The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform
Gokhan Koyluoglu - One of the best experts on this subject based on the ideXlab platform.
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effects of topical application of platelet rich plasma on esophageal stricture and oxidative stress after Caustic Burn in rats is autologous treatment possible
Journal of Pediatric Surgery, 2019Co-Authors: Mustafa Onur Oztan, Sule Oztan, Fatma Demet Arslan, Gulden Diniz, Gokhan KoyluogluAbstract:Abstract Background Caustic esophageal Burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after Caustic esophageal injury in rats. Methods Twenty-one rats were divided into three groups [Sham operation (n = 8), corrosive esophageal Burn with 30% NaOH (n = 6), topical PRP application after corrosive Burn (n = 7)]. On the postoperative 21st day, oxidative markers were measured in the serum, and collagen accumulation and stenosis index were measured histopathologically to assess the efficacy of PRP treatment. Results Postoperative weight was higher than preoperative weight in Sham and PRP groups, but lower in the Burn group (p Conclusion For the first time in the literature, these results indicate that topical PRP treatment after the experimental corrosive Burn has a positive effect on oxidative stress, mucosal healing and decreased stricture development. PRP may be an alternative at the clinical treatment because it can be used during diagnostic esophagoscopy. Type of study Treatment study Level I (randomized controlled trial).
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The effect of platelet-rich plasma on motility changes in experimental Caustic esophageal Burn
Esophagus, 2018Co-Authors: Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan KoyluogluAbstract:Background Besides stricture formation, diminished esophageal motility after Caustic esophageal Burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of Caustic Burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes. Methods Twenty-one Wistar albino rats were divided into three groups [Sham operation ( n = 8), Caustic esophageal Burn with NaOH ( n = 6), PRP treatment after Caustic Burn ( n = 7)]. After 3 weeks, esophagectomy was performed and contractions and EFS responses were evaluated in the organ bath. Results KCl- and acetylcholine-induced responses were reduced in the Burn group, but increased in Sham and PRP groups ( p
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The effect of platelet-rich plasma on motility changes in experimental Caustic esophageal Burn.
Esophagus : official journal of the Japan Esophageal Society, 2018Co-Authors: Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan KoyluogluAbstract:Background Besides stricture formation, diminished esophageal motility after Caustic esophageal Burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of Caustic Burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes.
Mustafa Onur Oztan - One of the best experts on this subject based on the ideXlab platform.
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effects of topical application of platelet rich plasma on esophageal stricture and oxidative stress after Caustic Burn in rats is autologous treatment possible
Journal of Pediatric Surgery, 2019Co-Authors: Mustafa Onur Oztan, Sule Oztan, Fatma Demet Arslan, Gulden Diniz, Gokhan KoyluogluAbstract:Abstract Background Caustic esophageal Burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after Caustic esophageal injury in rats. Methods Twenty-one rats were divided into three groups [Sham operation (n = 8), corrosive esophageal Burn with 30% NaOH (n = 6), topical PRP application after corrosive Burn (n = 7)]. On the postoperative 21st day, oxidative markers were measured in the serum, and collagen accumulation and stenosis index were measured histopathologically to assess the efficacy of PRP treatment. Results Postoperative weight was higher than preoperative weight in Sham and PRP groups, but lower in the Burn group (p Conclusion For the first time in the literature, these results indicate that topical PRP treatment after the experimental corrosive Burn has a positive effect on oxidative stress, mucosal healing and decreased stricture development. PRP may be an alternative at the clinical treatment because it can be used during diagnostic esophagoscopy. Type of study Treatment study Level I (randomized controlled trial).
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The effect of platelet-rich plasma on motility changes in experimental Caustic esophageal Burn
Esophagus, 2018Co-Authors: Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan KoyluogluAbstract:Background Besides stricture formation, diminished esophageal motility after Caustic esophageal Burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of Caustic Burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes. Methods Twenty-one Wistar albino rats were divided into three groups [Sham operation ( n = 8), Caustic esophageal Burn with NaOH ( n = 6), PRP treatment after Caustic Burn ( n = 7)]. After 3 weeks, esophagectomy was performed and contractions and EFS responses were evaluated in the organ bath. Results KCl- and acetylcholine-induced responses were reduced in the Burn group, but increased in Sham and PRP groups ( p
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The effect of platelet-rich plasma on motility changes in experimental Caustic esophageal Burn.
Esophagus : official journal of the Japan Esophageal Society, 2018Co-Authors: Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan KoyluogluAbstract:Background Besides stricture formation, diminished esophageal motility after Caustic esophageal Burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of Caustic Burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes.
Arnon Nagler - One of the best experts on this subject based on the ideXlab platform.
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Prevention of esophageal strictures in a Caustic Burn model using halofuginone, an inhibitor of collagen type I synthesis.
