The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Lee-shing Fang - One of the best experts on this subject based on the ideXlab platform.
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Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
Marine drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing FangAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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flexibilins a c new Cembrane type diterpenoids from the formosan soft coral sinularia flexibilis
Marine Drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Pingjyun SungAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum
Marine drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Lee-shing FangAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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lobocrassins a e new Cembrane type diterpenoids from the soft coral lobophytum crassum
Marine Drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Zhihong Wen, Pingjyun SungAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Wei-hsien Wang - One of the best experts on this subject based on the ideXlab platform.
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Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
Marine drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing FangAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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flexibilins a c new Cembrane type diterpenoids from the formosan soft coral sinularia flexibilis
Marine Drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Pingjyun SungAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum
Marine drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Lee-shing FangAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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lobocrassins a e new Cembrane type diterpenoids from the soft coral lobophytum crassum
Marine Drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Zhihong Wen, Pingjyun SungAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Tsong-long Hwang - One of the best experts on this subject based on the ideXlab platform.
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Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
Marine drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing FangAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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flexibilins a c new Cembrane type diterpenoids from the formosan soft coral sinularia flexibilis
Marine Drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Pingjyun SungAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum
Marine drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Lee-shing FangAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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lobocrassins a e new Cembrane type diterpenoids from the soft coral lobophytum crassum
Marine Drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Zhihong Wen, Pingjyun SungAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Pingjyun Sung - One of the best experts on this subject based on the ideXlab platform.
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New cembranoid diterpenes from the cultured octocoral Nephthea columnaris.
Molecules (Basel Switzerland), 2015Co-Authors: Ting Hsi Hsiao, Zhihong Wen, Ching Hsiao Cheng, Wu Fu Chen, Chang-feng Dai, Pingjyun SungAbstract:Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural Cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of Cembranes 1–3 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 1–4 against a panel of tumor cells is also described.
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flexibilins a c new Cembrane type diterpenoids from the formosan soft coral sinularia flexibilis
Marine Drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Pingjyun SungAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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lobocrassins a e new Cembrane type diterpenoids from the soft coral lobophytum crassum
Marine Drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Zhihong Wen, Pingjyun SungAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Yuehhsiung Kuo - One of the best experts on this subject based on the ideXlab platform.
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flexibilins a c new Cembrane type diterpenoids from the formosan soft coral sinularia flexibilis
Marine Drugs, 2013Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Pingjyun SungAbstract:Three new Cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known Cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of Cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
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Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum
Marine drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Lee-shing FangAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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lobocrassins a e new Cembrane type diterpenoids from the soft coral lobophytum crassum
Marine Drugs, 2011Co-Authors: Chia-ying Kao, Tsong-long Hwang, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Jih-jung Chen, Jyh-horng Sheu, Ching-feng Weng, Zhihong Wen, Pingjyun SungAbstract:Five new Cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of Cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known Cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known Cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.