The Experts below are selected from a list of 183 Experts worldwide ranked by ideXlab platform

W. Y. Chung - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of Endoscopic and Robotic Thyroidectomy
    Annals of Surgical Oncology, 2011
    Co-Authors: J. Lee, J. H. Lee, K. Y. Nah, E. Y. Soh, W. Y. Chung
    Abstract:

    Background Endoscopic thyroidectomy is a technically challenging procedure. Robot-assisted thyroidectomy has been recently introduced and offers improved visualization and dexterity. The present study compared conventional endoscopic and robotic thyroidectomy for thyroid cancer patients in terms of perioperative outcomes and learning curve. All operations were performed by the same surgeon. Materials and Methods Between April 2007 and March 2010, 96 patients underwent endoscopic thyroidectomy (endoscopy group) and 163 patients underwent robotic thyroidectomy (robot group). A gasless transaxillary approach was used in both groups. The 2 groups were compared in terms of patient characteristics, perioperative clinical results, complications, and pathologic details. Learning curves for the 2 procedures were compared based on the number of cases required to reach a consistent operation time. Results Patient characteristics were similar for both groups. The mean total operation time for thyroidectomy with Central compartment neck dissection was 142.7 ± 52.1 min in the endoscopy group and 110.1 ± 50.7 min in the robot group ( P  = .041). Both patient groups were similar in terms of pathological features including TNM stage, intraoperative blood loss, length of hospital stay, and complication rate. However, the mean number of retrieved Central Lymph Nodes was 2.4 ± 1.9 for the endoscopy group and 4.5 ± 1.5 for the robot group ( P  = .004). The learning curve was 55–60 cases for endoscopic thyroidectomy and 35–40 cases for robotic thyroidectomy. Conclusion Robotic thyroidectomy was found to be superior to endoscopic thyroidectomy in terms of operation time, Lymph node retrieval, and learning curve. Complication rates and postoperative hospital stay were similar for the 2 procedures.

Pintong Huang - One of the best experts on this subject based on the ideXlab platform.

  • Value of share wave elastography combined with BRAFV600E in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma
    2019
    Co-Authors: Jue Wang, Qing Wen, Zhifei Ben, Rufeng Dong, Lei Dai, Pintong Huang
    Abstract:

    Objective To investigate the value of share wave elastography (SWE) combined with BRAFV600E in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma (PTC). Methods This study collected 217 PTC from 217 patients diagnosed as PTC by surgical pathology,all patients are confirmed by conventional ultrasonography, SWE examination, BRAF V600E gene detection and Central neck dissection for preventive. Taking postoperative pathological results as gold standard, the independent t test was used to compared the differences in SWE between groups with and without Central Lymph Nodes metastasis; the chi-square test was used to compare the difference of BRAFV600E between the two groups; and to use the receiver operating characteristic (ROC) curve to investigate the diagnostic efficacy of SWE, BRAFV600E and their combination in predicting Central Lymph Nodes metastasis of PTC. Results The differences of PTC Emax, Emean, Emin between the two groups showed statistically significant (t=4.49, 8.11, 3.23, all P

  • value of share wave elastography combined with brafv600e in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma
    Chin J Med Ultrasound(Electronic Edition), 2019
    Co-Authors: Jue Wang, Qing Wen, Zhifei Ben, Rufeng Dong, Lei Dai, Pintong Huang
    Abstract:

