The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform

Amanda Worker - One of the best experts on this subject based on the ideXlab platform.

  • Diffusion Tensor Imaging of Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study
    2016
    Co-Authors: Amanda Worker, Camilla Blain, Gareth J Barker, Steve C.r. Williams, Richard G. Brown, Ray K Chaudhuri, Jozef Jarosz, Nigel P. Leigh, Andrew Simmons
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpu

  • diffusion tensor imaging of parkinson s disease multiple system atrophy and progressive supranuclear palsy a tract based spatial statistics study
    PLOS ONE, 2014
    Co-Authors: Amanda Worker, Camilla Blain, Jozef M. Jarosz, Gareth J Barker, Steve C.r. Williams, Ray K Chaudhuri, Richard G. Brown
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar Peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and Cerebral Peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD.

Yan Zhuo - One of the best experts on this subject based on the ideXlab platform.

  • lack of the Cerebral Peduncle involvement in a series of adult supratentorial avm a diffusion tensor imaging study
    Neuroscience Letters, 2010
    Co-Authors: Jizong Zhao, Bo Wang, Mingqi Yang, Yan Zhuo
    Abstract:

    Congenital as arteriovenous malformation(AVM) is, most patients with AVM would be asymptomatic until adults. During the past 2 years, 23 cases of adult supratentorial AVM patients had DTI after admission. The region of interest was placed in the Cerebral Peduncle. Their FA value and fiber number was compared with those of cavernous malformation (CM) and tumor (glioma and meningioma). In the AVM group, there was no significant difference in FA of the Cerebral Peduncle (ipsilateral 0.758 ± 0.055 versus contralateral 0.755 ± 0.049; P > 0.05) and fiber number (319.6 ± 82.9 versus 304.7 ± 89.1; P > 0.05). In the CM group, FA of the Cerebral Peduncle on ipsilateral side (0.711 ± 0.092) was significantly lower than that of contralateral side (0.768 ± 0.043) (P < 0.01). Similar result was in fiber number of the CM group (251 ± 82.1 versus 307.3 ± 77.0; P < 0.05). In tumor group, FA of ipsilateral side (0.713 ± 0.084) was lower than that of contralateral (0.751 ± 0.052) without significant difference. There was no significant difference in fiber number between ipsilateral and contralateral sides in the tumor group (308.9 ± 112.4 versus 287.9 ± 62.4). Unlike non-AVM lesions (CM and tumor), FA value and fiber number of the ipsilateral Cerebral Peduncle is less influenced in the AVM group. The lack of the Cerebral Peduncle involvement indicates that there is plasticity of white matter in AVM. © 2010 Elsevier Ireland Ltd. All rights reserved.

  • lack of the Cerebral Peduncle involvement in a series of adult supratentorial avm a diffusion tensor imaging study
    Neuroscience Letters, 2010
    Co-Authors: Jizong Zhao, Bo Wang, Mingqi Yang, Yan Zhuo
    Abstract:

    Congenital as arteriovenous malformation(AVM) is, most patients with AVM would be asymptomatic until adults. During the past 2 years, 23 cases of adult supratentorial AVM patients had DTI after admission. The region of interest was placed in the Cerebral Peduncle. Their FA value and fiber number was compared with those of cavernous malformation (CM) and tumor (glioma and meningioma). In the AVM group, there was no significant difference in FA of the Cerebral Peduncle (ipsilateral 0.758±0.055 versus contralateral 0.755±0.049; P>0.05) and fiber number (319.6±82.9 versus 304.7±89.1; P>0.05). In the CM group, FA of the Cerebral Peduncle on ipsilateral side (0.711±0.092) was significantly lower than that of contralateral side (0.768±0.043) (P<0.01). Similar result was in fiber number of the CM group (251±82.1 versus 307.3±77.0; P<0.05). In tumor group, FA of ipsilateral side (0.713±0.084) was lower than that of contralateral (0.751±0.052) without significant difference. There was no significant difference in fiber number between ipsilateral and contralateral sides in the tumor group (308.9±112.4 versus 287.9±62.4). Unlike non-AVM lesions (CM and tumor), FA value and fiber number of the ipsilateral Cerebral Peduncle is less influenced in the AVM group. The lack of the Cerebral Peduncle involvement indicates that there is plasticity of white matter in AVM.

