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V K Ghanta - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Dexamethasone on Conditioned Enhancement of Natural Killer Cell Activity
    Neuroimmunomodulation, 1994
    Co-Authors: C M Hsueh, R N Hiramoto, Carolyn F. Rogers, V K Ghanta
    Abstract:

    It is believed that the expression of the conditioned natural killer Cell Activity is regulated through the hypothalamus-pituitary axis. Since the conditioned expression of both the plasma level of adrenocorticotropic hormone and natural killer (NK) Cell Activity show a sequential rise after exposure to the conditioned stimulus, it was of interest to determine if treatment with dexamethasone could inhibit this response. These studies suggest that treatment with dexamethasone was able to block the expression of the conditioned NK Cell Activity but was unable to interfere with the pairing of the conditioned stimulus with the unconditioned stimulus. We conclude that the hypothalamic pituitary axis is an integral part of the pathway for stimulation of NK Cell Activity in the spleen.

  • The central effect of methionine-enkephalin on NK Cell Activity.
    Brain research, 1992
    Co-Authors: C M Hsueh, R N Hiramoto, V K Ghanta
    Abstract:

    The central effect of opioid peptide on natural killer (NK) Cell Activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02 microgram/mouse or 1 microgram/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK Cell Activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK Cell Activity when given to the mouse intraperitoneally or intravenously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1 microgram/kg, had no effect on NK Cell Activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK Cell response in the periphery.

  • The central effect of methionine-enkephalin on NK Cell Activity.
    Brain Research, 1992
    Co-Authors: C M Hsueh, R N Hiramoto, V K Ghanta
    Abstract:

    Abstract The central effect of opioid peptide on natural killer (NK) Cell Activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02 μg/mouse or 1 μg/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK Cell Activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK Cell Activity when given to the mouse intraperitoneally or intraveneously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1 μg/kg, had no effect on NK Cell Activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK Cell response in the periphery.

C M Hsueh - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Dexamethasone on Conditioned Enhancement of Natural Killer Cell Activity
    Neuroimmunomodulation, 1994
    Co-Authors: C M Hsueh, R N Hiramoto, Carolyn F. Rogers, V K Ghanta
    Abstract:

    It is believed that the expression of the conditioned natural killer Cell Activity is regulated through the hypothalamus-pituitary axis. Since the conditioned expression of both the plasma level of adrenocorticotropic hormone and natural killer (NK) Cell Activity show a sequential rise after exposure to the conditioned stimulus, it was of interest to determine if treatment with dexamethasone could inhibit this response. These studies suggest that treatment with dexamethasone was able to block the expression of the conditioned NK Cell Activity but was unable to interfere with the pairing of the conditioned stimulus with the unconditioned stimulus. We conclude that the hypothalamic pituitary axis is an integral part of the pathway for stimulation of NK Cell Activity in the spleen.

  • The central effect of methionine-enkephalin on NK Cell Activity.
    Brain research, 1992
    Co-Authors: C M Hsueh, R N Hiramoto, V K Ghanta
    Abstract:

    The central effect of opioid peptide on natural killer (NK) Cell Activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02 microgram/mouse or 1 microgram/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK Cell Activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK Cell Activity when given to the mouse intraperitoneally or intravenously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1 microgram/kg, had no effect on NK Cell Activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK Cell response in the periphery.

  • The central effect of methionine-enkephalin on NK Cell Activity.
    Brain Research, 1992
    Co-Authors: C M Hsueh, R N Hiramoto, V K Ghanta
    Abstract:

    Abstract The central effect of opioid peptide on natural killer (NK) Cell Activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02 μg/mouse or 1 μg/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK Cell Activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK Cell Activity when given to the mouse intraperitoneally or intraveneously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1 μg/kg, had no effect on NK Cell Activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK Cell response in the periphery.

Hiroshi Kanetake - One of the best experts on this subject based on the ideXlab platform.

