The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform
A M Lenno - One of the best experts on this subject based on the ideXlab platform.
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Chelating Agents in root canal treatment mode of action and indications for their use
International Endodontic Journal, 2003Co-Authors: Michael Hulsma, M Heckendorff, A M LennoAbstract:Chelating Agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Ostby. A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability. Although the efficacy of EDTA preparations in softening root dentine has been debated, chelator preparations have regained popularity recently. Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 15-17% EDTA solutions to dissolve the smear layer is recommended in many textbooks. This paper reviews the relevant literature on Chelating Agents, presents an overview of the chemical and pharmacological properties of EDTA preparations and makes recommendations for their clinical use.
Mark M. Jones - One of the best experts on this subject based on the ideXlab platform.
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The Design of Therapeutic Chelating Agents
Journal of Coordination Chemistry, 1991Co-Authors: Mark M. JonesAbstract:Abstract The factors involved in the design of therapeutic Chelating Agents are outlined on the basis of the theoretical analyses of ligand design and experimental data obtained in animal studies. The starting point in such design must always be those factors which assure that a sufficiently high stability constant be achieved, and here the analyses presented by Martell and his co-workers furnish a general approach. If the removal of intracellular metal deposits is to be achieved, additional factors need to be considered to incorporate variables which govern the interaction of the Chelating agent with the membrane systems of those organs within which the toxic metal is concentrated. For these, the QSAR (quantitative structure activity relationship) procedure of Hansch furnishes a useful guide. This allows the development of direct structure-efficacy correlations (DSEC) involving molecular parameters in addition to those which are directly involved in the determination of the stability constant. In several...
Michael Hulsma - One of the best experts on this subject based on the ideXlab platform.
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Chelating Agents in root canal treatment mode of action and indications for their use
International Endodontic Journal, 2003Co-Authors: Michael Hulsma, M Heckendorff, A M LennoAbstract:Chelating Agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Ostby. A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability. Although the efficacy of EDTA preparations in softening root dentine has been debated, chelator preparations have regained popularity recently. Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 15-17% EDTA solutions to dissolve the smear layer is recommended in many textbooks. This paper reviews the relevant literature on Chelating Agents, presents an overview of the chemical and pharmacological properties of EDTA preparations and makes recommendations for their clinical use.
M Heckendorff - One of the best experts on this subject based on the ideXlab platform.
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Chelating Agents in root canal treatment mode of action and indications for their use
International Endodontic Journal, 2003Co-Authors: Michael Hulsma, M Heckendorff, A M LennoAbstract:Chelating Agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Ostby. A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability. Although the efficacy of EDTA preparations in softening root dentine has been debated, chelator preparations have regained popularity recently. Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 15-17% EDTA solutions to dissolve the smear layer is recommended in many textbooks. This paper reviews the relevant literature on Chelating Agents, presents an overview of the chemical and pharmacological properties of EDTA preparations and makes recommendations for their clinical use.
Declan P. Bogan - One of the best experts on this subject based on the ideXlab platform.
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A Potentiometric Detection Technique for Chelating Agents after Separation by Capillary Zone Electrophoresis
Monatshefte für Chemie Chemical Monthly, 1998Co-Authors: Wolfgang Buchberger, Georg Niessner, Dietmar Aichhorn, Paul R Haddad, Declan P. BoganAbstract:Für die Bestimmung von Chelatbildnern wie Diethylentriaminpentaessigsäure wurde die Kombination der Kapillarzonenelektrophorese mit einer selektiven potentiometrischen Detektionstechnik untersucht. Der Detektor beinhaltet eine metallische Kupferelektrode mit einem Durchmesser von 100 μm, welche in einer end - capillary -Anordnung positioniert ist. Das Elektrodenpotential hängt von der Konzentration freier Kupferionen an der Elektrodenoberfläche ab und sinkt daher, wenn komplexierende Analyte die Elektrode passieren. In Verbindung mit einer UV-Detektion ist die simultane Erfassung von freien Liganden und deren Metallkomplexen möglich. The combination of capillary zone electrophoresis with potentiometric detection has been investigated for the determination of Chelating Agents such as diethylenetriaminepentaacetic acid. The detector consists of a metallic copper electrode with a diameter of 100 μm arranged in an end-capillary configuration. The electrode potential depends on the concentration of copper ions at the electrode surface and therefore decreases when Chelating Agents pass the electrode. In combination with UV detection, both free ligands and metal complexes could be detected.
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A Potentiometric Detection Technique for Chelating Agents after Separation by Capillary Zone Electrophoresis
Monatshefte Fur Chemie, 1998Co-Authors: Wolfgang Buchberger, Georg Niessner, Dietmar Aichhorn, Paul R Haddad, Declan P. BoganAbstract:The combination of capillary zone electrophoresis with potentiometric detection has been investigated for the determination of Chelating Agents such as diethylenetriaminepentaacetic acid. The detector consists of a metallic copper electrode with a diameter of 100 μm arranged in an end-capillary configuration. The electrode potential depends on the concentration of copper ions at the electrode surface and therefore decreases when Chelating Agents pass the electrode. In combination with UV detection, both free ligands and metal complexes could be detected.
