The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Larry G French - One of the best experts on this subject based on the ideXlab platform.
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isolation and structure elucidation of the terpene β thujone from Cedar Leaf Oil
Journal of Chemical Education, 2011Co-Authors: Larry G FrenchAbstract:Western red Cedar Leaf affords an essential Oil characterized by high thujone content. Students in an advanced organic chemistry lab course isolate a single thujone diastereoisomer from commercially available Cedar Leaf Oil. Treatment of crude Oil, containing roughly 70% thujone, predominately as α-thujone (6.5:1), with ethanolic sodium hydroxide leads to epimerization at the chiral α-carbon. Equilibration thus inverts the diastereoisomeric ratio in favor (roughly 2:1) of the β-thujone epimer. Selective formation of the bisulfite addition product from the β-isomer allows for a simple purification via filtration. Release of the free ketone upon treatment with Na2CO3 yields highly pure β-thujone, which is characterized and identified using IR, MS, and NMR spectroscopy.
Hudson James - One of the best experts on this subject based on the ideXlab platform.
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the activity of Cedar Leaf Oil vapor against respiratory viruses practical applications
2013Co-Authors: Vimalanathan Selvarani, Hudson JamesAbstract:Article history: Received on: 25/09/2013 Revised on: 10/10/2013 Accepted on: 11/11/2013 Available online: 29/11/2013 Respiratory viruses continue to cause frequent acute and chronic infections, for which few satisfactory treatments are available. Some essential Oils possess antiviral properties, but these have usually been tested as liquids, which have limited applications. In this study the vapor of Cedar Leaf Oil (CLO vapor) was evaluated for antiviral activity, in addition to its possible anti-inflammatory activity. The viruses tested, Influenza viruses, Rhinovirus, Adenovirus, and Herpes simplex viruses 1 and 2, in the form of dried films, were all inactivated by exposure to CLO vapor. In assays for influenza viral hemagglutinin (HA) the HA activity was inhibited by CLO vapor. Exposure of human lung epithelial cell monolayers to the vapor showed inhibition of rhinovirus virus-induced cytokine IL-6, but the cells themselves were not adversely affected by short exposure to the vapor. However the two major volatile components of CLO, thujone and pinene, did not show activity against influenza viral infectivity or hemagglutinin, indicating possible synergistic effects of the whole vapor. We conclude that CLO vapor has potential applications in the control of viral respiratory infections.
Vimalanathan Selvarani - One of the best experts on this subject based on the ideXlab platform.
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the activity of Cedar Leaf Oil vapor against respiratory viruses practical applications
2013Co-Authors: Vimalanathan Selvarani, Hudson JamesAbstract:Article history: Received on: 25/09/2013 Revised on: 10/10/2013 Accepted on: 11/11/2013 Available online: 29/11/2013 Respiratory viruses continue to cause frequent acute and chronic infections, for which few satisfactory treatments are available. Some essential Oils possess antiviral properties, but these have usually been tested as liquids, which have limited applications. In this study the vapor of Cedar Leaf Oil (CLO vapor) was evaluated for antiviral activity, in addition to its possible anti-inflammatory activity. The viruses tested, Influenza viruses, Rhinovirus, Adenovirus, and Herpes simplex viruses 1 and 2, in the form of dried films, were all inactivated by exposure to CLO vapor. In assays for influenza viral hemagglutinin (HA) the HA activity was inhibited by CLO vapor. Exposure of human lung epithelial cell monolayers to the vapor showed inhibition of rhinovirus virus-induced cytokine IL-6, but the cells themselves were not adversely affected by short exposure to the vapor. However the two major volatile components of CLO, thujone and pinene, did not show activity against influenza viral infectivity or hemagglutinin, indicating possible synergistic effects of the whole vapor. We conclude that CLO vapor has potential applications in the control of viral respiratory infections.
Selvarani Vimalanathan - One of the best experts on this subject based on the ideXlab platform.
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the antimicrobial properties of Cedar Leaf thuja plicata Oil a safe and efficient decontamination agent for buildings
International Journal of Environmental Research and Public Health, 2011Co-Authors: J B Hudson, Selvarani VimalanathanAbstract:Cedar Leaf Oil (CLO), derived from the Western red Cedar, Thuja plicata, was evaluated as a safe and acceptable broad spectrum antimicrobial agent, with a view to its potential applications in buildings, including the alleviation of sick building syndrome. Various Gram-positive and Gram-negative human bacteria, and two fungal organisms, all known to be common environmental sources of potential infection, were selected and tested quantitatively, and all of them were found to be susceptible to CLO liquid and vapor. Bacterial spores and Aspergillus niger were sensitive, although less so than the vegetative bacteria. Similar tests with cultured human lung cells showed that continuous exposure to CLO vapor for at least 60 minutes was not toxic to the cells. Based on these results, CLO shows promise as a prospective safe, green, broad-spectrum anti-microbial agent for decontamination of buildings.
J B Hudson - One of the best experts on this subject based on the ideXlab platform.
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the antimicrobial properties of Cedar Leaf thuja plicata Oil a safe and efficient decontamination agent for buildings
International Journal of Environmental Research and Public Health, 2011Co-Authors: J B Hudson, Selvarani VimalanathanAbstract:Cedar Leaf Oil (CLO), derived from the Western red Cedar, Thuja plicata, was evaluated as a safe and acceptable broad spectrum antimicrobial agent, with a view to its potential applications in buildings, including the alleviation of sick building syndrome. Various Gram-positive and Gram-negative human bacteria, and two fungal organisms, all known to be common environmental sources of potential infection, were selected and tested quantitatively, and all of them were found to be susceptible to CLO liquid and vapor. Bacterial spores and Aspergillus niger were sensitive, although less so than the vegetative bacteria. Similar tests with cultured human lung cells showed that continuous exposure to CLO vapor for at least 60 minutes was not toxic to the cells. Based on these results, CLO shows promise as a prospective safe, green, broad-spectrum anti-microbial agent for decontamination of buildings.
