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Ji Hoe Heo - One of the best experts on this subject based on the ideXlab platform.
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serum alkaline phosphatase and phosphate in Cerebral Atherosclerosis and functional outcomes after Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with Cerebral Atherosclerosis and prognosis in patients with acute stroke is not well known. Methods—In 1034 patients with first-ever acute Cerebral infarction, levels of ALP and phosphate were compared with (1) Cerebral Atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. Results—ALP levels were not associated with Cerebral Atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04–1.50). Phosphate was associated with neither Cerebral Atherosclerosis nor functional outcome. Conclusions—A higher level of ALP was not associated with Cerebral Atherosclerosis but was an independent prognostic factor for long-term f...
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plasma osteoprotegerin levels increase with the severity of Cerebral artery Atherosclerosis
Clinical Biochemistry, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Seung Hee Yang, Ok Hee Lee, Eun Hee Kim, Ji Hoe HeoAbstract:Abstract Objectives Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of Atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of Cerebral Atherosclerosis. Design and methods We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute Cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with Cerebral Atherosclerosis (≥ 50% stenosis). Results Of 107 patients, 73 (68.2%) had Cerebral Atherosclerosis. OPG levels were increased in patients with Cerebral Atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p = 0.006). OPG levels showed positive correlation with the number of Cerebral arteries with Atherosclerosis (Spearman's rho = 0.342, p 229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57–13.55, p = 0.005, binary logistic regression] of Cerebral Atherosclerosis and number [OR 3.20, 95% CI 1.26–8.12, p = 0.014, ordinal logistic regression] of arteries with Cerebral Atherosclerosis. Conclusions Plasma OPG levels were significantly associated with the presence and severity of Cerebral Atherosclerosis. This finding suggests that plasma OPG might have a role in Cerebral Atherosclerosis.
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nonrelevant Cerebral Atherosclerosis is a strong prognostic factor in acute Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—We investigated whether the presence of nonrelevant Cerebral Atherosclerosis (NRCA) had prognostic value in patients with acute stroke. Methods—We compared prognosis in 780 consecutive patients with first-ever acute Cerebral infarction who underwent Cerebral angiography and diffusion-weighted MRI. Results—NRCA was present in 267 patients (34.2%). Multivariate analysis demonstrated that the presence of NRCA was independently associated with less improvement in National Institute of Health Stroke Scale score during the first 7 days (P=0.004), and a poor functional outcome (modified Rankin Scale score >2) after 3 months (odds ratio, 2.51; 95% confidence interval, 1.55–4.07). An increase in burden count of NRCA was also associated with poor outcomes. Conclusions—The presence and burden count of NRCA were associated with poor neurological outcomes in patients with acute Cerebral infarction.
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the association between Cerebral Atherosclerosis and arterial stiffness in acute ischemic stroke
Atherosclerosis, 2011Co-Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Myoung Jin Cha, Dong Hyun Lee, Ji Hoe HeoAbstract:Abstract Objective Arterial stiffness is associated with cardiovascular risk factors and Atherosclerosis. Measurement of pulse wave velocity (PWV) is one of the most representative and noninvasive techniques for assessing arterial stiffness. We investigated the association of Cerebral Atherosclerosis with brachial-ankle PWV (baPWV) in acute ischemic stroke patients. If present, we sought to determine whether the relationship differed between Atherosclerosis in the intracranial artery and Atherosclerosis in the extracranial artery. Methods We included 801 patients with acute ischemic stroke who had undergone angiographic study and baPWV measurement between January 2007 and May 2010. Patients with Cerebral artery Atherosclerosis were categorized into those with intracranial Atherosclerosis, those with extracranial Atherosclerosis and those with both intracranial and extracranial Atherosclerosis. We determined factors that were associated with baPWV. Results Univariate and multivariate analyses showed that high baPWV was significantly associated with older age, lower body mass index, higher brachial systolic pressure, and diabetes mellitus. Increased baPWV was associated with the presence of Atherosclerosis (≥50% stenosis) in the intracranial Cerebral artery as well as in both the intracranial and extracranial arteries, but not with Atherosclerosis in the extracranial Cerebral artery. The burden of intracranial Cerebral Atherosclerosis, which was assessed based on the number of arteries with Atherosclerosis, was also closely associated with baPWV. Conclusion Arterial stiffness was associated with the presence and burden of intracranial Cerebral Atherosclerosis in stroke patients, but was not associated with the extracranial Cerebral Atherosclerosis. These findings suggest a potential pathophysiological association between increased arterial stiffness and intracranial Cerebral Atherosclerosis.
