The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Eelco F M Wijdicks - One of the best experts on this subject based on the ideXlab platform.
-
Predictors of Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage
Stroke, 2005Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Background— Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P
-
predictors of Cerebral Infarction in aneurysmal subarachnoid hemorrhage
Stroke, 2004Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Background— Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P<0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P<0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P<0.01) and evidence of vasospasm on TCD or angiogram predicted Cerebral Infarction (P<0.01)....
-
Predictors of Cerebral Infarction in aneurysmal subarachnoid hemorrhage.
Stroke, 2004Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P<0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P<0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P<0.01) and evidence of vasospasm on TCD or angiogram predicted Cerebral Infarction (P<0.01). TCD and angiogram agreed on the diagnosis of vasospasm in 73% of cases (95% CI, 63% to 81%), but the diagnostic accuracy of this combination of tests was suboptimal for the prediction of Cerebral Infarction occurrence (sensitivity, 0.72; specificity, 0.68; positive predictive value, 0.67; negative predictive value, 0.72). Location of the Cerebral Infarction on delayed CT was predicted by neurological symptoms in 74%, by aneurysm location in 77%, and by angiographic vasospasm in 67%. Evidence of vasospasm on TCD and angiogram is predictive of Cerebral Infarction on CT scan but sensitivity and specificity are suboptimal. Cerebral Infarction location cannot be predicted in one quarter to one third of patients by any of the studied clinical or radiological variables.
Alejandro A Rabinstein - One of the best experts on this subject based on the ideXlab platform.
-
Cerebral Infarction in poems syndrome incidence risk factors and imaging characteristics
Neurology, 2009Co-Authors: Stefan A Dupont, Alejandro A Rabinstein, Angela Dispenzieri, Michelle L Mauermann, Robert D BrownAbstract:Objectives: To determine the risk factors and incidence of Cerebral Infarction associated with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome. Methods: The Mayo Clinic dysproteinemia database was queried to identify patients with coded diagnosis of POEMS syndrome. Patients with Cerebral Infarction, occurring after the onset of POEMS-related symptoms, were selected. A retrospective observational study design was used to evaluate potential predictors of stroke in patients with POEMS syndrome. Results: A total of 9 patients (10%; 95% confidence interval 5.4–17.9) with Cerebral Infarction were identified (2 women, 22%). Traditional stroke risk factors were not significantly different between the stroke and nonstroke subgroups, but hematologic abnormalities such as elevated platelet count and bone marrow plasmacytosis differed between the 2 groups. Cerebral Infarction occurrence after successful treatment of the underlying condition was not observed. CT and MRI data demonstrated a wide spectrum of infarct topography in these patients. Common stroke etiologies comprised suspected vascular structural abnormalities leading to vessel dissection and stenosis, in addition to embolism from a proximal source. Conclusions: The 5-year risk of Cerebral Infarction in patients with POEMS syndrome is 13.4%. Evidence of plasma cell proliferation within the bone marrow and elevated serum platelet count led to increased risk of Cerebral Infarction in this population. We conclude that known modifiable stroke risk factors should be aggressively managed. Treatment of thrombocytosis should be considered in patients without a contraindication. Treatment of the syndrome may be the best approach to decreasing risk of Cerebral Infarction in these patients.
-
Predictors of Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage
Stroke, 2005Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Background— Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P
-
predictors of Cerebral Infarction in aneurysmal subarachnoid hemorrhage
Stroke, 2004Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Background— Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P<0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P<0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P<0.01) and evidence of vasospasm on TCD or angiogram predicted Cerebral Infarction (P<0.01)....
-
Predictors of Cerebral Infarction in aneurysmal subarachnoid hemorrhage.
