The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Myriam Hemberger - One of the best experts on this subject based on the ideXlab platform.
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epigenetic dynamics of stem Cells and Cell Lineage commitment digging waddington s canal
Nature Reviews Molecular Cell Biology, 2009Co-Authors: Wendy Dean, Wolf Reik, Myriam HembergerAbstract:The life cycle of an organism is characterized by phases of reprogramming and differentiation during development from the zygote to the adult organism. Lineage-determining transcription factors and epigenetic mechanisms form inseparable strands that regulate pluripotency and early Cell Lineage decisions.
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epigenetic restriction of embryonic Cell Lineage fate by methylation of elf5
Nature Cell Biology, 2008Co-Authors: Ray Kit Ng, Wendy Dean, Claire Dawson, Diana Lucifero, Zofia E Madeja, Wolf Reik, Myriam HembergerAbstract:A genome-wide screen reveals that the transcription factor Elf5 is epigenetically silenced in the embryonic Cell Lineage and that its expression is restricted to the trophoblast, where it creates a positive-feedback loop with Cdx2 and Eomes.
Wolf Reik - One of the best experts on this subject based on the ideXlab platform.
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epigenetic dynamics of stem Cells and Cell Lineage commitment digging waddington s canal
Nature Reviews Molecular Cell Biology, 2009Co-Authors: Wendy Dean, Wolf Reik, Myriam HembergerAbstract:The life cycle of an organism is characterized by phases of reprogramming and differentiation during development from the zygote to the adult organism. Lineage-determining transcription factors and epigenetic mechanisms form inseparable strands that regulate pluripotency and early Cell Lineage decisions.
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epigenetic restriction of embryonic Cell Lineage fate by methylation of elf5
Nature Cell Biology, 2008Co-Authors: Ray Kit Ng, Wendy Dean, Claire Dawson, Diana Lucifero, Zofia E Madeja, Wolf Reik, Myriam HembergerAbstract:A genome-wide screen reveals that the transcription factor Elf5 is epigenetically silenced in the embryonic Cell Lineage and that its expression is restricted to the trophoblast, where it creates a positive-feedback loop with Cdx2 and Eomes.
Dennis E. Discher - One of the best experts on this subject based on the ideXlab platform.
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matrix elasticity directs stem Cell Lineage specification
Cell, 2006Co-Authors: Adam J. Engler, Lee H Sweeney, Dennis E. DischerAbstract:SUMMARY Microenvironments appear important in stem Cell Lineage specification but can be difficult to adequately characterize or control with soft tissues. Naive mesenchymal stem Cells (MSCs) areshownheretospecifyLineageandcommitto phenotypes with extreme sensitivity to tissuelevel elasticity. Soft matrices that mimic brain are neurogenic, stiffer matricesthat mimicmuscle are myogenic, and comparatively rigid matrices that mimic collagenous bone prove osteogenic. During the initial week in culture, reprogramming of these Lineages is possible with addition of soluble induction factors, but after several weeks in culture, the Cells commit to the Lineage specified by matrix elasticity, consistent with the elasticity-insensitive commitment of differentiated Cell types. Inhibition of nonmuscle myosin II blocks all elasticitydirected Lineage specification‐without strongly perturbing many other aspects of Cell function and shape. The results have significant implications for understanding physical effects of the in vivo microenvironmentandalso for therapeutic uses of stem Cells.
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Matrix Elasticity Directs Stem Cell Lineage Specification
Cell, 2006Co-Authors: Adam J. Engler, Shamik Sen, H. Lee Sweeney, Dennis E. DischerAbstract:Microenvironments appear important in stem Cell Lineage specification but can be difficult to adequately characterize or control with soft tissues. Naive mesenchymal stem Cells (MSCs) are shown here to specify Lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity. Soft matrices that mimic brain are neurogenic, stiffer matrices that mimic muscle are myogenic, and comparatively rigid matrices that mimic collagenous bone prove osteogenic. During the initial week in culture, reprogramming of these Lineages is possible with addition of soluble induction factors, but after several weeks in culture, the Cells commit to the Lineage specified by matrix elasticity, consistent with the elasticity-insensitive commitment of differentiated Cell types. Inhibition of nonmuscle myosin II blocks all elasticity-directed Lineage specification-without strongly perturbing many other aspects of Cell function and shape. The results have significant implications for understanding physical effects of the in vivo microenvironment and also for therapeutic uses of stem Cells. © 2006 Elsevier Inc. All rights reserved.
Gunnar Nilsson - One of the best experts on this subject based on the ideXlab platform.
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the chemokine receptor cxcr4 is expressed within the mast Cell Lineage and its ligand stromal Cell derived factor 1α acts as a mast Cell chemotaxin
European Journal of Immunology, 2000Co-Authors: Mikael Juremalm, Malin Hjertson, Niclas Olsson, Ilkka T Harvima, Kenneth Nilsson, Gunnar NilssonAbstract:The chemokine receptor CXCR4 is expressed on the mast Cell Lineage and its ligand SDF-1 acts as a mast Cell chemotaxin
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The chemokine receptor CXCR4 is expressed within the mast Cell Lineage and its ligand stromal Cell‐derived factor‐1α acts as a mast Cell chemotaxin
European Journal of Immunology, 2000Co-Authors: Mikael Juremalm, Malin Hjertson, Niclas Olsson, Ilkka T Harvima, Kenneth Nilsson, Gunnar NilssonAbstract:The chemokine receptor CXCR4 is expressed on the mast Cell Lineage and its ligand SDF-1 acts as a mast Cell chemotaxin
Wendy Dean - One of the best experts on this subject based on the ideXlab platform.
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epigenetic dynamics of stem Cells and Cell Lineage commitment digging waddington s canal
Nature Reviews Molecular Cell Biology, 2009Co-Authors: Wendy Dean, Wolf Reik, Myriam HembergerAbstract:The life cycle of an organism is characterized by phases of reprogramming and differentiation during development from the zygote to the adult organism. Lineage-determining transcription factors and epigenetic mechanisms form inseparable strands that regulate pluripotency and early Cell Lineage decisions.
-
epigenetic restriction of embryonic Cell Lineage fate by methylation of elf5
Nature Cell Biology, 2008Co-Authors: Ray Kit Ng, Wendy Dean, Claire Dawson, Diana Lucifero, Zofia E Madeja, Wolf Reik, Myriam HembergerAbstract:A genome-wide screen reveals that the transcription factor Elf5 is epigenetically silenced in the embryonic Cell Lineage and that its expression is restricted to the trophoblast, where it creates a positive-feedback loop with Cdx2 and Eomes.