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increases in Cerebral Atherosclerosis according to chads2 scores in patients with stroke with nonvalvular atrial fibrillation
T201100861.pdf, 2011Co-Authors: Young Dae Kim, Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Myoung Jin Cha, Dong Hyun Lee, Ji Hoe HeoAbstract:Background and Purpose—The CHADS2 score is used for risk stratification of ischemic stroke in patients with nonvalvular atrial fibrillation and high CHADS2 scores are associated with increased risk of stroke. Most components of the CHADS2 score are also risk factors for Atherosclerosis. Therefore, high CHADS2 scores can be associated with concomitant Cerebral Atherosclerosis and subsequently atherothrombotic stroke. The aim of this study was to determine whether there are differences in the presence and burden of concomitant Cerebral Atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation. Methods—We included 780 consecutive patients with nonvalvular atrial fibrillation who had undergone angiographic studies at index stroke between August 1994 and March 2010 in the present study. We investigated the relationships between the CHADS2 score and the presence, severity, and pattern of Cerebral Atherosclerosis and stroke mechanism. Results—Of the 780 patients, con...
Jinkwon Kim - One of the best experts on this subject based on the ideXlab platform.
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plasma fibroblast growth factor 23 concentration is associated with intracranial Cerebral Atherosclerosis in acute ischemic stroke patients
Journal of Clinical Neurology, 2020Co-Authors: Yoonkyung Chang, Jinkwon Kim, Ho Geol Woo, Dongryeol Ryu, Tae Jin SongAbstract:BACKGROUND AND PURPOSE Fibroblast growth factor 23 (FGF23) is associated with Atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization. This study aimed to determine the association of the plasma FGF23 concentration with intracranial Cerebral Atherosclerosis (ICAS) and extracranial Cerebral Atherosclerosis (ECAS). METHODS We prospectively enrolled 262 first-ever ischemic stroke patients in whom brain magnetic resonance was performed and a blood sample acquired within 24 h after admission. Plasma FGF23 concentrations were measured using an enzyme-linked immunosorbent assay. The presence of ICAS or ECAS was defined as a ≥50% decrease in arterial diameter in magnetic resonance angiography. The burden of Cerebral Atherosclerosis was calculated by adding the total number of vessels defined as ICAS or ECAS. RESULTS Our study population included 152 (58.0%) males. The mean age was 64.7 years, and the plasma FGF23 concentration was 347.5±549.6 pg/mL (mean±SD). ICAS only, ECAS only, and both ICAS and ECAS were present in 31.2% (n=82), 4.9% (n=13), and 6.8% (n=18) of the subjects, respectively. In multivariate binary and ordinal logistic analyses, after adjusting for sex, age, and variables for which p<0.1 in the univariate analysis, the plasma FGF23 concentration (per 100 pg/mL) was positively correlated with the presence of ICAS [odds ratio (OR)=1.07, 95% CI=1.00-1.15, p=0.039], burden of ICAS (OR=1.09, 95% CI=1.04-1.15, p=0.001), and burden of ECAS (OR=1.06, 95% CI=1.00-1.12, p=0.038), but it was not significantly related to the presence of ECAS (OR=1.05, 95% CI=0.99-1.12, p=0.073). CONCLUSIONS The plasma FGF23 may be a potential biomarker for Cerebral Atherosclerosis, particularly the presence and burden of ICAS in stroke patients.
