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Jost B. Jonas - One of the best experts on this subject based on the ideXlab platform.

  • Frequency of spontaneous pulsations of the Central Retinal Vein in glaucoma.
    Journal of glaucoma, 2009
    Co-Authors: Ulrich Legler, Jost B. Jonas
    Abstract:

    Purpose To assess the prevalence of spontaneous pulsations of the Central Retinal Vein in eyes with chronic open-angle glaucoma versus normal eyes in the setting of a general ophthalmic practice. Methods The clinical observational case-series study included 167 eyes of 84 subjects with chronic open-angle glaucoma and 704 eyes (352 subjects) of a control group. The optic disc was ophthalmoscopically examined using a noncontact ophthalmoscopic lens at the slit lamp in medical mydriasis. Results Spontaneous pulsations of the Central Retinal Vein were observed in significantly (P=0.005; odds ratio, 0.59; 95% confidence interval, 0.41-0.84) fewer eyes of the glaucoma group (107/167 or 64.1%±3.7%%) than in the eyes of the control group (530/704 or 75.3%±1.6%). In both groups, the presence of a spontaneous Central Retinal Vein pulsation was statistically (P>0.10) independent of age, sex, refractive error, and intraocular pressure. Conclusions As examined in a nonreferral ophthalmic practice, eyes with chronic open-angle glaucoma compared with normal eyes show a significantly lower frequency of detected spontaneous pulsations of the Central Retinal Vein. Confirming previous hospital-based studies, the results suggest that assessment of the Central Retinal vessel pulsations, as part of an optic disc examination may clinically be useful for the diagnosis of glaucoma.

  • Assessment of the spontaneous pulsations of the Central Retinal Vein in daily ophthalmic practice
    Clinical & experimental ophthalmology, 2007
    Co-Authors: Ulrich Legler, Jost B. Jonas
    Abstract:

    The purpose of this study is to assess the frequency of eyes with a spontaneous pulsation of the Central Retinal Vein in the setting of a busy daily ophthalmic practice. The clinical observational case-series study included 690 eyes (345 subjects). The optic disc was ophthalmoscopically assessed using a non-contact ophthalmoscopic lens at the slit lamp. Out of the study population, 526 eyes (76.2%) of 265 (76.8%) subjects showed a detected spontaneous pulsation of the Central Retinal Vein (prevalence rate: 76.2 +/- 1.6% [mean +/- standard error] per eye, and 76.8 +/- 2.3% per subject). In univariate analysis, the presence of a detected spontaneous Central Retinal Vein pulsations was statistically associated with systolic systemic blood pressure (P = 0.04) and with the ocular perfusion pressure (P = 0.03). The results suggest that as examined in the setting of a busy daily ophthalmic practice, the Central Retinal Vein was found to show a spontaneous pulsation in about 80% of the subjects.

  • Frequency of spontaneous pulsations of the Central Retinal Vein
    The British journal of ophthalmology, 2007
    Co-Authors: Bjoern Harder, Jost B. Jonas
    Abstract:

    The Central Retinal Vein is the only structure in the body which can be examined non-invasively, runs through the cerebrospinal fluid space, and has a shape that depends on the relationship between its internal pressure and the pressure in the space surrounding it. Estimation of Central Retinal Vein pressure is, therefore, helpful in the assessment of cerebrospinal fluid pressure—that is, the intracranial pressure.1–4 Central Retinal Vein pressure may be assessed by determining the external pressure at which the Central Retinal Vein starts to pulsate. This method of assessment is similar to Riva-Rocci’s method of indirect measurement of arterial blood presure. For the Central Retinal Vein, the external pressure is the intraocular pressure. The purpose of the present study was to find out the proportion percentage of subjects in whom the Central Retinal Vein shows spontaneous pulsations, indicating that the pressure in the Vein is lower than the intraocular pressure. The assessment of spontaneous Retinal venous pulsations may be very useful …

  • Ophthalmodynamometry of Central Retinal Vein collapse pressure in idiopathic intracranial hypertension
    Klinische Monatsblatter fur Augenheilkunde, 2007
    Co-Authors: Harder B, Jost B. Jonas
    Abstract:

