The Experts below are selected from a list of 20355 Experts worldwide ranked by ideXlab platform
Marc Lecuit - One of the best experts on this subject based on the ideXlab platform.
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mycobacterium genavense as a cause of subacute pneumonia in patients with severe Cellular Immunodeficiency
BMC Infectious Diseases, 2011Co-Authors: Blandine Rammaert, Louis-jean Couderc, Elisabeth Rivaud, Patrick Honderlick, Pierre Cahen, Emmanuel Bille, David Zucman, Marc Lecuit, Marie-france MamzerAbstract:Mycobacterium genavense is a rare nontuberculous mycobacteria (NTM). Human infections are mostly disseminated in the setting of the AIDS epidemic or the use of aggressive immunosuppressive treatments. M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization. We report here two patients with pneumonia as the predominant manifestation of M. genavense infection: one kidney transplanted patient and one HIV-infected patient. Both patients were initially treated with anti-tuberculous drugs before the identification of M. genavense on sputum or broncho-alveolar lavage fluid culture. A four-drug regimen including clarithromycin and rifabutin was started. Gamma interferon has been helpful in addition to antimycobacterial treatment for one patient. Clinicians should be aware that M. genavense could be the etiologic agent of sub-acute pneumonia mimicking tuberculosis in patients with Cellular Immunodeficiency status.
Blandine Rammaert - One of the best experts on this subject based on the ideXlab platform.
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mycobacterium genavense as a cause of subacute pneumonia in patients with severe Cellular Immunodeficiency
BMC Infectious Diseases, 2011Co-Authors: Blandine Rammaert, Louis-jean Couderc, Elisabeth Rivaud, Patrick Honderlick, Pierre Cahen, Emmanuel Bille, David Zucman, Marc Lecuit, Marie-france MamzerAbstract:Mycobacterium genavense is a rare nontuberculous mycobacteria (NTM). Human infections are mostly disseminated in the setting of the AIDS epidemic or the use of aggressive immunosuppressive treatments. M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization. We report here two patients with pneumonia as the predominant manifestation of M. genavense infection: one kidney transplanted patient and one HIV-infected patient. Both patients were initially treated with anti-tuberculous drugs before the identification of M. genavense on sputum or broncho-alveolar lavage fluid culture. A four-drug regimen including clarithromycin and rifabutin was started. Gamma interferon has been helpful in addition to antimycobacterial treatment for one patient. Clinicians should be aware that M. genavense could be the etiologic agent of sub-acute pneumonia mimicking tuberculosis in patients with Cellular Immunodeficiency status.
Andrew Saxon - One of the best experts on this subject based on the ideXlab platform.
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Pneumocystis Carinii Pneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men. Evidence of a New Acquired Cellular Immunodeficiency
Journal of Urology, 2017Co-Authors: M.s. Gottlieb, R. Schroff, H.m. Schanker, J.d. Weisman, P.t. Fan, R A Wolf, Andrew SaxonAbstract:Four previously healthy homosexual men contracted Pneumocystis carinii pneumonia, extensive mucosal candidiasis, and multiple viral infections. In three of the patients these infections followed prolonged fevers of unknown origin. In all four cytomegalovirus was recovered from secretions. Kaposi's sarcoma developed in one patient eight months after he presented with esophageal candidiasis. All patients were anergic and lymphopenic; they had no lymphocyte proliferative responses to soluble antigens, and their responses to phytohemagglutinin were markedly reduced. Monoclonal-antibody analysis of peripheral-blood T-cell subpopulations revealed virtual elimination of the Leu-3 / helper/inducer subset, an increased percentage of the Leu-2 + suppressor/cytoxic subset, and an increased percentage of cells bearing the thymocyte-associated antigen T10. The inversion of the T/ helper to suppressor/cytotoxic ratio suggested that cytomegalovirus infection was an important factor in the pathogenesis of the immunodeficient state. A high level of exposure of male homosexuals to cytomegalovirus-infected secretions may account for the occurrence of this immune deficiency.
Chaim M Roifman - One of the best experts on this subject based on the ideXlab platform.
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human immune disorder arising from mutation of the α chain of the interleukin 2 receptor
Proceedings of the National Academy of Sciences of the United States of America, 1997Co-Authors: Nigel Sharfe, Harjit Dadi, Michal Shahar, Chaim M RoifmanAbstract:Profound Cellular Immunodeficiency occurs as the result of mutations in proteins involved in both the differentiation and function of mature lymphoid cells. We describe here a novel human immune aberration arising from a truncation mutation of the interleukin-2 receptor α chain (CD25), a subunit of the tripartite high-affinity receptor for interleukin 2. This Immunodeficiency is characterized by decreased numbers of peripheral T cells displaying abnormal proliferation but normal B cell development. Extensive lymphocytic infiltration of tissues, including lung, liver, gut, and bone, is observed, accompanied by tissue atrophy and inflammation. Although mature T cells are present, the absence of CD25 does affect the differentiation of thymocytes. While displaying normal development of CD2, CD3, CD4, and CD8 expression, CD25-deficient cortical thymocytes do not express CD1, and furthermore they fail to normally down-regulate levels of the anti-apoptotic protein bcl-2.
David Zucman - One of the best experts on this subject based on the ideXlab platform.
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mycobacterium genavense as a cause of subacute pneumonia in patients with severe Cellular Immunodeficiency
BMC Infectious Diseases, 2011Co-Authors: Blandine Rammaert, Louis-jean Couderc, Elisabeth Rivaud, Patrick Honderlick, Pierre Cahen, Emmanuel Bille, David Zucman, Marc Lecuit, Marie-france MamzerAbstract:Mycobacterium genavense is a rare nontuberculous mycobacteria (NTM). Human infections are mostly disseminated in the setting of the AIDS epidemic or the use of aggressive immunosuppressive treatments. M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization. We report here two patients with pneumonia as the predominant manifestation of M. genavense infection: one kidney transplanted patient and one HIV-infected patient. Both patients were initially treated with anti-tuberculous drugs before the identification of M. genavense on sputum or broncho-alveolar lavage fluid culture. A four-drug regimen including clarithromycin and rifabutin was started. Gamma interferon has been helpful in addition to antimycobacterial treatment for one patient. Clinicians should be aware that M. genavense could be the etiologic agent of sub-acute pneumonia mimicking tuberculosis in patients with Cellular Immunodeficiency status.