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serum alkaline phosphatase and phosphate in Cerebral Atherosclerosis and functional outcomes after Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with Cerebral Atherosclerosis and prognosis in patients with acute stroke is not well known. Methods—In 1034 patients with first-ever acute Cerebral infarction, levels of ALP and phosphate were compared with (1) Cerebral Atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. Results—ALP levels were not associated with Cerebral Atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04–1.50). Phosphate was associated with neither Cerebral Atherosclerosis nor functional outcome. Conclusions—A higher level of ALP was not associated with Cerebral Atherosclerosis but was an independent prognostic factor for long-term f...
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plasma osteoprotegerin levels increase with the severity of Cerebral artery Atherosclerosis
Clinical Biochemistry, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Seung Hee Yang, Ok Hee Lee, Eun Hee Kim, Ji Hoe HeoAbstract:Abstract Objectives Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of Atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of Cerebral Atherosclerosis. Design and methods We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute Cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with Cerebral Atherosclerosis (≥ 50% stenosis). Results Of 107 patients, 73 (68.2%) had Cerebral Atherosclerosis. OPG levels were increased in patients with Cerebral Atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p = 0.006). OPG levels showed positive correlation with the number of Cerebral arteries with Atherosclerosis (Spearman's rho = 0.342, p 229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57–13.55, p = 0.005, binary logistic regression] of Cerebral Atherosclerosis and number [OR 3.20, 95% CI 1.26–8.12, p = 0.014, ordinal logistic regression] of arteries with Cerebral Atherosclerosis. Conclusions Plasma OPG levels were significantly associated with the presence and severity of Cerebral Atherosclerosis. This finding suggests that plasma OPG might have a role in Cerebral Atherosclerosis.
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nonrelevant Cerebral Atherosclerosis is a strong prognostic factor in acute Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—We investigated whether the presence of nonrelevant Cerebral Atherosclerosis (NRCA) had prognostic value in patients with acute stroke. Methods—We compared prognosis in 780 consecutive patients with first-ever acute Cerebral infarction who underwent Cerebral angiography and diffusion-weighted MRI. Results—NRCA was present in 267 patients (34.2%). Multivariate analysis demonstrated that the presence of NRCA was independently associated with less improvement in National Institute of Health Stroke Scale score during the first 7 days (P=0.004), and a poor functional outcome (modified Rankin Scale score >2) after 3 months (odds ratio, 2.51; 95% confidence interval, 1.55–4.07). An increase in burden count of NRCA was also associated with poor outcomes. Conclusions—The presence and burden count of NRCA were associated with poor neurological outcomes in patients with acute Cerebral infarction.
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the association between Cerebral Atherosclerosis and arterial stiffness in acute ischemic stroke
Atherosclerosis, 2011Co-Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Myoung Jin Cha, Dong Hyun Lee, Ji Hoe HeoAbstract:Abstract Objective Arterial stiffness is associated with cardiovascular risk factors and Atherosclerosis. Measurement of pulse wave velocity (PWV) is one of the most representative and noninvasive techniques for assessing arterial stiffness. We investigated the association of Cerebral Atherosclerosis with brachial-ankle PWV (baPWV) in acute ischemic stroke patients. If present, we sought to determine whether the relationship differed between Atherosclerosis in the intracranial artery and Atherosclerosis in the extracranial artery. Methods We included 801 patients with acute ischemic stroke who had undergone angiographic study and baPWV measurement between January 2007 and May 2010. Patients with Cerebral artery Atherosclerosis were categorized into those with intracranial Atherosclerosis, those with extracranial Atherosclerosis and those with both intracranial and extracranial Atherosclerosis. We determined factors that were associated with baPWV. Results Univariate and multivariate analyses showed that high baPWV was significantly associated with older age, lower body mass index, higher brachial systolic pressure, and diabetes mellitus. Increased baPWV was associated with the presence of Atherosclerosis (≥50% stenosis) in the intracranial Cerebral artery as well as in both the intracranial and extracranial arteries, but not with Atherosclerosis in the extracranial Cerebral artery. The burden of intracranial Cerebral Atherosclerosis, which was assessed based on the number of arteries with Atherosclerosis, was also closely associated with baPWV. Conclusion Arterial stiffness was associated with the presence and burden of intracranial Cerebral Atherosclerosis in stroke patients, but was not associated with the extracranial Cerebral Atherosclerosis. These findings suggest a potential pathophysiological association between increased arterial stiffness and intracranial Cerebral Atherosclerosis.