    BACKGROUND The diagnosis of idiopathic intracranial hypertension results from a synopsis of standardised examinations including MRI. Since the cerebrospinal fluid pressure influences the pressure of the Central Retinal Vein, it was the purpose of the present study to evaluate whether the ophthalmodynamometric estimation of the Central Retinal Vein collapse pressure is helpful for the diagnosis of idiopathic intracranial hypertension. PATIENTS AND METHODS The study included 5 patients with idiopathic intracranial hypertension with a mean age of 38.3+/-10.8 years and 88 subjects of a control group with a mean age of 66.8+/-13.1 years. Using a modified corneal contact lens-associated ophthalmodynamometry, the collapse pressure of the Central Retinal Vein was estimated. RESULTS The Central Retinal Vein collapse pressure was significantly higher in the study group (33.0+/-27.3 relative units) than in the control group (2.0+/-6.7 relative units) (p

Birgitta Bauer - One of the best experts on this subject based on the ideXlab platform.

  • Fluorescein angiography versus ERG for predicting the prognosis in Central Retinal Vein occlusion.
    Acta ophthalmologica Scandinavica, 1998
    Co-Authors: Jörgen Larsson, Birgitta Bauer, Ulla Cavallin‐sjöberg, Sten Andréasson
    Abstract:

    PURPOSE It is not easy to predict which patients with a Central Retinal Vein occlusion will develop rubeosis and which will not. We have compared two methods for doing so, fluorescein angiography and full-field electroretinogram (ERG). Our aim was to improve our possibilities for predicting rubeosis in patients with Central Vein occlusion. METHODS 32 patients with a Central Retinal Vein occlusion with a duration of less than 14 days were included in the study. Fluorescein angiography and ERG were performed in all patients. The fluorescein angiograms were studied by two independent examiners in a masked mode. The patients were then followed for at least one year. RESULTS Development of rubeosis in patients with Central Retinal Vein occlusion could be predicted by fluorescein angiography in 82% of the patients and with ERG in 94% of the patients. The non-ischemic Central Retinal Vein occlusions were identified in 62% by fluorescein angiography and in 100% with ERG. Fluorescein angiography misjudged 9 patients 28%, whereas ERG only misjudged 1 patient, 3%. CONCLUSION ERG seems to be a better method for predicting the prognosis in Central Retinal Vein occlusion than fluorescein angiography.

  • Activated protein C resistance in patients with Central Retinal Vein occlusion
    The British journal of ophthalmology, 1997
    Co-Authors: Jörgen Larsson, A Sellman, Birgitta Bauer
    Abstract:

    AIM/BACKGROUND—A new defect in the anticoagulant system has recently been discovered—activated protein C resistance. The frequency of this disorder has been shown to be increased in young patients ( 50 years of age with Central Retinal Vein occlusion. METHODS—Blood samples were obtained from 83 patients >50 years of age and with a history of Central Retinal Vein occlusion. The blood samples were analysed for activated protein C resistance with standard clinical laboratory methods. RESULTS—In this material 11% of the patients were resistant to activated protein C. The normal incidence of activated protein C resistance in the same geographical area is 10-11%. CONCLUSION—Activated protein C resistance does not seem to be a cause of Central Retinal Vein occlusion in people older than 50 years.

  • Activated protein C resistance in young adults with Central Retinal Vein occlusion.
    The British journal of ophthalmology, 1996
    Co-Authors: Jörgen Larsson, E. Olafsdottir, Birgitta Bauer
    Abstract:

    BACKGROUND: Central Retinal Vein occlusion is a disease that is most common in old people. While the disease in old people often is associated with atherosclerosis, hypertension, diabetes, or glaucoma, this is much less evident in young people. However, a new defect in the anticoagulant system has recently been discovered, activated protein C resistance. This hereditary defect may well be associated with Central Retinal Vein occlusion, and so this factor was analysed in patients younger than 50 years with a history of Central Retinal Vein occlusion. METHODS: Blood samples were obtained from 31 patients younger than 50 years with a history of Central Retinal Vein occlusion, and analysed for activated protein C resistance with standard clinical laboratory methods. RESULTS: In this material 26% of all the patients and 36% of the patients younger than 45 years were resistant to activated protein C. The normal incidence of activated protein C resistance is 2-7%. CONCLUSION: Activated protein C resistance seems to be the most common known cause of Central Retinal Vein occlusion in young people.

