The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform

Jason R. Lees - One of the best experts on this subject based on the ideXlab platform.

  • Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development.
    Immunology, 2013
    Co-Authors: Jason R. Lees
    Abstract:

    In region‐specific forms of experimental autoimmune encephalomyelitis (EAE), lesion initiation is regulated by T‐cell‐produced interferon‐γ (IFN‐γ) resulting in spinal cord Disease in the presence of IFN‐γ and cerebellar Disease in the absence of IFN‐γ. Although this role for IFN‐γ in regional Disease initiation is well defined, little is known about the consequences of previous tissue inflammation on subsequent regional Disease, information vital to the development of therapeutics in established Disease states. This study addressed the hypothesis that previous establishment of regional EAE would determine subsequent tissue localization of new T‐cell invasion and associated symptoms regardless of the presence or absence of IFN‐γ production. Serial transfer of optimal or suboptimal doses of encephalitogenic IFN‐γ‐sufficient or ‐deficient T‐cell lines was used to examine the development of new clinical responses associated with the spinal cord and Cerebellum at various times after EAE initiation. Previous inflammation within either Cerebellum or spinal cord allowed subsequent T‐cell driven inflammation within that tissue regardless of IFN‐γ presence. Further, T‐cell IFN‐γ production after initial lesion formation exacerbated Disease within the Cerebellum, suggesting that IFN‐γ plays different roles at different stages of cerebellar Disease. For the spinal cord, IFN‐γ‐deficient cells (that are ordinarily Cerebellum Disease initiators) were capable of driving new spinal‐cord‐associated clinical symptoms more than 60 days after the initial acute EAE resolution. These data suggest that previous inflammation modulates the molecular requirements for new neuroinflammation development.

Luc Devriese - One of the best experts on this subject based on the ideXlab platform.

  • Experimental Streptococcus bovis infections in pigeons
    Avian Diseases, 1992
    Co-Authors: P. De Herdt, M. Desmidt, Richard Ducatelle, Freddy Haesebrouck, Luc Devriese
    Abstract:

    SUMMARY. Thirty pigeons were experimentally infected with Streptococcus bovis using an intravenous infection model. Ninety percent of the inoculated pigeons developed clinical Disease. Disease signs included acute death, inability to fly, lameness, inappetence, emaciation, polyuria, and the production of slimy, green droppings. At necropsy, the septicemic character of the Disease was evident. Typical lesions included extensive well-circumscribed areas of necrosis in the pectoral muscle, tenosynovitis of the tendon of the Musculus pectoralis profundus, and arthritis of the stifle, tibiotarsal, or shoulder joints. Focal myocardial necrosis also was seen. Meningitis and encephalitis occurred in the cerebrum and the Cerebellum. Disease signs and lesions described here after experimental infection were similar to those in naturally occurring cases of S. bovis septicemia.

Shang Weihong - One of the best experts on this subject based on the ideXlab platform.

  • Value of MRI diagnose on Cerebellum Disease
    Heilongjiang Medicine and Pharmacy, 2011
    Co-Authors: Shang Weihong
    Abstract:

    Objective:To evaluate the value of magnetic resonance imaging(MRI) diagnosis and differential diagnosis on cerebellar Disease.Methods:A retrospective analysis of 86 cases of cerebellar lesions examined under MRI in our hospital from April 2009 to April 2010,combined with pathological findings and clinical diagnosis and treatment information,to study diagnostic method of the Cerebellum lesions.Results:In 86 patients 15 cases of lesions,38 cases of cerebral infarction,hemorrhage in 4 cases,6 cases of cerebellar atrophy limited,23 cases of cerebellar tonsillar herniation can be found.Overall correct diagnosis rate was 95.7%.Conclusion:MRI scans of the cerebellar lesion has a certain role in the diagnosis and differential diagnosis.

P. De Herdt - One of the best experts on this subject based on the ideXlab platform.

  • Experimental Streptococcus bovis infections in pigeons
    Avian Diseases, 1992
    Co-Authors: P. De Herdt, M. Desmidt, Richard Ducatelle, Freddy Haesebrouck, Luc Devriese
    Abstract:

    SUMMARY. Thirty pigeons were experimentally infected with Streptococcus bovis using an intravenous infection model. Ninety percent of the inoculated pigeons developed clinical Disease. Disease signs included acute death, inability to fly, lameness, inappetence, emaciation, polyuria, and the production of slimy, green droppings. At necropsy, the septicemic character of the Disease was evident. Typical lesions included extensive well-circumscribed areas of necrosis in the pectoral muscle, tenosynovitis of the tendon of the Musculus pectoralis profundus, and arthritis of the stifle, tibiotarsal, or shoulder joints. Focal myocardial necrosis also was seen. Meningitis and encephalitis occurred in the cerebrum and the Cerebellum. Disease signs and lesions described here after experimental infection were similar to those in naturally occurring cases of S. bovis septicemia.

Kunikatsu Takase - One of the best experts on this subject based on the ideXlab platform.

  • Construction of gait adaptation model in human splitbelt treadmill walking
    Applied Bionics and Biomechanics, 2009
    Co-Authors: Yuji Otoda, Hiroshi Kimura, Kunikatsu Takase
    Abstract:

    There are a huge number of studies that measure kinematics, dynamics, the oxygen uptake and so on in human walking on the treadmill. Especially in walking on the splitbelt treadmill where the speed of the right and left belt is different, remarkable differences in kinematics are seen between normal and cerebellar Disease subjects. In order to construct the gait adaptation model of such human splitbelt treadmill walking, we proposed a simple control model and made a newly developed 2D biped robot walk on the splitbelt treadmill. We combined the conventional limit-cycle based control consisting of joint PD-control, cyclic motion trajectory planning and a stepping reflex with a newly proposed adjustment of P-gain at the hip joint of the stance leg. We showed that the data of robot normal subject model and Cerebellum Disease subject model experiments had high similarities with the data of normal subjects and Cerebellum Disease subjects experiments carried out by Reisman et al. 2005 and Morton and Bastian 2006 in ratios and patterns. We also showed that P-gain at the hip joint of the stance leg was the control parameter of adaptation for symmetric gaits in splitbelt walking and P-gain adjustment corresponded to muscle stiffness adjustment by the Cerebellum. Consequently, we successfully proposed the gait adaptation model in human splitbelt treadmill walking and confirmed the validity of our hypotheses and the proposed model using the biped robot.