Richard G. Brown - One of the best experts on this subject based on the ideXlab platform.

  • Diffusion Tensor Imaging of Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study
    2016
    Co-Authors: Amanda Worker, Camilla Blain, Gareth J Barker, Steve C.r. Williams, Richard G. Brown, Ray K Chaudhuri, Jozef Jarosz, Nigel P. Leigh, Andrew Simmons
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpu

  • diffusion tensor imaging of parkinson s disease multiple system atrophy and progressive supranuclear palsy a tract based spatial statistics study
    PLOS ONE, 2014
    Co-Authors: Amanda Worker, Camilla Blain, Jozef M. Jarosz, Gareth J Barker, Steve C.r. Williams, Ray K Chaudhuri, Richard G. Brown
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar Peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and Cerebral Peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD.

Gareth J Barker - One of the best experts on this subject based on the ideXlab platform.

  • Diffusion Tensor Imaging of Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study
    2016
    Co-Authors: Amanda Worker, Camilla Blain, Gareth J Barker, Steve C.r. Williams, Richard G. Brown, Ray K Chaudhuri, Jozef Jarosz, Nigel P. Leigh, Andrew Simmons
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpu

  • diffusion tensor imaging of parkinson s disease multiple system atrophy and progressive supranuclear palsy a tract based spatial statistics study
    PLOS ONE, 2014
    Co-Authors: Amanda Worker, Camilla Blain, Jozef M. Jarosz, Gareth J Barker, Steve C.r. Williams, Ray K Chaudhuri, Richard G. Brown
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar Peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and Cerebral Peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD.

  • Anisotropy of water diffusion in corona radiata and Cerebral Peduncle in patients with hemiparesis.
    NeuroImage, 1999
    Co-Authors: U. C. Wieshmann, Gareth J Barker, Chris A. Clark, Mark R. Symms, Florence Franconi, Simon Shorvon
    Abstract:

    Diffusion tensor imaging is a magnetic resonance method which provides quantitative measurements of the directionality (anisotropy) of diffusion. Anisotropy measurements can be used to obtain quantitative information about the microstructural integrity of white matter tracts. In intact tracts diffusion is restricted and directional because water molecules move predominantly longitudinally to tracts. The aim of this study was to measure the anisotropy of diffusion in patients with chronic hemiparesis. We measured in the corona radiata and the Cerebral Peduncle in 10 patients with a chronic hemiparesis and supratentorial lesions and 10 control subjects in regions of interest. In all patients anisotropy was reduced in the coronal radiata contralateral to the hemiparesis by more than 3 SD compared to control subjects. In three patients, each of which had a severe hemiparesis, anisotropy in the Cerebral Peduncle was reduced by more than 3 SD compared to normal control subjects. Our findings suggest that reduced anisotropy is associated with chronic hemiparesis.

Camilla Blain - One of the best experts on this subject based on the ideXlab platform.

  • Diffusion Tensor Imaging of Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study
    2016
    Co-Authors: Amanda Worker, Camilla Blain, Gareth J Barker, Steve C.r. Williams, Richard G. Brown, Ray K Chaudhuri, Jozef Jarosz, Nigel P. Leigh, Andrew Simmons
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpu

  • diffusion tensor imaging of parkinson s disease multiple system atrophy and progressive supranuclear palsy a tract based spatial statistics study
    PLOS ONE, 2014
    Co-Authors: Amanda Worker, Camilla Blain, Jozef M. Jarosz, Gareth J Barker, Steve C.r. Williams, Ray K Chaudhuri, Richard G. Brown
    Abstract:

    Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar Peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, Cerebral Peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar Peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and Cerebral Peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD.