The Experts below are selected from a list of 8752296 Experts worldwide ranked by ideXlab platform
Thelma Beatriz González-castro - One of the best experts on this subject based on the ideXlab platform.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC Psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Sherezada Pool García, Martha Patricia Velázquez-sánchez, Alma Genis, Lilia López NarváezAbstract:Background The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. Methods We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. Results We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Conclusion Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Martha Patricia Velázquez-sánchez, Alma Genis, Sherezada Pool García, Lilia López NarváezAbstract:The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
Lilia López Narváez - One of the best experts on this subject based on the ideXlab platform.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Martha Patricia Velázquez-sánchez, Alma Genis, Sherezada Pool García, Lilia López NarváezAbstract:The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
Lilia López Narváez - One of the best experts on this subject based on the ideXlab platform.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC Psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Sherezada Pool García, Martha Patricia Velázquez-sánchez, Alma Genis, Lilia López NarváezAbstract:Background The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. Methods We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. Results We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Conclusion Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
Carlos Tovilla-zárate - One of the best experts on this subject based on the ideXlab platform.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC Psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Sherezada Pool García, Martha Patricia Velázquez-sánchez, Alma Genis, Lilia López NarváezAbstract:Background The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. Methods We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. Results We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Conclusion Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Martha Patricia Velázquez-sánchez, Alma Genis, Sherezada Pool García, Lilia López NarváezAbstract:The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
Isela Juárez-rojop - One of the best experts on this subject based on the ideXlab platform.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC Psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Sherezada Pool García, Martha Patricia Velázquez-sánchez, Alma Genis, Lilia López NarváezAbstract:Background The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. Methods We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. Results We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Conclusion Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
-
Association of the 5HTR2A gene with suicidal behavior: Case-Control Study and updated meta-analysis
BMC psychiatry, 2013Co-Authors: Thelma Beatriz González-castro, Humberto Nicolini, Carlos Tovilla-zárate, Isela Juárez-rojop, Martha Patricia Velázquez-sánchez, Alma Genis, Sherezada Pool García, Lilia López NarváezAbstract:The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present Study was to examine the association between T102C with suicidal behavior in a case–control Study and, to assess the combined evidence – this case–control Study and available data from other related studies – we carried out a meta-analysis. We conducted a case–control Study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control Study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09). Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control Study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
