The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Wanhong Yin - One of the best experts on this subject based on the ideXlab platform.
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therapy of Central Pontine Myelinolysis following living donor liver transplantation report of three cases
World Journal of Gastroenterology, 2009Co-Authors: Zhongwei Zhang, Yan Kang, Lijing Deng, Chuanxing Luo, Yan Zhou, Xinsheng Xue, Dong Wang, Wanhong YinAbstract:We analyzed the clinical manifestations and experiences of diagnosing and treating Central Pontine Myelinolysis following living donor liver transplantation. The clinical data of three patients with Central Pontine Myelinolysis following living donor liver transplantation from January 2005 to November 2007 were retrospectively analyzed at the West China Hospital, Sichuan University, China. The three patients developed hyponatremia prior to surgery. Case 1 suffered locked-in syndrome following surgery, and received a large dose of gamma globulin, and subsequently recovered. Case 2 was in a coma for three days, and received hyperbaric chamber treatment. This patient remained in a mild coma for six months following surgery. Case 3 developed consciousness disturbances, gradually went into a coma following surgery, and died due to pulmonary infection. Central Pontine Myelinolysis is a severe complication in patients following living donor liver transplantation. Large-dose gamma globulin treatment, as well as hyperbaric oxygen, might be effective therapeutic methods.
Koichi Tanaka - One of the best experts on this subject based on the ideXlab platform.
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subclinical Central Pontine Myelinolysis following liver transplantation
Brain & Development, 2002Co-Authors: Takeo Kato, Haruo Hattori, Masako Nagato, Tetsuya Kiuchi, Shinji Uemoto, Tatsutoshi Nakahata, Koichi TanakaAbstract:Central Pontine Myelinolysis (CPM) is a demyelinating disorder of unknown origin that almost exclusively affects the Central portion of the basis pontis, and is one of the fatal neurological complications after liver transplantation. We describe two children with CPM detected incidentally after liver transplantation. To our knowledge, this is the first report of CPM diagnosed antemortem in children who had undergone liver transplantation. In our patients, there were no clinical manifestations associated with CPM. We conclude that, including silent cases such as our patients, CPM may be more prevalent than previously appreciated following liver transplantation.
Zhongwei Zhang - One of the best experts on this subject based on the ideXlab platform.
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therapy of Central Pontine Myelinolysis following living donor liver transplantation report of three cases
World Journal of Gastroenterology, 2009Co-Authors: Zhongwei Zhang, Yan Kang, Lijing Deng, Chuanxing Luo, Yan Zhou, Xinsheng Xue, Dong Wang, Wanhong YinAbstract:We analyzed the clinical manifestations and experiences of diagnosing and treating Central Pontine Myelinolysis following living donor liver transplantation. The clinical data of three patients with Central Pontine Myelinolysis following living donor liver transplantation from January 2005 to November 2007 were retrospectively analyzed at the West China Hospital, Sichuan University, China. The three patients developed hyponatremia prior to surgery. Case 1 suffered locked-in syndrome following surgery, and received a large dose of gamma globulin, and subsequently recovered. Case 2 was in a coma for three days, and received hyperbaric chamber treatment. This patient remained in a mild coma for six months following surgery. Case 3 developed consciousness disturbances, gradually went into a coma following surgery, and died due to pulmonary infection. Central Pontine Myelinolysis is a severe complication in patients following living donor liver transplantation. Large-dose gamma globulin treatment, as well as hyperbaric oxygen, might be effective therapeutic methods.
Seung-bae Hwang - One of the best experts on this subject based on the ideXlab platform.
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Corticospinal Tract and Pontocerebellar Fiber of Central Pontine Myelinolysis
2016Co-Authors: Yong Min, Sung-hee Park, Seung-bae HwangAbstract:Central Pontine Myelinolysis is a rare neurologic disorder that is defined by demyelination of longitudinally descending tracts and transversly crossing fibers in the basis pontis. Frequently observed clinical manifestations of this disorder include sudden weakness, dysphagia, loss of consciouness and locked-in syndrome. However, there have been a few studies that reported a benign course of this disease, which include cerebellar signs, such as ataxia, intention tremor, and dysarthria. Here we report on a 53-year-old male with a history of liver cirrhosis who showed the cerebellar type of Central Pontine Myelinolysis. The patient was diagnosed with Central Pontine Myelinolysis based on clinical presentations and magnetic resonance imaging findings after a liver transplantation. Conventional magenetic resonance imaging (MRI) revealed the preservation of the corticospinal tract and abnormal pontocerebellar fibers. However, these findings were not sufficient to define the pathophysiology of our patient. Electrophysiologic analysis and diffusion tensor imaging (DTI) were performed to investigate cerebellar signs in this case. Delayed Central motor conduction time (CMCT) to the tibialis anterior muscle with transcranial magnetic stimulation (TMS) was observed, which indicated demyelination of the corticospinal tract. Also, diffusion tensor imaging showed abnormal pontocerebellar fibers, which might have been caused by cerebellar dysfunction in our patient. A combination of TMS and DTI was also used to determine the pathophysiology of this disease. Key Words Myelinolysis, Central motor conduction time, Transcranial magnetic stimulation, Diffusion tensor im-agin
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Corticospinal Tract and Pontocerebellar Fiber of Central Pontine Myelinolysis
Annals of rehabilitation medicine, 2012Co-Authors: Yong Min, Sung-hee Park, Seung-bae HwangAbstract:Central Pontine Myelinolysis is a rare neurologic disorder that is defined by demyelination of longitudinally descending tracts and transversly crossing fibers in the basis pontis. Frequently observed clinical manifestations of this disorder include sudden weakness, dysphagia, loss of consciouness and locked-in syndrome. However, there have been a few studies that reported a benign course of this disease, which include cerebellar signs, such as ataxia, intention tremor, and dysarthria. Here we report on a 53-year-old male with a history of liver cirrhosis who showed the cerebellar type of Central Pontine Myelinolysis. The patient was diagnosed with Central Pontine Myelinolysis based on clinical presentations and magnetic resonance imaging findings after a liver transplantation. Conventional magenetic resonance imaging (MRI) revealed the preservation of the corticospinal tract and abnormal pontocerebellar fibers. However, these findings were not sufficient to define the pathophysiology of our patient. Electrophysiologic analysis and diffusion tensor imaging (DTI) were performed to investigate cerebellar signs in this case. Delayed Central motor conduction time (CMCT) to the tibialis anterior muscle with transcranial magnetic stimulation (TMS) was observed, which indicated demyelination of the corticospinal tract. Also, diffusion tensor imaging showed abnormal pontocerebellar fibers, which might have been caused by cerebellar dysfunction in our patient. A combination of TMS and DTI was also used to determine the pathophysiology of this disease.
L. G. Hunsicker - One of the best experts on this subject based on the ideXlab platform.
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Temporal Changes of MR Findings in Central Pontine Myelinolysis
American Journal of Neuroradiology, 1995Co-Authors: William T. C. Yuh, T. M. Simonson, Michael P. D'alessandro, K. S. Smith, L. G. HunsickerAbstract:We report Central Pontine Myelinolysis in orthotopic liver transplant patients. Sequential MR imaging of these patients with Central Pontine Myelinolysis shows progressive decrease of T2-weighted MR signal in the pons, which may not resolve despite complete neurologic recovery.