The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform

Fuchun Lin - One of the best experts on this subject based on the ideXlab platform.

  • altered activation in Cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in parkinson s disease a short term regional homogeneity fmri study
    PLOS ONE, 2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    Background Ventral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear. Purpose We used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression. Methods 26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined. Results The impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively. Conclusion The specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

  • Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson’s Disease: A Short-Term Regional Homogeneity fMRI Study
    2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    BackgroundVentral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear.PurposeWe used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression.Methods26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined.ResultsThe impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively.ConclusionThe specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

Zhi Wen - One of the best experts on this subject based on the ideXlab platform.

  • altered activation in Cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in parkinson s disease a short term regional homogeneity fmri study
    PLOS ONE, 2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    Background Ventral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear. Purpose We used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression. Methods 26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined. Results The impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively. Conclusion The specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

  • Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson’s Disease: A Short-Term Regional Homogeneity fMRI Study
    2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    BackgroundVentral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear.PurposeWe used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression.Methods26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined.ResultsThe impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively.ConclusionThe specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

Jie Zhang - One of the best experts on this subject based on the ideXlab platform.

  • altered activation in Cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in parkinson s disease a short term regional homogeneity fmri study
    PLOS ONE, 2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    Background Ventral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear. Purpose We used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression. Methods 26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined. Results The impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively. Conclusion The specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

  • Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson’s Disease: A Short-Term Regional Homogeneity fMRI Study
    2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    BackgroundVentral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear.PurposeWe used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression.Methods26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined.ResultsThe impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively.ConclusionThe specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

Jiankun Dai - One of the best experts on this subject based on the ideXlab platform.

  • altered activation in Cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in parkinson s disease a short term regional homogeneity fmri study
    PLOS ONE, 2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    Background Ventral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear. Purpose We used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression. Methods 26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined. Results The impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively. Conclusion The specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

  • Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson’s Disease: A Short-Term Regional Homogeneity fMRI Study
    2016
    Co-Authors: Zhi Wen, Jie Zhang, Jiankun Dai, Fuchun Lin
    Abstract:

    BackgroundVentral intermediate nucleus thalamotomy is an effective treatment for Parkinson’s disease tremor. However, its mechanism is still unclear.PurposeWe used resting-state fMRI to investigate short-term ReHo changes after unilateral thalamotomy in tremor-dominant PD, and to speculate about its possible mechanism on tremor suppression.Methods26 patients and 31 healthy subjects (HS) were recruited. Patients were divided into two groups according to right- (rPD) and left-side (lPD) thalamotomy. Tremor was assessed using the 7-item scale from the Unified Parkinson’s disease rating scale motor score (mUPDRS). Patients were scanned using resting state fMRI after 12h withdrawal of medication, both preoperatively (PDpre) and 7- day postoperatively (PDpost), whereas healthy subjects were scanned once. The regions associated with tremor and altered ReHo due to thalamic ablation were examined.ResultsThe impact of unilateral VIM thalamotomy was characterized in the frontal, parietal, temporal regions, basal ganglia, thalamus, and Cerebellum. Compared with PDpre, significantly reduced ReHo was found in the left Cerebellum in patients with rPDpost, and slightly decreased ReHo in the Cerebellum Vermis in patients with lPDpost, which was significantly higher than HS. We demonstrated a positive correlation between the ReHo values in the Cerebellum (in rPD, peak coordinate [-12, -54, -21], R = 0.64, P = 0.0025, and peak coordinate [-9, -54, -18], R = 0.71, P = 0.0025; in lPD, peak coordinate [3, -45, -15], R = 0.71, P = 0.004) in the pre-surgical condition, changes of ReHo induced by thalamotomy (in rPD, R = 0.63, P = 0.021, R = 0.6, P = 0.009; in lPD, R = 0.58, P = 0.028) and tremor scores contralateral to the surgical side, respectively.ConclusionThe specific area that may be associated with PD tremor and altered ReHo due to thalamic ablation is the Cerebellum. The neural basis underlying thalamotomy is complex; Cerebellum involvement is far beyond cerebello-thalamic tract breakage.

Srinivasan Latha - One of the best experts on this subject based on the ideXlab platform.

  • Biometric assessments of the posterior fossa by fetal MRI: A systematic review.
    'Wiley', 2020
    Co-Authors: Mckinnon Katie, Kendall, Giles S, Tann, Cally J, Dyet Leigh, Sokolska Magdalena, Baruteau, Kelly Pegoretti, Marlow Neil, Robertson, Nicola J, Peebles Donald, Srinivasan Latha
    Abstract:

    BACKGROUND: Posterior fossa abnormalities (PFAs) are commonly identified within routine screening and are a frequent indication for fetal magnetic resonance imaging (MRI). Although biometric measurements of the posterior fossa (PF) are established on fetal ultrasound and MRI, qualitative visual assessments are predominantly used to differentiate PFAs. OBJECTIVES: This systematic review aimed to assess 2-dimensional (2D) biometric measurements currently in use for assessing the PF on fetal MRI to delineate different PFAs. METHODS: The protocol was registered (PROSPERO ID CRD42019142162). Eligible studies included T2-weighted MRI PF measurements in fetuses with and without PFAs, including measurements of the PF, or other brain areas relevant to PFAs. RESULTS: 59 studies were included - 6859 fetuses had 62 2D PF and related measurements. These included linear, area and angular measurements, representing measures of PF size, Cerebellum/Vermis, brainstem, and supratentorial measurements. 11 measurements were used in 10 or more studies and at least 1200 fetuses. These dimensions were used to characterise normal for gestational age, diagnose a range of pathologies, and predict outcome. CONCLUSION: A selection of validated 2D biometric measurements of the PF on fetal MRI may be useful for identification of PFA in different clinical settings. Consistent use of these measures, both clinically and for research, is recommended

  • Biometric assessments of the posterior fossa by fetal MRI: a systematic review.
    'Wiley', 2020
    Co-Authors: Mckinnon Katie, Kendall, Giles S, Tann, Cally J, Dyet Leigh, Sokolska Magdalena, Baruteau, Kelly Pegoretti, Marlow Neil, Robertson, Nicola J, Peebles Donald, Srinivasan Latha
    Abstract:

    Posterior fossa abnormalities (PFAs) are commonly identified within routine screening and are a frequent indication for fetal magnetic resonance imaging (MRI). Although biometric measurements of the posterior fossa (PF) are established on fetal ultrasound and MRI, qualitative visual assessments are predominantly used to differentiate PFAs. This systematic review aimed to assess 2-dimensional (2D) biometric measurements currently in use for assessing the PF on fetal MRI to delineate different PFAs. The protocol was registered (PROSPERO ID CRD42019142162). Eligible studies included T2-weighted MRI PF measurements in fetuses with and without PFAs, including measurements of the PF, or other brain areas relevant to PFAs. 59 studies were included - 6859 fetuses had 62 2D PF and related measurements. These included linear, area and angular measurements, representing measures of PF size, Cerebellum/Vermis, brainstem, and supratentorial measurements. 11 measurements were used in 10 or more studies and at least 1200 fetuses. These dimensions were used to characterise normal for gestational age, diagnose a range of pathologies, and predict outcome. A selection of validated 2D biometric measurements of the PF on fetal MRI may be useful for identification of PFA in different clinical settings. Consistent use of these measures, both clinically and for research, is recommended. This article is protected by copyright. All rights reserved