The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform

Keith A. Josephs - One of the best experts on this subject based on the ideXlab platform.

  • rates of Cerebral Atrophy in autopsy confirmed progressive supranuclear palsy
    Annals of Neurology, 2006
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

  • Rates of Cerebral Atrophy in autopsy‐confirmed progressive supranuclear palsy
    Annals of neurology, 2005
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

Clifford R. Jack - One of the best experts on this subject based on the ideXlab platform.

  • rates of Cerebral Atrophy in autopsy confirmed progressive supranuclear palsy
    Annals of Neurology, 2006
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

  • Rates of Cerebral Atrophy in autopsy‐confirmed progressive supranuclear palsy
    Annals of neurology, 2005
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

Jennifer L. Whitwell - One of the best experts on this subject based on the ideXlab platform.

  • rates of Cerebral Atrophy in autopsy confirmed progressive supranuclear palsy
    Annals of Neurology, 2006
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

  • Rates of Cerebral Atrophy in autopsy‐confirmed progressive supranuclear palsy
    Annals of neurology, 2005
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

  • change in rates of Cerebral Atrophy over time in early onset alzheimer s disease longitudinal mri study
    The Lancet, 2003
    Co-Authors: Dennis Chan, Jennifer L. Whitwell, Martin N Rossor, J C Janssen, Hilary Watt, Rhian Jenkins, Chris Frost
    Abstract:

    The extent to which Cerebral Atrophy in Alzheimer's disease changes with time is unknown. We used multiple MRI scans to measure progression of Cerebral Atrophy in 12 patients with Alzheimer's disease who were followed up from a presymptomatic stage through to moderately severe dementia. Analysis with hierarchical regression models with quadratic terms in time provided evidence of increasing yearly percentage losses in brain volume. At the time when patients were judged to have mild dementia (mini-mental state examination score MMSE=23), mean yearly loss of brain volume was 2.8% (95% CI 2.3-3.3), which rose by 0.32% per year (0.15-0.50). Our findings reinforce the need for early diagnosis and therapeutic intervention in Alzheimer's disease.

Maria M. Shiung - One of the best experts on this subject based on the ideXlab platform.

  • rates of Cerebral Atrophy in autopsy confirmed progressive supranuclear palsy
    Annals of Neurology, 2006
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

  • Rates of Cerebral Atrophy in autopsy‐confirmed progressive supranuclear palsy
    Annals of neurology, 2005
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

Joseph E. Parisi - One of the best experts on this subject based on the ideXlab platform.

  • rates of Cerebral Atrophy in autopsy confirmed progressive supranuclear palsy
    Annals of Neurology, 2006
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006

  • Rates of Cerebral Atrophy in autopsy‐confirmed progressive supranuclear palsy
    Annals of neurology, 2005
    Co-Authors: Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack
    Abstract:

    Objective To determine the rates of Cerebral Atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of Cerebral Atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of Cerebral Atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006