The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform

Michel Rigoulet - One of the best experts on this subject based on the ideXlab platform.

  • Cell Energy metabolism: An update
    Biochimica et Biophysica Acta, 2020
    Co-Authors: Michel Rigoulet, Cyrielle Bouchez, Patrick Paumard, Stéphane Ransac, S. Cuvellier, Stéphane Duvezin-caubet, Jean-pierre Mazat, Anne Devin
    Abstract:

    Abstract In living Cells, growth is the result of coupling between substrate catabolism and multiple metabolic processes that take place during net biomass formation and maintenance processes. During growth, both ATP/ADP and NADH/NAD+ molecules play a key role. Cell Energy metabolism hence refers to metabolic pathways involved in ATP synthesis linked to NADH turnover. Two main pathways are thus involved in Cell Energy metabolism: glycolysis/fermentation and oxidative phosphorylation. Glycolysis and mitochondrial oxidative phosphorylation are intertwined through thermodynamic and kinetic constraints that are reviewed herein. Further, our current knowledge of short-term and long term regulation of Cell Energy metabolism will be reviewed using examples such as the Crabtree and the Warburg effect.

  • tumor Cell Energy metabolism and its common features with yeast metabolism
    Biochimica et Biophysica Acta, 2009
    Co-Authors: R Diazruiz, Michel Rigoulet, Anne Devin, Salvador Uribecarvajal
    Abstract:

    Abstract During the last decades a considerable amount of research has been focused on cancer. A number of genetic and signaling defects have been identified. This has allowed the design and screening of a number of anti-tumor drugs for therapeutic use. One of the main challenges of anti-cancer therapy is to specifically target these drugs to malignant Cells. Recently, tumor Cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display an enhanced glycolytic activity and oxidative phosphorylation down-regulation (Warburg effect). Therefore, it seems reasonable that disruption of glycolysis might be a promising candidate for specific anti-cancer therapy. Nonetheless, the concept of aerobic glycolysis as the paradigm of tumor Cell metabolism has been challenged, as some tumor Cells use oxidative phosphorylation. Mitochondria are of special interest in cancer Cell Energy metabolism, as their physiology is linked to the Warburg effect. Besides, their central role in apoptosis makes these organelles a promising “dual hit target” for selectively eliminate tumor Cells. Thus, it is desirable to have an easy-to-use and reliable model in order to do the screening for Energy metabolism-inhibiting drugs to be used in cancer therapy. From a metabolic point of view, the fermenting yeast Saccharomyces cerevisiae and tumor Cells share several features. In this paper we will review these common metabolic properties and we will discuss the possibility of using S. cerevisiae as an early screening test in the research for novel anti-tumor compounds used for the inhibition of tumor Cell metabolism.

M. Hashem Nehrir - One of the best experts on this subject based on the ideXlab platform.

  • power management of a stand alone wind photovoltaic fuel Cell Energy system
    IEEE Transactions on Energy Conversion, 2008
    Co-Authors: Caisheng Wang, M. Hashem Nehrir
    Abstract:

    This paper proposes an AC-linked hybrid wind/photovoltaic (PV)/fuel Cell (FC) alternative Energy system for stand-alone applications. Wind and PV are the primary power sources of the system, and an FC-electrolyzer combination is used as a backup and a long-term storage system. An overall power management strategy is designed for the proposed system to manage power flows among the different Energy sources and the storage unit in the system. A simulation model for the hybrid Energy system has been developed using MATLAB/Simulink. The system performance under different scenarios has been verified by carrying out simulation studies using a practical load demand profile and real weather data.