Jörgen Larsson - One of the best experts on this subject based on the ideXlab platform.

  • Hyperhomocysteinemia and the MTHFR C677T mutation in Central Retinal Vein occlusion.
    Acta ophthalmologica Scandinavica, 2000
    Co-Authors: Jörgen Larsson, B. Hultberg, A. Hillarp
    Abstract:

    . Background: Hyperhomocysteinemia is a factor that predisposes to thrombosis, and the C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) is known to give increased plasma homocysteine. We wanted to investigate if these factors were overrepresented in a group of patients with Central Retinal Vein occlusion. Methods: 116 patients with a history of Central Retinal Vein occlusion were examined for the presence of hyperhomocysteinemia and the MTHFR C677T mutation. Results: Compared to the control groups, there was no significant increase, neither in plasma homocysteine nor in the frequency of the MTHFR C677T mutation in the patients. Even when we looked selectively at the young patients, age less than 50 years, no difference could be detected. Conclusion: It seems that neither hyperhomocysteinemia nor the MTHFR C677T mutation is an important risk factor for the aetiology of Central Retinal Vein occlusion.

  • Fluorescein angiography versus ERG for predicting the prognosis in Central Retinal Vein occlusion.
    Acta ophthalmologica Scandinavica, 1998
    Co-Authors: Jörgen Larsson, Birgitta Bauer, Ulla Cavallin‐sjöberg, Sten Andréasson
    Abstract:

    PURPOSE It is not easy to predict which patients with a Central Retinal Vein occlusion will develop rubeosis and which will not. We have compared two methods for doing so, fluorescein angiography and full-field electroretinogram (ERG). Our aim was to improve our possibilities for predicting rubeosis in patients with Central Vein occlusion. METHODS 32 patients with a Central Retinal Vein occlusion with a duration of less than 14 days were included in the study. Fluorescein angiography and ERG were performed in all patients. The fluorescein angiograms were studied by two independent examiners in a masked mode. The patients were then followed for at least one year. RESULTS Development of rubeosis in patients with Central Retinal Vein occlusion could be predicted by fluorescein angiography in 82% of the patients and with ERG in 94% of the patients. The non-ischemic Central Retinal Vein occlusions were identified in 62% by fluorescein angiography and in 100% with ERG. Fluorescein angiography misjudged 9 patients 28%, whereas ERG only misjudged 1 patient, 3%. CONCLUSION ERG seems to be a better method for predicting the prognosis in Central Retinal Vein occlusion than fluorescein angiography.

  • Activated protein C resistance in patients with Central Retinal Vein occlusion
    The British journal of ophthalmology, 1997
    Co-Authors: Jörgen Larsson, A Sellman, Birgitta Bauer
    Abstract:

    AIM/BACKGROUND—A new defect in the anticoagulant system has recently been discovered—activated protein C resistance. The frequency of this disorder has been shown to be increased in young patients ( 50 years of age with Central Retinal Vein occlusion. METHODS—Blood samples were obtained from 83 patients >50 years of age and with a history of Central Retinal Vein occlusion. The blood samples were analysed for activated protein C resistance with standard clinical laboratory methods. RESULTS—In this material 11% of the patients were resistant to activated protein C. The normal incidence of activated protein C resistance in the same geographical area is 10-11%. CONCLUSION—Activated protein C resistance does not seem to be a cause of Central Retinal Vein occlusion in people older than 50 years.

  • Activated protein C resistance in young adults with Central Retinal Vein occlusion.
    The British journal of ophthalmology, 1996
    Co-Authors: Jörgen Larsson, E. Olafsdottir, Birgitta Bauer
    Abstract:

    BACKGROUND: Central Retinal Vein occlusion is a disease that is most common in old people. While the disease in old people often is associated with atherosclerosis, hypertension, diabetes, or glaucoma, this is much less evident in young people. However, a new defect in the anticoagulant system has recently been discovered, activated protein C resistance. This hereditary defect may well be associated with Central Retinal Vein occlusion, and so this factor was analysed in patients younger than 50 years with a history of Central Retinal Vein occlusion. METHODS: Blood samples were obtained from 31 patients younger than 50 years with a history of Central Retinal Vein occlusion, and analysed for activated protein C resistance with standard clinical laboratory methods. RESULTS: In this material 26% of all the patients and 36% of the patients younger than 45 years were resistant to activated protein C. The normal incidence of activated protein C resistance is 2-7%. CONCLUSION: Activated protein C resistance seems to be the most common known cause of Central Retinal Vein occlusion in young people.

