The Experts below are selected from a list of 1023 Experts worldwide ranked by ideXlab platform

Phillip B. Storm - One of the best experts on this subject based on the ideXlab platform.

  • Cerebral Salt Wasting Syndrome in Post-Operative Pediatric Brain Tumor Patients
    Neurocritical Care, 2012
    Co-Authors: Douglas A. Hardesty, Todd J. Kilbaugh, Phillip B. Storm
    Abstract:

    Background Cerebral salt wasting Syndrome (CSWS) and the Syndrome of inappropriate antidiuretic hormone (SIADH) are both causes of hyponatremia in pediatric neurosurgical patients often with similar presenting symptoms; however, despite similar clinical characteristics the treatment for CSWS and SIADH can be drastically different, which makes the distinction critical for post-operative treatment. Further complicating matters, are the exact mechanism for CSWS which remains unclear, and the incidence and severity of CSWS is not well studied in pediatric neurosurgical patients. We hypothesized that CSWS occurs frequently in post-operative brain tumor patients and is an important cause of post-operative hyponatremia in these patients. Methods We designed a single institution retrospective cohort study of all pediatric brain tumor patients undergoing craniotomy for tumor resection at our institution between January 2005 and December 2009. Results Of the 282 patients undergoing 291 operations, post-operative CSWS was identified in 15 cases (5%), and was more frequently observed than SIADH (nine cases, 3%). Median onset of CSWS was on post-operative day 3, lasting a median of 2.5 days. Patients with CSWS were more likely to have suffered post-operative stroke (40 vs. 4.6%, P  

  • Cerebral salt wasting Syndrome in post-operative pediatric brain tumor patients.
    Neurocritical care, 2011
    Co-Authors: Douglas A. Hardesty, Todd J. Kilbaugh, Phillip B. Storm
    Abstract:

    Background Cerebral salt wasting Syndrome (CSWS) and the Syndrome of inappropriate antidiuretic hormone (SIADH) are both causes of hyponatremia in pediatric neurosurgical patients often with similar presenting symptoms; however, despite similar clinical characteristics the treatment for CSWS and SIADH can be drastically different, which makes the distinction critical for post-operative treatment. Further complicating matters, are the exact mechanism for CSWS which remains unclear, and the incidence and severity of CSWS is not well studied in pediatric neurosurgical patients. We hypothesized that CSWS occurs frequently in post-operative brain tumor patients and is an important cause of post-operative hyponatremia in these patients.

Douglas A. Hardesty - One of the best experts on this subject based on the ideXlab platform.

  • Cerebral Salt Wasting Syndrome in Post-Operative Pediatric Brain Tumor Patients
    Neurocritical Care, 2012
    Co-Authors: Douglas A. Hardesty, Todd J. Kilbaugh, Phillip B. Storm
    Abstract:

    Background Cerebral salt wasting Syndrome (CSWS) and the Syndrome of inappropriate antidiuretic hormone (SIADH) are both causes of hyponatremia in pediatric neurosurgical patients often with similar presenting symptoms; however, despite similar clinical characteristics the treatment for CSWS and SIADH can be drastically different, which makes the distinction critical for post-operative treatment. Further complicating matters, are the exact mechanism for CSWS which remains unclear, and the incidence and severity of CSWS is not well studied in pediatric neurosurgical patients. We hypothesized that CSWS occurs frequently in post-operative brain tumor patients and is an important cause of post-operative hyponatremia in these patients. Methods We designed a single institution retrospective cohort study of all pediatric brain tumor patients undergoing craniotomy for tumor resection at our institution between January 2005 and December 2009. Results Of the 282 patients undergoing 291 operations, post-operative CSWS was identified in 15 cases (5%), and was more frequently observed than SIADH (nine cases, 3%). Median onset of CSWS was on post-operative day 3, lasting a median of 2.5 days. Patients with CSWS were more likely to have suffered post-operative stroke (40 vs. 4.6%, P  

  • Cerebral salt wasting Syndrome in post-operative pediatric brain tumor patients.
    Neurocritical care, 2011
    Co-Authors: Douglas A. Hardesty, Todd J. Kilbaugh, Phillip B. Storm
    Abstract:

    Background Cerebral salt wasting Syndrome (CSWS) and the Syndrome of inappropriate antidiuretic hormone (SIADH) are both causes of hyponatremia in pediatric neurosurgical patients often with similar presenting symptoms; however, despite similar clinical characteristics the treatment for CSWS and SIADH can be drastically different, which makes the distinction critical for post-operative treatment. Further complicating matters, are the exact mechanism for CSWS which remains unclear, and the incidence and severity of CSWS is not well studied in pediatric neurosurgical patients. We hypothesized that CSWS occurs frequently in post-operative brain tumor patients and is an important cause of post-operative hyponatremia in these patients.

I. Runkle - One of the best experts on this subject based on the ideXlab platform.

  • Prolonged coexistent central diabetes insipidus and Cerebral salt wasting Syndrome following neurosurgery
    Open Journal of Pediatrics, 2013
    Co-Authors: D. López De Lara, B. Joyanes, A. Llaneza, O. Pérez, B. Llorente, I. Runkle
    Abstract:

    The coexistence of different water homeostasis abnormalities following neurosurgery represents a diagnostic and therapeutic challenge for intensive care units. This paper reports the case of a 13 year-old boy who underwent surgery for a suprasellar tumour and, immediately after surgery, developed a Cerebral abscess, persistent diabetes insipidus (DI) as well as Cerebral salt wasting Syndrome (CSWS). The early onset of CSWS following DI has been associated with a poor prognosis and increased mortality. In cases in which these abnormalities coexist, the increased polyuria secondary to the rise in natriuresis associated with CSWS might be erroneously interpreted as a sign of poor control of the DI, thereby leading to therapeutic mistakes. Treatment basically consists of restoring electrolytes and the joint administration of desmopressin and fludrocortisone.