Randall T Higashida - One of the best experts on this subject based on the ideXlab platform.
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reporting standards for angioplasty and stent assisted angioplasty for intracranial Atherosclerosis
Stroke, 2009Co-Authors: Christian H Schumacher, Randall T Higashida, Philip M Meyers, David Sacks, Colin P Derdeyn, Sean D Lavine, Gary M Nesbit, Peter A Rasmussen, Lawrence R WechslerAbstract:Background and purpose Intracranial Cerebral Atherosclerosis causes ischemic stroke in a significant number of patients. Technological advances over the past 10 years have enabled endovascular treatment of intracranial atherosclerotic stenosis. The number of patients treated with angioplasty or stent-assisted angioplasty for this condition is increasing. Given the lack of universally accepted definitions, the goal of this document is to provide consensus recommendations for reporting standards, terminology, and written definitions when reporting clinical and radiological evaluation, technique, and outcome of endovascular treatment using angioplasty or stent-assisted angioplasty for stenotic and occlusive intracranial Atherosclerosis. Summary of report This article was written under the auspices of Joint Writing Group of the Technology Assessment Committee, Society of Neurolnterventional Surgery, Society of Interventional Radiology; Joint Section on Cerebro-vascular Neurosurgery of the American Association of Neurological Surgeons and Congress of Neurological Surgeons; and the Section of Stroke and Interventional Neurology of the American Academy of Neurology. A computerized search of the National Library of Medicine database of literature (PubMed) from January 1997 to December 2007 was conducted with the goal to identify published endovascular cerebrovascular interventional data in stenotic intracranial Atherosclerosis that could be used as benchmarks for quality assessment. We sought to identify those risk adjustment variables that affect the likelihood of success and complications. This document offers the rationale for different clinical and technical considerations that may be important during the design of clinical trials for endovascular treatment of intracranial stenotic and occlusive Atherosclerosis. Included in this guidance document are suggestions for uniform reporting standards for such trials. These definitions and standards are primarily intended for research purposes; however, they should also be helpful in clinical practice and applicable to all publications. Conclusion In summary, the definitions proposed represent recommendations for constructing useful research data sets. The intent is to facilitate production of scientifically rigorous results capable of reliable comparisons between and among similar studies. In some cases, the definitions contained here are recommended by consensus of a panel of experts in this writing group for consistency in reporting and publication. These definitions should allow different groups to publish results that are directly comparable.
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intracranial angioplasty stenting for Cerebral Atherosclerosis a position statement of the american society of interventional and therapeutic neuroradiology society of interventional radiology and the american society of neuroradiology
Int J Cerebrovasc Dis, 2008Co-Authors: Randall T Higashida, Philip M Meyers, John J Connors, David Sacks, Charles M Strother, John D Barr, Joan C Wojak, Gary Duckwiler, 周志明 译Abstract:在北美、欧洲和亚洲，卒中是第3位死亡原因和成人残疾的首要病因。颅内动脉粥样硬化所致的卒中约占所有缺血性卒中的8％～10％，据报道，在亚洲、非洲和西班牙裔人群中这一比例更高。其危险因素包括胰岛素依赖性糖尿病、高胆固醇血症、高血压和吸烟。在美国，估计每年有40000～60000例新发卒中是由于颅内动脉粥样硬化所致。
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intracranial angioplasty and stenting for Cerebral Atherosclerosis new treatments for stroke are needed
Neuroradiology, 2006Co-Authors: Randall T Higashida, Philip M MeyersAbstract:Intracranial Atherosclerosis is a common cause of stroke. Recent technological developments offer improved methods for endovascular revascularization of symptomatic and asymptomatic Cerebral artery stenosis. Identification of appropriate patients remains a diagnostic challenge, and our knowledge about the natural history of the disease remains limited. At this time, patients with significant intracranial stenosis should receive counseling on the benefits and risks of revascularization therapy. Ultimately, determination of which patients should undergo revascularization procedures will require carefully planned, randomized clinical trials.
