The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
D. K. Hossfeld - One of the best experts on this subject based on the ideXlab platform.
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Translocation (14; 18) and (8; 22) in three patients with acute leukemia/Lymphoma following centrocytic/Centroblastic non-Hodgkin's Lymphoma
Annals of Hematology, 1991Co-Authors: W. Fiedler, W. Zeller, C. Fonatsch, J. Hillion, C. Larsen, B. Wörmann, D. K. HossfeldAbstract:Three patients with centrocytic/Centroblastic Lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
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translocation 14 18 and 8 22 in three patients with acute leukemia Lymphoma following centrocytic Centroblastic non hodgkin s Lymphoma
Annals of Hematology, 1991Co-Authors: W. Fiedler, W. Zeller, C. Fonatsch, J. Hillion, C. Larsen, B. Wörmann, D. K. HossfeldAbstract:Three patients with centrocytic/Centroblastic Lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
Isaac Tafur - One of the best experts on this subject based on the ideXlab platform.
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cytokeratin positive cd45 negative primary Centroblastic Lymphoma of the adrenal gland
2009Co-Authors: Ludvik R Donner, Frank E Mott, Isaac TafurAbstract:Abstract We report a case of cytokeratin-positive, CD45-negative primary polymorphic Centroblastic Lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 a...
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cytokeratin positive cd45 negative primary Centroblastic Lymphoma of the adrenal gland a potential for a diagnostic pitfall
Archives of Pathology & Laboratory Medicine, 2001Co-Authors: Ludvik R Donner, Frank E Mott, Isaac TafurAbstract:We report a case of cytokeratin-positive, CD45-negative primary polymorphic Centroblastic Lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 and K light chain, as well as detection of the monoclonal rearrangement of the immunoglobulin heavy chain gene, helped to establish the diagnosis of Lymphoma and to rule out an initially favored diagnosis of poorly differentiated carcinoma.
Ludvik R Donner - One of the best experts on this subject based on the ideXlab platform.
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cytokeratin positive cd45 negative primary Centroblastic Lymphoma of the adrenal gland
2009Co-Authors: Ludvik R Donner, Frank E Mott, Isaac TafurAbstract:Abstract We report a case of cytokeratin-positive, CD45-negative primary polymorphic Centroblastic Lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 a...
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cytokeratin positive cd45 negative primary Centroblastic Lymphoma of the adrenal gland a potential for a diagnostic pitfall
Archives of Pathology & Laboratory Medicine, 2001Co-Authors: Ludvik R Donner, Frank E Mott, Isaac TafurAbstract:We report a case of cytokeratin-positive, CD45-negative primary polymorphic Centroblastic Lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 and K light chain, as well as detection of the monoclonal rearrangement of the immunoglobulin heavy chain gene, helped to establish the diagnosis of Lymphoma and to rule out an initially favored diagnosis of poorly differentiated carcinoma.
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Cytogenetics of Lymphomas: A brief review of its theoretical and practical significance
Cancer Genetics and Cytogenetics, 1997Co-Authors: Ludvik R DonnerAbstract:Abstract The following specific or characteristic chromosomal abnormalities are known: t(11;18)(q21;q21) in a subset of marginal zone Lymphoma, t(14;18)(q32.3;q21.3) in Centroblastic-centrocytic Lymphoma, t(11;14)(q13;q32) in mantle cell Lymphoma, rearrangement 3q27 in Centroblastic Lymphoma, t(8;14)(q24;q32) in Burkitt's Lymphoma, t(2;5)(p23;q35) in large cell anaplastic Lymphoma of T-type and O-type, i(7)(q10) in hepatosplenic γδ T-cell Lymphoma, and t(8;13)(p11;q11–12) in T-cell lymphoblastic Lymphoma with eosinophilia and myeloid malignancy.
W. Fiedler - One of the best experts on this subject based on the ideXlab platform.
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Translocation (14; 18) and (8; 22) in three patients with acute leukemia/Lymphoma following centrocytic/Centroblastic non-Hodgkin's Lymphoma
Annals of Hematology, 1991Co-Authors: W. Fiedler, W. Zeller, C. Fonatsch, J. Hillion, C. Larsen, B. Wörmann, D. K. HossfeldAbstract:Three patients with centrocytic/Centroblastic Lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
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translocation 14 18 and 8 22 in three patients with acute leukemia Lymphoma following centrocytic Centroblastic non hodgkin s Lymphoma
Annals of Hematology, 1991Co-Authors: W. Fiedler, W. Zeller, C. Fonatsch, J. Hillion, C. Larsen, B. Wörmann, D. K. HossfeldAbstract:Three patients with centrocytic/Centroblastic Lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
W. Zeller - One of the best experts on this subject based on the ideXlab platform.
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Translocation (14; 18) and (8; 22) in three patients with acute leukemia/Lymphoma following centrocytic/Centroblastic non-Hodgkin's Lymphoma
Annals of Hematology, 1991Co-Authors: W. Fiedler, W. Zeller, C. Fonatsch, J. Hillion, C. Larsen, B. Wörmann, D. K. HossfeldAbstract:Three patients with centrocytic/Centroblastic Lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
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translocation 14 18 and 8 22 in three patients with acute leukemia Lymphoma following centrocytic Centroblastic non hodgkin s Lymphoma
Annals of Hematology, 1991Co-Authors: W. Fiedler, W. Zeller, C. Fonatsch, J. Hillion, C. Larsen, B. Wörmann, D. K. HossfeldAbstract:Three patients with centrocytic/Centroblastic Lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.