  • ok432 induced killer Cell Activity potential method for monitoring immunological complications after renal transplantation
    Nephrology Dialysis Transplantation, 2001
    Co-Authors: Masaharu Nishikido, Tatsuo Kiyohara, Shigehiko Koga, Fukuzo Matsuya, K Shindo, Yutaka Saito, Hiroshi Kanetake
    Abstract:

    Background. Various clinical and biochemical parameters are currently in use for monitoring allograft rejection. However, the mechanism of allograft rejection is complex and it is frequently difficult to obtain a prompt and accurate diagnosis. We examined the usefulness of OK432-induced killer Cell Activity as an immunological monitoring system for acute renal rejection after renal transplantation. Methods. Twenty-four renal transplant recipients, seven patients on haemodialysis, and 10 normal volunteers were enrolled in our study. The killer Cell Activity of peripheral blood mononuclear Cells was induced by culturing these Cells with the immunopotentiator, OK432, a heat and penicillin-treated lyophilized powder of the Su-strain of Streptococcus pyogenes. Results. The OK432-induced killer Cell Activity of renal transplant recipients without acute rejection (stable recipients) was significantly lower than in normal volunteers. In four renal transplant recipients with acute rejection, the killer Cell Activity was significantly higher than in stable recipients. In three recipients suffering from opportunistic infections, killer Cell Activity was significantly suppressed compared with stable recipients. Conclusions. Our new test utilizing OK432-induced killer Cell Activity is potentially useful for monitoring the immunological state and complications after renal transplantation.

R N Hiramoto - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Dexamethasone on Conditioned Enhancement of Natural Killer Cell Activity
    Neuroimmunomodulation, 1994
    Co-Authors: C M Hsueh, R N Hiramoto, Carolyn F. Rogers, V K Ghanta
    Abstract:

    It is believed that the expression of the conditioned natural killer Cell Activity is regulated through the hypothalamus-pituitary axis. Since the conditioned expression of both the plasma level of adrenocorticotropic hormone and natural killer (NK) Cell Activity show a sequential rise after exposure to the conditioned stimulus, it was of interest to determine if treatment with dexamethasone could inhibit this response. These studies suggest that treatment with dexamethasone was able to block the expression of the conditioned NK Cell Activity but was unable to interfere with the pairing of the conditioned stimulus with the unconditioned stimulus. We conclude that the hypothalamic pituitary axis is an integral part of the pathway for stimulation of NK Cell Activity in the spleen.

  • The central effect of methionine-enkephalin on NK Cell Activity.
    Brain research, 1992
    Co-Authors: C M Hsueh, R N Hiramoto, V K Ghanta
    Abstract:

    The central effect of opioid peptide on natural killer (NK) Cell Activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02 microgram/mouse or 1 microgram/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK Cell Activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK Cell Activity when given to the mouse intraperitoneally or intravenously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1 microgram/kg, had no effect on NK Cell Activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK Cell response in the periphery.

  • The central effect of methionine-enkephalin on NK Cell Activity.
    Brain Research, 1992
    Co-Authors: C M Hsueh, R N Hiramoto, V K Ghanta
    Abstract:

    Abstract The central effect of opioid peptide on natural killer (NK) Cell Activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02 μg/mouse or 1 μg/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK Cell Activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK Cell Activity when given to the mouse intraperitoneally or intraveneously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1 μg/kg, had no effect on NK Cell Activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK Cell response in the periphery.

Panteleimon Rompolas - One of the best experts on this subject based on the ideXlab platform.

  • two photon microscopy for intracutaneous imaging of stem Cell Activity in mice
    Experimental Dermatology, 2017
    Co-Authors: Sixia Huang, Panteleimon Rompolas
    Abstract:

    The adult skin is a typical example of a highly regenerative tissue. Terminally differentiated keratinocytes are shed from the external layers of the epidermis or extruded from the skin as part of the growing hair shaft on a daily basis. These are effectively replenished through the Activity of skin-resident stem Cells. Precise regulation of stem Cell Activity is critical for normal skin homoeostasis or wound healing and irregular stem Cell proliferation or differentiation can lead to skin disease. The scarcity and dynamic nature of stem Cells presents a major challenge for elucidating their mechanism of action. To address this, we have recently established a system for visualizing stem Cell Activity, in real time or long term, in the intact skin of live mice using two-photon microscopy. The purpose of this review was to provide essential information to researchers who wish to incorporate two-photon microscopy and live imaging into their experimental toolbox for studying aspects of skin and stem biology in the mouse model. We discuss fundamental principles of the method, instrumentation and basic experimental approaches to interrogate stem Cell Activity in the interfollicular epidermis and hair follicle.