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intracranial angioplasty stenting for Cerebral Atherosclerosis a position statement of the american society of interventional and therapeutic neuroradiology society of interventional radiology and the american society of neuroradiology
American Journal of Neuroradiology, 2005Co-Authors: Randall T Higashida, Philip M Meyers, John J Connors, David Sacks, Charles M Strother, John D Barr, Joan C Wojak, Gary DuckwilerAbstract:STROKE is the third leading cause of death and the leading cause of adult disability in North America, Europe, and Asia (1,2). Intracranial Cerebral Atherosclerosis accounts for approximately 8 to 10% of all ischemic strokes with a higher reported incidence in the Asian, African, and Hispanic descent populations (3–5). Risk factors include insulin-dependent diabetes mellitus, hypercholesterolemia, hypertension, and cigarette smoking (6–8). In the United States, it is estimated that 40,000 to 60,000 new strokes per year are due to intracranial Cerebral Atherosclerosis.
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intracranial angioplasty and stent placement for Cerebral Atherosclerosis
Journal of Vascular and Interventional Radiology, 2004Co-Authors: Christian H Schumacher, Philip M Meyers, Alexander V Khaw, Rishi Gupta, Randall T HigashidaAbstract:Intracranial atherosclerotic stenoses have been estimated to account for 8%–10% of all ischemic strokes. A substantial number of patients fail the best medical treatment, which includes control of vascular risk factors and administration of antithrombotics (platelet-active drugs or warfarin), statins, and angiotensin-converting enzyme inhibitors. In these patients, angioplasty with stent placement is one reasonable treatment option for preventing massive ischemic stroke. Herein, we discuss basic pathophysiologic concepts and their effect on endovascular revascularization procedures.
Tae Jin Song - One of the best experts on this subject based on the ideXlab platform.
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plasma fibroblast growth factor 23 concentration is associated with intracranial Cerebral Atherosclerosis in acute ischemic stroke patients
Journal of Clinical Neurology, 2020Co-Authors: Yoonkyung Chang, Jinkwon Kim, Ho Geol Woo, Dongryeol Ryu, Tae Jin SongAbstract:BACKGROUND AND PURPOSE Fibroblast growth factor 23 (FGF23) is associated with Atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization. This study aimed to determine the association of the plasma FGF23 concentration with intracranial Cerebral Atherosclerosis (ICAS) and extracranial Cerebral Atherosclerosis (ECAS). METHODS We prospectively enrolled 262 first-ever ischemic stroke patients in whom brain magnetic resonance was performed and a blood sample acquired within 24 h after admission. Plasma FGF23 concentrations were measured using an enzyme-linked immunosorbent assay. The presence of ICAS or ECAS was defined as a ≥50% decrease in arterial diameter in magnetic resonance angiography. The burden of Cerebral Atherosclerosis was calculated by adding the total number of vessels defined as ICAS or ECAS. RESULTS Our study population included 152 (58.0%) males. The mean age was 64.7 years, and the plasma FGF23 concentration was 347.5±549.6 pg/mL (mean±SD). ICAS only, ECAS only, and both ICAS and ECAS were present in 31.2% (n=82), 4.9% (n=13), and 6.8% (n=18) of the subjects, respectively. In multivariate binary and ordinal logistic analyses, after adjusting for sex, age, and variables for which p<0.1 in the univariate analysis, the plasma FGF23 concentration (per 100 pg/mL) was positively correlated with the presence of ICAS [odds ratio (OR)=1.07, 95% CI=1.00-1.15, p=0.039], burden of ICAS (OR=1.09, 95% CI=1.04-1.15, p=0.001), and burden of ECAS (OR=1.06, 95% CI=1.00-1.12, p=0.038), but it was not significantly related to the presence of ECAS (OR=1.05, 95% CI=0.99-1.12, p=0.073). CONCLUSIONS The plasma FGF23 may be a potential biomarker for Cerebral Atherosclerosis, particularly the presence and burden of ICAS in stroke patients.
