The Experts below are selected from a list of 885 Experts worldwide ranked by ideXlab platform

Steven Rogers - One of the best experts on this subject based on the ideXlab platform.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced map kinase nf kb mediated severe sepsis
    Data in Brief, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Jane Y, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in Caenorhabditis elegans
    Sage Open Medicine, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Kun He, Tolou Shokuhfar, Eric R Blough
    Abstract:

    OBJECTIVE: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO2) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17-17.21 µg/mL) of aggregated CeO2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans. METHODS: Caenorhabditis elegans were exposed to different concentrations of CeO2 Nanoparticles and evaluated. RESULTS: Our findings demonstrate that chronic exposure of CeO2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans, but not mortality. Conversely, CeO2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. CONCLUSION: The data obtained from this study reveal the sublethal toxic effects of CeO2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO2 may affect the environment.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
    Elsevier, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in
    SAGE Publishing, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Tolou Shokuhfar, Eric R Blough
    Abstract:

    Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO 2 ) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17–17.21 µg/mL) of aggregated CeO 2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans . Methods: Caenorhabditis elegans were exposed to different concentrations of CeO 2 Nanoparticles and evaluated. Results: Our findings demonstrate that chronic exposure of CeO 2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans , but not mortality. Conversely, CeO 2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. Conclusion: The data obtained from this study reveal the sublethal toxic effects of CeO 2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO 2 may affect the environment

Tolou Shokuhfar - One of the best experts on this subject based on the ideXlab platform.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced map kinase nf kb mediated severe sepsis
    Data in Brief, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Jane Y, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in Caenorhabditis elegans
    Sage Open Medicine, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Kun He, Tolou Shokuhfar, Eric R Blough
    Abstract:

    OBJECTIVE: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO2) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17-17.21 µg/mL) of aggregated CeO2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans. METHODS: Caenorhabditis elegans were exposed to different concentrations of CeO2 Nanoparticles and evaluated. RESULTS: Our findings demonstrate that chronic exposure of CeO2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans, but not mortality. Conversely, CeO2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. CONCLUSION: The data obtained from this study reveal the sublethal toxic effects of CeO2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO2 may affect the environment.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
    Elsevier, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in
    SAGE Publishing, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Tolou Shokuhfar, Eric R Blough
    Abstract:

    Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO 2 ) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17–17.21 µg/mL) of aggregated CeO 2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans . Methods: Caenorhabditis elegans were exposed to different concentrations of CeO 2 Nanoparticles and evaluated. Results: Our findings demonstrate that chronic exposure of CeO 2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans , but not mortality. Conversely, CeO 2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. Conclusion: The data obtained from this study reveal the sublethal toxic effects of CeO 2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO 2 may affect the environment

Vellaisamy Selvaraj - One of the best experts on this subject based on the ideXlab platform.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced map kinase nf kb mediated severe sepsis
    Data in Brief, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Jane Y, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in Caenorhabditis elegans
    Sage Open Medicine, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Kun He, Tolou Shokuhfar, Eric R Blough
    Abstract:

    OBJECTIVE: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO2) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17-17.21 µg/mL) of aggregated CeO2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans. METHODS: Caenorhabditis elegans were exposed to different concentrations of CeO2 Nanoparticles and evaluated. RESULTS: Our findings demonstrate that chronic exposure of CeO2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans, but not mortality. Conversely, CeO2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. CONCLUSION: The data obtained from this study reveal the sublethal toxic effects of CeO2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO2 may affect the environment.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
    Elsevier, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in
    SAGE Publishing, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Tolou Shokuhfar, Eric R Blough
    Abstract:

    Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO 2 ) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17–17.21 µg/mL) of aggregated CeO 2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans . Methods: Caenorhabditis elegans were exposed to different concentrations of CeO 2 Nanoparticles and evaluated. Results: Our findings demonstrate that chronic exposure of CeO 2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans , but not mortality. Conversely, CeO 2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. Conclusion: The data obtained from this study reveal the sublethal toxic effects of CeO 2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO 2 may affect the environment