The Laryngoscope, 2005Co-Authors: Dan Arbell, Raphael Udassin, Benjamin Z. Koplewitz, Meir Ohana, Olga Genina, Mark Pines, Arnon NaglerAbstract:Objective: Esophageal strictures caused by Caustic injury continue to be a plaguing problem. Halofuginone (HF) has been proven to inhibit the formation of fibrosis in various animal models and human diseases. Its mechanism appears to be through the suppression of the production of collagen α1(I) and transforming growth factor-β signaling pathway. We tried to assess whether HF would have an effect on the formation of strictures after inducing Caustic esophageal. Materials and Methods: Esophageal injury was caused by injecting 25% NaOH to an isolated esophageal segment. Study group rats were treated with HF orally for 3 consecutive days before the injury and afterward. Control group rats received regular chow. The results were evaluated by upper gastrointestinal series (UGI) and through pathologic studies. Results: HF treatment resulted in marked improvement in the esophageal strictures. The UGI series showed esophageal patency of 73% (45%–100%) in the treated animals (n = 7) as compared with almost no patency, 11% (5–16%), in the controls (n = 4) (P = .018). The histologic examination showed significantly less stricture and scarring in the treated group. Whereas the ratio between the esophageal wall thickness to mucosal thickness was 2.34 ± 0.23 in the study group, the control group had a ratio of 9.56 ± 0.69 (P = .0044). Finally, whereas 86% of the study group survived, all the rats in the control group died by day 20. Conclusions: HF modulated the wound healing reaction caused by Caustic injury of the esophagus in a rat model, resulting in increased esophageal patency, reduction in esophageal wall thickness, and increased survival.
Sule Oztan - One of the best experts on this subject based on the ideXlab platform.
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effects of topical application of platelet rich plasma on esophageal stricture and oxidative stress after Caustic Burn in rats is autologous treatment possible
Journal of Pediatric Surgery, 2019Co-Authors: Mustafa Onur Oztan, Sule Oztan, Fatma Demet Arslan, Gulden Diniz, Gokhan KoyluogluAbstract:Abstract Background Caustic esophageal Burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after Caustic esophageal injury in rats. Methods Twenty-one rats were divided into three groups [Sham operation (n = 8), corrosive esophageal Burn with 30% NaOH (n = 6), topical PRP application after corrosive Burn (n = 7)]. On the postoperative 21st day, oxidative markers were measured in the serum, and collagen accumulation and stenosis index were measured histopathologically to assess the efficacy of PRP treatment. Results Postoperative weight was higher than preoperative weight in Sham and PRP groups, but lower in the Burn group (p Conclusion For the first time in the literature, these results indicate that topical PRP treatment after the experimental corrosive Burn has a positive effect on oxidative stress, mucosal healing and decreased stricture development. PRP may be an alternative at the clinical treatment because it can be used during diagnostic esophagoscopy. Type of study Treatment study Level I (randomized controlled trial).
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The effect of platelet-rich plasma on motility changes in experimental Caustic esophageal Burn
Esophagus, 2018Co-Authors: Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan KoyluogluAbstract:Background Besides stricture formation, diminished esophageal motility after Caustic esophageal Burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of Caustic Burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes. Methods Twenty-one Wistar albino rats were divided into three groups [Sham operation ( n = 8), Caustic esophageal Burn with NaOH ( n = 6), PRP treatment after Caustic Burn ( n = 7)]. After 3 weeks, esophagectomy was performed and contractions and EFS responses were evaluated in the organ bath. Results KCl- and acetylcholine-induced responses were reduced in the Burn group, but increased in Sham and PRP groups ( p
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The effect of platelet-rich plasma on motility changes in experimental Caustic esophageal Burn.
Esophagus : official journal of the Japan Esophageal Society, 2018Co-Authors: Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan KoyluogluAbstract:Background Besides stricture formation, diminished esophageal motility after Caustic esophageal Burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of Caustic Burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes.
Dan Arbell - One of the best experts on this subject based on the ideXlab platform.
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Prevention of esophageal strictures in a Caustic Burn model using halofuginone, an inhibitor of collagen type I synthesis.
The Laryngoscope, 2005Co-Authors: Dan Arbell, Raphael Udassin, Benjamin Z. Koplewitz, Meir Ohana, Olga Genina, Mark Pines, Arnon NaglerAbstract:Objective: Esophageal strictures caused by Caustic injury continue to be a plaguing problem. Halofuginone (HF) has been proven to inhibit the formation of fibrosis in various animal models and human diseases. Its mechanism appears to be through the suppression of the production of collagen α1(I) and transforming growth factor-β signaling pathway. We tried to assess whether HF would have an effect on the formation of strictures after inducing Caustic esophageal. Materials and Methods: Esophageal injury was caused by injecting 25% NaOH to an isolated esophageal segment. Study group rats were treated with HF orally for 3 consecutive days before the injury and afterward. Control group rats received regular chow. The results were evaluated by upper gastrointestinal series (UGI) and through pathologic studies. Results: HF treatment resulted in marked improvement in the esophageal strictures. The UGI series showed esophageal patency of 73% (45%–100%) in the treated animals (n = 7) as compared with almost no patency, 11% (5–16%), in the controls (n = 4) (P = .018). The histologic examination showed significantly less stricture and scarring in the treated group. Whereas the ratio between the esophageal wall thickness to mucosal thickness was 2.34 ± 0.23 in the study group, the control group had a ratio of 9.56 ± 0.69 (P = .0044). Finally, whereas 86% of the study group survived, all the rats in the control group died by day 20. Conclusions: HF modulated the wound healing reaction caused by Caustic injury of the esophagus in a rat model, resulting in increased esophageal patency, reduction in esophageal wall thickness, and increased survival.