The Experts below are selected from a list of 216 Experts worldwide ranked by ideXlab platform

Masahiro Takigawa - One of the best experts on this subject based on the ideXlab platform.

  • CD7-positive Sézary syndrome with a Th1 cytokine profile.
    Journal of the American Academy of Dermatology, 1996
    Co-Authors: Hiroaki Yagi, Yoshiki Tokura, Fukumi Furukawa, Masahiro Takigawa
    Abstract:

    Sézary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with Cerebriform Nuclei in the peripheral blood. Recent observations have suggested that Sézary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sézary cells. We describe a case of Sézary syndrome in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor V alpha 2V beta 17, indicative of the expression of CD7 in the Sézary cells. Although the circulating Sézary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skin-infiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a V beta 17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-alpha, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sézary syndrome with a cytokine profile characteristic of Th1 cells.

  • CD7-positive Sezary syndrome with a TH1 cytokine profile
    Journal of Dermatological Science, 1994
    Co-Authors: Hiroaki Yagi, Yoshiki Tokura, Fukumi Furukawa, Masahiro Takigawa
    Abstract:

    Sezary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with Cerebriform Nuclei in the peripheral blood. Recent observations have suggested that Sezary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sezary cells. We describe a case of Sezary syndroem in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor Vα2Vβ17, indicative of the expression of CD7 as well as a homogeneous Although the circulating Sezary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skininfiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a Vβ17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-α, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sezary syndrome with a cytokine profile characteristic of Th1 cells.

Hiroaki Yagi - One of the best experts on this subject based on the ideXlab platform.

  • CD7-positive Sézary syndrome with a Th1 cytokine profile.
    Journal of the American Academy of Dermatology, 1996
    Co-Authors: Hiroaki Yagi, Yoshiki Tokura, Fukumi Furukawa, Masahiro Takigawa
    Abstract:

    Sézary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with Cerebriform Nuclei in the peripheral blood. Recent observations have suggested that Sézary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sézary cells. We describe a case of Sézary syndrome in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor V alpha 2V beta 17, indicative of the expression of CD7 in the Sézary cells. Although the circulating Sézary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skin-infiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a V beta 17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-alpha, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sézary syndrome with a cytokine profile characteristic of Th1 cells.

  • CD7-positive Sezary syndrome with a TH1 cytokine profile
    Journal of Dermatological Science, 1994
    Co-Authors: Hiroaki Yagi, Yoshiki Tokura, Fukumi Furukawa, Masahiro Takigawa
    Abstract:

    Sezary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with Cerebriform Nuclei in the peripheral blood. Recent observations have suggested that Sezary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sezary cells. We describe a case of Sezary syndroem in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor Vα2Vβ17, indicative of the expression of CD7 as well as a homogeneous Although the circulating Sezary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skininfiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a Vβ17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-α, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sezary syndrome with a cytokine profile characteristic of Th1 cells.

Daniel Catovsky - One of the best experts on this subject based on the ideXlab platform.

  • Relationship of T leukaemias with Cerebriform Nuclei to T-prolymphocytic leukaemia: a cytogenetic analysis with in situ hybridization
    British journal of haematology, 1997
    Co-Authors: Vasantha Brito-babapulle, S. Hoda Maljaie, Estella Matutes, Michael Hedges, Martin R. Yuille, Daniel Catovsky
    Abstract:

    Sezary cell leukaemia (SCL) is a mature T-cell leukaemia with characteristic Cerebriform Nuclei, whereas Sezary syndrome (SS) involves a mature T-cell lymphoma with a similar nuclear morphology. We have examined these diseases by cytogenetics chromosome painting and fluorescence in situ hybridization (FISH). Both diseases had complex cytogenetic abnormalities. All three cases of SCL investigated had inv(14)(q11:q32) and two had iso(8q). No case of SS had these abnormalities but, instead, iso(17q) or 17p+ was present in the three cases of SS investigated and FISH indicated loss of heterozygosity due to deletion of a region at 17p 13 that included the tumour suppressor gene P53, implicating it in this malignancy. One case of SCL had iso(17q). The abnormalities of chromosomes 8 and 14 in SCL are commonly observed in T-prolymphocytic leukaemia (T-PLL) and suggest that SCL may be a variant of T-PLL rather than of SS.

Chou-zen Giam - One of the best experts on this subject based on the ideXlab platform.

  • Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis
    Journal of virology, 2002
    Co-Authors: Min-hui Liang, Thomas W. Geisbert, Yao Yao, Steven H. Hinrichs, Chou-zen Giam
    Abstract:

    Human T-lymphotropic virus type 1 (HTLV-1) Tax exerts pleiotropic effects on multiple cellular regulatory processes to bring about NF-κB activation, aberrant cell cycle progression, and cell transformation. Here we report that Tax stimulates cellular G1/S entry but blocks mitosis. Tax expression in naive cells transduced with a retroviral vector, pBabe-Tax, leads to a significant increase in the number of cells in the S phase, with an accompanying rise in the population of cells with a DNA content of 4N or more. In all cell types tested, including BHK-21, mouse NIH 3T3, and human diploid fibroblast WI-38, Tax causes an uncoupling of DNA synthesis from cell division, resulting in the formation of multinucleated giant cells and cells with decondensed, highly convoluted and lobulated Nuclei that are reminiscent of the large lymphocytes with cleaved or Cerebriform Nuclei seen in HTLV-1-positive individuals. This contrasts with the Tax-transformed cell lines, PX1 (fibroblast) and MT4 (lymphocyte), which produce Tax at high levels, but without the accompanying late-stage cell cycle abnormalities. PX1 and MT4 may have been selected to harbor somatic mutations that allow a bypass of the Tax-induced block in mitosis.

Fukumi Furukawa - One of the best experts on this subject based on the ideXlab platform.

  • CD7-positive Sézary syndrome with a Th1 cytokine profile.
    Journal of the American Academy of Dermatology, 1996
    Co-Authors: Hiroaki Yagi, Yoshiki Tokura, Fukumi Furukawa, Masahiro Takigawa
    Abstract:

    Sézary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with Cerebriform Nuclei in the peripheral blood. Recent observations have suggested that Sézary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sézary cells. We describe a case of Sézary syndrome in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor V alpha 2V beta 17, indicative of the expression of CD7 in the Sézary cells. Although the circulating Sézary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skin-infiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a V beta 17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-alpha, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sézary syndrome with a cytokine profile characteristic of Th1 cells.

  • CD7-positive Sezary syndrome with a TH1 cytokine profile
    Journal of Dermatological Science, 1994
    Co-Authors: Hiroaki Yagi, Yoshiki Tokura, Fukumi Furukawa, Masahiro Takigawa
    Abstract:

    Sezary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with Cerebriform Nuclei in the peripheral blood. Recent observations have suggested that Sezary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sezary cells. We describe a case of Sezary syndroem in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor Vα2Vβ17, indicative of the expression of CD7 as well as a homogeneous Although the circulating Sezary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skininfiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a Vβ17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-α, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sezary syndrome with a cytokine profile characteristic of Th1 cells.