedrich F Hennig, Erich Salomonowitz, Siegfried Trattnig
    Abstract:

    The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of Cartilage repair tissue maturation after matrix-associated autologous chondrocyte Transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 +/- 12.1 months after Cartilage Transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 +/- 12.0 months after surgery), a longitudinal 1-year follow-up MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steady-state sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the Cartilage repair area and in control Cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy Cartilage and Cartilage repair tissue (p 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of Cartilage repair tissue.

  • magnetization transfer contrast and t2 mapping in the evaluation of Cartilage repair tissue with 3t mri
    Journal of Magnetic Resonance Imaging, 2008
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Siegfried Trattnig, K Scheffler, Pavol Szomonanyi, S Quirbach, Stephan Domayer, Oliver Bieri, Tallal C Mamisch
    Abstract:

    PURPOSE: To use magnetization transfer (MT) imaging in the visualization of healthy articular Cartilage and Cartilage repair tissue after different Cartilage repair procedures, and to assess global as well as zonal values and compare the results to T2-relaxation. MATERIALS AND METHODS: Thirty-four patients (17 after microfracture [MFX] and 17 after matrix-associated autologous Cartilage Transplantation [MACT]) were examined with 3T MRI. The MT ratio (MTR) was calculated from measurements with and without MT contrast. T2-values were evaluated using a multiecho, spin-echo approach. Global (full thickness of Cartilage) and zonal (deep and superficial aspect) region-of-interest assessment of Cartilage repair tissue and normal-appearing Cartilage was performed. RESULTS: In patients after MFX and MACT, the global MTR of Cartilage repair tissue was significantly lower compared to healthy Cartilage. In contrast, using T2, Cartilage repair tissue showed significantly lower T2 values only after MFX, whereas after MACT, global T2 values were comparable to healthy Cartilage. For zonal evaluation, MTR and T2 showed a significant stratification within healthy Cartilage, and T2 additionally within Cartilage repair tissue after MACT. CONCLUSION: MT imaging is capable and sensitive in the detection of differences between healthy Cartilage and areas of Cartilage repair and might be an additional tool in biochemical Cartilage imaging. For both MTR and T2 mapping, zonal assessment is desirable.

  • steady state diffusion imaging for mr in vivo evaluation of reparative Cartilage after matrix associated autologous chondrocyte Transplantation at 3 tesla preliminary results
    European Journal of Radiology, 2008
    Co-Authors: Tallal C Mamisch, Goetz H Welsch, Stefan Marlovits, Erich Salomonowitz, Pavol Szomolanyi, Marion I Menzel, Bernd Bittersohl, J Kordelle, Siegfried Trattnig
    Abstract:

    Abstract Objectives To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of Cartilage and Cartilage transplants in a clinical study. Material and Methods In a cross-sectional study 15 patients underwent MRI using a 3D partially balanced steady-state gradient echo pulse sequence with and without diffusion weighting at two different time points after matrix-associated autologous Cartilage Transplantation (MACT). Mean diffusion quotients (signal intensity without diffusion-weighting divided by signal intensity with diffusion weighting) within the Cartilage transplants were compared to diffusion quotients found in normal Cartilage. Results The global diffusion quotient found in repair Cartilage was significantly higher than diffusion values in normal Cartilage ( p Conclusions In-vivo diffusion-weighted imaging based on the PSIF technique is possible. Our preliminary results show follow-up of Cartilage transplant maturation in patients may provide additional information to morphological assessment.

  • quantitative t2 mapping of matrix associated autologous chondrocyte Transplantation at 3 tesla an in vivo cross sectional study
    Investigative Radiology, 2007
    Co-Authors: Siegfried Trattnig, Goetz H Welsch, Tallal C Mamisch, C Glaser, Pavol Szomolanyi, Simone Gebetsroither, Oliver Stastny, Wilhelm Horger, Steven Millington, Stefan Marlovits
    Abstract:

    Objectives:To evaluate magnetic resonance (MR) T2 mapping for characterization of Cartilage repair tissue following matrix-associated autologous Cartilage Transplantation (MACT).Materials and Methods:Fifteen patients were evaluated following MACT using a 3T MR scanner. Patients were categorized into

Tallal C Mamisch - One of the best experts on this subject based on the ideXlab platform.