Ulrich Legler - One of the best experts on this subject based on the ideXlab platform.

  • Frequency of spontaneous pulsations of the Central Retinal Vein in glaucoma.
    Journal of glaucoma, 2009
    Co-Authors: Ulrich Legler, Jost B. Jonas
    Abstract:

    Purpose To assess the prevalence of spontaneous pulsations of the Central Retinal Vein in eyes with chronic open-angle glaucoma versus normal eyes in the setting of a general ophthalmic practice. Methods The clinical observational case-series study included 167 eyes of 84 subjects with chronic open-angle glaucoma and 704 eyes (352 subjects) of a control group. The optic disc was ophthalmoscopically examined using a noncontact ophthalmoscopic lens at the slit lamp in medical mydriasis. Results Spontaneous pulsations of the Central Retinal Vein were observed in significantly (P=0.005; odds ratio, 0.59; 95% confidence interval, 0.41-0.84) fewer eyes of the glaucoma group (107/167 or 64.1%±3.7%%) than in the eyes of the control group (530/704 or 75.3%±1.6%). In both groups, the presence of a spontaneous Central Retinal Vein pulsation was statistically (P>0.10) independent of age, sex, refractive error, and intraocular pressure. Conclusions As examined in a nonreferral ophthalmic practice, eyes with chronic open-angle glaucoma compared with normal eyes show a significantly lower frequency of detected spontaneous pulsations of the Central Retinal Vein. Confirming previous hospital-based studies, the results suggest that assessment of the Central Retinal vessel pulsations, as part of an optic disc examination may clinically be useful for the diagnosis of glaucoma.

  • Assessment of the spontaneous pulsations of the Central Retinal Vein in daily ophthalmic practice
    Clinical & experimental ophthalmology, 2007
    Co-Authors: Ulrich Legler, Jost B. Jonas
    Abstract:

    The purpose of this study is to assess the frequency of eyes with a spontaneous pulsation of the Central Retinal Vein in the setting of a busy daily ophthalmic practice. The clinical observational case-series study included 690 eyes (345 subjects). The optic disc was ophthalmoscopically assessed using a non-contact ophthalmoscopic lens at the slit lamp. Out of the study population, 526 eyes (76.2%) of 265 (76.8%) subjects showed a detected spontaneous pulsation of the Central Retinal Vein (prevalence rate: 76.2 +/- 1.6% [mean +/- standard error] per eye, and 76.8 +/- 2.3% per subject). In univariate analysis, the presence of a detected spontaneous Central Retinal Vein pulsations was statistically associated with systolic systemic blood pressure (P = 0.04) and with the ocular perfusion pressure (P = 0.03). The results suggest that as examined in the setting of a busy daily ophthalmic practice, the Central Retinal Vein was found to show a spontaneous pulsation in about 80% of the subjects.

Shaul Merin - One of the best experts on this subject based on the ideXlab platform.

  • Central Retinal Vein occlusions in young adults
    Acta ophthalmologica, 2009
    Co-Authors: Joseph Frucht, L. Yanko, Shaul Merin
    Abstract:

    This study was a long term follow-up of 11 young adults aged 15-45 with Central Retinal Vein occlusion (CRVO). Seven patients classified as the ischemic type of CRVO showed a poor visual acuity at the first examination and did not improve throughout the study. In addition, systemic diseases were found in all these patients. Four patients classified as venous stasis retinopathy type of CRVO, had, in contrast, fairly good visual acuity at the first examination and showed additional improvement during the follow-up period. No systemic diseases were detected. Physical examinations are recommended periodically for young adults with ischemic type of Central Retinal Vein occlusion.