Kevin M Rice - One of the best experts on this subject based on the ideXlab platform.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced map kinase nf kb mediated severe sepsis
    Data in Brief, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Jane Y, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in Caenorhabditis elegans
    Sage Open Medicine, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Kun He, Tolou Shokuhfar, Eric R Blough
    Abstract:

    OBJECTIVE: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO2) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17-17.21 µg/mL) of aggregated CeO2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans. METHODS: Caenorhabditis elegans were exposed to different concentrations of CeO2 Nanoparticles and evaluated. RESULTS: Our findings demonstrate that chronic exposure of CeO2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans, but not mortality. Conversely, CeO2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. CONCLUSION: The data obtained from this study reveal the sublethal toxic effects of CeO2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO2 may affect the environment.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
    Elsevier, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in
    SAGE Publishing, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Tolou Shokuhfar, Eric R Blough
    Abstract:

    Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO 2 ) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17–17.21 µg/mL) of aggregated CeO 2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans . Methods: Caenorhabditis elegans were exposed to different concentrations of CeO 2 Nanoparticles and evaluated. Results: Our findings demonstrate that chronic exposure of CeO 2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans , but not mortality. Conversely, CeO 2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. Conclusion: The data obtained from this study reveal the sublethal toxic effects of CeO 2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO 2 may affect the environment

Nandini D P K Manne - One of the best experts on this subject based on the ideXlab platform.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced map kinase nf kb mediated severe sepsis
    Data in Brief, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Jane Y, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in Caenorhabditis elegans
    Sage Open Medicine, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Kun He, Tolou Shokuhfar, Eric R Blough
    Abstract:

    OBJECTIVE: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO2) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17-17.21 µg/mL) of aggregated CeO2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans. METHODS: Caenorhabditis elegans were exposed to different concentrations of CeO2 Nanoparticles and evaluated. RESULTS: Our findings demonstrate that chronic exposure of CeO2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans, but not mortality. Conversely, CeO2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. CONCLUSION: The data obtained from this study reveal the sublethal toxic effects of CeO2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO2 may affect the environment.

  • Cerium Oxide Nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
    Elsevier, 2015
    Co-Authors: Vellaisamy Selvaraj, Steven Rogers, Kevin M Rice, Nandini D P K Manne, Niraj Nepal, Ravikumar Arvapalli, Shinichi Asano, Erin Fankenhanel, Tolou Shokuhfar
    Abstract:

    The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by Cerium Oxide Nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of Cerium Oxide Nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of Cerium Oxide Nanoparticle demonstrate that concentration of Cerium Oxide Nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay

  • Cerium Oxide Nanoparticle aggregates affect stress response and function in
    SAGE Publishing, 2015
    Co-Authors: Steven Rogers, Vellaisamy Selvaraj, Kevin M Rice, Nandini D P K Manne, Tolou Shokuhfar, Eric R Blough
    Abstract:

    Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of Nanoparticles on the environmental and human health. Recent studies suggest that Cerium Oxide (CeO 2 ) Nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17–17.21 µg/mL) of aggregated CeO 2 Nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans . Methods: Caenorhabditis elegans were exposed to different concentrations of CeO 2 Nanoparticles and evaluated. Results: Our findings demonstrate that chronic exposure of CeO 2 Nanoparticle aggregates is associated with increased levels of reactive oxygen species and heat shock stress response (HSP-4) in Caenorhabditis elegans , but not mortality. Conversely, CeO 2 aggregates promoted strain-dependent decreases in animal fertility, a decline in stress resistance as measured by thermotolerance, and shortened worm length. Conclusion: The data obtained from this study reveal the sublethal toxic effects of CeO 2 Nanoparticle aggregates in Caenorhabditis elegans and contribute to our understanding of how exposure to CeO 2 may affect the environment