The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform
L F Barros - One of the best experts on this subject based on the ideXlab platform.
-
atp steal between Cation Pumps a mechanism linking na influx to the onset of necrotic ca2 overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
-
ATP steal between Cation Pumps: a mechanism linking Na^+ influx to the onset of necrotic Ca^2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:We set out to identify molecular mechanisms underlying the onset of necrotic Ca^2+ overload, triggered in two epithelial cell lines by oxidative stress or metabolic depletion. As reported earlier, the overload was inhibited by extracellular Ca^2+ chelation and the Cation channel blocker gadolinium. However, the surface permeability to Ca^2+ was reduced by 60%, thus discarding a role for Ca^2+ channel/carrier activation. Instead, we registered a collapse of the plasma membrane Ca^2+ ATPase (PMCA). Remarkably, inhibition of the Na^+/K^+ ATPase rescued the PMCA and reverted the Ca^2+ rise. Thermodynamic considerations suggest that the Ca^2+ overload develops when the Na^+/K^+ ATPase, by virtue of the Na^+ overload, clamps the ATP phosphorylation potential below the minimum required by the PMCA. In addition to providing the mechanism for the onset of Ca^2+ overload, the crosstalk between Cation Pumps offers a novel explanation for the role of Na^+ in cell death.
-
ATP steal between Cation Pumps : a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
Joel Castro - One of the best experts on this subject based on the ideXlab platform.
-
atp steal between Cation Pumps a mechanism linking na influx to the onset of necrotic ca2 overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
-
ATP steal between Cation Pumps: a mechanism linking Na^+ influx to the onset of necrotic Ca^2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:We set out to identify molecular mechanisms underlying the onset of necrotic Ca^2+ overload, triggered in two epithelial cell lines by oxidative stress or metabolic depletion. As reported earlier, the overload was inhibited by extracellular Ca^2+ chelation and the Cation channel blocker gadolinium. However, the surface permeability to Ca^2+ was reduced by 60%, thus discarding a role for Ca^2+ channel/carrier activation. Instead, we registered a collapse of the plasma membrane Ca^2+ ATPase (PMCA). Remarkably, inhibition of the Na^+/K^+ ATPase rescued the PMCA and reverted the Ca^2+ rise. Thermodynamic considerations suggest that the Ca^2+ overload develops when the Na^+/K^+ ATPase, by virtue of the Na^+ overload, clamps the ATP phosphorylation potential below the minimum required by the PMCA. In addition to providing the mechanism for the onset of Ca^2+ overload, the crosstalk between Cation Pumps offers a novel explanation for the role of Na^+ in cell death.
-
ATP steal between Cation Pumps : a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
Omar Porras - One of the best experts on this subject based on the ideXlab platform.
-
atp steal between Cation Pumps a mechanism linking na influx to the onset of necrotic ca2 overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
-
ATP steal between Cation Pumps: a mechanism linking Na^+ influx to the onset of necrotic Ca^2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:We set out to identify molecular mechanisms underlying the onset of necrotic Ca^2+ overload, triggered in two epithelial cell lines by oxidative stress or metabolic depletion. As reported earlier, the overload was inhibited by extracellular Ca^2+ chelation and the Cation channel blocker gadolinium. However, the surface permeability to Ca^2+ was reduced by 60%, thus discarding a role for Ca^2+ channel/carrier activation. Instead, we registered a collapse of the plasma membrane Ca^2+ ATPase (PMCA). Remarkably, inhibition of the Na^+/K^+ ATPase rescued the PMCA and reverted the Ca^2+ rise. Thermodynamic considerations suggest that the Ca^2+ overload develops when the Na^+/K^+ ATPase, by virtue of the Na^+ overload, clamps the ATP phosphorylation potential below the minimum required by the PMCA. In addition to providing the mechanism for the onset of Ca^2+ overload, the crosstalk between Cation Pumps offers a novel explanation for the role of Na^+ in cell death.
-
ATP steal between Cation Pumps : a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
C M Flores - One of the best experts on this subject based on the ideXlab platform.
-
atp steal between Cation Pumps a mechanism linking na influx to the onset of necrotic ca2 overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
-
ATP steal between Cation Pumps: a mechanism linking Na^+ influx to the onset of necrotic Ca^2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:We set out to identify molecular mechanisms underlying the onset of necrotic Ca^2+ overload, triggered in two epithelial cell lines by oxidative stress or metabolic depletion. As reported earlier, the overload was inhibited by extracellular Ca^2+ chelation and the Cation channel blocker gadolinium. However, the surface permeability to Ca^2+ was reduced by 60%, thus discarding a role for Ca^2+ channel/carrier activation. Instead, we registered a collapse of the plasma membrane Ca^2+ ATPase (PMCA). Remarkably, inhibition of the Na^+/K^+ ATPase rescued the PMCA and reverted the Ca^2+ rise. Thermodynamic considerations suggest that the Ca^2+ overload develops when the Na^+/K^+ ATPase, by virtue of the Na^+ overload, clamps the ATP phosphorylation potential below the minimum required by the PMCA. In addition to providing the mechanism for the onset of Ca^2+ overload, the crosstalk between Cation Pumps offers a novel explanation for the role of Na^+ in cell death.
-
ATP steal between Cation Pumps : a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
T Hermosilla - One of the best experts on this subject based on the ideXlab platform.
-
atp steal between Cation Pumps a mechanism linking na influx to the onset of necrotic ca2 overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload
-
ATP steal between Cation Pumps: a mechanism linking Na^+ influx to the onset of necrotic Ca^2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:We set out to identify molecular mechanisms underlying the onset of necrotic Ca^2+ overload, triggered in two epithelial cell lines by oxidative stress or metabolic depletion. As reported earlier, the overload was inhibited by extracellular Ca^2+ chelation and the Cation channel blocker gadolinium. However, the surface permeability to Ca^2+ was reduced by 60%, thus discarding a role for Ca^2+ channel/carrier activation. Instead, we registered a collapse of the plasma membrane Ca^2+ ATPase (PMCA). Remarkably, inhibition of the Na^+/K^+ ATPase rescued the PMCA and reverted the Ca^2+ rise. Thermodynamic considerations suggest that the Ca^2+ overload develops when the Na^+/K^+ ATPase, by virtue of the Na^+ overload, clamps the ATP phosphorylation potential below the minimum required by the PMCA. In addition to providing the mechanism for the onset of Ca^2+ overload, the crosstalk between Cation Pumps offers a novel explanation for the role of Na^+ in cell death.
-
ATP steal between Cation Pumps : a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Cell Death & Differentiation, 2006Co-Authors: Joel Castro, I Ruminot, Omar Porras, C M Flores, T Hermosilla, E Verdugo, F Venegas, S Hartel, L Michea, L F BarrosAbstract:ATP steal between Cation Pumps: a mechanism linking Na + influx to the onset of necrotic Ca 2+ overload