  • Prolonged coexistent central diabetes insipidus and Cerebral salt wasting Syndrome following neurosurgery
    2013
    Co-Authors: López D. De Lara, B. Joyanes, A. Llaneza, O. Pérez, B. Llorente, I. Runkle
    Abstract:

    Copyright © 2013 D. López de Lara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The coexistence of different water homeostasis ab-normalities following neurosurgery represents a di-agnostic and therapeutic challenge for intensive care units. This paper reports the case of a 13 year-old boy who underwent surgery for a suprasellar tumour and, immediately after surgery, developed a Cerebral ab-scess, persistent diabetes insipidus (DI) as well as Cerebral salt wasting Syndrome (CSWS). The early onset of CSWS following DI has been associated with a poor prognosis and increased mortality. In cases in which these abnormalities coexist, the increased poly-uria secondary to the rise in natriuresis associated with CSWS might be erroneously interpreted as a sign of poor control of the DI, thereby leading to therapeutic mistakes. Treatment basically consists of restoring electrolytes and the joint administration of desmopressin and fludrocortisone

Liangfu Zhou - One of the best experts on this subject based on the ideXlab platform.

  • Diagnosis and Management of Combined Central Diabetes Insipidus and Cerebral Salt Wasting Syndrome After Traumatic Brain Injury.
    World neurosurgery, 2015
    Co-Authors: Xiaolan Zhou, Liang Gao, Ying Mao, Li Fei, Liangfu Zhou
    Abstract:

    Background Combined central diabetes insipidus and Cerebral salt wasting Syndrome after traumatic brain injury (TBI) is rare, is characterized by massive polyuria leading to severe water and electrolyte disturbances, and usually is associated with very high mortality mainly as a result of delayed diagnosis and improper management. Methods We retrospectively reviewed the clinical presentation, management, and outcomes of 11 patients who developed combined central diabetes insipidus and Cerebral salt wasting Syndrome after traumatic brain injury to define distinctive features for timely diagnosis and proper management. Results The most typical clinical presentation was massive polyuria (10,000 mL/24 hours or >1000 mL/hour) refractory to vasopressin alone but responsive to vasopressin plus cortisone acetate. Other characteristic presentations included low central venous pressure, high brain natriuretic peptide precursor level without cardiac dysfunction, high 24-hour urine sodium excretion and hypovolemia, and much higher urine than serum osmolarity; normal serum sodium level and urine specific gravity can also be present. Timely and adequate infusion of sodium chloride was key in treatment. Of 11 patients, 5 had a good prognosis 3 months later (Extended Glasgow Outcome Scale score ≥6), 1 had an Extended Glasgow Outcome Scale score of 4, 2 died in the hospital of brain hernia, and 3 developed a vegetative state. Conclusions For combined diabetes insipidus and Cerebral salt wasting Syndrome after traumatic brain injury, massive polyuria is a major typical presentation, and intensive monitoring of fluid and sodium status is key for timely diagnosis. To achieve a favorable outcome, proper sodium chloride supplementation and cortisone acetate and vasopressin coadministration are key.

  • Combined central diabetes insipidus and Cerebral salt wasting Syndrome after traumatic brain injury
    Chinese Journal of Neurosurgery, 2011
    Co-Authors: Liang Gao, Li-qin Lang, Yi Jin, Ying Mao, Liangfu Zhou
    Abstract:

    Objective To discuss the diagnosis coexistence of central diabetes insipidus and Cerebral salt wasting Syndrome promptly and treat properly.Method Six patients who suffered central diabetes insipidus combined Cerebral salt wasting Syndrome were analyzed retrospectively.Its characteristics was massive polyuria which can not be controlled by vasopressin alone,but can be controlled by both vasopresin and cortisone acetate.Sodium chloride saline were mainly used to make up for the loss of water and salt.Other charactefistcs were including low CVP,high Pro - BNP,high 24 h urine sodium evacuation with normal serum sodium level,higher osmolarity in urine than in serum which was at normal level,and usually normal urine specific gravity.Results One died and one became vegetative state,other four patients discharged with Glasgow Coma Scale 15.Conclusions Monitoring of water and sodium metabolism systemically were critical to diagnose the concurrent DI and CSW.Slow sodium chloride saline supplement,cortisone acetate and desmopressin were the keys to deal with concurrent DI and CSW.With exact diagnosis and treatment promptly,favourable outcome can be achieved. Key words: Craniocerbral trauma;  Diabetes insipidus;  Cerebral salt wasting Syndrome

F Villamil - One of the best experts on this subject based on the ideXlab platform.

  • Early hyponatraemia after pituitary surgery: Cerebral Salt-Wasting Syndrome.
    European journal of endocrinology, 2007
    Co-Authors: R Guerrero, A Pumar, Alfonso Soto, M A Pomares, S Palma, M A Mangas, A Leal, F Villamil
    Abstract:

    Hyponatraemia is a common complication in patients undergoing neurosurgery. It can be caused either by the Syndrome of inappropriate secretion of antidiuretic hormone or by the Cerebral Salt-Wasting Syndrome (CSWS). CSWS frequently occurs in patients suffering from subarachnoid haemorrhage and brain injury, but it is rare after pituitary tumour surgery. However, this diagnostic possibility should be considered as these disorders require specific treatment and have different prognoses. In this article, we present a case of acute and early hyponatraemia caused by CSWS after pituitary tumour surgery. We also revise the aetiology, mechanisms, differential diagnosis and treatment of hyponatraemia after pituitary surgery.