The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform

Karina Yazdanbakhsh - One of the best experts on this subject based on the ideXlab platform.

  • Development of complement therapeutics for inhibition of immune‐mediated red Cell Destruction
    Transfusion, 2005
    Co-Authors: Karina Yazdanbakhsh
    Abstract:

    A major objective of my National Blood Foundation (NBF)-funded proposal was to produce recombinant soluble forms of a complement regulatory protein called complement receptor 1 (CR1) that carries the Knops blood group system antigens to perform antibody neutralization studies. By generating these recombinant proteins, we were able to inhibit several Knops antibodies in patient serum samples, thereby demonstrating their usefulness for clinical use. Interestingly, the recombinant CR1 proteins generated through NBF funding were also found to strongly reduce complement-mediated red Cell Destruction in a mouse hemolytic transfusion model. In this review, I will outline our NBF-funded studies, give an overview of recent advances from our group and others in the development of complement therapeutics, and highlight their potential use in the transfusion medicine setting.

  • Controlling the complement system for prevention of red Cell Destruction.
    Current opinion in hematology, 2005
    Co-Authors: Karina Yazdanbakhsh
    Abstract:

    Purpose of review Complement sensitization of red blood Cells (RBCs) can lead to both intravascular and extravascular red Cell Destruction. Altered levels of naturally occurring complement regulatory proteins on red Cells can result in hemolysis, while defective expression of these proteins on immune Cells can cause breakdown of tolerance to self antigens and is associated with autoimmune disease. Recent findings To date several complement inhibitors, including recombinant forms of complement regulatory proteins, humanized antibodies, and synthetic molecules have been described that limit complement activation by interfering with different steps in the complement cascade. However, few have been evaluated for prevention of complement-mediated RBC Destruction. In this review, possible applications of these complement inhibitors for treatment of complement-mediated hemolysis in specific disease states are described. Furthermore, the implication of the regulatory role of complement in the development of autoimmune hemolytic anemia is discussed. Summary Complement therapeutics has potential for effective and safe prophylactic use and treatment of hemolytic transfusion reactions and complement-mediated hemolytic diseases. Furthermore, the regulatory function of complement may be exploited to prevent and treat autoimmune hemolytic anemia.

Jimmy S. M. Lai - One of the best experts on this subject based on the ideXlab platform.

  • Toxic endothelial Cell Destruction syndrome after intraocular lens repositioning with intracameral epinephrine.
    Journal of cataract and refractive surgery, 2008
    Co-Authors: Jeffrey C. F. Pong, Wilson Wai-tat Tang, Jimmy S. M. Lai
    Abstract:

    A 66-year-old Chinese man developed corneal endothelial decompensation after intraocular lens (IOL) repositioning using intracameral epinephrine was performed. The presentation was compatible with toxic endothelial Cell Destruction syndrome, which is caused by prolonged, direct exposure of the corneal endothelium to relatively high concentrations of intracameral epinephrine. Despite its effective and immediate mydriatic effect, intracameral epinephrine is not recommended for intraoperative mydriasis in procedures such as IOL repositioning or secondary IOL implantation in which minimal irrigating solution is used.

Dariusz Leszczynski - One of the best experts on this subject based on the ideXlab platform.

  • laser beam triggered microcavitation a novel method for selective Cell Destruction
    Radiation Research, 2001
    Co-Authors: Dariusz Leszczynski, Costas Pitsillides, Riikka Pastila, R. Rox Anderson, Charles P. Lin
    Abstract:

    Abstract Leszczynski, D., Pitsillides, C. M., Pastila, R. K., Anderson, R. R. and Lin, C. P. Laser-Beam-Triggered Microcavitation: A Novel Method for Selective Cell Destruction. Radiat. Res. 156, 399–407 (2001). We describe a new method of Cell Destruction that may have potential for use in antitumor therapy. Cells are loaded by phagocytosis with microparticles (<1 μm) and irradiated with short laser pulses. Absorption of laser energy by the microparticles causes localized vaporization of the fluid surrounding the microparticles, leading to the generation of transient vapor bubbles (microcavitation) around the microparticles. Using cultures of bovine aortic endothelial Cells, we demonstrate that induction of intralysosomal microcavitation is an efficient, rapid and selective method of Cell killing that is dependent on the number of microparticles, the number of laser pulses, and the fluence of the laser pulses. Cell killing by microcavitation is a very selective process that is restricted to Cells contain...

