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Jean-philippe Lavigne - One of the best experts on this subject based on the ideXlab platform.

  • first report of Cavitary Pneumonia due to community acquired acinetobacter pittii study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, (p > 0,05). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h (p < 0.0001), BFI = 6.3 ± 0.17 vs 1.87 ± 0.12 at 3 h (p < 0.0001) and BFI = 3.67 ± 0.41 vs 1.7 ± 0.06 after 4 h of incubation (p < 0.01). Community-acquired A. pittii should be considered as possible cause of sub-acute Cavitary Pneumonia particularly in a smoking and/or immunocompromised patient despite its low virulence potential.

  • First report of Cavitary Pneumonia due to community-acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Background Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. Case presentation A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, ( p > 0,05 ). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h ( p 

Romaric Larcher - One of the best experts on this subject based on the ideXlab platform.

  • first report of Cavitary Pneumonia due to community acquired acinetobacter pittii study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, (p > 0,05). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h (p < 0.0001), BFI = 6.3 ± 0.17 vs 1.87 ± 0.12 at 3 h (p < 0.0001) and BFI = 3.67 ± 0.41 vs 1.7 ± 0.06 after 4 h of incubation (p < 0.01). Community-acquired A. pittii should be considered as possible cause of sub-acute Cavitary Pneumonia particularly in a smoking and/or immunocompromised patient despite its low virulence potential.

  • First report of Cavitary Pneumonia due to community-acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Background Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. Case presentation A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, ( p > 0,05 ). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h ( p 

Erik Arnaud - One of the best experts on this subject based on the ideXlab platform.

  • first report of Cavitary Pneumonia due to community acquired acinetobacter pittii study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, (p > 0,05). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h (p < 0.0001), BFI = 6.3 ± 0.17 vs 1.87 ± 0.12 at 3 h (p < 0.0001) and BFI = 3.67 ± 0.41 vs 1.7 ± 0.06 after 4 h of incubation (p < 0.01). Community-acquired A. pittii should be considered as possible cause of sub-acute Cavitary Pneumonia particularly in a smoking and/or immunocompromised patient despite its low virulence potential.

  • First report of Cavitary Pneumonia due to community-acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Background Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. Case presentation A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, ( p > 0,05 ). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h ( p 

Albert Sotto - One of the best experts on this subject based on the ideXlab platform.

  • first report of Cavitary Pneumonia due to community acquired acinetobacter pittii study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, (p > 0,05). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h (p < 0.0001), BFI = 6.3 ± 0.17 vs 1.87 ± 0.12 at 3 h (p < 0.0001) and BFI = 3.67 ± 0.41 vs 1.7 ± 0.06 after 4 h of incubation (p < 0.01). Community-acquired A. pittii should be considered as possible cause of sub-acute Cavitary Pneumonia particularly in a smoking and/or immunocompromised patient despite its low virulence potential.

  • First report of Cavitary Pneumonia due to community-acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Background Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. Case presentation A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, ( p > 0,05 ). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h ( p 

Alix Pantel - One of the best experts on this subject based on the ideXlab platform.

  • first report of Cavitary Pneumonia due to community acquired acinetobacter pittii study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, (p > 0,05). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h (p < 0.0001), BFI = 6.3 ± 0.17 vs 1.87 ± 0.12 at 3 h (p < 0.0001) and BFI = 3.67 ± 0.41 vs 1.7 ± 0.06 after 4 h of incubation (p < 0.01). Community-acquired A. pittii should be considered as possible cause of sub-acute Cavitary Pneumonia particularly in a smoking and/or immunocompromised patient despite its low virulence potential.

  • First report of Cavitary Pneumonia due to community-acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment
    BMC Infectious Diseases, 2017
    Co-Authors: Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-philippe Lavigne
    Abstract:

    Background Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for Cavitary community-acquired Pneumonia and study its virulence, and discuss its pathogenesis and treatment options. Case presentation A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks. Thoracic CT scanner showed Cavitary Pneumonia. Broncho-alveolar lavage cultures found community-acquired Acinetobacter calcoaceticus-baumannii complex. The clinical outcome was favourable after twenty-one days of antimicrobial treatment by piperacillin/tazobactam and amikacin then cefepime. Multilocus sequence typing (MLST) analyses identified an A. pittii ST249. Despite the atypical clinical presentation with an unexpected partial destruction of lung parenchyma, we found very low virulence potential of the A. pittii strain with nematode killing assays and biofilm formation test. The median time required to kill 50% of the nematodes was 7 ± 0.3 days for A. pittii ST249, 7 ± 0.2 days for A. baumanii NAB ST2 and 8 ± 0.2 days for E. coli OP50, ( p > 0,05 ). A. pittii ST249 showed significantly slower biofilm formation than A. baumanii NAB ST2: BFI = 8.83 ± 0.59 vs 3.93 ± 0.27 at 2 h ( p