The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform

G M Eccleston - One of the best experts on this subject based on the ideXlab platform.

  • thermal investigation into the interaction of Cetostearyl Alcohol and a Cetostearyl Alcohol sodium lauryl sulphate mixed emulsifier with liquid paraffin
    Journal of Pharmacy and Pharmacology, 2008
    Co-Authors: J J Rouse, J H Kim, M J Lawrence, G M Eccleston
    Abstract:

    In previous work, mobile nanoemulsions were prepared by the ultrasonication of liquid paraffin (LP) in water macroemulsions containing the mixed emulsifier (ME) sodium lauryl sulphate (SLS) and Cetostearyl Alcohol (CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when the ME interacts with water (ternary system), were not present in freshly prepared nanoemulsions. In these systems, the endotherm associated with the lamellar phase was absent and replaced by a prominent, broad unidentified endotherm between 50 and 60C. The aim of this work was to identify the nature of this endotherm to gain a better understanding of nanoemulsion microstructure. To this end, the interactions of the ME and its components in oil were investigated.

J J Rouse - One of the best experts on this subject based on the ideXlab platform.

  • thermal investigation into the interaction of Cetostearyl Alcohol and a Cetostearyl Alcohol sodium lauryl sulphate mixed emulsifier with liquid paraffin
    Journal of Pharmacy and Pharmacology, 2008
    Co-Authors: J J Rouse, J H Kim, M J Lawrence, G M Eccleston
    Abstract:

    In previous work, mobile nanoemulsions were prepared by the ultrasonication of liquid paraffin (LP) in water macroemulsions containing the mixed emulsifier (ME) sodium lauryl sulphate (SLS) and Cetostearyl Alcohol (CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when the ME interacts with water (ternary system), were not present in freshly prepared nanoemulsions. In these systems, the endotherm associated with the lamellar phase was absent and replaced by a prominent, broad unidentified endotherm between 50 and 60C. The aim of this work was to identify the nature of this endotherm to gain a better understanding of nanoemulsion microstructure. To this end, the interactions of the ME and its components in oil were investigated.

M J Lawrence - One of the best experts on this subject based on the ideXlab platform.

  • thermal investigation into the interaction of Cetostearyl Alcohol and a Cetostearyl Alcohol sodium lauryl sulphate mixed emulsifier with liquid paraffin
    Journal of Pharmacy and Pharmacology, 2008
    Co-Authors: J J Rouse, J H Kim, M J Lawrence, G M Eccleston
    Abstract:

    In previous work, mobile nanoemulsions were prepared by the ultrasonication of liquid paraffin (LP) in water macroemulsions containing the mixed emulsifier (ME) sodium lauryl sulphate (SLS) and Cetostearyl Alcohol (CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when the ME interacts with water (ternary system), were not present in freshly prepared nanoemulsions. In these systems, the endotherm associated with the lamellar phase was absent and replaced by a prominent, broad unidentified endotherm between 50 and 60C. The aim of this work was to identify the nature of this endotherm to gain a better understanding of nanoemulsion microstructure. To this end, the interactions of the ME and its components in oil were investigated.

J H Kim - One of the best experts on this subject based on the ideXlab platform.

  • thermal investigation into the interaction of Cetostearyl Alcohol and a Cetostearyl Alcohol sodium lauryl sulphate mixed emulsifier with liquid paraffin
    Journal of Pharmacy and Pharmacology, 2008
    Co-Authors: J J Rouse, J H Kim, M J Lawrence, G M Eccleston
    Abstract:

    In previous work, mobile nanoemulsions were prepared by the ultrasonication of liquid paraffin (LP) in water macroemulsions containing the mixed emulsifier (ME) sodium lauryl sulphate (SLS) and Cetostearyl Alcohol (CSA; Kim et al 2007). It was shown that the lamellar gel networks, formed when the ME interacts with water (ternary system), were not present in freshly prepared nanoemulsions. In these systems, the endotherm associated with the lamellar phase was absent and replaced by a prominent, broad unidentified endotherm between 50 and 60C. The aim of this work was to identify the nature of this endotherm to gain a better understanding of nanoemulsion microstructure. To this end, the interactions of the ME and its components in oil were investigated.

Tamer Guneri - One of the best experts on this subject based on the ideXlab platform.

  • extended release lipophilic indomethacin microspheres formulation factors and mathematical equations fitted drug release rates
    European Journal of Pharmaceutical Sciences, 2003
    Co-Authors: Ercument Karasulu, Yesim H Karasulu, Gokhan Ertan, Levent Kirilmaz, Tamer Guneri
    Abstract:

    Abstract Extended release liphophilic microspheres of indomethacin were prepared using Cetostearyl Alcohol (CsA), stearyl Alcohol (SA) and cetyl Alcohol (CA) in the various drug–lipid ratios. The release of indometacin was studied on the basis of USP criteria and the effects of drug–lipid ratio, the size of microspheres and carboxymethylcellulose sodium (CMC-Na) added as a hydrophilic polymer on the drug release were investigated. In vitro dissolution studies were performed using USP XXIII apparatus I at pH 6.2. Release profiles were evaluated according to first order, Higuchi square root of time and Hixson-Crowell cube root models. The best fit was found with the square root of time model (r2=0.991) for the microspheres (125–250 μm) prepared in 1:4:1 drug–lipid–copolymer ratio using stearyl Alcohol. With a further regression analysis, an excellent equation ( Release %=−10.721+42.549* t −4.027*t ) was developed for empirical drug estimation (r2=0.998).