  • quantitative t2 mapping during follow up after matrix associated autologous chondrocyte Transplantation mact full thickness and zonal evaluation to visualize the maturation of Cartilage repair tissue
    Journal of Orthopaedic Research, 2009
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, C Glaser, Klaus M Friedrich, Friedrich F Hennig, Erich Salomonowitz, Siegfried Trattnig
    Abstract:

    The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of Cartilage repair tissue maturation after matrix-associated autologous chondrocyte Transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 +/- 12.1 months after Cartilage Transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 +/- 12.0 months after surgery), a longitudinal 1-year follow-up MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steady-state sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the Cartilage repair area and in control Cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy Cartilage and Cartilage repair tissue (p 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of Cartilage repair tissue.

  • magnetization transfer contrast and t2 mapping in the evaluation of Cartilage repair tissue with 3t mri
    Journal of Magnetic Resonance Imaging, 2008
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Siegfried Trattnig, K Scheffler, Pavol Szomonanyi, S Quirbach, Stephan Domayer, Oliver Bieri, Tallal C Mamisch
    Abstract:

    PURPOSE: To use magnetization transfer (MT) imaging in the visualization of healthy articular Cartilage and Cartilage repair tissue after different Cartilage repair procedures, and to assess global as well as zonal values and compare the results to T2-relaxation. MATERIALS AND METHODS: Thirty-four patients (17 after microfracture [MFX] and 17 after matrix-associated autologous Cartilage Transplantation [MACT]) were examined with 3T MRI. The MT ratio (MTR) was calculated from measurements with and without MT contrast. T2-values were evaluated using a multiecho, spin-echo approach. Global (full thickness of Cartilage) and zonal (deep and superficial aspect) region-of-interest assessment of Cartilage repair tissue and normal-appearing Cartilage was performed. RESULTS: In patients after MFX and MACT, the global MTR of Cartilage repair tissue was significantly lower compared to healthy Cartilage. In contrast, using T2, Cartilage repair tissue showed significantly lower T2 values only after MFX, whereas after MACT, global T2 values were comparable to healthy Cartilage. For zonal evaluation, MTR and T2 showed a significant stratification within healthy Cartilage, and T2 additionally within Cartilage repair tissue after MACT. CONCLUSION: MT imaging is capable and sensitive in the detection of differences between healthy Cartilage and areas of Cartilage repair and might be an additional tool in biochemical Cartilage imaging. For both MTR and T2 mapping, zonal assessment is desirable.

  • steady state diffusion imaging for mr in vivo evaluation of reparative Cartilage after matrix associated autologous chondrocyte Transplantation at 3 tesla preliminary results
    European Journal of Radiology, 2008
    Co-Authors: Tallal C Mamisch, Goetz H Welsch, Stefan Marlovits, Erich Salomonowitz, Pavol Szomolanyi, Marion I Menzel, Bernd Bittersohl, J Kordelle, Siegfried Trattnig
    Abstract:

    Abstract Objectives To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of Cartilage and Cartilage transplants in a clinical study. Material and Methods In a cross-sectional study 15 patients underwent MRI using a 3D partially balanced steady-state gradient echo pulse sequence with and without diffusion weighting at two different time points after matrix-associated autologous Cartilage Transplantation (MACT). Mean diffusion quotients (signal intensity without diffusion-weighting divided by signal intensity with diffusion weighting) within the Cartilage transplants were compared to diffusion quotients found in normal Cartilage. Results The global diffusion quotient found in repair Cartilage was significantly higher than diffusion values in normal Cartilage ( p Conclusions In-vivo diffusion-weighted imaging based on the PSIF technique is possible. Our preliminary results show follow-up of Cartilage transplant maturation in patients may provide additional information to morphological assessment.