Stroke, 2004Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P<0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P<0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P<0.01) and evidence of vasospasm on TCD or angiogram predicted Cerebral Infarction (P<0.01). TCD and angiogram agreed on the diagnosis of vasospasm in 73% of cases (95% CI, 63% to 81%), but the diagnostic accuracy of this combination of tests was suboptimal for the prediction of Cerebral Infarction occurrence (sensitivity, 0.72; specificity, 0.68; positive predictive value, 0.67; negative predictive value, 0.72). Location of the Cerebral Infarction on delayed CT was predicted by neurological symptoms in 74%, by aneurysm location in 77%, and by angiographic vasospasm in 67%. Evidence of vasospasm on TCD and angiogram is predictive of Cerebral Infarction on CT scan but sensitivity and specificity are suboptimal. Cerebral Infarction location cannot be predicted in one quarter to one third of patients by any of the studied clinical or radiological variables.
Barry M. Massie - One of the best experts on this subject based on the ideXlab platform.
-
Silent Cerebral Infarction in Heart Failure: Vascular or Thromboembolic?
Journal of cardiac failure, 2005Co-Authors: Ronald S. Freudenberger, Barry M. MassieAbstract:Silent Cerebral Infarction in heart failure as reported by Siachos et al is significantly higher than reports of symptomatic Cerebral Infarction. Are we underestimating the occurrence of silent Cerebral Infarction, or can this finding be accounted for by concomitant conditions?
Ronald S. Freudenberger - One of the best experts on this subject based on the ideXlab platform.
-
Silent Cerebral Infarction in Heart Failure: Vascular or Thromboembolic?
Journal of cardiac failure, 2005Co-Authors: Ronald S. Freudenberger, Barry M. MassieAbstract:Silent Cerebral Infarction in heart failure as reported by Siachos et al is significantly higher than reports of symptomatic Cerebral Infarction. Are we underestimating the occurrence of silent Cerebral Infarction, or can this finding be accounted for by concomitant conditions?
Jimmy R Fulgham - One of the best experts on this subject based on the ideXlab platform.
-
Predictors of Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage
Stroke, 2005Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Background— Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P
-
predictors of Cerebral Infarction in aneurysmal subarachnoid hemorrhage
Stroke, 2004Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Background— Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. Methods— We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Results— Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P<0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P<0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P<0.01) and evidence of vasospasm on TCD or angiogram predicted Cerebral Infarction (P<0.01)....
-
Predictors of Cerebral Infarction in aneurysmal subarachnoid hemorrhage.
Stroke, 2004Co-Authors: Alejandro A Rabinstein, Jonathan A Friedman, Stephen D Weigand, Robyn L Mcclelland, Jimmy R Fulgham, Edward M Manno, John L D Atkinson, Eelco F M WijdicksAbstract:Clinical and radiologic predictors of Cerebral Infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied. We evaluated all patients admitted to our hospital with aneurysmal subarachnoid hemorrhage between 1998 and 2000. Cerebral Infarction was defined as a new hypodensity located in a vascular distribution on computed tomography (CT) scan. Fifty-seven of 143 patients (40%) developed a Cerebral Infarction. On univariate analysis, occurrence of Cerebral Infarction was associated with a worse World Federation of Neurological Surgeons grade (P=0.01), use of ventriculostomy catheter (P=0.01), preoperative vasospasm (P=0.03), surgical clipping (P=0.02), symptomatic vasospasm (P<0.01), and vasospasm on transcranial Doppler ultrasonography (TCD) or repeat angiogram (P<0.01). On multivariable analysis, only presence of symptoms ascribed to vasospasm (P<0.01) and evidence of vasospasm on TCD or angiogram predicted Cerebral Infarction (P<0.01). TCD and angiogram agreed on the diagnosis of vasospasm in 73% of cases (95% CI, 63% to 81%), but the diagnostic accuracy of this combination of tests was suboptimal for the prediction of Cerebral Infarction occurrence (sensitivity, 0.72; specificity, 0.68; positive predictive value, 0.67; negative predictive value, 0.72). Location of the Cerebral Infarction on delayed CT was predicted by neurological symptoms in 74%, by aneurysm location in 77%, and by angiographic vasospasm in 67%. Evidence of vasospasm on TCD and angiogram is predictive of Cerebral Infarction on CT scan but sensitivity and specificity are suboptimal. Cerebral Infarction location cannot be predicted in one quarter to one third of patients by any of the studied clinical or radiological variables.