    Objective To investigate the value of share wave elastography (SWE) combined with BRAFV600E in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma (PTC). Methods This study collected 217 PTC from 217 patients diagnosed as PTC by surgical pathology,all patients are confirmed by conventional ultrasonography, SWE examination, BRAF V600E gene detection and Central neck dissection for preventive. Taking postoperative pathological results as gold standard, the independent t test was used to compared the differences in SWE between groups with and without Central Lymph Nodes metastasis; the chi-square test was used to compare the difference of BRAFV600E between the two groups; and to use the receiver operating characteristic (ROC) curve to investigate the diagnostic efficacy of SWE, BRAFV600E and their combination in predicting Central Lymph Nodes metastasis of PTC. Results The differences of PTC Emax, Emean, Emin between the two groups showed statistically significant (t=4.49, 8.11, 3.23, all P<0.01), and the predictive value of Emean was higher than Emax、Emin. The difference of BRAFV600E between the two groups showed statistically significant (χ2=16.16, P<0.01). The specificity, accuracy, negative predictive value and positive predictive value of SWE combined with BRAFV600E were all higher than single SWE and BRAFV600E with statistical significant (χ2=64.769, 35.406, 22.647, 20.247, all P<0.01). Conclusions SWE combined with BRAFV600E can significantly improve the specificity, accuracy, negative predictive value and positive predictive value in predicting Central Lymph Nodes metastasis of PTC. Key words: Thyroid neoplasms; Shear wave elastography; BRAFV600E; Lymphatic metastasis

Soo Geun Wang - One of the best experts on this subject based on the ideXlab platform.

  • nodal status of Central Lymph Nodes as a negative prognostic factor for papillary thyroid carcinoma
    Journal of Surgical Oncology, 2013
    Co-Authors: Yoon Se Lee, Soo Geun Wang, Yunsung Lim, Jinchoon Lee, Inju Kim, Seokman Son, Dong Hoon Shin, Byungjoo Lee
    Abstract:

    Background The status of metastatic Lymph Nodes, including the size and extracapsular spread (ECS), in papillary thyroid cancer (PTC) has not been well established. This study evaluated the correlation between the specific status of Central Lymph node metastases (CLNM) and negative prognostic factors. Methods We reviewed 243 patients who underwent total thyroidectomy and neck dissection. The CLNM slides were reviewed and the relationship between the CLNM status and risk factors was analyzed. Results CLNM were found in 111 patients. ECS (+) was related to a large tumor, high number of CLNM, and large node (P < 0.05). Tumor size and number of CLNM were related to the ECS rate (OR = 3.861 and 2.491, respectively; P < 0.01) in a multivariate analysis. Large Nodes (≥6 mm) were related to large tumor size, extrathyroidal extension, number of CLNM, and lateral cervical Lymph node metastasis (LNM). Tumor size and LNM (OR = 4.519 and 7.811, respectively; P < 0.05) were related to large Nodes in a multivariate analysis. Conclusions ECS was related to node size, tumor size, and number of CLNM. Node size was related to tumor size and LNM. Thus, specific nodal status is a possible prognostic factor for PTC. J. Surg. Oncol. 2013;107:777–782. © 2012 Wiley Periodicals, Inc.

  • Quantitative Frozen Biopsy of Central Metastasis in PTC
    Otolaryngology-Head and Neck Surgery, 2011
    Co-Authors: Soo Geun Wang
    Abstract:

    Objective: Nodal metastasis in PTC occurs in the Central compartment of the ipsilateral neck and spreads laterally. Occult lateral neck metastasis can be predictable by Lymphatic status of Central compartment. This study was to evaluate the diagnostic accuracy of frozen biopsy for quantitative nodal evaluation of Central neck metastasis.Method: A total of 264 patients with papillary thyroid cancer underwent total thyroidectomy with Central compartment neck dissection as an initial operation. All fresh tissues from ipsilateral Central neck dissection were examined by frozen biopsy for Central neck metastasis with quantitative nodal analysis.Results: Among them, 134 patients (51% [134/262]) had Central neck metastasis. The sensitivity and specificity of frozen biopsy for the detection of Central neck metastasis were 100% and 99.2% in 264 patients who underwent total thyroidectomy with bilateral Central neck dissection. The diagnostic accuracy for the number of metastatic ipsilateral Central Lymph Nodes was ...