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interarm systolic and diastolic blood pressure difference is diversely associated with Cerebral Atherosclerosis in noncardioembolic stroke patients
American Journal of Hypertension, 2018Co-Authors: Yoonkyung Chang, Gyeong Seon Choi, Soo Mee Lim, Yongjae Kim, Tae Jin SongAbstract:BACKGROUND Interarm systolic and diastolic blood pressure differences (IASBD, IADBD) are not infrequent in various populations. Cerebral Atherosclerosis, including extracranial Cerebral Atherosclerosis (ECAS) and intracranial Cerebral Atherosclerosis (ICAS), is an important risk factor for stroke. In this study, we aimed to investigate the relationship of IASBD, IADBD with presence and burden of ICAS and ECAS. METHODS This was a retrospective hospital-based cross-sectional study. In total, 1,063 consecutive noncardioembolic ischemic stroke patients, who were checked for bi-brachial blood pressures from ankle-brachial index and brain magnetic resonance angiographic images of Cerebral arteries, were included. The IASBD and IADBD were defined as absolute value of the blood pressure difference in both arms. RESULTS In all included patients, patients with IASBD ≥10 and IADBD ≥10 were noted in 9.4% (100/1,063) and 5.3% (56/1,063). The patients with IASBD ≥10 mm Hg were more frequently burdened with ICAS (P = 0.001) and ECAS (P = 0.027) and patients with IADBD ≥10 mm Hg were more frequently burdened with ICAS (P = 0.042) but not ECAS (P = 0.187). Multivariate analysis after adjusting gender, age, and a P value <0.1 in univariate analysis showed IASBD ≥10 mm Hg was associated with the presence of both ECAS and ICAS [odds ratio (OR): 2.96, 95% confidence interval (CI): 1.65-5.31]. The IADBD ≥10 mm Hg was related with presence of ICAS only (OR: 1.87, 95% CI: 1.05-3.37) but not with ECAS only (OR: 1.50, 95% CI: 0.73-3.06). CONCLUSIONS Our study showed IASBD and IADBD were diversely associated with Cerebral Atherosclerosis. In noncardioembolic stroke patients with IASBD ≥10 or IADBD ≥10, the possibility of accompanying Cerebral Atherosclerosis should be considered.
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is obstructive sleep apnea associated with the presence of intracranial Cerebral Atherosclerosis
Sleep and Breathing, 2017Co-Authors: Tae Jin Song, Yoonkyung Chang, Yongjae Kim, Junghyun Park, Kang Hyun Choi, Ju Hee Kim, Yunseo Choi, Hyeon Jin Kim, Jangsup Moon, Hyang Woon LeeAbstract:Intracranial Cerebral Atherosclerosis (ICAS) is one of critical Atherosclerosis which closely related with stroke. Obstructive sleep apnea (OSA) is associated with systemic Atherosclerosis, but it is unclear whether OSA is related with the presence of ICAS. We aimed to investigate the association between the presence of ICAS and severity of OSA in patients with suspected OSA. This retrospective, cross-sectional study included 283 patients who suspected OSA (presence of one or more OSA-related symptom and high-risk category in Berlin questionnaire) and underwent polysomnography and brain magnetic resonance angiography (MRA). The ICAS was defined as ≥50% decrease of luminal diameter in MRA. The severity of OSA was defined by apnea-hypopnea index (AHI). The mean age was 60.7 ± 13.5 years, and 55.8% (158/283) were male in all included patients. The 53 (18.7%) patients had ICAS and 117 (41.3%) patients had moderate to severe OSA (AHI ≥ 15). Higher AHI was noted in patients with ICAS compared to those without ICAS (31.7 ± 25.8 versus 15.2 ± 17.4, p = 0.001). In multivariable logistic analyses, after adjusting for age, sex, and variables with p < 0.1 in univariable analyses (hypertension, diabetes mellitus, atrial fibrillation, previous stroke history, body mass index, lipid-lowing agents, arousal index, and minimum oxygen saturation), moderate to severe OSA were independently related with the presence of ICAS (odds ratio 4.17, 95% confidence interval 1.40–12.40, p = 0.010). Our findings suggest that moderate to severe OSA is associated with the presence of ICAS in patients with suspected OSA.
