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Haim Sohmer - One of the best experts on this subject based on the ideXlab platform.
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contribution of the eighth nerve and cranial nerve nuclei to the short latency vestibular evoked potentials in cats
Otolaryngology-Head and Neck Surgery, 1997Co-Authors: Gang Li, Yulia Meyler, Josef Elidan, Haim SohmerAbstract:Abstract The object of this study was to assess the contributions of the vestibular nerve and various cranial nerve nuclei to the short-latency vestibular evoked potentials in cat. The following nuclei were investigated: vestibular nuclei and the third, sixth, and tenth cranial nerve nuclei. In unilateral labyrinthectomized cats, we performed suboccipital craniectomy and partial Cerebellectomy to place bipolar electrodes into the neural structures under investigation. The surface-recorded vestibular evoked potentials (far field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injection of lidocaine 2%. The results indicate that the first wave of the vestibular evoked potentials originates in the vestibular nerve, and the second wave is mainly generated in the superior and medial vestibular nuclei. The third, sixth, and tenth cranial nerve nuclei apparently contribute to the later waves of the vestibular evoked potentials, particularly waves 3 and 4. (Otolaryngol Head Neck Surg 1997;116:181-8.)
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the contribution of cranial nerve nuclei to the short latency vestibular evoked potentials in cat
Acta Oto-laryngologica, 1995Co-Authors: Josef Elidan, Gang Li, Haim SohmerAbstract:The object of this study was to assess the contributions of various cranial nerve nuclei to the short latency vestibular evoked potentials (VsEPs) in cat. The following nuclei were investigated: vestibular nuclei, and 3rd, 6th and 10th cranial nerve nuclei. In unilateral labyrinthectomized cats, suboccipital craniectomy and partial Cerebellectomy were carried out in order to place bipolar electrodes into the neural structures under investigation. The surface recorded VsEPs (far-field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injecting of lignocaine 2%. The results indicate that the 2nd wave (P2) is mainly generated in the superior and medial vestibular nuclei. The 3rd, 6th and 10th cranial nerve nuclei apparently contribute to the later waves of the VsEPs, particularly P3 and P4
Gang Li - One of the best experts on this subject based on the ideXlab platform.
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contribution of the eighth nerve and cranial nerve nuclei to the short latency vestibular evoked potentials in cats
Otolaryngology-Head and Neck Surgery, 1997Co-Authors: Gang Li, Yulia Meyler, Josef Elidan, Haim SohmerAbstract:Abstract The object of this study was to assess the contributions of the vestibular nerve and various cranial nerve nuclei to the short-latency vestibular evoked potentials in cat. The following nuclei were investigated: vestibular nuclei and the third, sixth, and tenth cranial nerve nuclei. In unilateral labyrinthectomized cats, we performed suboccipital craniectomy and partial Cerebellectomy to place bipolar electrodes into the neural structures under investigation. The surface-recorded vestibular evoked potentials (far field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injection of lidocaine 2%. The results indicate that the first wave of the vestibular evoked potentials originates in the vestibular nerve, and the second wave is mainly generated in the superior and medial vestibular nuclei. The third, sixth, and tenth cranial nerve nuclei apparently contribute to the later waves of the vestibular evoked potentials, particularly waves 3 and 4. (Otolaryngol Head Neck Surg 1997;116:181-8.)
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the contribution of cranial nerve nuclei to the short latency vestibular evoked potentials in cat
Acta Oto-laryngologica, 1995Co-Authors: Josef Elidan, Gang Li, Haim SohmerAbstract:The object of this study was to assess the contributions of various cranial nerve nuclei to the short latency vestibular evoked potentials (VsEPs) in cat. The following nuclei were investigated: vestibular nuclei, and 3rd, 6th and 10th cranial nerve nuclei. In unilateral labyrinthectomized cats, suboccipital craniectomy and partial Cerebellectomy were carried out in order to place bipolar electrodes into the neural structures under investigation. The surface recorded VsEPs (far-field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injecting of lignocaine 2%. The results indicate that the 2nd wave (P2) is mainly generated in the superior and medial vestibular nuclei. The 3rd, 6th and 10th cranial nerve nuclei apparently contribute to the later waves of the VsEPs, particularly P3 and P4