  • quantitative t2 mapping of matrix associated autologous chondrocyte Transplantation at 3 tesla an in vivo cross sectional study
    Investigative Radiology, 2007
    Co-Authors: Siegfried Trattnig, Goetz H Welsch, Tallal C Mamisch, C Glaser, Pavol Szomolanyi, Simone Gebetsroither, Oliver Stastny, Wilhelm Horger, Steven Millington, Stefan Marlovits
    Abstract:

    Objectives:To evaluate magnetic resonance (MR) T2 mapping for characterization of Cartilage repair tissue following matrix-associated autologous Cartilage Transplantation (MACT).Materials and Methods:Fifteen patients were evaluated following MACT using a 3T MR scanner. Patients were categorized into

Goetz H Welsch - One of the best experts on this subject based on the ideXlab platform.

  • quantitative t2 mapping during follow up after matrix associated autologous chondrocyte Transplantation mact full thickness and zonal evaluation to visualize the maturation of Cartilage repair tissue
    Journal of Orthopaedic Research, 2009
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, C Glaser, Klaus M Friedrich, Friedrich F Hennig, Erich Salomonowitz, Siegfried Trattnig
    Abstract:

    The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of Cartilage repair tissue maturation after matrix-associated autologous chondrocyte Transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 +/- 12.1 months after Cartilage Transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 +/- 12.0 months after surgery), a longitudinal 1-year follow-up MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steady-state sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the Cartilage repair area and in control Cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy Cartilage and Cartilage repair tissue (p 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of Cartilage repair tissue.

  • magnetization transfer contrast and t2 mapping in the evaluation of Cartilage repair tissue with 3t mri
    Journal of Magnetic Resonance Imaging, 2008
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Siegfried Trattnig, K Scheffler, Pavol Szomonanyi, S Quirbach, Stephan Domayer, Oliver Bieri, Tallal C Mamisch
    Abstract:

    PURPOSE: To use magnetization transfer (MT) imaging in the visualization of healthy articular Cartilage and Cartilage repair tissue after different Cartilage repair procedures, and to assess global as well as zonal values and compare the results to T2-relaxation. MATERIALS AND METHODS: Thirty-four patients (17 after microfracture [MFX] and 17 after matrix-associated autologous Cartilage Transplantation [MACT]) were examined with 3T MRI. The MT ratio (MTR) was calculated from measurements with and without MT contrast. T2-values were evaluated using a multiecho, spin-echo approach. Global (full thickness of Cartilage) and zonal (deep and superficial aspect) region-of-interest assessment of Cartilage repair tissue and normal-appearing Cartilage was performed. RESULTS: In patients after MFX and MACT, the global MTR of Cartilage repair tissue was significantly lower compared to healthy Cartilage. In contrast, using T2, Cartilage repair tissue showed significantly lower T2 values only after MFX, whereas after MACT, global T2 values were comparable to healthy Cartilage. For zonal evaluation, MTR and T2 showed a significant stratification within healthy Cartilage, and T2 additionally within Cartilage repair tissue after MACT. CONCLUSION: MT imaging is capable and sensitive in the detection of differences between healthy Cartilage and areas of Cartilage repair and might be an additional tool in biochemical Cartilage imaging. For both MTR and T2 mapping, zonal assessment is desirable.