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serum alkaline phosphatase and phosphate in Cerebral Atherosclerosis and functional outcomes after Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with Cerebral Atherosclerosis and prognosis in patients with acute stroke is not well known. Methods—In 1034 patients with first-ever acute Cerebral infarction, levels of ALP and phosphate were compared with (1) Cerebral Atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. Results—ALP levels were not associated with Cerebral Atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04–1.50). Phosphate was associated with neither Cerebral Atherosclerosis nor functional outcome. Conclusions—A higher level of ALP was not associated with Cerebral Atherosclerosis but was an independent prognostic factor for long-term f...
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plasma osteoprotegerin levels increase with the severity of Cerebral artery Atherosclerosis
Clinical Biochemistry, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Seung Hee Yang, Ok Hee Lee, Eun Hee Kim, Ji Hoe HeoAbstract:Abstract Objectives Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of Atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of Cerebral Atherosclerosis. Design and methods We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute Cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with Cerebral Atherosclerosis (≥ 50% stenosis). Results Of 107 patients, 73 (68.2%) had Cerebral Atherosclerosis. OPG levels were increased in patients with Cerebral Atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p = 0.006). OPG levels showed positive correlation with the number of Cerebral arteries with Atherosclerosis (Spearman's rho = 0.342, p 229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57–13.55, p = 0.005, binary logistic regression] of Cerebral Atherosclerosis and number [OR 3.20, 95% CI 1.26–8.12, p = 0.014, ordinal logistic regression] of arteries with Cerebral Atherosclerosis. Conclusions Plasma OPG levels were significantly associated with the presence and severity of Cerebral Atherosclerosis. This finding suggests that plasma OPG might have a role in Cerebral Atherosclerosis.
Young Dae Kim - One of the best experts on this subject based on the ideXlab platform.
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serum alkaline phosphatase and phosphate in Cerebral Atherosclerosis and functional outcomes after Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with Cerebral Atherosclerosis and prognosis in patients with acute stroke is not well known. Methods—In 1034 patients with first-ever acute Cerebral infarction, levels of ALP and phosphate were compared with (1) Cerebral Atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale >2 at 3 months after stroke onset. Results—ALP levels were not associated with Cerebral Atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04–1.50). Phosphate was associated with neither Cerebral Atherosclerosis nor functional outcome. Conclusions—A higher level of ALP was not associated with Cerebral Atherosclerosis but was an independent prognostic factor for long-term f...
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plasma osteoprotegerin levels increase with the severity of Cerebral artery Atherosclerosis
Clinical Biochemistry, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Seung Hee Yang, Ok Hee Lee, Eun Hee Kim, Ji Hoe HeoAbstract:Abstract Objectives Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of Atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of Cerebral Atherosclerosis. Design and methods We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute Cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with Cerebral Atherosclerosis (≥ 50% stenosis). Results Of 107 patients, 73 (68.2%) had Cerebral Atherosclerosis. OPG levels were increased in patients with Cerebral Atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p = 0.006). OPG levels showed positive correlation with the number of Cerebral arteries with Atherosclerosis (Spearman's rho = 0.342, p 229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57–13.55, p = 0.005, binary logistic regression] of Cerebral Atherosclerosis and number [OR 3.20, 95% CI 1.26–8.12, p = 0.014, ordinal logistic regression] of arteries with Cerebral Atherosclerosis. Conclusions Plasma OPG levels were significantly associated with the presence and severity of Cerebral Atherosclerosis. This finding suggests that plasma OPG might have a role in Cerebral Atherosclerosis.