J. Caston - One of the best experts on this subject based on the ideXlab platform.
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Differential Roles of Cerebellar Cortex and Deep Cerebellar Nuclei in Learning and Retention of a Spatial Task: Studies in Intact and Cerebellectomized Lurcher Mutant Mice
Behavior Genetics, 1998Co-Authors: P. Hilber, F. Jouen, N. Delhaye-bouchaud, J. Mariani, J. CastonAbstract:Lurcher mutant mice (+/Lc) exhibit a massive loss of neurons in the cerebellar cortex and the inferior olivary nucleus, while deep cerebellar nuclei are essentially intact. To discriminate the relative participation of the cerebellar cortex and deep structures in learning and memory, 3 to 6-month-old +/Lc mice were subjected to a spatial learning task derived from the Morris water escape. They were able to learn to escape as well as their strain-matched controls (+/+). Seven days later, their scores showed that they had memorized the spatial environment but not as accurately as +/+ mice. Cerebellectomy before training did not significantly alter the escape learning capabilities of either group, whereas Cerebellectomy performed after learning completely abolished retention in +/+, as well as in +/Lc, mice. These results suggest that the cerebellum, although not necessary for learning a spatial task, plays a crucial role in its retention, and that the storing structure of spatial information differs in +/+ and +/Lc mice.
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Differential roles of cerebellar cortex and deep cerebellar nuclei in the learning of the equilibrium behavior: studies in intact and cerebellectomized lurcher mutant mice.
Brain research. Developmental brain research, 1995Co-Authors: J. Caston, T. Stelz, N. Delhaye-bouchaud, F Vasseur, C Chianale, J. MarianiAbstract:Three- to 6-month-old lurcher mutant mice (+/lc), which exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus but whose deep cerebellar nuclei are essentially intact, were trained daily, for 9 days, to maintain their equilibrium upon a rota rod rotating at 20 or 30 revolutions per minute (rpm). Their scores were measured and their behavior upon the rotating rod quantified in comparison to those of matched control (+/+) mice. Lurcher mice were able to learn to maintain their equilibrium efficiently when rotated at 20 rpm but were not when rotated at 30 rpm. After Cerebellectomy, the equilibrium capabilities of the animals were much altered, especially in +/lc. These results show that the deep cerebellar nuclei are sufficient for motor learning, provided the task is not too difficult (20 rpm), but that the cerebellar cortex is required when the task is more difficult (30 rpm). Therefore, it can be concluded that the adaptive motor capabilities of lurcher mice are less developed than those of control animals.
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Role of preoperative and postoperative sensorimotor training on restoration of the equilibrium behavior in adult mice following Cerebellectomy.
Neurobiology of learning and memory, 1995Co-Authors: J. Caston, Nicola Jones, T. StelzAbstract:The equilibrium behavior of cerebellectomized C57/BL6 adult mice was studied on a rota rod rotating at 20 revolutions per minute and the influence of preoperative or/and postoperative training on restoration of equilibrium capabilities investigated. The duration of the preoperative training was either short (1 day) or long (7 days). The postoperative training began either the day after Cerebellectomy or was delayed by 7 days. The results demonstrate that postoperative training was efficient in restoring the equilibrium behavior in all cases, except for the animals which were trained for a long period (7 days) before the lesion. Preoperative training was also efficient providing it was long enough (7 days), except for the animals which postoperative training began the day after Cerebellectomy. It can be stated that both preoperative and postoperative trainings influence the restoration of the equilibrium following a Cerebellectomy and that, in some instances, preoperative training can be as efficient as postoperative.