  • Laser-Beam-Triggered Microcavitation: A Novel Method for Selective Cell Destruction
    Radiation research, 2001
    Co-Authors: Dariusz Leszczynski, Costas Pitsillides, Riikka Pastila, R. Rox Anderson, Charles P. Lin
    Abstract:

    Abstract Leszczynski, D., Pitsillides, C. M., Pastila, R. K., Anderson, R. R. and Lin, C. P. Laser-Beam-Triggered Microcavitation: A Novel Method for Selective Cell Destruction. Radiat. Res. 156, 399–407 (2001). We describe a new method of Cell Destruction that may have potential for use in antitumor therapy. Cells are loaded by phagocytosis with microparticles (

Kenji Hirayama - One of the best experts on this subject based on the ideXlab platform.

  • Rate of red blood Cell Destruction varies in different strains of mice infected with Plasmodium berghei-ANKA after chronic exposure.
    Malaria journal, 2009
    Co-Authors: Gideon Kofi Helegbe, Nguyen Tien Huy, Tetsuo Yanagi, Mohammed Nasir Shuaibu, Akiko Yamazaki, Mihoko Kikuchi, Michio Yasunami, Kenji Hirayama
    Abstract:

    Background Severe malaria anaemia in the semi-immune individuals in the holo-endemic area has been observed to occur at low parasite density with individual variation in the responses. Thus the following has been thought to be involved: auto-immune-mediated mechanisms of uninfected red blood Cell Destruction, and host genetic factors to explain the differences in individual responses under the same malaria transmission. In this study, the extent of red blood Cell (RBC) Destruction in different strains of semi-immune mice model at relatively low parasitaemia was studied.

Charles P. Lin - One of the best experts on this subject based on the ideXlab platform.

  • laser beam triggered microcavitation a novel method for selective Cell Destruction
    Radiation Research, 2001
    Co-Authors: Dariusz Leszczynski, Costas Pitsillides, Riikka Pastila, R. Rox Anderson, Charles P. Lin
    Abstract:

    Abstract Leszczynski, D., Pitsillides, C. M., Pastila, R. K., Anderson, R. R. and Lin, C. P. Laser-Beam-Triggered Microcavitation: A Novel Method for Selective Cell Destruction. Radiat. Res. 156, 399–407 (2001). We describe a new method of Cell Destruction that may have potential for use in antitumor therapy. Cells are loaded by phagocytosis with microparticles (<1 μm) and irradiated with short laser pulses. Absorption of laser energy by the microparticles causes localized vaporization of the fluid surrounding the microparticles, leading to the generation of transient vapor bubbles (microcavitation) around the microparticles. Using cultures of bovine aortic endothelial Cells, we demonstrate that induction of intralysosomal microcavitation is an efficient, rapid and selective method of Cell killing that is dependent on the number of microparticles, the number of laser pulses, and the fluence of the laser pulses. Cell killing by microcavitation is a very selective process that is restricted to Cells contain...

  • Laser-Beam-Triggered Microcavitation: A Novel Method for Selective Cell Destruction
    Radiation research, 2001
    Co-Authors: Dariusz Leszczynski, Costas Pitsillides, Riikka Pastila, R. Rox Anderson, Charles P. Lin
    Abstract:

    Abstract Leszczynski, D., Pitsillides, C. M., Pastila, R. K., Anderson, R. R. and Lin, C. P. Laser-Beam-Triggered Microcavitation: A Novel Method for Selective Cell Destruction. Radiat. Res. 156, 399–407 (2001). We describe a new method of Cell Destruction that may have potential for use in antitumor therapy. Cells are loaded by phagocytosis with microparticles (