The Experts below are selected from a list of 16374 Experts worldwide ranked by ideXlab platform
Roeland M H Merks - One of the best experts on this subject based on the ideXlab platform.
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Cell Contractility facilitates alignment of Cells and tissues to static uniaxial stretch
Biophysical Journal, 2017Co-Authors: Elisabeth G Rens, Roeland M H MerksAbstract:During animal development and homeostasis, the structure of tissues, including muscles, blood vessels, and connective tissues, adapts to mechanical strains in the extraCellular matrix (ECM). These strains originate from the differential growth of tissues or forces due to muscle contraction or gravity. Here we show using a computational model that by amplifying local strain cues, active Cell Contractility can facilitate and accelerate the reorientation of single Cells to static strains. At the collective Cell level, the model simulations show that active Cell Contractility can facilitate the formation of strings along the orientation of stretch. The computational model is based on a hybrid Cellular Potts and finite-element simulation framework describing a mechanical Cell-substrate feedback, where: 1) Cells apply forces on the ECM, such that 2) local strains are generated in the ECM and 3) Cells preferentially extend protrusions along the strain orientation. In accordance with experimental observations, simulated Cells align and form stringlike structures parallel to static uniaxial stretch. Our model simulations predict that the magnitude of the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between stringlike patterns and vascular networklike patterns. Our simulations also suggest that at high population densities, less Cell cohesion promotes string formation.
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Biophysical Journal - Cell Contractility Facilitates Alignment of Cells and Tissues to Static Uniaxial Stretch
Biophysical journal, 2017Co-Authors: Elisabeth G Rens, Roeland M H MerksAbstract:During animal development and homeostasis, the structure of tissues, including muscles, blood vessels, and connective tissues, adapts to mechanical strains in the extraCellular matrix (ECM). These strains originate from the differential growth of tissues or forces due to muscle contraction or gravity. Here we show using a computational model that by amplifying local strain cues, active Cell Contractility can facilitate and accelerate the reorientation of single Cells to static strains. At the collective Cell level, the model simulations show that active Cell Contractility can facilitate the formation of strings along the orientation of stretch. The computational model is based on a hybrid Cellular Potts and finite-element simulation framework describing a mechanical Cell-substrate feedback, where: 1) Cells apply forces on the ECM, such that 2) local strains are generated in the ECM and 3) Cells preferentially extend protrusions along the strain orientation. In accordance with experimental observations, simulated Cells align and form stringlike structures parallel to static uniaxial stretch. Our model simulations predict that the magnitude of the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between stringlike patterns and vascular networklike patterns. Our simulations also suggest that at high population densities, less Cell cohesion promotes string formation.
Elisabeth G Rens - One of the best experts on this subject based on the ideXlab platform.
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Cell Contractility facilitates alignment of Cells and tissues to static uniaxial stretch
Biophysical Journal, 2017Co-Authors: Elisabeth G Rens, Roeland M H MerksAbstract:During animal development and homeostasis, the structure of tissues, including muscles, blood vessels, and connective tissues, adapts to mechanical strains in the extraCellular matrix (ECM). These strains originate from the differential growth of tissues or forces due to muscle contraction or gravity. Here we show using a computational model that by amplifying local strain cues, active Cell Contractility can facilitate and accelerate the reorientation of single Cells to static strains. At the collective Cell level, the model simulations show that active Cell Contractility can facilitate the formation of strings along the orientation of stretch. The computational model is based on a hybrid Cellular Potts and finite-element simulation framework describing a mechanical Cell-substrate feedback, where: 1) Cells apply forces on the ECM, such that 2) local strains are generated in the ECM and 3) Cells preferentially extend protrusions along the strain orientation. In accordance with experimental observations, simulated Cells align and form stringlike structures parallel to static uniaxial stretch. Our model simulations predict that the magnitude of the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between stringlike patterns and vascular networklike patterns. Our simulations also suggest that at high population densities, less Cell cohesion promotes string formation.
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Biophysical Journal - Cell Contractility Facilitates Alignment of Cells and Tissues to Static Uniaxial Stretch
Biophysical journal, 2017Co-Authors: Elisabeth G Rens, Roeland M H MerksAbstract:During animal development and homeostasis, the structure of tissues, including muscles, blood vessels, and connective tissues, adapts to mechanical strains in the extraCellular matrix (ECM). These strains originate from the differential growth of tissues or forces due to muscle contraction or gravity. Here we show using a computational model that by amplifying local strain cues, active Cell Contractility can facilitate and accelerate the reorientation of single Cells to static strains. At the collective Cell level, the model simulations show that active Cell Contractility can facilitate the formation of strings along the orientation of stretch. The computational model is based on a hybrid Cellular Potts and finite-element simulation framework describing a mechanical Cell-substrate feedback, where: 1) Cells apply forces on the ECM, such that 2) local strains are generated in the ECM and 3) Cells preferentially extend protrusions along the strain orientation. In accordance with experimental observations, simulated Cells align and form stringlike structures parallel to static uniaxial stretch. Our model simulations predict that the magnitude of the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between stringlike patterns and vascular networklike patterns. Our simulations also suggest that at high population densities, less Cell cohesion promotes string formation.
Peter Kohl - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Contractility in intact ventricular cardiomyocytes using the dimensionless ‘Frank–Starling Gain’ index
Pflügers Archiv - European Journal of Physiology, 2011Co-Authors: Christian Bollensdorff, Oleg Lookin, Peter KohlAbstract:This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain’, calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of Cell Contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
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Assessment of Contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index.
Pflügers Archiv - European Journal of Physiology, 2011Co-Authors: Christian Bollensdorff, Oleg Lookin, Peter KohlAbstract:This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain’, calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of Cell Contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
Christian Bollensdorff - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Contractility in intact ventricular cardiomyocytes using the dimensionless ‘Frank–Starling Gain’ index
Pflügers Archiv - European Journal of Physiology, 2011Co-Authors: Christian Bollensdorff, Oleg Lookin, Peter KohlAbstract:This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain’, calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of Cell Contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
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Assessment of Contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index.
Pflügers Archiv - European Journal of Physiology, 2011Co-Authors: Christian Bollensdorff, Oleg Lookin, Peter KohlAbstract:This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain’, calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of Cell Contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
Oleg Lookin - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Contractility in intact ventricular cardiomyocytes using the dimensionless ‘Frank–Starling Gain’ index
Pflügers Archiv - European Journal of Physiology, 2011Co-Authors: Christian Bollensdorff, Oleg Lookin, Peter KohlAbstract:This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain’, calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of Cell Contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
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Assessment of Contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index.
Pflügers Archiv - European Journal of Physiology, 2011Co-Authors: Christian Bollensdorff, Oleg Lookin, Peter KohlAbstract:This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain’, calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of Cell Contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.