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CEREBELLUM AND MEMORY : AN EXPERIMENTAL STUDY IN THE RAT USING A PASSIVE AVOIDANCE CONDITIONING TEST
Physiology & behavior, 1991Co-Authors: S. Guillaumin, M. Dahhaoui, J. CastonAbstract:Adult DA/HAN strain rats were submitted to a one-trial passive avoidance conditioning procedure consisting in associating darkness with a nociceptive stimulus. Seven or fourteen days after the one-trial initial experience, they were tested again in order to know whether they had forgotten it or not. The animals were divided into two experimental groups, the rats being either conditioned (COC group) or not (NOC group) before Cerebellectomy, and two control groups, the animals being either intact (C group) or sham-operated (SO group). Each group was divided into two subgroups, one being given the retrieval test 7 days and the other 14 days after the initial conditioning. The results show that retention in C, SO and NOC rats was similar whether the animals were tested 7 days or 14 days after the initial one-trial conditioning. Seven days after their initial experience and the Cerebellectomy, the retention in COC rats was null while when they were tested 14 days after cerebellar removal these animals had much better scores, significantly higher than 7 days after the lesion. It is concluded that the cerebellum is involved in the consolidation processes of the memory trace but is not the site of memory storage.
Josef Elidan - One of the best experts on this subject based on the ideXlab platform.
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contribution of the eighth nerve and cranial nerve nuclei to the short latency vestibular evoked potentials in cats
Otolaryngology-Head and Neck Surgery, 1997Co-Authors: Gang Li, Yulia Meyler, Josef Elidan, Haim SohmerAbstract:Abstract The object of this study was to assess the contributions of the vestibular nerve and various cranial nerve nuclei to the short-latency vestibular evoked potentials in cat. The following nuclei were investigated: vestibular nuclei and the third, sixth, and tenth cranial nerve nuclei. In unilateral labyrinthectomized cats, we performed suboccipital craniectomy and partial Cerebellectomy to place bipolar electrodes into the neural structures under investigation. The surface-recorded vestibular evoked potentials (far field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injection of lidocaine 2%. The results indicate that the first wave of the vestibular evoked potentials originates in the vestibular nerve, and the second wave is mainly generated in the superior and medial vestibular nuclei. The third, sixth, and tenth cranial nerve nuclei apparently contribute to the later waves of the vestibular evoked potentials, particularly waves 3 and 4. (Otolaryngol Head Neck Surg 1997;116:181-8.)
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the contribution of cranial nerve nuclei to the short latency vestibular evoked potentials in cat
Acta Oto-laryngologica, 1995Co-Authors: Josef Elidan, Gang Li, Haim SohmerAbstract:The object of this study was to assess the contributions of various cranial nerve nuclei to the short latency vestibular evoked potentials (VsEPs) in cat. The following nuclei were investigated: vestibular nuclei, and 3rd, 6th and 10th cranial nerve nuclei. In unilateral labyrinthectomized cats, suboccipital craniectomy and partial Cerebellectomy were carried out in order to place bipolar electrodes into the neural structures under investigation. The surface recorded VsEPs (far-field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injecting of lignocaine 2%. The results indicate that the 2nd wave (P2) is mainly generated in the superior and medial vestibular nuclei. The 3rd, 6th and 10th cranial nerve nuclei apparently contribute to the later waves of the VsEPs, particularly P3 and P4
Yulia Meyler - One of the best experts on this subject based on the ideXlab platform.
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contribution of the eighth nerve and cranial nerve nuclei to the short latency vestibular evoked potentials in cats
Otolaryngology-Head and Neck Surgery, 1997Co-Authors: Gang Li, Yulia Meyler, Josef Elidan, Haim SohmerAbstract:Abstract The object of this study was to assess the contributions of the vestibular nerve and various cranial nerve nuclei to the short-latency vestibular evoked potentials in cat. The following nuclei were investigated: vestibular nuclei and the third, sixth, and tenth cranial nerve nuclei. In unilateral labyrinthectomized cats, we performed suboccipital craniectomy and partial Cerebellectomy to place bipolar electrodes into the neural structures under investigation. The surface-recorded vestibular evoked potentials (far field) were compared with the potentials recorded intracranially in response to the same acceleration impulses. The exact locations were later confirmed histologically. Reversible lesions also were induced by injection of lidocaine 2%. The results indicate that the first wave of the vestibular evoked potentials originates in the vestibular nerve, and the second wave is mainly generated in the superior and medial vestibular nuclei. The third, sixth, and tenth cranial nerve nuclei apparently contribute to the later waves of the vestibular evoked potentials, particularly waves 3 and 4. (Otolaryngol Head Neck Surg 1997;116:181-8.)