  • Power management of a stand-alone wind/photovoltaic/fuel Cell Energy system
    IEEE Transactions on Energy Conversion, 2008
    Co-Authors: Caisheng Wang, M. Hashem Nehrir
    Abstract:

    This paper proposes an AC-linked hybrid wind/photovoltaic (PV)/fuel Cell (FC) alternative Energy system for stand-alone applications. Wind and PV are the primary power sources of the system, and an FC-electrolyzer combination is used as a backup and a long-term storage system. An overall power management strategy is designed for the proposed system to manage power flows among the different Energy sources and the storage unit in the system. A simulation model for the hybrid Energy system has been developed using MATLAB/Simulink. The system performance under different scenarios has been verified by carrying out simulation studies using a practical load demand profile and real weather data.

Caisheng Wang - One of the best experts on this subject based on the ideXlab platform.

  • power management of a stand alone wind photovoltaic fuel Cell Energy system
    IEEE Transactions on Energy Conversion, 2008
    Co-Authors: Caisheng Wang, M. Hashem Nehrir
    Abstract:

    This paper proposes an AC-linked hybrid wind/photovoltaic (PV)/fuel Cell (FC) alternative Energy system for stand-alone applications. Wind and PV are the primary power sources of the system, and an FC-electrolyzer combination is used as a backup and a long-term storage system. An overall power management strategy is designed for the proposed system to manage power flows among the different Energy sources and the storage unit in the system. A simulation model for the hybrid Energy system has been developed using MATLAB/Simulink. The system performance under different scenarios has been verified by carrying out simulation studies using a practical load demand profile and real weather data.

  • Power management of a stand-alone wind/photovoltaic/fuel Cell Energy system
    IEEE Transactions on Energy Conversion, 2008
    Co-Authors: Caisheng Wang, M. Hashem Nehrir
    Abstract:

    This paper proposes an AC-linked hybrid wind/photovoltaic (PV)/fuel Cell (FC) alternative Energy system for stand-alone applications. Wind and PV are the primary power sources of the system, and an FC-electrolyzer combination is used as a backup and a long-term storage system. An overall power management strategy is designed for the proposed system to manage power flows among the different Energy sources and the storage unit in the system. A simulation model for the hybrid Energy system has been developed using MATLAB/Simulink. The system performance under different scenarios has been verified by carrying out simulation studies using a practical load demand profile and real weather data.

Anne Devin - One of the best experts on this subject based on the ideXlab platform.

  • Cell Energy metabolism: An update
    Biochimica et Biophysica Acta, 2020
    Co-Authors: Michel Rigoulet, Cyrielle Bouchez, Patrick Paumard, Stéphane Ransac, S. Cuvellier, Stéphane Duvezin-caubet, Jean-pierre Mazat, Anne Devin
    Abstract:

    Abstract In living Cells, growth is the result of coupling between substrate catabolism and multiple metabolic processes that take place during net biomass formation and maintenance processes. During growth, both ATP/ADP and NADH/NAD+ molecules play a key role. Cell Energy metabolism hence refers to metabolic pathways involved in ATP synthesis linked to NADH turnover. Two main pathways are thus involved in Cell Energy metabolism: glycolysis/fermentation and oxidative phosphorylation. Glycolysis and mitochondrial oxidative phosphorylation are intertwined through thermodynamic and kinetic constraints that are reviewed herein. Further, our current knowledge of short-term and long term regulation of Cell Energy metabolism will be reviewed using examples such as the Crabtree and the Warburg effect.

  • tumor Cell Energy metabolism and its common features with yeast metabolism
    Biochimica et Biophysica Acta, 2009
    Co-Authors: R Diazruiz, Michel Rigoulet, Anne Devin, Salvador Uribecarvajal
    Abstract:

    Abstract During the last decades a considerable amount of research has been focused on cancer. A number of genetic and signaling defects have been identified. This has allowed the design and screening of a number of anti-tumor drugs for therapeutic use. One of the main challenges of anti-cancer therapy is to specifically target these drugs to malignant Cells. Recently, tumor Cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display an enhanced glycolytic activity and oxidative phosphorylation down-regulation (Warburg effect). Therefore, it seems reasonable that disruption of glycolysis might be a promising candidate for specific anti-cancer therapy. Nonetheless, the concept of aerobic glycolysis as the paradigm of tumor Cell metabolism has been challenged, as some tumor Cells use oxidative phosphorylation. Mitochondria are of special interest in cancer Cell Energy metabolism, as their physiology is linked to the Warburg effect. Besides, their central role in apoptosis makes these organelles a promising “dual hit target” for selectively eliminate tumor Cells. Thus, it is desirable to have an easy-to-use and reliable model in order to do the screening for Energy metabolism-inhibiting drugs to be used in cancer therapy. From a metabolic point of view, the fermenting yeast Saccharomyces cerevisiae and tumor Cells share several features. In this paper we will review these common metabolic properties and we will discuss the possibility of using S. cerevisiae as an early screening test in the research for novel anti-tumor compounds used for the inhibition of tumor Cell metabolism.

Masoud Aliakbar Golkar - One of the best experts on this subject based on the ideXlab platform.

  • Intelligent Power Management of a Hybrid Fuel Cell/Energy Storage Distributed Generator
    Smart Power Grids 2011, 2020
    Co-Authors: Amin Hajizadeh, Ali Feliachi, Masoud Aliakbar Golkar
    Abstract:

    This book chapter addresses the intelligent power management of a hybrid ( fuel Cell/Energy storage( distributed generator connected to a power grid. It presents an adaptive neuro-fuzzy control strategy to manage the active power between the two power sources: fuel Cell and battery. A validated PEM (Proton Exchange membrane) fuel Cell dynamic model along with dynamic models for the battery bank, the boost DC/DC converter and the three-phase grid-connected inverter are given. Simulation results are provided to illustrate the power management scheme. They show that the real and reactive power delivered by the fuel Cell system to the utility grid can be controlled as desired, while the state of charge of the battery and the utilization factor of the fuel Cell are maintained well within their prescribed ranges.

  • control of hybrid fuel Cell Energy storage distributed generation system against voltage sag
    International Journal of Electrical Power & Energy Systems, 2010
    Co-Authors: Amin Hajizadeh, Masoud Aliakbar Golkar
    Abstract:

    Fuel Cell (FC) and Energy storage (ES) based hybrid distributed power generation systems appear to be very promising for satisfying high Energy and high power requirements of power quality problems in distributed generation (DG) systems. In this study, design of control strategy for hybrid fuel Cell/Energy storage distributed power generation system during voltage sag has been presented. The proposed control strategy allows hybrid distributed generation system works properly when a voltage disturbance occurs in distribution system and hybrid system stays connected to the main grid. Hence, modeling, controller design, and simulation study of a hybrid distributed generation system are investigated. The physical model of the fuel Cell stack, Energy storage and the models of power conditioning units are described. Then the control design methodology for each component of the hybrid system is proposed. Simulation results are given to show the overall system performance including active power control and voltage sag ride-through capability of the hybrid distributed generation system.

  • Control of hybrid fuel Cell/Energy storage distributed generation system against voltage sag
    International Journal of Electrical Power & Energy Systems, 2010
    Co-Authors: Amin Hajizadeh, Masoud Aliakbar Golkar
    Abstract:

    Fuel Cell (FC) and Energy storage (ES) based hybrid distributed power generation systems appear to be very promising for satisfying high Energy and high power requirements of power quality problems in distributed generation (DG) systems. In this study, design of control strategy for hybrid fuel Cell/Energy storage distributed power generation system during voltage sag has been presented. The proposed control strategy allows hybrid distributed generation system works properly when a voltage disturbance occurs in distribution system and hybrid system stays connected to the main grid. Hence, modeling, controller design, and simulation study of a hybrid distributed generation system are investigated. The physical model of the fuel Cell stack, Energy storage and the models of power conditioning units are described. Then the control design methodology for each component of the hybrid system is proposed. Simulation results are given to show the overall system performance including active power control and voltage sag ride-through capability of the hybrid distributed generation system.