  • steady state diffusion imaging for mr in vivo evaluation of reparative Cartilage after matrix associated autologous chondrocyte Transplantation at 3 tesla preliminary results
    European Journal of Radiology, 2008
    Co-Authors: Tallal C Mamisch, Goetz H Welsch, Stefan Marlovits, Erich Salomonowitz, Pavol Szomolanyi, Marion I Menzel, Bernd Bittersohl, J Kordelle, Siegfried Trattnig
    Abstract:

    Abstract Objectives To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of Cartilage and Cartilage transplants in a clinical study. Material and Methods In a cross-sectional study 15 patients underwent MRI using a 3D partially balanced steady-state gradient echo pulse sequence with and without diffusion weighting at two different time points after matrix-associated autologous Cartilage Transplantation (MACT). Mean diffusion quotients (signal intensity without diffusion-weighting divided by signal intensity with diffusion weighting) within the Cartilage transplants were compared to diffusion quotients found in normal Cartilage. Results The global diffusion quotient found in repair Cartilage was significantly higher than diffusion values in normal Cartilage ( p Conclusions In-vivo diffusion-weighted imaging based on the PSIF technique is possible. Our preliminary results show follow-up of Cartilage transplant maturation in patients may provide additional information to morphological assessment.

  • quantitative t2 mapping of matrix associated autologous chondrocyte Transplantation at 3 tesla an in vivo cross sectional study
    Investigative Radiology, 2007
    Co-Authors: Siegfried Trattnig, Goetz H Welsch, Tallal C Mamisch, C Glaser, Pavol Szomolanyi, Simone Gebetsroither, Oliver Stastny, Wilhelm Horger, Steven Millington, Stefan Marlovits
    Abstract:

    Objectives:To evaluate magnetic resonance (MR) T2 mapping for characterization of Cartilage repair tissue following matrix-associated autologous Cartilage Transplantation (MACT).Materials and Methods:Fifteen patients were evaluated following MACT using a 3T MR scanner. Patients were categorized into

Stefan Marlovits - One of the best experts on this subject based on the ideXlab platform.

  • quantitative t2 mapping during follow up after matrix associated autologous chondrocyte Transplantation mact full thickness and zonal evaluation to visualize the maturation of Cartilage repair tissue
    Journal of Orthopaedic Research, 2009
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, C Glaser, Klaus M Friedrich, Friedrich F Hennig, Erich Salomonowitz, Siegfried Trattnig
    Abstract:

    The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of Cartilage repair tissue maturation after matrix-associated autologous chondrocyte Transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 +/- 12.1 months after Cartilage Transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 +/- 12.0 months after surgery), a longitudinal 1-year follow-up MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steady-state sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the Cartilage repair area and in control Cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy Cartilage and Cartilage repair tissue (p 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of Cartilage repair tissue.

  • magnetization transfer contrast and t2 mapping in the evaluation of Cartilage repair tissue with 3t mri
    Journal of Magnetic Resonance Imaging, 2008
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Siegfried Trattnig, K Scheffler, Pavol Szomonanyi, S Quirbach, Stephan Domayer, Oliver Bieri, Tallal C Mamisch
    Abstract:

    PURPOSE: To use magnetization transfer (MT) imaging in the visualization of healthy articular Cartilage and Cartilage repair tissue after different Cartilage repair procedures, and to assess global as well as zonal values and compare the results to T2-relaxation. MATERIALS AND METHODS: Thirty-four patients (17 after microfracture [MFX] and 17 after matrix-associated autologous Cartilage Transplantation [MACT]) were examined with 3T MRI. The MT ratio (MTR) was calculated from measurements with and without MT contrast. T2-values were evaluated using a multiecho, spin-echo approach. Global (full thickness of Cartilage) and zonal (deep and superficial aspect) region-of-interest assessment of Cartilage repair tissue and normal-appearing Cartilage was performed. RESULTS: In patients after MFX and MACT, the global MTR of Cartilage repair tissue was significantly lower compared to healthy Cartilage. In contrast, using T2, Cartilage repair tissue showed significantly lower T2 values only after MFX, whereas after MACT, global T2 values were comparable to healthy Cartilage. For zonal evaluation, MTR and T2 showed a significant stratification within healthy Cartilage, and T2 additionally within Cartilage repair tissue after MACT. CONCLUSION: MT imaging is capable and sensitive in the detection of differences between healthy Cartilage and areas of Cartilage repair and might be an additional tool in biochemical Cartilage imaging. For both MTR and T2 mapping, zonal assessment is desirable.

