The Experts below are selected from a list of 1833984 Experts worldwide ranked by ideXlab platform
Donald E Texada - One of the best experts on this subject based on the ideXlab platform.
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orbital sporadic burkitt lymphoma in an adult diabetic african american female and a review of adult orbital cases
Clinical Ophthalmology, 2011Co-Authors: John Carmody, Raghunath P Misra, Marlyn P Langford, William A Byrd, Lauren Ditta, Bryan Vekovius, Donald E TexadaAbstract:A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a “starry sky” appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein–Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.
John Carmody - One of the best experts on this subject based on the ideXlab platform.
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orbital sporadic burkitt lymphoma in an adult diabetic african american female and a review of adult orbital cases
Clinical Ophthalmology, 2011Co-Authors: John Carmody, Raghunath P Misra, Marlyn P Langford, William A Byrd, Lauren Ditta, Bryan Vekovius, Donald E TexadaAbstract:A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a “starry sky” appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein–Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.
Steven H Kroft - One of the best experts on this subject based on the ideXlab platform.
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Hematopathology / PRECURSOR B-CELL LYMPHOBLASTIC LYMPHOMA 868 Am J Clin Pathol 2001;115:868-875 © American Society of Clinical Pathologists Precursor B-Cell Lymphoblastic Lymphoma A Study of Nine Cases Lacking Blood and Bone Marrow Involvement and Revie
2016Co-Authors: Anirban Maitra, Robert W Mckenna, Arthur G Weinberg, Nancy R Schneider, Steven H KroftAbstract:A b s t r a c t We describe 9 cases of precursor B-cell lymphoblastic lymphoma (LYL) without evidence of marrow or blood involvement. Four patients had superficial nodal disease, 2 cutaneous involvement, and 1 each ovarian, retroperitoneal, or tonsillar primary tumor. Six patients had limited disease; 3 patients were stage III. Immunophenotyping revealed a terminal deoxynucleotidyl transferase (TdT)-positive, immature B-cell population with variable expression of CD10, CD20, and CD45. All patients are in complete clinical remission (median follow-up, 14 months). A literature review yielded 105 patients with a diagnosis of precursor B-cell LYL based on less than 25 % marrow involvement. Of these, 64 % were younger than 1
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precursor b cell lymphoblastic lymphoma a study of nine cases lacking blood and bone marrow involvement and review of the literature
American Journal of Clinical Pathology, 2001Co-Authors: Anirban Maitra, Robert W Mckenna, Arthur G Weinberg, Nancy R Schneider, Steven H KroftAbstract:We describe 9 cases of precursor B-cell lymphoblastic lymphoma (LYL) without evidence of marrow or blood involvement. Four patients had superficial nodal disease, 2 cutaneous involvement, and 1 each ovarian, retroperitoneal, or tonsillar primary tumor. Six patients had limited disease; 3 patients were stage III. Immunophenotyping revealed a terminal deoxynucleotidyl transferase (TdT)-positive, immature B-cell population with variable expression of CD10, CD20, and CD45. All patients are in complete clinical remission (median follow-up, 14 months). A literature review yielded 105 patients with a diagnosis of precursor B-cell LYL based on less than 25% marrow involvement. Of these, 64% were younger than 18 years. Skin, lymph nodes, and bone were the most common sites of disease. Mediastinal involvement was uncommon. TdT, CD19, CD79a, CD10, and HLA-DR were the most frequently expressed antigens, while CD45 and CD20 were expressed in only two thirds of the cases. Cytogenetic analysis showed additional 21q material as a recurring karyotypic abnormality. At a median follow-up of 26 months, 74% of patients were alive; the median survival was 19 months for patients dying of disease. Comparison with precursor B-cell acute lymphoblastic leukemia showed several overlapping features, although distinct differences were identified.
Bryan Vekovius - One of the best experts on this subject based on the ideXlab platform.
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orbital sporadic burkitt lymphoma in an adult diabetic african american female and a review of adult orbital cases
Clinical Ophthalmology, 2011Co-Authors: John Carmody, Raghunath P Misra, Marlyn P Langford, William A Byrd, Lauren Ditta, Bryan Vekovius, Donald E TexadaAbstract:A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a “starry sky” appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein–Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.
Lauren Ditta - One of the best experts on this subject based on the ideXlab platform.
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orbital sporadic burkitt lymphoma in an adult diabetic african american female and a review of adult orbital cases
Clinical Ophthalmology, 2011Co-Authors: John Carmody, Raghunath P Misra, Marlyn P Langford, William A Byrd, Lauren Ditta, Bryan Vekovius, Donald E TexadaAbstract:A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a “starry sky” appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein–Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.