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nonrelevant Cerebral Atherosclerosis is a strong prognostic factor in acute Cerebral infarction
Stroke, 2013Co-Authors: Jinkwon Kim, Tae Jin Song, Dongbeom Song, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe HeoAbstract:Background and Purpose—We investigated whether the presence of nonrelevant Cerebral Atherosclerosis (NRCA) had prognostic value in patients with acute stroke. Methods—We compared prognosis in 780 consecutive patients with first-ever acute Cerebral infarction who underwent Cerebral angiography and diffusion-weighted MRI. Results—NRCA was present in 267 patients (34.2%). Multivariate analysis demonstrated that the presence of NRCA was independently associated with less improvement in National Institute of Health Stroke Scale score during the first 7 days (P=0.004), and a poor functional outcome (modified Rankin Scale score >2) after 3 months (odds ratio, 2.51; 95% confidence interval, 1.55–4.07). An increase in burden count of NRCA was also associated with poor outcomes. Conclusions—The presence and burden count of NRCA were associated with poor neurological outcomes in patients with acute Cerebral infarction.
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the association between Cerebral Atherosclerosis and arterial stiffness in acute ischemic stroke
Atherosclerosis, 2011Co-Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Myoung Jin Cha, Dong Hyun Lee, Ji Hoe HeoAbstract:Abstract Objective Arterial stiffness is associated with cardiovascular risk factors and Atherosclerosis. Measurement of pulse wave velocity (PWV) is one of the most representative and noninvasive techniques for assessing arterial stiffness. We investigated the association of Cerebral Atherosclerosis with brachial-ankle PWV (baPWV) in acute ischemic stroke patients. If present, we sought to determine whether the relationship differed between Atherosclerosis in the intracranial artery and Atherosclerosis in the extracranial artery. Methods We included 801 patients with acute ischemic stroke who had undergone angiographic study and baPWV measurement between January 2007 and May 2010. Patients with Cerebral artery Atherosclerosis were categorized into those with intracranial Atherosclerosis, those with extracranial Atherosclerosis and those with both intracranial and extracranial Atherosclerosis. We determined factors that were associated with baPWV. Results Univariate and multivariate analyses showed that high baPWV was significantly associated with older age, lower body mass index, higher brachial systolic pressure, and diabetes mellitus. Increased baPWV was associated with the presence of Atherosclerosis (≥50% stenosis) in the intracranial Cerebral artery as well as in both the intracranial and extracranial arteries, but not with Atherosclerosis in the extracranial Cerebral artery. The burden of intracranial Cerebral Atherosclerosis, which was assessed based on the number of arteries with Atherosclerosis, was also closely associated with baPWV. Conclusion Arterial stiffness was associated with the presence and burden of intracranial Cerebral Atherosclerosis in stroke patients, but was not associated with the extracranial Cerebral Atherosclerosis. These findings suggest a potential pathophysiological association between increased arterial stiffness and intracranial Cerebral Atherosclerosis.
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increases in Cerebral Atherosclerosis according to chads2 scores in patients with stroke with nonvalvular atrial fibrillation
T201100861.pdf, 2011Co-Authors: Young Dae Kim, Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Myoung Jin Cha, Dong Hyun Lee, Ji Hoe HeoAbstract:Background and Purpose—The CHADS2 score is used for risk stratification of ischemic stroke in patients with nonvalvular atrial fibrillation and high CHADS2 scores are associated with increased risk of stroke. Most components of the CHADS2 score are also risk factors for Atherosclerosis. Therefore, high CHADS2 scores can be associated with concomitant Cerebral Atherosclerosis and subsequently atherothrombotic stroke. The aim of this study was to determine whether there are differences in the presence and burden of concomitant Cerebral Atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation. Methods—We included 780 consecutive patients with nonvalvular atrial fibrillation who had undergone angiographic studies at index stroke between August 1994 and March 2010 in the present study. We investigated the relationships between the CHADS2 score and the presence, severity, and pattern of Cerebral Atherosclerosis and stroke mechanism. Results—Of the 780 patients, con...