  • lateral cervical Lymph node metastases from papillary thyroid carcinoma predictive factors of nodal metastasis
    Surgery, 2011
    Co-Authors: Soo Geun Wang
    Abstract:

    Background Papillary thyroid carcinoma (PTC) frequently metastasizes to the regional neck; skip metastasis (metastasis to the lateral compartment in the absence of Central disease) is uncommon. This prospective study was to evaluate the incidence of occult lateral neck metastasis (LNM) and elucidated the factors that predict LNM in PTC with Central neck metastasis (CNM) by performing prophylactic selective lateral neck dissection (SND). Methods Sixty-two patients with PTC without clinical LNM underwent total thyroidectomy with Central compartment neck dissection and prophylactic SND consecutively after ipsilateral CNM was confirmed by intraoperative frozen biopsy. Results The incidence of occult LNM in PTC was 55%. Patients with LNM had a larger primary tumor and more positive ipsilateral and bilateral Central Lymph Nodes than patients without LNM. There were no differences between patients with and without LNM with regard to age and extrathyroidal extension. The incidence of occult LNM increased significantly as the number of metastatic ipsilateral and bilateral Lymph Nodes increased. Independent risk factors for occult LNM were tumor size and the number of positive bilateral Lymph Nodes (odds ratio [OR] = 1.449; OR = 1.110, respectively). The most common metastatic site was level III (68%: 23/34), followed by level IV (59%: 20/34) and level II (21%: 7/34). Conclusion The important risk factors for LNM in PTC are primary tumor size and the number of positive bilateral Central Lymph Nodes. Prophylactic SND may be considered in selected patients with a large number of positive Central Lymph Nodes and large tumors.

J. Lee - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of Endoscopic and Robotic Thyroidectomy
    Annals of Surgical Oncology, 2011
    Co-Authors: J. Lee, J. H. Lee, K. Y. Nah, E. Y. Soh, W. Y. Chung
    Abstract:

    Background Endoscopic thyroidectomy is a technically challenging procedure. Robot-assisted thyroidectomy has been recently introduced and offers improved visualization and dexterity. The present study compared conventional endoscopic and robotic thyroidectomy for thyroid cancer patients in terms of perioperative outcomes and learning curve. All operations were performed by the same surgeon. Materials and Methods Between April 2007 and March 2010, 96 patients underwent endoscopic thyroidectomy (endoscopy group) and 163 patients underwent robotic thyroidectomy (robot group). A gasless transaxillary approach was used in both groups. The 2 groups were compared in terms of patient characteristics, perioperative clinical results, complications, and pathologic details. Learning curves for the 2 procedures were compared based on the number of cases required to reach a consistent operation time. Results Patient characteristics were similar for both groups. The mean total operation time for thyroidectomy with Central compartment neck dissection was 142.7 ± 52.1 min in the endoscopy group and 110.1 ± 50.7 min in the robot group ( P  = .041). Both patient groups were similar in terms of pathological features including TNM stage, intraoperative blood loss, length of hospital stay, and complication rate. However, the mean number of retrieved Central Lymph Nodes was 2.4 ± 1.9 for the endoscopy group and 4.5 ± 1.5 for the robot group ( P  = .004). The learning curve was 55–60 cases for endoscopic thyroidectomy and 35–40 cases for robotic thyroidectomy. Conclusion Robotic thyroidectomy was found to be superior to endoscopic thyroidectomy in terms of operation time, Lymph node retrieval, and learning curve. Complication rates and postoperative hospital stay were similar for the 2 procedures.

Lei Dai - One of the best experts on this subject based on the ideXlab platform.

  • transoral endoscopic thyroidectomy vestibular approach versus endoscopic thyroidectomy via areola approach for patients with unilateral papillary thyroid carcinoma a retrospective study
    Surgical Laparoscopy Endoscopy & Percutaneous Techniques, 2021
    Co-Authors: Weidong Zhang, Lei Dai, Yingchun Wang, Yunyun Xie, Jianyao Guo
    Abstract:

    BACKGROUND Endoscopic thyroidectomy via areola approach (ETA) has been widely used in thyroidectomy for many years as it can effectively avoid a scar in the neck. Transoral endoscopic thyroidectomy vestibular approach (TOETVA) is newly applied and has gained popularity quickly. This study is to compare the safety and effectiveness of TOETVA and ETA. MATERIALS AND METHODS A total of 95 patients who underwent TOETVA or ETA with unilateral papillary thyroid carcinoma were enrolled in this study from March 2019 to February 2020. The basic information (such as gender, age), intraoperative hemorrhage, postoperative drainage volume, hospital durations, intraoperative and postoperative complications, operative time, Central Lymph node dissection time, total number of Central Lymph Nodes, and number of metastatic Central Lymph Nodes were compared. RESULTS The operative time of the TOETVA group was significantly longer than the ETA group (148.11±19.78 vs. 135.90±12.77 min, P<0.05). However, the result was opposite when Central Lymph node dissection time was compared (10.31±2.93 vs. 12.48±3.55, P<0.05). TOETVA had an advantage on total number of Central Lymph Nodes over ETA (7.82±3.35 vs. 5.26±2.45, P<0.05). No differences were found between the 2 groups on other data. CONCLUSION TOETVA and ETA have the similarity on surgical safety and effectiveness. TOETVA has its advantage on Central Lymph node dissection and might be a reasonable alternative for ETA and open surgery in the future.

  • Value of share wave elastography combined with BRAFV600E in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma
    2019
    Co-Authors: Jue Wang, Qing Wen, Zhifei Ben, Rufeng Dong, Lei Dai, Pintong Huang
    Abstract:

    Objective To investigate the value of share wave elastography (SWE) combined with BRAFV600E in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma (PTC). Methods This study collected 217 PTC from 217 patients diagnosed as PTC by surgical pathology,all patients are confirmed by conventional ultrasonography, SWE examination, BRAF V600E gene detection and Central neck dissection for preventive. Taking postoperative pathological results as gold standard, the independent t test was used to compared the differences in SWE between groups with and without Central Lymph Nodes metastasis; the chi-square test was used to compare the difference of BRAFV600E between the two groups; and to use the receiver operating characteristic (ROC) curve to investigate the diagnostic efficacy of SWE, BRAFV600E and their combination in predicting Central Lymph Nodes metastasis of PTC. Results The differences of PTC Emax, Emean, Emin between the two groups showed statistically significant (t=4.49, 8.11, 3.23, all P

  • value of share wave elastography combined with brafv600e in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma
    Chin J Med Ultrasound(Electronic Edition), 2019
    Co-Authors: Jue Wang, Qing Wen, Zhifei Ben, Rufeng Dong, Lei Dai, Pintong Huang
    Abstract:

    Objective To investigate the value of share wave elastography (SWE) combined with BRAFV600E in predicting Central Lymph Nodes metastasis of papillary thyroid carcinoma (PTC). Methods This study collected 217 PTC from 217 patients diagnosed as PTC by surgical pathology,all patients are confirmed by conventional ultrasonography, SWE examination, BRAF V600E gene detection and Central neck dissection for preventive. Taking postoperative pathological results as gold standard, the independent t test was used to compared the differences in SWE between groups with and without Central Lymph Nodes metastasis; the chi-square test was used to compare the difference of BRAFV600E between the two groups; and to use the receiver operating characteristic (ROC) curve to investigate the diagnostic efficacy of SWE, BRAFV600E and their combination in predicting Central Lymph Nodes metastasis of PTC. Results The differences of PTC Emax, Emean, Emin between the two groups showed statistically significant (t=4.49, 8.11, 3.23, all P<0.01), and the predictive value of Emean was higher than Emax、Emin. The difference of BRAFV600E between the two groups showed statistically significant (χ2=16.16, P<0.01). The specificity, accuracy, negative predictive value and positive predictive value of SWE combined with BRAFV600E were all higher than single SWE and BRAFV600E with statistical significant (χ2=64.769, 35.406, 22.647, 20.247, all P<0.01). Conclusions SWE combined with BRAFV600E can significantly improve the specificity, accuracy, negative predictive value and positive predictive value in predicting Central Lymph Nodes metastasis of PTC. Key words: Thyroid neoplasms; Shear wave elastography; BRAFV600E; Lymphatic metastasis