  • steady state diffusion imaging for mr in vivo evaluation of reparative Cartilage after matrix associated autologous chondrocyte Transplantation at 3 tesla preliminary results
    European Journal of Radiology, 2008
    Co-Authors: Tallal C Mamisch, Goetz H Welsch, Stefan Marlovits, Erich Salomonowitz, Pavol Szomolanyi, Marion I Menzel, Bernd Bittersohl, J Kordelle, Siegfried Trattnig
    Abstract:

    Abstract Objectives To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of Cartilage and Cartilage transplants in a clinical study. Material and Methods In a cross-sectional study 15 patients underwent MRI using a 3D partially balanced steady-state gradient echo pulse sequence with and without diffusion weighting at two different time points after matrix-associated autologous Cartilage Transplantation (MACT). Mean diffusion quotients (signal intensity without diffusion-weighting divided by signal intensity with diffusion weighting) within the Cartilage transplants were compared to diffusion quotients found in normal Cartilage. Results The global diffusion quotient found in repair Cartilage was significantly higher than diffusion values in normal Cartilage ( p Conclusions In-vivo diffusion-weighted imaging based on the PSIF technique is possible. Our preliminary results show follow-up of Cartilage transplant maturation in patients may provide additional information to morphological assessment.

  • quantitative t2 mapping of matrix associated autologous chondrocyte Transplantation at 3 tesla an in vivo cross sectional study
    Investigative Radiology, 2007
    Co-Authors: Siegfried Trattnig, Goetz H Welsch, Tallal C Mamisch, C Glaser, Pavol Szomolanyi, Simone Gebetsroither, Oliver Stastny, Wilhelm Horger, Steven Millington, Stefan Marlovits
    Abstract:

    Objectives:To evaluate magnetic resonance (MR) T2 mapping for characterization of Cartilage repair tissue following matrix-associated autologous Cartilage Transplantation (MACT).Materials and Methods:Fifteen patients were evaluated following MACT using a 3T MR scanner. Patients were categorized into

C Glaser - One of the best experts on this subject based on the ideXlab platform.

  • quantitative t2 mapping during follow up after matrix associated autologous chondrocyte Transplantation mact full thickness and zonal evaluation to visualize the maturation of Cartilage repair tissue
    Journal of Orthopaedic Research, 2009
    Co-Authors: Goetz H Welsch, Stefan Marlovits, Tallal C Mamisch, C Glaser, Klaus M Friedrich, Friedrich F Hennig, Erich Salomonowitz, Siegfried Trattnig
    Abstract:

    The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of Cartilage repair tissue maturation after matrix-associated autologous chondrocyte Transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 +/- 12.1 months after Cartilage Transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 +/- 12.0 months after surgery), a longitudinal 1-year follow-up MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steady-state sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the Cartilage repair area and in control Cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy Cartilage and Cartilage repair tissue (p 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of Cartilage repair tissue.

  • quantitative t2 mapping of matrix associated autologous chondrocyte Transplantation at 3 tesla an in vivo cross sectional study
    Investigative Radiology, 2007
    Co-Authors: Siegfried Trattnig, Goetz H Welsch, Tallal C Mamisch, C Glaser, Pavol Szomolanyi, Simone Gebetsroither, Oliver Stastny, Wilhelm Horger, Steven Millington, Stefan Marlovits
    Abstract:

    Objectives:To evaluate magnetic resonance (MR) T2 mapping for characterization of Cartilage repair tissue following matrix-associated autologous Cartilage Transplantation (MACT).Materials and Methods:Fifteen patients were evaluated following MACT using a 3T MR scanner. Patients were categorized into